| Sunday, January 28 |
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3:00 - 7:30 PM
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Registration
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Longs Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 7:45 PM
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Welcoming Remarks
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David P. Bartel,
Massachusetts Institute of Technology
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John M. Maraganore,
Alnylam Pharmaceuticals Inc.
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Stephen H. Friend,
Sage Bionetworks
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7:30 - 10:00 PM
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Opening Session (Joint)
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Grays Peak/Longs Peak
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Victor R. Ambros,
University of Massachusetts
Functions of microRNAs in Animal Development
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Phillip A. Sharp,
Massachusetts Institute of Technology
RNA Biology
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Gregory J. Hannon,
Cold Spring Harbor Laboratory
Unexpected Complexity in Plant and Animal Small RNAs
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| Monday, January 29 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:00 AM
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siRNAs and Chromatin Silencing
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Longs Peak
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James C. Carrington,
Oregon State University
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Marjori Ann Matzke,
Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences
RNA-Directed DNA Methylation: A Versatile Pathway for Transcriptional Gene Silencing
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Shiv I. S. Grewal,
NCI, National Institutes of Health
RNAi and Heterochromatin Assembly in S. pombe
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Steven E. Jacobsen,
HHMI/University of California, Los Angeles
RNAi-mediated Chromatin Silencing in Arabidopsis
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Martin A. Gorovsky,
University of Rochester
RNAi and Genome Rearrangements in Tetrahymena thermophila
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Elissa P. Lei,
NIDDK, National Institutes of Health
Short Talk: Identification of Small RNAs Associated with the Gypsy Chromatin Insulator
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:30 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Shavano/Torreys
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Endogenous siRNAs and Silencing II
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Longs Peak
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Marjori Ann Matzke,
Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences
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Andrew Fire,
Stanford University
Roles of RdRPs in Amplifying the RNAi Response and Distinct Modes of Primary and Secondary siRNA Biogenesis in C. elegans
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Sarah C.R. Elgin,
Washington University
Heterochromatin Formation and Gene Silencing in Drosophila Melanogaster
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Ramin Shiekhattar,
Wistar Institute
Biochemistry of RNAi Effector Complexes
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Christophe Antoniewski,
Institut Pasteur
Short Talk: Using Viral Suppressors of RNA Silencing to Explore the Diversity and Functions of Small RNAs in Drosophila
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 1
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Shavano/Torreys
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| Tuesday, January 30 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:30 AM
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MicroRNA Biogenesis and Function
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Longs Peak
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Thomas Tuschl,
Rockefeller University
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V. Narry Kim,
Seoul National University
Primary microRNA Processing: When Does It Take Place and How Are the Processing Factors Regulated?
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James C. Carrington,
Oregon State University
Small RNA-Directed Pathways in Plants
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Richard W. Carthew,
Northwestern University
MicroRNAs in Drosophila
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Olivier Voinnet,
Institut de Biologie Moléculaire des Plantes
Forward Genetic Approach of miRNA Biogenesis and Function in Arabidopsis
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Mikiko C. Siomi,
Keio University School of Medicine
Piwi Subfamily Proteins and their Associated Small RNAs in Drosophila Germlines
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Eric C. Lai,
Sloan-Kettering Institute
Short Talk: Drosophila miR-315 Regulates Wingless Signaling by Inhibiting Axin and Notum
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:30 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Shavano/Torreys
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2:30 - 4:30 PM
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Workshop 1: miRNA and piRNA Function
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Longs Peak
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Elisa Izaurralde,
MPI for Developmental Biology
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Antonio J. Giraldez,
Yale School of Medicine
Sex, Fish and MicroRNAs: the Regulation of the Germ Line
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Chang-Zheng Chen,
Stanford University
MiR-181a As a T Cell Sensitivity Rheostat
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Trinna Lee Cuellar,
Genentech
Development of a Mouse Model to Study Dicer Function in the Brain
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Anindya Dutta,
University of Virginia
Muscle-Differentiation-Induced MicroRNA miR-206 Promotes Muscle Differentiation and Cell Quiescence by Post-Transcriptional Degradation of Target by mRNAs.
