Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Mechanisms Linking Inflammation and Cancer (B6)

Organizer(s): Lisa M. Coussens, Frances R. Balkwill and Glenn Dranoff
February 10 - 15, 2007
Hilton Santa Fe/Historic Plaza · Santa Fe, New Mexico
Abstract Deadline: October 10, 2006
Late Abstract Deadline: November 9, 2006
Scholarship Deadline: October 10, 2006
Early Registration Deadline: December 11, 2006

Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2007 season.

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Summary of Meeting
Our appreciation of the complexity of tumor biology has led us from considering tumors as autonomous masses of mutant cells to an awareness of tumors as entities that can hijack and exploit various normal physiologic processes of the host. The frequent presence of inflammatory cell infiltrates and chemical mediators of inflammation in tumors has been recognized for over a century, although an understanding of their role during cancer development has been elusive. Leukocytic infiltrates and cytokine/chemokine networks in premalignant tissues and tumors can be distinct, depending upon the stage of malignant development and organ microenvironment. Current thinking is that activated immune cells provide both anti- and pro-tumorigenic signals, thus representing targets to be harnessed or attacked for therapeutic advantage depending upon environmental and/or cellular context. T lymphocytes are being exploited for their ability to induce tumor regression, as are strategies that disable innate immune cells or neutralize immunosuppressive or pro-inflammatory microenvironments. Such approaches may also provide clinical benefit for at-risk cancer patients and those with pre-malignant lesions. This meeting will link innate and adaptive immune regulatory mechanisms with cancer development and cancer treatment by focusing on relevant basic research, preclinical, translational and clinical studies.

Objectives
Upon completion of this conference, participants should be able to:

To demonstrate an understanding of how infection and inflammation potentiate cancer risk and ability to describe mechanistic roles for inflammation during the initiation and progression phases of cancer development.
To differentiate current strategies for modeling inflammation and cancer in vivo.
To summarize epidemeologic data indicating the chemopreventative potential of targeting inflammation for anti-cancer therapy.
To discuss therapeutic strategies to neutralize pro-tumor properties of innate immune cells and strategies to bolster anti-tumor properties of adaptive immune cells.

Saturday, February 10
3:00 - 7:30 PM	Registration	Promenade
6:30 - 7:30 PM	Refreshments	Promenade
7:30 - 8:30 PM	Keynote Session: Cancer as an Evolving Organ: A Central Role for Inflammation and the Microenviroment	Mesa A-B
	Zena Werb, University of California, San Francisco The Co-Evolution of Neoplastic Cells and Their Microenvironment During Tumor Progression

Sunday, February 11
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Infection, Persistent Inflammation and Epidemiology: Linking Inflammation and Cancer	Mesa A-B
	Martin J. Blaser, New York University School of Medicine Genomic Plasticity of Persistent Microbial Colonizers Affects Host Cell Phenotypes: A Model for Carcinogenesis
	* Richard M. Peek, Jr., Vanderbilt University Pathogenesis of H. pylori-Induced Carcinogenesis
	Hui Xiao, Cleveland Clinic Foundation Short Talk: The Regulatory Role of SIGIRR in Colonic Epithelial Homeostasis, Inflammation and Tumorigenesis

	Khashayarsha Khazaie, Northwestern University Short Talk: Inflammation is an Inherent and Essential Component of Colon Cancer.
	Mirna Perez-Moreno, Rockefeller University Links Between Cell Adhesion, Inflammation and Cancer

9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM - 1:00 PM	Poster Setup	Ortiz
1:00 - 10:00 PM	Poster Viewing	Ortiz
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:15 PM	INITIATION: Mechanisms Linking Inflammation and Cancer - A	Mesa A-B
	Anil K. Sood, University of Texas MD Anderson Cancer Center Influence of Biobehavioral Factors on Tumor Biology: Pathways and Mechanisms
	Sonia Vallet, Dana Farber Cancer Institute The Role of MIP1alpha/CCR1 in the Pathogenesis of Osteolytic Bone Lesions in Multiple Myeloma


	* Dafna Bar-Sagi, New York University School of Medicine Assessing the Link Between Chronic Pancreatitis and the Evolution of Pancreatic Cancer
	David H. Raulet, University of California, Berkeley Natural Killer Cells, DNA Damage and Cancer
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Ortiz/Chamisa
7:30 - 10:00 PM	Poster Session 1	Ortiz/Chamisa
Monday, February 12
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	PROMOTION: Mechanisms Linking Inflammation and Cancer - B	Mesa A-B
	* Alberto Mantovani, Istituto Clinico Humanitas Tumor-Associated Macrophages in Extrinsic and Intrinsic Pathways of Tumor Promotion
	Merav Darash-Yahana, NIAID, National Institutes of Health Short Talk: A Possible Role for the Transmembrane Chemokine CXCL16 in Inflammation-Associated Cancers
	Michael Karin, University of California, San Diego Crosstalk Between Inflammation Cells and Carcinomas
	Barrett J. Rollins, Dana Farber Cancer Institute Chemokines as Soluble Mediators
	Roberta B. Ness, University of Texas Inflammation and Ovarian Cancer: An Epidemiologist’s Perspective

