Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Molecular Mechanisms of Neurodegeneration (A4)

Organizer(s): Harry T. Orr, Stephen T. Warren and Huda Y. Zoghbi
January 16 - 21, 2007
Sagebrush Inn and Conference Center · Taos, New Mexico
Abstract Deadline: September 18, 2006
Late Abstract Deadline: October 19, 2006
Scholarship Deadline: September 18, 2006
Early Registration Deadline: November 16, 2006

Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2007 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Neurodegenerative Diseases: The Molecular and Cellular Basis for Neurodegeneration (F2)
February 21 - 26, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Evidence is accumulating that in chronic neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are due to a combination of events triggered by expression and accumulation of misfolded proteins that impair neuronal function. More recent developments have shown that, in certain diseases, a mutant RNA triggers the formation of nuclear inclusions and pathogenesis. In this meeting, emphasis will placed on understanding cellular pathways that are implicated in some of the more common and intriguing neurodegenerative disorders, with the aim of providing a foundation for their treatment.

Objectives
Upon completion of this conference, participants should be able to:

To analyze the basic mechanisms by which cells (neurons) fold proteins, and recognize and process misfolded proteins.
To examine the extent to which protein misfolding underlies pathogenesis for several key neruodegenerative disorders (e.g. Alzheimer disease, ALS, and the polyglutamine disease).
To consider the role of various cellular pathways leading to neurodegeneration and how the presence of misfolded proteins may alter the function of these pathways.
To discuss potential strategies for the development of new treatments for neurodegeneration.

Tuesday, January 16
3:00 - 7:30 PM	Registration	Chamisa Lobby
6:30 - 7:30 PM	Refreshments	Chamisa Lobby
7:30 - 8:30 PM	Keynote Address	Chamisa Ballroom 1
	Hidde L. Ploegh, Whitehead Institute for Biomedical Research Cellular Response to Misfolded Proteins
Wednesday, January 17
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Misfolded Proteins and Neurodegenerative Disease	Chamisa Ballroom 1
	* Harry T. Orr, University of Minnesota
	Richard I. Morimoto, Northwestern University Protein Misfolding in Aging and Neurodegenerative Diseases
	Nancy M. Bonini, University of Pennsylvania Drosophila as a Model for Human Neurodegenerative Disease: Modifier Pathways of Ataxin-3 Toxicity
	Huda Y. Zoghbi, Howard Hughes Medical Institute, Baylor College of Medicine The Role of Protein Conformation and Interactions in SCA1 Pathogenesis
	Ron R. Kopito, Stanford University Ubiquitin in Neurodegnerative Disease
	Yong Shen, Sun Health Research Institute Short Talk: Novel Roles of Complement C1q Protein in Amyloid Beta Protein Clearance
	Rishi Rakhit, University of Toronto Short Talk: An Immunological Epitope Selective for Pathological Monomer/Misfolded SOD1 in ALS
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Cellular Pathways in Neurodegenerative Disease-I (AD)	Chamisa Ballroom 1
	* Nancy M. Bonini, University of Pennsylvania

	Thomas C. Südhof, Stanford School of Medicine Synuclein: Normal Function vs. Neurodegeneration
	Karen Hsiao Ashe, University of Minnesota Amyloid-β Molecules Impairing Memory in Alzheimer's Disease
	Lawrence S. B. Goldstein, University of California, San Diego Axonal Transport and Neurodegeneration in AD
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 1	Chamisa Ballroom 2
Thursday, January 18
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:00 AM	Cellular Pathways in Neurodegenerative Disease II (PD)	Chamisa Ballroom 1
	* Karen Hsiao Ashe, University of Minnesota

	Ted M. Dawson, Johns Hopkins School of Medicine The Role of Defective Genes in Parkinson’s Disease
	Asa Abeliovich, Columbia University Making and Saving Dopamine Neuron
	Jie Shen, Harvard Medical School Dopaminergic Circuit Dysfunction and Parkinson’s Disease

	Ming Guo, University of California, Los Angeles Short Talk: Drosophila Pink1 is Required for Mitochondrial Function and Interacts Genetically with Parkin
	Patrick A. Lewis, Institute of Neurology Short Talk: Biochemical Analysis of LRRK2
	S. Pablo Sardi, Children's Hospital Boston Short Talk: Presenilin-Dependent erbB4 Nuclear Signaling Regulates Neural Stem Cell Fate Choices
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:00 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Prion Disease: Basic Biology & Therapy	Chamisa Ballroom 1
	* Richard I. Morimoto, Northwestern University
	Joan Durbin, Ohio State University Intra- and Inter-Molecular Modifiers of PolyQ Toxicity


