Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Metabolic Syndrome and Cardiovascular Risk (Z2)

Organizer(s): Bart Staels, Jean E. Schaffer and Juleen R. Zierath
March 27 - April 1, 2007
Sheraton Steamboat Resort · Steamboat Springs, Colorado
Abstract Deadline: November 27, 2006
Late Abstract Deadline: December 28, 2006
Scholarship Deadline: November 27, 2006
Early Registration Deadline: January 29, 2007

Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Nuclear Receptor Pathways to Metabolic Regulation (Z1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2007 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The metabolic syndrome is a complex entity of metabolic disorders clustering around acquired visceral obesity. These metabolic abnormalities include alterations in glucose homeostasis associated with insulin resistance, atherogenic dyslipidemia, coagulation disturbances and, in many cases, hypertension. Metabolic syndrome patients are at high risk to develop type 2 diabetes and most often die from cardiovascular diseases. Already identified in the early 1950’s and formally presented as syndrome X in the 1980’s, the metabolic syndrome is achieving epidemic proportions in the 21st century, due to global changes in life-style. In this meeting, the most recent conceptual advances in our understanding of the pathogenesis of the metabolic syndrome, its different metabolic components as well as its cardiovascular complications, will be discussed. This meeting aims to integrate approaches from basic and translational science, with an overall goal of understanding 1) how to translate this science into a more optimal lifestyle management and 2) the prospects for therapeutic intervention.

Objectives
Upon completion of this conference, participants should be able to:

To examine the pathogenesis of the metabolic syndrome, including the mechanisms and impact of hepatic steatosis and the specific dyslipidemia observed in patients with the metabolic syndrome.
To assess novel data on the impact of mitochondrial dysfunction and endoplasmatic reticulum stress as well as signalling cascades involved in the development of insulin resistance.
To assess novel targets for the treatment of the different components of the metabolic syndrome.
To describe the therapeutic options for treating the metabolic syndrome and its associated cardiovascular risk.

Tuesday, March 27
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 9:30 PM	Keynote Session: Clinical and Epidemiological Definition of the Metabolic Syndrome (Joint)	Ballroom
	* Bart Staels, Institut Pasteur de Lille, University of Lille 2
	* Mitchell A. Lazar, University of Pennsylvania School of Medicine
	Gerald M. Reaven, Stanford University Insulin Resistance and the Many Faces of the Metabolic Syndrome
	Elizabeth G. Nabel, National Institutes of Health Obesity, Risk Factors and CV Disease: NHLBI Perspectives
Wednesday, March 28
7:00 - 8:00 AM	Breakfast	3 Saddles/Bear River
8:00 - 11:00 AM	NR and the MS I (Joint)	Ballroom
	* Sheila Collins, Burnham Institute for Medical Research of Lake Mona
	Christopher K. Glass, University of California, San Diego Nuclear Receptors, Inflammation, and metabolic syndrome
	Ronald M. Evans, The Salk Institute ERR alpha & PGC-1 beta: a Gateway to INFgamma Signaling in Innate Immunity: Balancing the Fat Equation
	Bruce M. Spiegelman, Harvard Medical School Transcriptional Control of Energy Homeostasis and Metabolic Disease
	Peter Tontonoz, University of California, Los Angeles PPAR gamma as a Central Regulator of Adipocyte Differentiation and Lipid/Glucose Metabolism

	Philipp E. Scherer, University of Texas Southwestern Medical Center Short Talk: Novel Role of Adiponectin in PPAR gamma-Mediated Gene Regulation
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Rainbow/Twilight/Sunrise/Sunshine
1:00 - 10:00 PM	Poster Viewing	Rainbow/Twilight/Sunrise/Sunshine
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Novel Therapeutics for the MS	Sunshine
	* Dawn M. Waterworth, GlaxoSmithKline

	Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health 11beta-Hydroxysteroid Dehydrogenase Type 1 and teh Metabolic Syndrome

	Anne-Marie Galzin, Sanofi-Aventis Research & Development The Endocannabinoid System as a Target for Managing Obesity / Cardio-Metabolic Risk Factors

	Bei B. Zhang, Merck Research Laboratories Targeting the Glucagon Receptor for Glycemia Control and Beyond
	Shin-ichiro Imai, Washington University School of Medicine Short Talk: Nampt/PBEF/Visfatin Regulates Insulin Secretion in Beta Cells as a Systemic NAD Biosynthetic Enzyme
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rainbow/Twilight/Sunrise/Sunshine
7:30 - 10:00 PM	Poster Session 1	Rainbow/Twilight/Sunrise/Sunshine
Thursday, March 29
7:00 - 8:00 AM	Breakfast	3 Saddles/Bear River
8:00 - 11:15 AM	Hepatic Steatosis: Cause or Consequence of the MS?	Sunshine
	* Anna Krook, Karolinska Institutet
	Hannele Yki-Järvinen, University of Helsinki Clinical Relevance and Pathogenesis of Hepatic Steatosis
	C. Ronald Kahn, Joslin Diabetes Center Independent Pathways of Insulin Action In Regulation Of Glucose and Lipid Metabolism
	Jay D. Horton, University of Texas Southwestern Medical Center SREBPs and Components of the Metabolic Syndrome
	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center Impact of Inflammation as a Pathogenic Mediator in the Metabolic Syndrome
	Carl de Luca, University of California, San Diego Short Talk: Myeloid-Derived Toll-Like Receptor 4 (TLR4) is Required for High Fat Diet Induced Hepatic Insulin Resistance
	Kristiaan Wouters, Institut Pasteur de Lille Short Talk: Hyperactivation of Macrophage TNF Signaling Inhibits Steatosis
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Rainbow/Twilight/Sunrise/Sunshine
1:00 - 10:00 PM	Poster Viewing	Rainbow/Twilight/Sunrise/Sunshine
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Cardiovascular Disease in the MS	Sunshine
	* Nikolaus Marx, University Hospital Aachen
	Daniel S. Ory, Washington University in St. Louis Deficiency of an Endogenous LXR Ligand Promotes Atherosclerosis


