| Sunday, January 6 |
|
3:00 - 7:30 PM
|
Registration
|
Foyer
|
|
6:30 - 7:30 PM
|
Refreshments
|
Foyer
|
|
7:30 - 9:30 PM
|
Keynote Session (Joint)
|
Sunshine/Mt. Werner/Storm Peak
|
|
*
Wolfgang P. Baumeister,
Max Planck Institute of Biochemistry
|
|
|
*
Ian A. Wilson,
The Scripps Research Institute
|
|
|
|
|
|
|
|
|
Michael G. Rossmann,
Purdue University
Hybrid Structural Approaches: The Study of Viruses
|
|
|
Jeffrey I. Gordon,
Washington University School of Medicine
The Human Microbiome: Exploring the Microbial Side of Ourselves
|
|
| Monday, January 7 |
|
7:00 - 8:00 AM
|
Breakfast
|
3 Saddles/Bear River
|
|
8:00 - 11:15 AM
|
Advances in Protein Production and Crystallization
|
Sunshine
|
|
*
Aled M. Edwards,
University of Toronto
|
|
|
Lance Stewart,
Emerald BioStructures
Synthetic Gene Design for Structural Proteomics
|
|
|
Yaeta Endo,
Ehime University
Advances in the Cell-Free Protein Production for Protein Biology
|
|
|
Neil Isaacs,
University of Glasgow
Methods of Membrane Protein Production
|
|
|
Andrzej Joachimiak,
Argonne National Laboratory
Lessons Learned from High-throughput Protein Production
|
|
|
Ian A. Wilson,
The Scripps Research Institute
Can We Predict Which Proteins Will Crystallize
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Foyer
|
|
11:15 AM - 12:00 PM
|
Open Meeting of the Protein Structure Initiative (PSI)
|
Sunshine
|
|
*
John C. Norvell,
NIGMS, National Institutes of Health
|
|
|
12:00 - 1:00 PM
|
Poster Setup
|
Rainbow/Twilight/Sunset/Skyline
|
|
1:00 - 10:00 PM
|
Poster Viewing
|
Rainbow/Twilight/Sunset/Skyline
|
|
2:00 - 4:30 PM
|
Workshop 1: Applications of Structural Genomics for Structural Biology
|
Sunshine
|
|
*
Lance Stewart,
Emerald BioStructures
|
|
|
John Walchli,
deCODE Biostructures, Inc.
Gene Composer: A Construct and Codon Engineering Tool for Synthetic Structural Biology
|
|
|
Martin Hammarström,
Karolinska Institute
The Use of Systematic N- and C-terminal Deletions to Promote Production and Structural Studies of Recombinant Proteins
|
|
|
Asli Ertekin,
Rutgers University
Using Mass Spectrometry-based Amide Hydrogen/Deuterium Exchange in Optimizing Protein Constructs for NMR Structure Determination
|
|
|
David C. Wood,
Pfizer, St. Louis
Parallel Protein Expression, Purification and Analysis for Structural Biology
|
|
|
David Cooper,
University of Virginia
The SER Salvage Strategy
|
|
|
Heath E. Klock,
Genomics Institute of the Novartis Research Foundation
Salvage Pathways for Problematic Targets: Lessons Learned from Structural Genomics
|
|
|
Matthew D. Zimmerman,
University of Virginia
Efficient Experimental Design and Quantitative Analysis of Crystallization Experiments with the Xtaldb Expert System
|
|
|
Edward H. Snell,
Hauptman Woodward Medical Research Institute
Order from Chaos - the Design and Interpretation of High Throughput Crystallization Screens to Guide Optimization
|
|
|
Shohei Koide,
University of Chicago
Protein Engineering Pipeline for
Chaperone-Assisted Crystallography
|
|
|
Markus G. Grütter,
University of Zurich
Technological Advances for Supramolecular Assemblies
|
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Foyer
|
|
5:00 - 7:00 PM
|
Pushing the Limits of Structural Biology I: Membrane Proteins (Joint)
|
Sunshine/Mt. Werner/Storm Peak
|
|
*
Robert M. Stroud,
University of California, San Francisco
|
|
|
Wayne A. Hendrickson,
Columbia University
Ligand Stimulated Transitions in Nicotinic Acetylcholine Receptor á9
|
|
|
|
|
|
|
|
|
|
|
|
Kurt Wüthrich,
ETH Zurich/The Scripps Research Institute
Solution NMR Spectroscopy in Membrane Protein Structural Genomics
|
|
|
|
|
|
|
|
|
Raymond C. Stevens,
The Scripps Research Institute
High Resolution Crystal Structures of the Human b2-Adrenergic Receptor and Implications in GPCR Biology and Drug Discovery
|
|
|
Tony Kossiakoff,
University of Chicago
Short Talk: Structures of Open and Closed Forms of Full-Length KcsA Channel Using Chaperone-Assisted Crystallography: Application to Solving the Structure of the Closed and Open Forms of KcsA
|
|
|
7:00 - 8:00 PM
|
Social Hour
|
Rainbow/Twilight/Sunset/Skyline
|
|
7:30 - 10:00 PM
|
Poster Session 1: Protein Prediction, Structure Determination and Methods
|
Rainbow/Twilight/Sunset/Skyline
|
| Tuesday, January 8 |
|
7:00 - 8:00 AM
|
Breakfast
|
3 Saddles/Bear River
|
|
8:00 - 11:00 AM
|
Advances in X-ray and NMR Structure Determination. Session Supported in part by Bruker BioSpin Corp. and Bruker AXS Inc.
