Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2)

Organizer(s): Qimin Zhan, Yang Ke, Xin Wei Wang, Raymond DuBois and Zongtang Sun
October 14 - 19, 2007
Capital Hotel · Beijing, China
Abstract Deadline: July 17, 2007
Late Abstract Deadline: July 17, 2007
Scholarship Deadline: June 14, 2007
Early Registration Deadline: August 14, 2007

In Collaboration with and Cosponsored by Chinese Academy of Medical Sciences and Peking University Health Science Center

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2007 season.

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Summary of Meeting
Gastrointestinal (GI) malignancies account for a large fraction of human cancers. They are almost without exception incurable when gross metastases exist. Three of the 20 top leading causes of worldwide mortality are related to GI malignancies. For example, liver cancer is the third leading cause of worldwide cancer deaths and most of them (>79%) are in Asia. Liver and gastric cancers are the leading cause of cancer deaths in China. There is a strong need to discuss and develop a coherent strategy by joining efforts from both east and west to study GI malignancies. The Keystone Symposia is an excellent platform for a conference on GI malignancies because of its high scientific standard and impact. An in depth discussion of the interest in molecular epidemiology, GI cancer models, molecular diagnostic/prognostic, therapeutic strategies and cancer stem cells in the context of rapid development of these areas is therefore timely. The goals of this symposium are to bring together Academia, Government and Industry laboratories from Asia, North America and Europe working on gastroenterological malignancies, to exchange state-of-the-art and late-breaking discoveries, and to update consensus strategies in a fight against these malignancies.

Sunday, October 14
3:00 - 7:00 PM	Registration	Jinyun Foyer
6:00 - 7:00 PM	Refreshments	Jinyun Foyer
7:00 - 7:15 PM	Opening Remarks	Jinyun Ballroom
7:15 - 8:15 PM	Keynote Session	Jinyun Ballroom
	Carlo M. Croce, Ohio State University



Monday, October 15
7:30 - 8:30 AM	Breakfast	Coffee House
8:30 - 11:45 AM	Biology and Genetics of GI Malignancies I	Jinyun Ballroom
	* Michael Karin, University of California, San Diego
	* Xiaodong Wang, University of Texas Southwestern Medical Center

	Joanna L. Groden, Ohio State University DNA Repair and Colon Cancer

	Benjamin C.Y. Wong, University of Hong Kong Stomach Cancer: Molecular Targets for Prevention and Treatment
	Scott W. Lowe, Cold Spring Harbor Laboratory Probing the genetics and biology of liver carcinoma using mouse models and RNA interference


	Vincent W. Yang, Emory University Krüppel-Like Factors (KLFs) and Intestinal Tumorigenesis


	Ursula Barbara Kurzik-Dumke, Institute of Medical Microbiology and Hygiene, Comparative Tumor Biology Short Talk: Htid-1, the Human Homolog of the Drosophila Melanogaster l(2)tid Tumor Suppressor, is a Novel Physiological Ligand of APC Associated with Progression of Colorectal Cancer
	Lin Yang, University of Texas, MD Anderson Cancer Center ZNF306, a Novel “Master Regulator” of Gene Expression, Drives Progression of Colorectal Cancers Unaltered for Commonly-mutated Genes

9:45 - 10:15 AM	Coffee Break	Jinyun Foyer
12:00 - 1:00 PM	Poster Setup	Jinyun Foyer
3:30 - 5:30 PM	Poster Session 1	Jinyun Foyer
4:30 - 5:30 PM	Coffee & Snacks Available	Jinyun Foyer
5:30 - 6:30 PM	Evening Keynote Address	Jinyun Ballroom
	* Qimin Zhan, Chinese Academy of Medical Sciences
	Xiaodong Wang, University of Texas Southwestern Medical Center Apoptosis and Cancer
6:30 - 7:45 PM	Cancer Biology and Genetics of GI Malignancies II	Jinyun Ballroom
	* Xin Wei Wang, NCI, National Institutes of Health
	Qimin Zhan, Chinese Academy of Medical Sciences The Cell Cycle Regulator in Malignant Development of Human Esophageal Cancer
	Hong-Yang Wang, International Cooperation Laboratory on Signal Transduction, SMMU Cell Signaling and Human Hepatocellular Carcinoma


