| Sunday, January 28 |
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3:00 - 7:30 PM
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Registration
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Longs Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 7:45 PM
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Welcoming Remarks
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David P. Bartel,
Massachusetts Institute of Technology
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John M. Maraganore,
Alnylam Pharmaceuticals Inc.
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Stephen H. Friend,
Sage Bionetworks
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7:30 - 10:00 PM
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Opening Session (Joint)
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Grays Peak/Longs Peak
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Victor R. Ambros,
University of Massachusetts
Functions of microRNAs in Animal Development
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Phillip A. Sharp,
Massachusetts Institute of Technology
RNA Biology
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Gregory J. Hannon,
Cold Spring Harbor Laboratory
Unexpected Complexity in Plant and Animal Small RNAs
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| Monday, January 29 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:30 AM
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RNAi for Target Validation: Technologies and Applications I
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Grays Peak
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Stephen W. Fesik,
Vanderbilt University School of Medicine
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Peter S. Linsley,
Regulus Therapeutics LLC
Insights into the Design of siRNAs for Increased Specificity and Potency
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Thijn Brummelkamp,
Whitehead Institute for Biomedical Research
Identification of Cancer Relevant Genes using RNAi Library Screens
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William S. Marshall,
miRagen Therapeutics
The Use of Synthetic siRNA Libraries for Target Validation
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Vivek Mittal,
Cold Spring Harbor Laboratory
Blocking Angiogenesis-Mediated Tumor Growth and Metastasis by RNAi in Mice
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Peng Jin,
Emory University School of Medicine
Short Talk: A Small Molecule Enhances RNA Interference and Promotes the Processing of microRNAs
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Christophe J. Echeverri,
Cenix BioScience GmbH
Short Talk: RNAi-based discovery and validation of novel anti-malarial lead compounds
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:45 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Shavano/Torreys
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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RNAi for Target Validation: Technologies and Applications II
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Grays Peak
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*
Peter S. Linsley,
Regulus Therapeutics LLC
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Stephen W. Fesik,
Vanderbilt University School of Medicine
Cancer Target Identification and Validation with RNAi
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Jonathan Hall,
Institute of Pharmaceutical Sciences
RNAi in Target Discovery and Validation
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Klaus Giese,
Silence Therapeutics AG
AtuPLEX a Novel RNAi-Based Delivery System for Cancer Therapies
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Jost Seibler,
TaconicArtemis
Short Talk: Reversible Gene Knockdown in Mice using a Tight, Inducible shRNA Expression System
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 1: RNAi Therapeutic Discovery and Development
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Shavano/Torreys
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| Tuesday, January 30 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:30 AM
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Therapeutic RNAi: Direct Delivery
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Grays Peak
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John J. Rossi,
Beckman Research Institute of the City of Hope
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Beverly L. Davidson,
University of Iowa
The use of Expression-based RNAi to Treat Neurological Disease
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Neil Aronin,
University of Massachusetts Medical School
Advances in the use of Synthetic siRNAs in the Treatment of Huntington's Disease Models
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Ralph A. Tripp,
University of Georgia
RNAi as a Therapeutic Strategy for the Treatment of Viral Respiratory Disease
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Josephine Lai,
University of Arizona
Treating Neuropathic Pain with RNA Interference
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Joerg F. Rippmann,
Boehringer Ingelheim Pharma GmbH & Co. KG
Short Talk: LXR Alpha Knock Down in an Obese Mouse Model Results in Improved Lipid Parameters but Organ Toxicity
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Xavier J. de Mollerat du Jeu,
Invitrogen
Short Talk: Targeting APP with Chemically Modified siRNA (stealthRNAi™) Ameliorates Alzheimer’s Disease Neuropathology in a Transgenic Mouse Model
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Daniel G. Anderson,
Massachusetts Institute of Technology
Short Talk: Combinatorial Libraries of Lipidoids for Systemic siRNA Delivery
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:30 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
|
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1:00 - 10:00 PM
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Poster Viewing
|
Shavano/Torreys
|
|
4:30 - 5:00 PM
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Coffee Available
|
Longs Peak Foyer
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5:00 - 7:00 PM
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Therapeutic RNAi: Systemic Delivery I
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Grays Peak
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*
Beverly L. Davidson,
University of Iowa
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Mark A. Kay,
Stanford University
Making Viruses to Attack Other Viruses
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John J. Rossi,
Beckman Research Institute of the City of Hope
RNAi Based Gene Therapy and the Treatment of HIV Infection
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Tracy Zimmermann,
Alnylam Pharmaceuticals Inc.
