Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Drugs Against Protozoan Parasites (B1)

Organizer(s): Daniel E. Goldberg, R. Kip Guy and Stephen A. Ward
January 28 - February 1, 2007
Granlibakken Resort · Tahoe City, California
Abstract Deadline: September 28, 2006
Late Abstract Deadline: October 27, 2006
Scholarship Deadline: September 28, 2006
Early Registration Deadline: November 28, 2006

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2007 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
This is a period of rapid progress for the field of anti-protozoal drug development. Genomic efforts have led to the identification of a myriad of new drug targets. Studies on the mechanisms of drug action and drug resistance have yielded new insights into how to improve on old agents. Promising development efforts span the spectrum from lead identification to clinical trials to registration. Key problems include target selection, drug development in an academia-centered environment, and performing trials in endemic areas. This meeting will bring together biologists and chemists with diverse backgrounds and scientists in academia and industry to work together towards solutions to these problems of global importance.

Objectives
Upon completion of this conference, participants should be able to:

To discuss recent advances in the field of anti-protozoal drug development and consider how old agents may be improved through recent genomic research applications.
To explain the mechanisms of drug action and drug resistance.
To demonstrate an understanding of the importance of chemical approaches to the research of the target organisms.

Sunday, January 28
3:00 - 7:30 PM	Registration	Prefunction
6:30 - 7:30 PM	Welcome and Buffet Dinner	Granhall
7:30 - 8:30 PM	Keynote Address	Mountain/Lake Rooms
	Peter A. Winstanley, University of Liverpool Tropical Drug Discovery - From Scientific Idea to Registered Product
Monday, January 29
7:00 - 8:00 AM	Breakfast	Granhall
8:00 - 11:00 AM	Targets	Mountain/Lake Rooms
	* James H. McKerrow, University of California, San Francisco

	Julio A. Urbina, Venezuelan Institute for Science Research Inhibitors of T. cruzi Lipid Biosynthesis as Specific Chemotherapeutic Agents for Chagas Disease
	Sylke Müller, University of Glasgow Antioxidant and Redox Systems of Plasmodium – Targets for Drug Design?

	R. Luise Krauth-Siegel, University of Heidelberg Enzymes of the Trypanothione Metabolism as Antitrypanosomal Drug Targets


	Raymond Hui, University of Toronto Short Talk: From Osteoporosis to Cryptosporidiosis: Inhibition of Cryptosporidium parvum Farnesyl Pyrophosphate Synthase by Bisphosphonates
	Silvia N. J. Moreno, University of Georgia Short Talk: A Bifunctional Enzyme in the Isoprenoid Pathway of Toxoplasma gondii is the Target for Bisphosphonates
	Rana Nagarkatti, FDA Short Talk: Targeting the Newly Characterized Plasmodium Protein HDP that Synthesizes Hemozoin; Identification of Novel Inhibitors by High Throughput Screening
9:20 - 9:40 AM	Coffee Break	Prefunction
11:00 AM - 1:00 PM	Poster Setup	Bay Room
1:00 - 10:00 PM	Poster Viewing	Bay Room
4:30 - 5:00 PM	Coffee Available	Prefunction
5:00 - 7:00 PM	Functional Genomics/Proteomics	Mountain/Lake Rooms
	* Ian Street, Walter and Eliza Hall Institute of Medical Research
	Joseph DeRisi, University of California, San Francisco Global Transcription Analysis for Drug Development

	Maria Manuel Dias da Mota, Instituto Gulbenkian Ciência Identification of Host Factors Relevant for Malaria Infection

	Marilyn Parsons, Seattle Biomedical Research Institute Drilling Down on the Kinome of Trypanosomatids
7:00 - 8:00 PM	Dinner	Granhall
7:30 - 10:00 PM	Poster Session 1	Bay Room
8:00 - 9:00 PM	Social Hour	Bay Room
Tuesday, January 30
7:00 - 8:00 AM	Breakfast	Granhall
8:00 - 11:15 AM	Compounds	Mountain/Lake Rooms
	* Els Torreele, Drugs for Neglected Diseases (DNDi)
	Norbert De Kimpe, Ghent University Anti-Leishmanial Natural Products from a Medicinal Plant
	Kelly Chibale, University of Cape Town Privileged Structures and Multi-Component Reaction Strategies in Antiprotozoal Drug Discovery
	H. Ulrich Göringer, Darmstadt University of Technology RNA Aptamers as Anti-Trypanosomal Agents

	Dennis E. Kyle, University of South Florida Artemisinin Resistance and Recrudescence Mechanisms
	Karl A. Werbovetz, Ohio State University Short Talk: Linear and Near-linear Diamidines with Potent Antileishmanial Activity
	Wayne M. Best, Murdoch University Short Talk: A Novel and Highly Potent Class of Compounds for the Treatment of Trypanosomiasis
9:20 - 9:40 AM	Coffee Break	Prefunction
11:15 AM - 1:00 PM	Poster Setup	Bay Room
1:00 - 10:00 PM	Poster Viewing	Bay Room
4:30 - 5:00 PM	Coffee Available	Prefunction
5:00 - 7:00 PM	Screening	Mountain/Lake Rooms
	* Marilyn Parsons, Seattle Biomedical Research Institute

	Ian Street, Walter and Eliza Hall Institute of Medical Research High Throughput Screening Based Drug Discovery: The Search for New and Effective Treatments for Tropical Diseases
	James C. Sacchettini, Texas A & M University Inhibition of Plasmodium falciparum Enoyl ACP Reductase as a Target for Antimalarial Drug Development

	Jun O. Liu, Johns Hopkins University School of Medicine Methionine Aminopeptidases as Antimalarial Drug Targets
7:00 - 8:00 PM	Dinner	Granhall
7:30 - 10:00 PM	Poster Session 2	Bay Room
8:00 - 9:00 PM	Social Hour	Bay Room
Wednesday, January 31
7:00 - 8:00 AM	Breakfast	Granhall
8:00 - 11:00 AM	Lead Optimization	Mountain/Lake Rooms
	* Kelly Chibale, University of Cape Town
	Jay D. Keasling, University of California, Berkeley Engineering Microorganisms for Production of Artemisinin
	Domingo Gargallo-Viola, GlaxoSmithKline Animal Models for Antimalarial Development
	James H. McKerrow, University of California, San Francisco Developing Drugs for Parasitic Diseases in an Academic Incubator
	Stephen A. Ward, University of Liverpool Quinoline Animalarials Targeting the Parasites Achilles Heel
9:20 - 9:40 AM	Coffee Break	Prefunction
4:30 - 5:00 PM	Coffee Available	Prefunction
5:00 - 7:00 PM	Drug Development	Mountain/Lake Rooms
	* Dennis E. Kyle, University of South Florida
	Richard R. Tidwell, University of North Carolina at Chapel Hill Development of Diamidines for Anti-protozoal Chemotherapy
	Henri Vial, Universite Montpellier II Development of Choline Inhibitors for Antimalarial Chemotherapy
	Els Torreele, Drugs for Neglected Diseases (DNDi) Rediscovering Nitro-Imidazoles as Promising Drug Candidates for Human African trypanosomiasis (HAT)

7:00 - 8:00 PM	Social Hour	Granhall
8:00 - 9:00 PM	Dinner	Granhall
8:00 - 11:00 PM	Entertainment	Granhall
Thursday, February 1
	Departure

*Session Chair †Speaker invited, not yet responded.