Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Ubiquitin and Signaling (B4)

Organizer(s): Brenda A. Schulman, Tony Hunter, Mark W. Hochstrasser and Claudio A.P. Joazeiro
February 4 - 9, 2007
Big Sky Resort · Big Sky, Montana
Abstract Deadline: October 4, 2006
Late Abstract Deadline: November 2, 2006
Scholarship Deadline: October 4, 2006
Early Registration Deadline: December 4, 2006

Supported by the Director's Fund

This meeting took place in the 2007 season.

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Summary of Meeting
Our understanding of how ubiquitin regulates cellular functions has greatly expanded in the past several years, spurred by discoveries of protein families involved in ubiquitin conjugation and deconjugation, and of nonproteasomal signaling functions for ubiquitin and ubiquitin-related proteins. The first Keystone meeting on Ubiquitin and Signaling, in February 2005, was highly successful, based on both strong attendance and feedback from the participants. The significance and timely nature of the ubiquitination problem is highlighted by the 2004 Nobel Prize in Chemistry honoring pioneers in the field. We anticipate a further explosion in our understanding of ubiquitination over the next few years, and propose a meeting that captures this momentum. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in numerous diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins, presenting the challenge to determine their functions and mechanistic links to the ubiquitin system. In addition, the ubiquitin system is now widely recognized as a target for pharmacological intervention in various diseases. The goal of the meeting is to bring together experts from different areas of ubiquitin research as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.

Sunday, February 4
3:00 - 7:30 PM	Registration	Lower Atrium
7:00 - 8:00 PM	Refreshments	Lower Atrium
8:00 - 9:00 PM	Keynote Address: The Cecile Pickart Memorial Lecture	Gallatin

	Alfred L. Goldberg, Harvard Medical School What We've Learned and What We Haven't Learned About Protein Degradation
Monday, February 5
7:00 - 8:00 AM	Breakfast	Jefferson/ Lake/ Canyon Rooms
8:00 - 11:15 AM	Regulation by E3 Ubiquitin Ligases	Gallatin/ Madison
	* Christopher D. Lima, Memorial Sloan-Kettering Cancer Center
	Michael Karin, University of California, San Diego Crosstalk Between Inflammation Cells and Carcinomas


	J. Wade Harper, Harvard Medical School Genetic Discovery in the Ubiquitin Proteasome Pathway
	Claudio A.P. Joazeiro, The Scripps Research Institute Functional Genomic Analyses of Ubiquitin Ligases
	Mark A. Estelle, University of California, San Diego The F-box Protein TIR1 is a Receptor for the Plant Hormone Auxin
	Bruce E. Clurman, Fred Hutchinson Cancer Research Center Fbw7 at the Crossroads of Cell Division, Growth, and Differentiation
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:00 AM - 1:00 PM	Poster Setup	Jefferson/ Lake/ Canyon Rooms
1:00 - 10:00 PM	Poster Viewing	Jefferson/ Lake/ Canyon Rooms
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Signal Transduction by Ubiquitin Conjugation and Deconjugation	Gallatin/ Madison
	* J. Wade Harper, Harvard Medical School
	Vishva M. Dixit, Genentech, Inc. ATM Mediated Auto-Degradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
	René Bernards, Netherlands Cancer Institute RNAi Screens to Identify Functions of DUBs
	Christian D. Schlieker, Whitehead Institute for Biomedical Research Short Talk: Structure of a Herpesvirus-Encoded Deubiquitinating Enzyme Reveals a New Class of Ubiquitin-Specific Proteases

	Paul J. Lehner, Cambridge Institute for Medical Research Short Talk: Lysine-63 Linked Ubiquitination is Required for Efficient Internalization and Endolysosomal Degradation of Critical Immunoreceptors
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Gallatin/Lake/Canyon Rooms
7:30 - 10:00 PM	Poster Session 1	Jefferson/ Lake/ Canyon Rooms
Tuesday, February 6
7:00 - 8:00 AM	Breakfast	Jefferson/ Lake/ Canyon Rooms
8:00 - 11:00 AM	Ubiquitin-Like Protein Pathways	Gallatin/ Madison
	* Daniel J. Finley, Harvard University
	Ronald T. Hay, University of Dundee Role of SUMO Modification in the Control of Gene Expression
	Christopher D. Lima, Memorial Sloan-Kettering Cancer Center SUMO: Insights into Ubiquitin and Ubiquitin-Like Protein Conjugation
	Frauke Melchior, University of Goettingen Functions and Regulation of SUMOylation
	Jorge A. Iñiguez-Lluhi, University of Michigan Short Talk: SUMO Modification Regulates Inactivation of the voltage-Gated Potassium Channel KV1.5
	Brenda A. Schulman, St. Jude Children's Research Hospital Structural Insights into Ubiquitin-like Protein Activation
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:00 AM - 1:00 PM	Poster Setup	Jefferson/ Lake/ Canyon Rooms
1:00 - 10:00 PM	Poster Viewing	Jefferson/ Lake/ Canyon Rooms
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Regulation of and by the Proteasome and Signalosome	Gallatin/ Madison
	* Alfred L. Goldberg, Harvard Medical School
	Xing Wang Deng, Yale University Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Cullin3-based E3 ligases
	Ning Zheng, University of Washington Mechanism of Auxin Perception by the TIR1 F-box Protein
	Daniel J. Finley, Harvard University Regulation of Proteasome Function
	Rina Rosenzweig, Israel Institute of Technology Short Talk: A Mason's Approach to the 19S Proteasome Regulator
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Gallatin/Lake/Canyon Rooms
7:30 - 10:00 PM	Poster Session 2	Jefferson/ Lake/ Canyon Rooms
Wednesday, February 7
7:00 - 8:00 AM	Breakfast	Jefferson/ Lake/ Canyon Rooms
8:00 - 11:00 AM	Ubiquitin and Subcellular Compartments	Gallatin/ Madison
	* Frauke Melchior, University of Goettingen
	Simona Polo, FIRC Institute of Molecular Oncology Molecular Mechanisms of Coupled Monoubiquitination