Achieving Therapeutic Gene Silencing in vivo with RNAi
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Matthew C. Catley,
UCB Celltech
Short Talk: Developing siRNA for Target Validation in the Rat lung: A Rational Approach
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 2: RNAi Toolkit: Sreening, Viral Vectors, and Delivery Technologies
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Shavano/Torreys
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| Wednesday, January 31 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:30 AM
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Posttrancriptional Silencing Mechanism II (Joint)
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Grays Peak/Longs Peak
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*
V. Narry Kim,
Seoul National University
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Phillip D. Zamore,
University of Massachusetts Medical School
RNAi and other Ancient Pathways
Programmed by Small RNA
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Thomas Tuschl,
Rockefeller University
Mechanisms of Small RNA Mediated Mammalian Gene Silencing
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Erik Sontheimer,
Northwestern University
Biochemical Analysis of RNAi
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Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research
Role of Dicer in RNAi/miRNA Pathways and Regulation of miRNA Repression in Mammalian Cells
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David P. Bartel,
Massachusetts Institute of Technology
MicroRNA Target Recognition
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
|
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11:30 AM - 1:00 PM
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Poster Setup
|
Shavano/Torreys
|
|
1:00 - 10:00 PM
|
Poster Viewing
|
Shavano/Torreys
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Longs Peak Foyer
|
|
5:00 - 7:00 PM
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Therapeutic RNAi: Systemic Delivery II
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Grays Peak
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*
Judy Lieberman,
Harvard Medical School
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Akshay Vaishnaw,
Alnylam Pharmaceuticals Inc.
Clinical Opportunities for RNAi Therapeutics
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Barry A. Polisky,
Sirna Therapeutics, Inc.
Advancing RNAi Drugs in the Clinic
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C. Frank Bennett,
ISIS Pharmaceuticals, Inc.
Oligonucleotide-Based Therapeutics: Oligonucleotides as Drugs
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Isidore Rigoutsos,
International Business Machines Corporation
Short Talk: Revisiting the Topics of MicroRNA Target Detection and MicroRNA Precursor Discovery
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 3: RNAi Biology: Mechanism of Action, Structure-Activity Relationship, and Other Topics
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Shavano/Torreys
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| Thursday, February 1 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:00 AM
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MicroRNAs in Development and Disease (Joint)
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Grays Peak/Longs Peak
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*
Phillip A. Sharp,
Massachusetts Institute of Technology
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Elisa Izaurralde,
MPI for Developmental Biology
Short Talk: Mechanisms of miRNA-Mediated Gene Silencing
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Carlo M. Croce,
Ohio State University
MicroRNAs in Cancer
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Ronald H. Plasterk,
Ministry of Education, Culture and Science
MicroRNAs in Animal Development
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Jan Krützfeldt,
ETH-Zurich
Therapeutic Strategies using the microRNA Pathway
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Anna M. Krichevsky,
Brigham and Women's Hospital, Harvard Medical School
MicroRNA in Brain and Brain Tumors
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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4:30 - 5:00 PM
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Coffee Available
|
Longs Peak Foyer
|
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5:00 - 7:00 PM
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Therapeutic RNAi: Delivery Technologies
|
Grays Peak
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*
C. Frank Bennett,
ISIS Pharmaceuticals, Inc.
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Judy Lieberman,
Harvard Medical School
Delivering RNA Interference: Appliations to Viral Infection and Cancer
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Dan McCallus,
Nucleonics
Gene-Expressed RNAi for Hepatitis B Virus
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Patrick Lu,
Intradigm Corporation
Nanoparticle Delivery of siRNA for Targeted Therapeutics
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Stephen Isaac Rudnick,
Fox Chase Cancer Center
Short Talk: Effects of Secondary Structure on Short Interfering RNA and Antisense Oligonucleotide Mediated mRNA Cleavage
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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8:00 - 11:00 PM
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Entertainment
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Shavano/Torreys
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| Friday, February 2 |
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Departure
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