Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

MicroRNA and Cancer (E1)

Organizer(s): Gregory J. Hannon, Carlo M. Croce and Scott Hammond
June 8 - 12, 2007
Keystone Resort · Keystone, Colorado
Abstract Deadline: February 8, 2007
Late Abstract Deadline: March 12, 2007
Scholarship Deadline: February 8, 2007
Early Registration Deadline: April 9, 2007

Supported by the Director's Fund

This meeting took place in the 2007 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
To date, most studies of the genetic mutations that contribute to tumor formation have focused on alterations in the sequence, gene structure, copy number and expression of protein coding genes. However, we find increasingly that the genome generates a diversity of non-coding RNAs, many of which have unknown functions. MicroRNAs act through the RNAi pathway to regulate the expression of protein coding genes, which they recognize through complementary base pairing. Accumulating data suggests causal roles for microRNAs in human cancer, including observations of microRNA genes at tumor-associated chromosomal lesions and direct demonstrations that altered expression of microRNAs can accelerate tumor development. Analysis of microRNA expression signatures may contribute to cancer diagnosis, and microRNAs themselves are potential targets for cancer therapy. This meeting will highlight emerging roles of microRNAs in tumorigenesis and place these in the context of microRNAs biochemistry and biology. Bringing together investigators from two distinct fields, namely RNA and cancer biology, will facilitate new ideas regarding the means by which microRNAs impact tumor initiation and progression.

Friday, June 8
3:00 - 7:30 PM	Registration	Shavano Peak Foyer
6:30 - 7:30 PM	Refreshments	Shavano Peak Foyer
Saturday, June 9
7:00 - 8:00 AM	Breakfast	Crestone/Red Cloud
8:00 - 11:00 AM	Small RNA Biology	Shavano Peak
	* Gregory J. Hannon, Cold Spring Harbor Laboratory

	Thomas R. Gingeras, Cold Spring Harbor Laboratory Genome-Wide Maps of the Human Transcriptome Reveal an Interleaved Organization and Novel Short and Long Classes of RNAs
	Amy E. Pasquinelli, University of California, San Diego Regulation of Gene Expression by MicroRNAs



	Andrew Grimson, Whitehead Institute for Biomedical Research miRNA Targeting: Determinants Beyond Seed Pairing
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM - 1:00 PM	Poster Setup	Crestone/Red Cloud
1:00 - 8:00 PM	Poster Viewing	Crestone/Red Cloud
2:30 - 3:00 PM	Coffee Available	Shavano Peak Foyer
3:00 - 5:15 PM	Measuring microRNA Expression	Shavano Peak
	* Scott M. Hammond, University of North Carolina at Chapel Hill

	Hui Wang, Agilent Technologies, Inc. Direct and Sensitive miRNA Profiling from Low-Input Total RNA
	Martina U. Muckenthaler, Children's Hospital, University of Heidelberg MiChip: A Microarray Platform for Expression Profiling of microRNAs Based on Locked-Nucleic Acid (LNA) Oligonucleotide Capture Probes
	Keld Sorensen, Luminex Short Talk: High Throughput microRNA Expression Profiling Using a Bead Based Multiplex System
	Caifu Chen, Applied Biosystems MicroRNA Expression Profiling from Single Cells using Multiplex PreAmp TaqMan® MicroRNA Assays
	Andreas G. Bader, Asuragen Inc. Clinical Applications of miRNAs
5:15 - 6:15 PM	Social Hour w/ Lite Bites	Crestone/Red Cloud
5:30 - 8:00 PM	Poster Session 1	Crestone/Red Cloud
Sunday, June 10
7:00 - 8:00 AM	Breakfast	Crestone/Red Cloud
8:00 - 11:00 AM	MicroRNAs and Cancer	Shavano Peak
	* Joshua Mendell, Johns Hopkins University

	Scott M. Hammond, University of North Carolina at Chapel Hill MicroRNA Expression in Cancer
	Lin He, University of California, Berkeley A microRNA Component of the p53 Tumor Suppressor Network
	Carlo M. Croce, Ohio State University MicroRNAs as oncogenes and tumor suppressors
	Christine Mayr, Whitehead Institute for Biomedical Research Short Talk: let-7 Represses Hmga2 to Prevent Human Tumors
	Katia Basso, Columbia University Short Talk: Identification of Normal and Neoplastic Human Mature B Cells “miRome”
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM - 1:00 PM	Poster Setup	Crestone/Red Cloud
1:00 - 8:00 PM	Poster Viewing	Crestone/Red Cloud
2:30 - 3:00 PM	Coffee Available	Shavano Peak Foyer
3:00 - 5:00 PM	MicroRNAs and Cancer	Shavano Peak
	* Carlo M. Croce, Ohio State University
	Reuven Agami, Netherlands Cancer Institute EMBO Young Investigator Lecture: MicroRNAs as Oncogenes

	Sakari Kauppinen, Santaris Pharma Antagonizing microRNAs for Therapeutics
	Joshua Mendell, Johns Hopkins University Reprogramming of MicroRNA Expression by Oncogenes and Tumor Suppressors

	Marcus E. Peter, University of Chicago Short Talk: Reduced Let-7 Expression is a Marker for CD95 Type I Cells Representing More Advanced and Less Differentiated Stages of Cancer
5:00 - 6:00 PM	Social Hour w/ Lite Bites	Crestone/Red Cloud
5:30 - 8:00 PM	Poster Session 2	Crestone/Red Cloud
Monday, June 11
7:00 - 8:00 AM	Breakfast	Crestone/Red Cloud
8:00 - 11:00 AM	MicroRNAs in Development	Shavano Peak
	* Frank J. Slack, Yale University


	Klaus Rajewsky, PCMM, Children's Hospital Boston, Immune Disease Institute MicroRNA Control in Lymphocytes
	Antonio J. Giraldez, Yale School of Medicine MicroRNAs in Vertebrate Development
	Antony Rodriguez, Wellcome Trust Sanger Institute Short Talk: miR-155/bic is Essential for Normal Immune Function in Mice

	María José Bueno, Universidad Autónoma de Madrid Short Talk: Genetic and Epigenetic Silencing of miR-203 Enhances ABL1 Oncogene Expresión in Hematopoietic Malignancies
	Sarah Kathryn Fineberg, University of Iowa Short Talk: miR-34a Modulates Neural Progenitor Cell Differentiation
	Rui Yi, Rockefeller University Short Talk: Functional Study of a Skin Specific microRNA in Embryonic Skin Development
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
2:30 - 3:00 PM	Coffee Available	Shavano Peak Foyer
3:00 - 5:00 PM	MicroRNAs in Cancer	Shavano Peak
	* Carlo M. Croce, Ohio State University

	Andrea Ventura, Memorial Sloan-Kettering Cancer Center On the Role of microRNAs in Mouse Development and Cancer

	Frank J. Slack, Yale University MicroRNAs in development and cancer

	Bill Piu Wong, Stanford University Short Talk: miR-142 is a Novel Collaborating Oncogene in Haematological Malignancies
	Christopher Y. Park, Stanford University Short Talk: miRNA Expression Profiling of Human Acute Myeloid Leukemia Reveals a Leukemia Stem Cell Signature
6:00 - 7:00 PM	Social Hour w/ Lite Bites	Gazebo
6:00 - 9:00 PM	Entertainment	Gazebo
Tuesday, June 12
	Departure

*Session Chair †Speaker invited, not yet responded.