|
Sunshine
|
|
*
Kurt Wüthrich,
ETH Zurich/The Scripps Research Institute
|
|
|
Masatsune Kainosho,
Nagoya University
Stereo-Array Isotope Labeling (SAIL) for NMR
|
|
|
|
|
|
Michael Nilges,
Institut Pasteur
New Calculation Protocols for Analyzing NOE Data: Solid State NMR, Synmetric Multimers and Inconsistent Data
|
|
|
Victor S. Lamzin,
BIOXHIT
A Highly Integrated Platform for Structural Biology and Advances in Ligand Fitting
|
|
|
John A. Tainer,
The Scripps Research Institute
Short Talk: X-ray Solution Scattering (SAXS) Combined with Crystallography and Computation: Defining Accurate Dynamic Macromolecular Assemblies in Solution
|
|
|
David Baker,
University of Washington
Structure Determination and Refinement from Limited Experimental Data Using Rosetta
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Foyer
|
|
11:00 AM - 1:00 PM
|
Poster Setup
|
Rainbow/Twilight/Sunset/Skyline
|
|
1:00 - 10:00 PM
|
Poster Viewing
|
Rainbow/Twilight/Sunset/Skyline
|
|
2:00 - 4:30 PM
|
Workshop 2: Advances in Methodologies/Tools for Structural Genomics and Structural Biology
Focusing on hardware, software, devices and databases.
|
Sunshine
|
|
*
Andrzej Joachimiak,
Argonne National Laboratory
|
|
|
Cory J. Gerdts,
Emerald BioSystems
The Microfluidic Protein Crystallization System (MPCS)
|
|
|
Andy May,
Fluidigm Corporation
Diffraction-Capable Microfluidic Crystallization Chips for Screening and Structure Determination
|
|
|
Stephen R. Wasserman,
SGX Pharmaceuticals, Inc
The Integration of Rapid Synchrotron-based X-ray Crystallography into Structural Genomics and Drug Development: The SGX-CAT Beamline at the Advanced Photon Source
|
|
|
Wuxian Shi,
Brookhaven National Laboratory
Metalloproteomics - High Throughput Metal Analysis of Proteins
|
|
|
Wladek Minor,
University of Virginia
HKL-3000 - Towards the Future of Protein Crystallography
|
|
|
Dusan Turk,
Jozef Stefan Institute
MAIN Entering 2008: Real Space Model Fitting – As Good As It Gets
|
|
|
George N. Phillips, Jr.,
University of Wisconsin, CESG
Map Interpretation and Ensemble Refinements
|
|
|
Ashley M. Deacon,
Stanford Synchrotron Radiation Laboratory
Maintaining High Quality Structure Depositions at JCSG
|
|
|
Thomas Andrew Binkowski,
Argonne National Laboratory
Comparison and Analysis of Protein Functional Surfaces
|
|
|
Subramanian Sri Krishna,
Burnham Institute
TOPSAN: A Community-driven Protein Knowledgebase for Structural Genomics
|
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Foyer
|
|
5:00 - 7:15 PM
|
Ligands as Probes for Function
|
Sunshine
|
|
*
Stephen K. Burley,
Eli Lilly and Company
|
|
|
Benjamin F. Cravatt III,
The Scripps Research Institute
Metabolomics and its Role in Enzyme Function Assignment
|
|
|
|
|
|
Janet M. Thornton,
European Bioinformatics Institute
Diversity of Ligands within Protein Families
|
|
|
Aled M. Edwards,
University of Toronto
Screening for Function
|
|
|
Chang-Yub Kim,
Los Alamos National Laboratory
Short Talk: Development of a High-Throughput Ligand Screening Technique and Application to Structural Genomics
|
|
|
|
|
|
Maurizio Pellecchia,
Burnham Institute
Short Talk: Targeting Apoptosis by Chemical Design: NMR Guided Reverse Chemical Genetics and Drug Discovery
|
|
|
7:15 - 8:15 PM
|
Social Hour w/ Lite Bites
|
Rainbow/Twilight/Sunset/Skyline
|
|
7:30 - 10:00 PM
|
Poster Session 2: Macromolecular Structure and Function
|
Rainbow/Twilight/Sunset/Skyline
|
| Wednesday, January 9 |
|
7:00 - 8:00 AM
|
Breakfast
|
3 Saddles/Bear River
|
|
8:00 - 11:00 AM
|
Exploiting the Expanding Protein Universe
|
Sunshine
|
|
*
Andrej Sali,
University of California, San Francisco
|
|
|
Jo Handelsman,
University of Wisconsin-Madison
Structure and Function of Microbial Communities
|
|
|
|
|
|
Robert M. Stroud,
University of California, San Francisco
Membrane Proteomics
|
|
|
John Moult,
University of Maryland Biotechnology Institute
Expanding Structure Coverage of the Protein Universe with Comparative Modeling
|
|
|
Helen M. Berman,
