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Cell Signaling and Proteomics (X6)

Organizer(s): John R. Yates III, Steven P. Gygi and Lewis C. Cantley
March 22 - 27, 2007
Sheraton Steamboat Resort  ·  Steamboat Springs, Colorado
Abstract Deadline: November 22, 2006
Late Abstract Deadline: December 21, 2006
Scholarship Deadline: November 22, 2006
Early Registration Deadline: January 23, 2007


Supported by the Director's Fund

Joint meeting: Systems Biology and Regulatory Networks (X5)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).



This meeting took place in the 2007 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Cell signaling is an essential physiological function in cells and developing a complete understanding of signaling pathways, networks and interactions is a major challenge in the field. The objective of this meeting is to combine cell signaling issues--frontiers, challenges, unanswered questions--with discussions of proteomic technology status and future directions related to challenges in the signaling area. In essence the meeting will provide an update on the current status of signaling research and proteomics technology with a dialogue between signaling researchers and proteomic technology developers. From this dialogue, we anticipate new directions in signaling and proteomics research and new collaborations and interactions that will push the frontiers of signaling research.

Thursday, March 22
3:00 - 7:30 PM Registration Foyer
6:30 - 7:30 PM Refreshments Foyer
7:30 - 9:30 PM Keynote Session (Joint) Mt. Werner/Sunshine
* John R. Yates, III, The Scripps Research Institute
Donald F. Hunt, University of Virginia
Innovative Technology for the Study of Cell Signaling
* Steven P. Gygi, Harvard Medical School
Lucy Shapiro, Stanford University
Spatial and Temporal Components of the Bacterial Cell Cycle Genetic Circuitry
Friday, March 23
7:00 - 8:00 AM Breakfast 3 Saddles/Bear River
8:00 - 11:00 AM Frontiers and Challenges in Signaling I Mt. Werner
* Michael J. Weber, University of Virginia
Anne Brunet, Stanford University
Signaling Networks in Aging and Longevity
Tony Hunter, The Salk Institute
Kinomics: Challenges for the Future
Lewis C. Cantley, Harvard Medical School
The Role of Phosphorylation in Signaling
Joris Benschop, University Medical Center Utrecht
Short Talk: Post-Translational Regulation of the Yeast Mediator Complex
Karl R. Clauser, Broad Institute of Massachusetts Institute of Technology, Harvard
Short Talk: Phosphoproteomic Screen Defines Polo-Box Domain Mitotic Interactome and Identifies the Cytokinesis Regulator Rho-Associated Kinase-2 as a Plk1 Substrate
9:20 - 9:40 AM Coffee Break Foyer
11:00 AM - 1:00 PM Poster Setup Storm Peak/Rainbow/Twilight
1:00 - 10:00 PM Poster Viewing Storm Peak/Rainbow/Twilight
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Posttranslational Networks (Joint) Mt Werner/Sunshine
Michael Snyder, Stanford University School of Medicine
Regulatory Networks in Eucaryotes
Steven P. Gygi, Harvard Medical School
Measuring Changes In Protein Phosphorylation State On A Proteome Scale
* Tony Pawson, Samuel Lunenfeld Research Institute
Interaction Domains in Cellular Regulation
7:00 - 8:00 PM Social Hour w/ Lite Bites Foyer
7:30 - 10:00 PM Poster Session 1 Storm Peak/Rainbow/Twilight
Saturday, March 24
7:00 - 8:00 AM Breakfast 3 Saddles/Bear River
8:00 - 11:00 AM Frontiers and Challenges in Signaling II Mt. Werner
* Lewis C. Cantley, Harvard Medical School
Tania A. Baker, Massachusetts Institute of Technology
Recognition Logic of the AAA+ Protein Unfolding ATPases
Michael J. Weber, University of Virginia
Cell Signaling by the Erk Pathway
James A. Wells, University of California, San Francisco
Degradomics: The Proteolysis of Cell Death
Marcus Smolka, Weill Institute for Cell and Molecular Biology - Cornell
Short Talk: Mapping the DNA Damage Signaling Network by a Global and Quantitative Phosphorylation Analysis