9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM - 1:00 PM	Poster Setup	Ortiz
1:00 - 10:00 PM	Poster Viewing	Ortiz
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:15 PM	PROGRESSION: Mechanisms Linking Inflammation and Cancer	Mesa A-B
	* Lisa M. Coussens, University of California, San Francisco Inflammation, Proteolysis and Cancer Development
	Sung Hee Baek, Seoul National University Short Talk: Macrophage and Hormone-Dependent Cancer
	Jeffrey W. Pollard, Albert Einstein College of Medicine Macrophages: A Cellular Toolbox Used by Tumors to Promote Progression and Metastasis
	Dmitry I. Gabrilovich, University of South Florida Dendritic Cells Inflammation and Cancer
	Laura Soucek, University of California, San Francisco Short Talk: Mast Cells Are Required for Expansion of Myc-Dependent Tumors
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Ortiz/Chamisa
7:30 - 10:00 PM	Poster Session 2	Ortiz/Chamisa
Tuesday, February 13
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Balancing Pro- and Anti-Tumor Responses	Mesa A-B
	* Suzanne Ostrand-Rosenberg, University of Maryland Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression
	Martin Oft, Merck IL-23 Subverts Immunesurveilance and Promotes Tumor Growth
	Christoffer Gebhardt, German Cancer Research Center Short Talk: The Receptor for Advanced Glycation End-Products (RAGE) Drives Tumor Development by Sustaining Inflammation
	Randall S. Johnson, University of California, San Diego Inflammatory Cell Production of HIF1alpha and VEGF During Cancer Development
	Luigi M. Naldini, San Raffaele Telethon Institute Tie2-Expressing Monocytes: A Novel Lineage of Proangiogenic Cells
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM - 1:00 PM	Poster Setup	Ortiz
1:00 - 10:00 PM	Poster Viewing	Ortiz
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Immune Resistance and Cancer	Mesa A-B
	Mark J. Smyth, Peter MacCallum Cancer Centre Host Immune Resistance and Regulation in Cancer
	Susan E. Erdman, Massachusetts Institute of Technology Protective Role of Regulatory T Cells in Inhibiting Inflammation-Induced Cancer
	George C. Prendergast, Lankenau Institute for Medical Research Short Talk: BAR Adapters and IDO in Tumoral Immune Escape
	* Robert D. Schreiber, Washington University School of Medicine The Role of Immunity in Cancer Protection, Persistence and Progression
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Ortiz/Chamisa
7:30 - 10:00 PM	Poster Session 3	Ortiz/Chamisa
Wednesday, February 14
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Mechanisms-Based Therapies for Innate Responses	Mesa A-B
	Raymond N. DuBois, University of Texas MD Anderson Cancer Center Inflammation and Cancer: The PGE2—COX-2—Wnt Pathway

	* Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School Inflammation and Cancer: The TNF-alpha Connection
	Anuradha Budhu, National Cancer Institute, National Institutes of Health Short Talk: A Predominant Th2 Cytokine Profile in the Hepatic Microenvironment of Metastatic Hepatocellular Carcinoma Patients May be Promoted by Colony Stimulating Factor 1/osteopontin

	Olivera J. Finn, University of Pittsburgh School of Medicine MUC1, Inflammation and Cancer
	Claire E. Lewis, University of Sheffield Medical School Hypoxic Macrophages in Tumors: Targets and Vehicles for Anti-Cancer Therapy
9:20 - 9:40 AM	Coffee Break	Promenade
2:30 - 4:30 PM	Workshop: Lymphocyte Responses to Cancer	Mesa A-B
	* Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School
	* Glenn Dranoff, Dana-Farber Cancer Institute
	* Lisa M. Coussens, University of California, San Francisco
	Sharon S. Evans, Roswell Park Memorial Institute Role of Interleukin-6 Trans-Signaling in Overcoming Hurdles to T Lymphocyte Trafficking in the Tumor Microenvironment
	Jennifer K.L. Colby, University of Texas M.D. Anderson Cancer Center Science Park Inflammatory Cell Infiltrate and Tumor Immune Tolerance in the BK5.COX-2 Mouse Model of Pancreatitis and Pancreatic Tumorigenesis
	Michael Girardi, Yale University School of Medicine Characterizing Tumor-Promoting T Cells in Chemically-Induced Cutaneous Carcinogenesis
	Lillian Maggio-Price, University of Washington Helicobacter-Infected Smad3-Deficient Mice with Impaired TGF-beta Signaling: A Model to Study Inflammation Associated Colon Cancer
	Jacqueline S. Papkoff, JSP3 Consulting Discovery and Validation of a Promising New Target for Therapeutic Monoclonal Antibodies: The Immuno-Modulatory Protein B7-H4 is Overexpressed in Human Breast and Ovarian Cancers

4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Mechanisms-Based Therapies for Adaptive Responses	Mesa A-B

	Marcin T. Kortylewski, Beckman Research Institute, City of Hope Targeting Stat3 Enhances CpG Based Therapy
	James P. Allison, Memorial Sloan-Kettering Cancer Center Progress with CTLA4-based Strategies
	* Glenn Dranoff, Dana-Farber Cancer Institute The Interplay of Inflammation and Cancer. Meeting Summary
8:00 - 9:00 PM	Social Hour w/ Lite Bites	Mesa C
9:00 - 11:00 PM	Entertainment	Mesa C
Thursday, February 15
	Departure

*Session Chair †Speaker invited, not yet responded.