	Thomas Sommer, Max Delbrück Center for Molecular Medicine Protein Quality Control by the HRD-Ligase Complex

	Mary Ann Osley, University of New Mexico Interplay between H2B Ubiquitylation and Histone Chaperones during Transcription Elongation
	Sylvie Urbé, University of Liverpool Control of Growth Factor Receptor Dynamics by Reversible Ubiquitination
	Vincent Chau, Pennsylvania State University College of Medicine Short Talk: The Crystal Structure of a RING-Ubc7 Fusion Reveals a Mechanism for the Activation of a Ubiquitin-Conjugating Enzyme
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:00 AM - 1:00 PM	Poster Setup	Jefferson/ Lake/ Canyon Rooms
1:00 - 10:00 PM	Poster Viewing	Jefferson/ Lake/ Canyon Rooms
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Novel Functions of Ubiquitin	Gallatin/ Madison
	* Simona Polo, FIRC Institute of Molecular Oncology
	Russell A. DeBose-Boyd, University of Texas Southwestern Medical Center Ubiquitination and Degradation of the Cholesterol Biosynthetic Enzyme, HMG CoA Reductase
	Mark W. Hochstrasser, Yale University Regulation of Ubiquitin Enzymes at the Endoplasmic Reticulum and Nuclear Envelope
	Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School Cell-Polarity Control of Protein Degradation in Intestinal Epithelial Cells
	Peter Kaiser, University of California, Irvine Short Talk: Proteolysis-Independent Regulation by Poly-Ubiquitination
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Gallatin/Lake/Canyon Rooms
7:30 - 10:00 PM	Poster Session 3	Jefferson/ Lake/ Canyon Rooms
Thursday, February 8
7:00 - 8:00 AM	Breakfast	Jefferson/ Lake/ Canyon Rooms
8:00 - 11:15 AM	The Ubiquitin System: Disease and Drug Targets	Gallatin/ Madison
	* Thomas Sommer, Max Delbrück Center for Molecular Medicine


	Tony Hunter, The Salk Institute Crosstalk Between Phosphorylation and Sumoylation Pathways and Ubiquitination
	Gentry N. Patrick, University of California, San Diego UPS and Mammalian CNS Synapses
	Ron R. Kopito, Stanford University Protein Aggregation and Neurodegeneration

	Laurent Coscoy, University of California, Berkeley Ubiquitination on Non-lysine Residues
	Agata M. Smogorzewska, Harvard Medical School, Massachusetts General Hospital Short Talk: Cloning and Characterization of FANCI, a Novel Component of the Fanconi Anemia Pathway
	Frédéric Colland, Hybrigenics Short Talk: Identification and Characterization of Small Molecule Inhibitors of Ubiquitin-Specific Protease 8, a Newly Validated Cancer Target
9:20 - 9:40 AM	Coffee Break	Lower Atrium
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Proteomics and Other Technology Trends	Gallatin/ Madison
	* William G. Kaelin Jr., Dana Farber Cancer Institute Pharmacodynamic Imaging with Degron-Containing Luciferase Fusion Proteins

	Steven P. Gygi, Harvard Medical School Mass Spectrometry Based Methods for Analysis of Site Specific Ubiquitination
	Dieter A. Wolf, Harvard School of Public Health Systematic Screening for Ubiquitylation Substrates
	Benjamin Nicholson, Progenra Short Talk: Mining the Deubiquitinase Space with a Novel Reporter Assay

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/ Madison
8:00 - 11:00 PM	Entertainment	Jefferson/ Madison
Friday, February 9
	Departure

*Session Chair †Speaker invited, not yet responded.