	Gwendalyn J. Randolph, Mount Sinai School of Medicine Monocyte Subpopulations: Evaluating their Roles
	E. Dale Abel, University of Utah School of Medicine Myocardial Mitochondrial Dysfunction in the Metabolic Syndrome-Molecular Mechanisms
	Martin E. Young, University Alabama Birmingham Short Talk: The Intrinsic Circadian Clock within the Cardiomyocyte Directly Regulates Myocardial Gene Expression, Metabolism, and Function
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rainbow/Twilight/Sunrise/Sunshine
7:30 - 10:00 PM	Poster Session 2	Rainbow/Twilight/Sunrise/Sunshine
Friday, March 30
7:00 - 8:00 AM	Breakfast	3 Saddles/Bear River
8:00 - 11:15 AM	Energy Metabolism, Mitochondrial Function and Lipotoxicity in the MS	Sunshine
	* Dennis Bruemmer, University of Kentucky
	Jean E. Schaffer, Washington University School of Medicine Lipotoxicity: A Cardiovascular Risk in the Metabolic Syndrome
	Robert V. Farese Jr., University of California, San Francisco Metabolic Syndrome and Triglyceride Synthesis

	Mary-Elizabeth Patti, Joslin Diabetes Center PGC-1 Dependent and Independent Pathways to MS and Diabetes Risk
	Karen Reue, University of California, Los Angeles The Role of Lipin Proteins in Metabolism
	Peter A. Crawford, Washington University School of Medicine Short Talk: Myocardial Physiology is Influenced by the Gut Microbiota
	Martin S. Obin, JMUSDA-HNRCA, Tufts University Short Talk: Obesity-Associated Adipocyte Death: Role in Inflammation, Peripheral Insulin Resistance and Hepatic Steatosis
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Rainbow/Twilight/Sunrise/Sunshine
1:00 - 10:00 PM	Poster Viewing	Rainbow/Twilight/Sunrise/Sunshine
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	NR and the MS II (Joint)	Ballroom
	* Sander Kersten, Wageningen University

	David J. Mangelsdorf, University of Texas Southwestern Medical Center Nuclear Receptors and FGFs: The New Endocrinology of Metabolism
	Takashi Kadowaki, University of Tokyo Adiponectin, PPARs, IRSs, and Metabolic Syndrome
	Daniel P. Kelly, Burnham at Lake Nona PPARs and Striated Muscle Lipid Metabolism
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rainbow/Twilight/Sunrise/Sunshine
7:30 - 10:00 PM	Poster Session 3	Rainbow/Twilight/Sunrise/Sunshine
Saturday, March 31
7:00 - 8:00 AM	Breakfast	3 Saddles/Bear River
8:00 - 11:15 AM	Signaling Cascades in the MS	Sunshine
	* Matthew Watt, Monash University
	Juleen R. Zierath, Karolinska Institutet Targeting Signaling Cascades in Insulin Resistance
	Gökhan S. Hotamisligil, Harvard University School of Public Health Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes
	D. Grahame Hardie, University of Dundee Role of the AMPK System in the Metabolic Syndrome
	Yannick Le Marchand-Brustel, INSERM Defects in Insulin Signaling in Metabolic Syndrome
	Daniel Lindén, AstraZeneca R&D Short Talk: Opposing Effects of Adiponectin Receptor 1 and 2 on Energy Metabolism
	Giovanni Solinas, University of California, San Diego Short Talk: JNK in Macrophages Plays a Key Role in the Development of Obesity-Induced Insulin Resistance
9:20 - 9:40 AM	Coffee Break	Foyer
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Dyslipidemia of the MS: The Atherogenic Triad	Sunshine
	* Ira J. Goldberg, Columbia University
	Henry N. Ginsberg, Columbia University College of Physicians and Surgeons Regulation of VLDL Metabolism: Substrates, Hormones, and PPARgamma

	Fred W. Turek, Northwestern University Circadian Control of Sleep and Energy Balance
	Bart Staels, Institut Pasteur de Lille, University of Lille 2 FXR: A Target For The Metabolic Syndrome?
	Brian N. Finck, Washington University School of Medicine Short Talk: Involvement of Lipin 1 in the Regulation of Hepatic Triglyceride Secretion
8:00 - 9:00 PM	Social Hour w/ Lite Bites	Storm Peak/Sunshine/Mt. Werner
8:00 - 11:00 PM	Entertainment	Storm Peak/Sunshine/Mt. Werner
Sunday, April 1
	Departure

*Session Chair †Speaker invited, not yet responded.