Joshua E. Elias, Harvard Medical School
Short Talk: Progress Towards Global Measurements of Protein Degradation in Cultured Steady-State Cells by Quantitative Mass Spectrometry
9:20 - 9:40 AM Coffee Break Foyer
11:00 AM - 1:00 PM Poster Setup Storm Peak/Rainbow/Twilight
1:00 - 10:00 PM Poster Viewing Storm Peak/Rainbow/Twilight
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Phosphorylation Profiling I Mt. Werner
* Steven P. Gygi, Harvard Medical School
Joshua J. Coon, University of Wisconsin
Tracking Kinase Signaling Cascades in Human Embryonic Stem Cells
Peipei Ping, University of California, Los Angeles
Regulation of Cardiac 20S Proteasome Complexes by Associating Partners
Cristian I. Ruse, The Scripps Research Institute
Barium Precipitation for Phosphopeptide Profiling
7:00 - 8:00 PM Social Hour w/ Lite Bites Foyer
7:30 - 10:00 PM Poster Session 2 Storm Peak/Rainbow/Twilight
Sunday, March 25
7:00 - 8:00 AM Breakfast 3 Saddles/Bear River
8:00 - 11:00 AM Frontiers and Challenges in Signaling III Mt. Werner
* Peipei Ping, University of California, Los Angeles
J. Wade Harper, Harvard Medical School
Control of Signaling Systems through the Ubiquitin Proteasome Pathway
Thibault Mayor, University of British Columbia
Profiling of Ubiquitylated Proteins using Quantitative Mass Spectrometry to Reveal Proteasome Substrates and Rpn10 Receptor Repertoire
H. Alex Brown, Vanderbilt University
Lipid Signaling Networks
Dorothea Fiedler, University of California, San Francisco
Short Talk: An E-MAP of Kinase and Phosphatase Signaling in Saccharomyces cerevisiae
Adam Friedman, Harvard Medical School
Short Talk: Functional Genomic Screens for Novel Regulators of Receptor Tyrosine Kinase and ERK Signaling Specificity
9:20 - 9:40 AM Coffee Break Foyer
11:00 AM - 1:00 PM Poster Setup Storm Peak/Rainbow/Twilight
1:00 - 10:00 PM Poster Viewing Storm Peak/Rainbow/Twilight
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Cascades Controlling Developmental Fates (Joint) Mt. Werner/Sunshine
Ronald M. Evans, The Salk Institute
Nuclear Receptors: Metabolic Engineering and the Dawn of Synthetic Physiology - Balancing the Fat Equation
Ulrike Gaul, Rockefeller University
Decoding Transcription Control in Drosophila Segmentation
* Roger Brent, Molecular Sciences Institute
Physiology and Genetic Regulation of Cellular Signal Transmission
7:00 - 8:00 PM Social Hour w/ Lite Bites Foyer
7:30 - 10:00 PM Poster Session 3 Storm Peak/Rainbow/Twilight
Monday, March 26
7:00 - 8:00 AM Breakfast 3 Saddles/Bear River
8:00 - 11:00 AM Microarray Technology for Signaling Mt. Werner
* Ole N. Jensen, University of Southern Denmark
Speaker to be Announced,
Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zurich
Topology and Dynamics of Protein Interaction Networks
Lawrence E. Goldfinger, University of California, San Diego
Short Talk: Discovering Novel Ras Effectors in Cell Migration
Neil E. Olszewski, University of Minnesota
Short Talk: Determining the Function of O-GlcNAc Modification in Signaling Pathways of Plants
Rune Linding, Institute of Cancer Research (ICR)
Short Talk: Systematic Discovery of In Vivo Phosphorylation Networks
9:20 - 9:40 AM Coffee Break Foyer
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Phosphorylation Profiling II Mt. Werner
* Joshua J. Coon, University of Wisconsin
Benjamin A. Garcia, University of Illinois at Urbana-Champaign
Top Down Protein Analysis to Identify PTMs
Ole N. Jensen, University of Southern Denmark
Analyzing Signaling in Membrane Proteins
Forest M. White, Massachusetts Institute of Technology
Quantitative Analysis of ErbB Cellular Signaling Networks
8:00 - 9:00 PM Social Hour w/ Lite Bites Storm Peak/Sunshine/Mt. Werner
8:00 - 11:00 PM Entertainment Storm Peak/Sunshine/Mt. Werner
Tuesday, March 27
Departure
*Session Chair   †Speaker invited, not yet responded.



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