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Sergey G. Shpiz,
Institute of Molecular Genetics
RNAi in the Functioning of Drosophila Telomeres
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Posttranscriptional Silencing Mechanism I
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Longs Peak
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Phillip D. Zamore,
University of Massachusetts Medical School
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Craig C. Mello,
University of Massachusetts Medical School
RNAi and Related Pathways in C. elegans
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David C. Baulcombe,
University of Cambridge
ARGONOMICS: The Roles of Argonaute Proteins in RNA Silencing
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Xuemei Chen,
University of California, Riverside
Role of Methlation in microRNA Metabolism in Plants
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Raul Andino,
University of California, San Francisco
Short Talk: Characterization of the Drosophila RNAi-based Antiviral Defense Mechanism
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 2
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Shavano/Torreys
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| Wednesday, January 31 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:30 AM
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Posttrancriptional Silencing Mechanism II (Joint)
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Grays Peak/Longs Peak
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V. Narry Kim,
Seoul National University
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Phillip D. Zamore,
University of Massachusetts Medical School
RNAi and other Ancient Pathways
Programmed by Small RNA
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Thomas Tuschl,
Rockefeller University
Mechanisms of Small RNA Mediated Mammalian Gene Silencing
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Erik Sontheimer,
Northwestern University
Biochemical Analysis of RNAi
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Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research
Role of Dicer in RNAi/miRNA Pathways and Regulation of miRNA Repression in Mammalian Cells
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David P. Bartel,
Massachusetts Institute of Technology
MicroRNA Target Recognition
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:30 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Shavano/Torreys
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Structural Biology of RNAi Machinery
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Longs Peak
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Xuemei Chen,
University of California, Riverside
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Dinshaw J. Patel,
Memorial Sloan-Kettering Cancer Center
Structural Biology of RNA Silencing
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Marianthi Kiriakidou,
University of Pennsylvania School of Medicine
Short Talk: An mRNA m7G cap Binding Motif within Human Argonaute2 Represses Translation
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Javier A. Martinez†,
Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Short Talk: hClp1 is a Novel Human RNA-Kinase that Phosphorylates siRNAs and 3' exons during tRNA Splicing
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Renée Schroeder,
Max F. Perutz Laboratories, University of Vienna
Short Talk: Mechanism of Risc-Mediated RNA Recognition and Cleavage is Revealed by Target RNA Requirements
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Chris Burge,
Massachusetts Institute of Technology
Short Talk: Determinants of Targeting by Endogenous and Exogenous MicroRNAs
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 3
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Shavano/Torreys
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| Thursday, February 1 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:00 AM
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MicroRNAs in Development and Disease (Joint)
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Grays Peak/Longs Peak
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Phillip A. Sharp,
Massachusetts Institute of Technology
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Elisa Izaurralde,
MPI for Developmental Biology
Short Talk: Mechanisms of miRNA-Mediated Gene Silencing
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Carlo M. Croce,
Ohio State University
MicroRNAs in Cancer
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Ronald H. Plasterk,
Ministry of Education, Culture and Science
MicroRNAs in Animal Development
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Jan Krützfeldt,
ETH-Zurich
Therapeutic Strategies using the microRNA Pathway
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Anna M. Krichevsky,
Brigham and Women's Hospital, Harvard Medical School
MicroRNA in Brain and Brain Tumors
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Silencing RNAs in Genetic Pathways
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Longs Peak
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Craig C. Mello,
University of Massachusetts Medical School
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Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine
Natural Selection on microRNA Targets, and Some Other Stories
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Jian-Kang Zhu,
University of California, Riverside
Stress Regulated Small RNAs and DNA Demethylation in Plants
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Kathryn Nicole Ivey,
J. David Gladstone Institutes
Short Talk: MicroRNAs Regulate Cardiomyocyte Differentiation from Embryonic Stem Cells
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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8:00 - 11:00 PM
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Entertainment
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Shavano/Torreys
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| Friday, February 2 |
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Departure
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