Tuesday, October 16
7:30 - 8:30 AM	Breakfast	Coffee House
8:30 - 11:45 AM	Role of Microenvironment and Inflammation in GI Cancers I	Jinyun Ballroom
	* Raymond N. DuBois, University of Texas MD Anderson Cancer Center
	Curtis C. Harris, NCI, National Institutes of Health Inflammation and Cancer: Interactions of the MicroRNA, p53 and Cytokine Pathways

	Martin J. Blaser, New York University School of Medicine Oncogenic Pathways Related to Helicobacter pylori
	Michael Karin, University of California, San Diego How Inflammation Affects Cancer Development and Progression: The IKK Complex and Beyond


	Timothy Cragin Wang, Irving Cancer Research Center, Columbia University The Role of Inflammation and Bone Marrow Progenitor Cells in the Pathogenesis of Gastric Cancer


	Anna Bigas, IDIBELL-Institut de Recerca Oncologica Short Talk: Notch Cooperates with Beta-catenin to Activate a Specific Gene Program

	Hiroyuki Marusawa, Kyoto University Short Talk: Activation-induced Cytidine Deaminase Links Liver Inflammation to Human Hepatocarcinogenesis
9:45 - 10:15 AM	Coffee Break	Jinyun Foyer
12:00 - 1:00 PM	Poster Setup	Jinyun Foyer
11:30 - 1:30 PM	Lunch	Coffee House
1:30 - 3:30 PM	Workshop	Jinyun Ballroom
	* Zongtang Sun, Chinese Academy of Medical Sciences
	* Xiaodong Wang, University of Texas Southwestern Medical Center
	François Boudreau, University of Sherbrooke Loss of Cathepsin L Activity Promotes Claudin-1 over Expression and Intestinal Neoplasia
	Rachid A. Karam, MD Anderson Cancer Center The NMD RNA Surveillance Pathway Degrades Aberrant E-Cadherin Transcripts in Hereditary Diffuse Gastric Cancer
	Giang Huong Nguyen, National Institutes of Health A Unique Inflammatory Gene Signature Associated with Reduced Survival in Esophageal Cancer
	Hui Xiao, Cleveland Clinic Foundation The Regulatory Role of SIGIRR in Colonic Epithelial Homeostasis, Inflammation and Tumorigenesis

	Ying Yang, Institute of Molecular Medicine, Peking University Shp2 Suppresses the mT-induced Transformation by Inhibiting Stat3 and mTOR/S6K1 Signaling Pathways
	Mi-Ock Lee, Seoul National University Hepatitis B Virus X Protein Induces the Expression of MTA1 and HDAC1, which Enhances Hypoxia Signaling in Hepatocellular Carcinoma Cells
	Siina Junnila, University of Helsinki Different Gastric Cancer Subtypes Exhibit Distinct Molecular Profiles by Gene Copy Number, Expression and Tissue Microarrays
3:30 - 5:30 PM	Poster Session 2	Jinyun Foyer
4:30 - 5:30 PM	Coffee & Snacks Available	Jinyun Foyer
5:30 - 7:30 PM	Role of Microenvironment and Inflammation in GI Cancers II	Jinyun Ballroom
	* Snorri S. Thorgeirsson, National Institutes of Health
	Varda Rotter, Weizmann Institute of Science Identification and Characterization “Gene Signatures” Involved in Cells Transformed in vitro

	Hiroshi Ohshima, University of Shizuoka Helicobacter pylori Infection, Oxidative and Nitrative Stress and Stomach Cancer