	Mathias Florian Heikenwälder, University Hospital Zürich Peripheral Prion Pathogenesis
	Jeppe Pedersen Falsig, H. Lundbeck A/S Short Talk: Prion Replication in Organotypic Slice Cultures in the Absence of Microglia

	Sam Saghafi, University of California, San Francisco Short Talk: Conformational Heterogeneity of PrPC Regulates Pro- and Anti-Apoptotic Functions in Health and Disease
	Giovanna Mallucci, Institute of Neurology, University College London Short Talk: Targeting Cellular Prion Protein Reverses Early Cognitive Deficits in Prion-Infected Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 2	Chamisa Ballroom 2
Friday, January 19
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Cellular Pathways in Neurodegenerative Disease III (HD)	Chamisa Ballroom 1
	* Huda Y. Zoghbi, Howard Hughes Medical Institute, Baylor College of Medicine
	Michael R. Hayden, University of British Columbia Proteolysis of Huntingtin and its Role in the Pathogenesis of Huntington Disease
	Marcy E. MacDonald, Massachusetts General Hospital Huntington's Disease Genetic Modifiers
	Elena Cattaneo, University of Milano Huntingtin Function in Huntington's Disease
	Xiao-Jiang Li, Emory University School of Medicine Glial Pathology in HD
	Marc I. Diamond, University of California, San Francisco Short Talk: Profilin, a Target of p160ROCK, Inhibits Polyglutamine Aggregation and Toxicity
	Lisa M. Imboden, Emory University School of Medicine Short Talk: Interaction of TorsinA with Novel Protein Printor is Disrupted by Dystonia-Associated Mutation
	Ronald D. McKay, National Institutes of Health Short Talk: The Floor Plate Forkhead Gene, foxa2, Is Required for the Differentiation and Survival of Midbrain Dopamine Neurons
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	RNA-Mediated Neurodegenerative Disease	Chamisa Ballroom 1
	* Beverly L. Davidson, University of Iowa
	Maurice S. Swanson, University of Florida RNA, Muscleblind and Myotonic Dystrophy
	Thomas A. Cooper, Baylor College of Medicine Disruption of Developmentally Regulated Alternative Splicing in Myotonic Dystrophy
	Stephen T. Warren, Emory University School of Medicine Fragile X-Associated Tremor/Ataxia Syndrome
	Jean-Marc Gallo, King's College London Short Talk: Characterization of the Neuronal RNA-Binding Protein CELF3, a Modulator of Tau Exon 10 Alternative Splicing
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 3	Chamisa Ballroom 2
Saturday, January 20
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Cellular Pathways in Neurodegenerative Disease IV	Chamisa Ballroom 1
	* Stephen T. Warren, Emory University School of Medicine
	Don W. Cleveland, University of California, San Diego Mechanisms of Motor Neuron Death in ALS: A Gene Therapy for Human Neurodegenerative Disease
	Laura Ranum, University of Minnesota Neurodegenerative Pathways: Lessons from the Ataxias
	Virginia M.-Y. Lee, University of Pennsylvania School of Medicine TDP-43 is the Disease Protein Ubiquitinated in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
	Robert B. Darnell, HHMI/Rockefeller University RNA and Splicing Regulation in Neurologic Disease
	Stanley H. Appel, Methodist Neurological Institute Short Talk: Do Microglia Contribute to the Pathogenesis of Motor Neuron Injury and Repair?
	Yang Lu, Johns Hopkins University Short Talk: Targeting of Viral Vectors to Motor Neurons by Botulinum Toxin Binding Domain to Treat ALS
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Therapeutic Approaches to Neurodegenerative Disease	Chamisa Ballroom 1
	* Don W. Cleveland, University of California, San Diego

	Toni Williamson, Amgen, Inc. Beta-Secretase
	Beverly L. Davidson, University of Iowa RNAi Approaches in Neurodegenerative Disease
	Jeffrey D. Rothstein, Johns Hopkins University ALS: Development of Small Molecule, Protein and Cellular Therapeutics
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
8:00 - 11:00 PM	Entertainment	Chamisa Ballroom 2
Sunday, January 21
	Departure

*Session Chair †Speaker invited, not yet responded.