Rutgers University
Short Talk: Harnessing Knowledge from Structural Genomics: the PSI Knowledgebase
|
|
|
|
|
|
Gaetano T. Montelione,
Rutgers University
Short Talk: Structural Genomics Provides Novel Hypotheses for Biology
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Foyer
|
|
11:00 AM - 1:00 PM
|
Poster Setup
|
Sunshine
|
|
1:00 - 10:00 PM
|
Poster Viewing
|
Sunshine
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Foyer
|
|
5:00 - 7:30 PM
|
Pushing the Limits of Structural Biology II: Advances in Methodologies for Structure Determination (Joint)
|
Sunshine/Mt. Werner/Storm Peak
|
|
*
Wayne A. Hendrickson,
Columbia University
|
|
|
Hartmut Oschkinat,
FMP Berlin
Solid State NMR Methods for Protein Structure Determination
|
|
|
|
|
|
Gerhard Wagner,
Harvard Medical School
Protein Complexes that Regulate Polypeptide Synthesis
|
|
|
Carolyn A. Larabell,
University of California, San Francisco
X-ray Tomography of Whole Cells at 50 nm Resolution
|
|
|
Wolfgang P. Baumeister,
Max Planck Institute of Biochemistry
Mapping Molecular Landscapes Inside Cells by Cryoelectron Tomography
|
|
|
Andreas Hoenger,
University of Colorado, Boulder
Short Talk: PEET (Particle Estimation for Electron Tomography: A New Software Package for 3D Alignment and Averaging of Volume
|
|
|
7:30 - 8:30 PM
|
Social Hour w/ Lite Bites
|
Rainbow/Twilight/Sunset/Skyline
|
|
8:00 - 10:00 PM
|
Workshop on World-Wide Structural Genomic and Structural Proteomic Centers
Structural genomic, structural proteomic and protein production centers and consortia present their platforms to highlight new methods, technologies, databases, and computational tools that have enabled advances in protein production and structure determination for all classes of targets from bacterial to challenging macromolecules , such as membrane proteins, eukaryotic proteins and protein-protein complexes. An emphasis will be placed on what can now be utilized by the entire community, including single investigator laboratories to increase success and throughput and lower costs.
|
Sunshine
|
| Thursday, January 10 |
|
7:00 - 8:00 AM
|
Breakfast
|
3 Saddles/Bear River
|
|
8:00 - 11:15 AM
|
Proteomics and Protein Assemblies/Networks
|
Sunshine
|
|
*
Janet M. Thornton,
European Bioinformatics Institute
|
|
|
Andrej Sali,
University of California, San Francisco
Modeling the Structures of Macromolecular Assemblies
|
|
|
David Eisenberg,
University of California, Los Angeles
Protein Assemblies in Health and Disease
|
|
|
Ruedi H. Aebersold,
Institute of Molecular Systems Biology, ETH Zurich
On the Characterization of Protein Complexes and Protein Interaction Networks
|
|
|
|
|
|
Adam Godzik,
Burnham Institute for Medical Research
Metabolic Reconstruction of Thermatoga Maritima
|
|
|
Alexander B. Sigalov,
University of Massachusetts Medical School
Short Talk: Homointeractions between Intrinsically Disordered Proteins: Unusual Structural Features and a Role in Immune Signaling
|
|
|
Akira Nozawa,
Ehime University
Short Talk: A Cell-free System-based Method for Comprehensive Analysis of DNA Binding to Human Hormone Nuclear Receptors by Fluorescence Correlation Spectroscopy
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Foyer
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Foyer
|
|
5:00 - 7:00 PM
|
Exploiting Structure for Function
|
Sunshine
|
|
*
Gaetano T. Montelione,
Rutgers University
|
|
|
Stephen K. Burley,
Eli Lilly and Company
Structural Genomics of Protein Phosphatases
|
|
|
Stefan Knapp,
Oxford University
The Protein Kinase Family
|
|
|
Christine A. Orengo,
University College London
Short Talk: Structural Genomics to Explore the Evolution of Protein Function
|
|
|
|
|
|
|
|
|
Peter Kuhn,
The Scripps Research Institute
Proteomic Analysis of nsp3, a Multifunctional 1922 Amino Acid Polypeptide in SARS CoV
|
|
|
8:00 - 9:00 PM
|
Social Hour w/ Lite Bites
|
Foyer
|
|
9:00 - 11:00 PM
|
Entertainment
|
Sunshine
|
| Friday, January 11 |
|
|
Departure
|
|