Wednesday, October 17
7:30 - 8:30 AM	Breakfast	Coffee House
8:30 - 11:45 AM	GI Cancer Epidemiology and Prevention I	Jinyun Ballroom
	* Curtis C. Harris, NCI, National Institutes of Health
	Yu-Tang Gao, Shanghai Cancer Institute Gastrointestinal Cancer Incidence and Trends in China

	Dongxin Lin, Chinese Academy of Medical Sciences & Peking Union Medical College Genetic Polymorphisms and Risk of Gastroesophageal Cancer
	Raymond N. DuBois, University of Texas MD Anderson Cancer Center Colorectal Cancer Prevention: Molecular Targets
	Yang Ke, Peking University HPV and Esophageal Cancer
	Wei-guo Zhu†, Peking University Health Sciences Center Short Talk: A Correlation Exists between Numb and Notch1 Expression in Colorectal Cancer with Clinicopathological Parameters
	Donghui Li, University of Texas, MD Anderson Cancer Center, Health Science Center Short Talk: Genetic Variations in Drug Metabolism and DNA Repair as Predictors for Clinical Outcomes of Pancreatic Adenocarcinoma
9:45 - 10:15 AM	Coffee Break	Jinyun Foyer
12:00 - 1:00 PM	Poster Setup	Jinyun Foyer
12:00 - 5:00 PM	Optional Tour with Lunch
5:00 - 5:30 PM	Coffee Available	Jinyun Foyer
5:30 - 7:30 PM	GI Cancer Epidemiology and Prevention II	Jinyun Ballroom
	* Edison T. Liu, Genome Institute of Singapore
	Thomas Ried, National Cancer Institute, National Institutes of Health Causes and Consequences of Chromosomal Aneuploidy in Colon Cancer

	Gangqiao Zhou, Beijing Proteom Research Center Genetic Susceptibility to Common Cancers of Chinese
	Suet Yi Leung, University of Hong Kong Microsatellite Instability in Hereditary and Sporadic Colorectal Cancer – Genetic and Epigenetic Mechanisms

7:30 - 8:30 PM	Social Hour w/ Lite Bites	Jinyun Foyer
7:30 - 10:00 PM	Poster Session 3	Jinyun Foyer
Thursday, October 18
7:30 - 8:30 AM	Breakfast	Coffee House
8:30 - 11:30 AM	New Horizon in Early Detection and Therapies I	Jinyun Ballroom
	* Peter R. Galle, University of Mainz


	Edison T. Liu, Genome Institute of Singapore Systems Pharmacology: Cancer Therapeutics
	Xin Wei Wang, NCI, National Institutes of Health Diagnostic and Prognostic Signatures of Liver Cancer
	Zhao-You Tang, Fudan University Liver Cancer Therapy at Liver Cancer Institute of Fudan University

	Frederic Hollande, Functional Genomics Institute Short Talk: Inhibition of Beta-catenin/Tcf-4 and Notch After Progastrin-Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors
	Guihua Wang, Tongji Hospital Short Talk: A Peptide Inhibitor Targeting p55PIK PI 3-Kinase Regulatory Subunit is Effective in Cancer Therapy

	XiangMei Chen, Peking University Short Talk: Aberrant Hypermethylation of Retinoic Acid Signaling Related Genes RARâ1/CRBP1/TIG1 in Gastric Carcinoma
9:45 - 10:15 AM	Coffee Break	Jinyun Foyer
5:00 - 5:30 PM	Coffee Available	Jinyun Foyer
5:30 - 7:30 PM	New Horizon in Early Detection and Therapies II	Jinyun Ballroom
	* Yang Ke, Peking University
	Snorri S. Thorgeirsson, National Institutes of Health Genomic Decoding of Human Liver Cancer
	Peter R. Galle, University of Mainz Signal Transduction Pathways and Targeted Therapies in HCC

7:30 - 8:30 PM	Social Hour w/ Lite Bites	Jinyun Foyer
Friday, October 19
	Departure

*Session Chair †Speaker invited, not yet responded.