Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Cancer Genomics and Epigenomics (C1)

Organizer(s): Andrew P. Feinberg, Greg J. Hannon and Rolf Ohlsson
February 19 - 24, 2008
Sagebrush Inn and Conference Center · Taos, New Mexico
Abstract Deadline: October 19, 2007
Late Abstract Deadline: November 19, 2007
Scholarship Deadline: October 19, 2007
Early Registration Deadline: December 19, 2007

Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2008 season.

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Summary of Meeting
In the “post-genome” era, in which the human DNA sequence is available, as are those of many animal models, cancer genetics is being transformed both by the access to this sequence and by the technology that the genome project facilitated. It is now clear that many genetic changes occur in tumors, including mutations and copy number changes, as well as an even larger number of epigenetic alterations, such as altered DNA methylation, chromatin modification, and loss of genomic imprinting. High-throughput genomic and epigenomic approaches are now available, but are also being developed to assess the scope of these genomic/epigenomic changes. There is also a deeper evolution of our understanding that the genome and epigenome may be intrinsically disrupted in tumors, for example by palindrome formation and whole-band methylation. These advances raise several major questions, including: • Which genetic and epigenetic changes play a causal role in tumor initiation and progression? • What is the genetic and epigenetic basis of cancer predisposition? • Is there large scale disruption of the cancer genome and epigenome and how does this arise? • And how can we exploit advances in cancer genomics and epigenomics? • What are the cutting edge technologies that will advance the sensitivity of detection of subpopulations such as cancer stem cells? This symposium will explore the technological developments, large scale alterations, and gene-specific changes emerging in the genome-wide approach to cancer, as well as the implications of these discoveries for cancer prevention and therapy.

Tuesday, February 19
3:00 - 7:30 PM	Registration	Chamisa Lobby
6:30 - 7:30 PM	Refreshments	Chamisa Lobby
7:30 - 8:30 PM	Keynote Address	Chamisa Ballroom 1
	* Andrew P. Feinberg, Johns Hopkins University School of Medicine
	Janet D. Rowley, University Of Chicago The Hidden Side of Leukemia Gene Expression

Wednesday, February 20
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:00 AM	High Throughput Genome, Epigenome, and Cell Biology Approaches (Technology)	Chamisa Ballroom 1

	Stephan Beck, University College London High-Throughput Approaches for DNA Methylation Profiling
	John A. Stamatoyannopoulos, University of Washington High Throughput Chromatin Analysis
	* Rolf Ohlsson, Karolinska Institute Chromosomal Networks: New Perspectives of Cancer Epigenomics
	Jeffrey A. Jeddeloh, Roche NimbleGen Short Talk: Sequence Capture: A Microarray Strategy for Genomic Selection Coupled to High-Throughput Sequencing Facilitates Genetic and Epigenetic Characterization upon Individual Alleles
	Christoph Bock, Harvard University Short Talk: Powerful and User-Friendly Bioinformatic Methods for Cancer Epigenomics
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:00 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 6:45 PM	High Throughput Sequencing of the Tumor Genome	Chamisa Ballroom 1
	* Richard Myers, Stanford University School of Medicine


	Matthew L. Meyerson, Dana Farber Cancer Institute Genomic Alterations in Human Cancers
	Aleksandar Milosavljevic, Baylor College of Medicine Short-Read Sequencing Applications
	Heidi Greulich, Dana Farber Cancer Institute Cancer Genome Sequencing

6:45 - 7:00 PM	Open Discussion of Sequencing Methods	Chamisa Ballroom 1
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 1	Chamisa Ballroom 2
Thursday, February 21
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:00 AM	Chromosome Abnormalities	Chamisa Ballroom 1
	* Donna G. Albertson, University of California, San Francisco Causes and Consequences of Genomic Instability in Cancer
	Michael H. Wigler, Cold Spring Harbor Laboratory Variation in Gene Copy Number and Methylation in Human Cancer

	Scott J. Diede, Fred Hutchinson Cancer Research Center DNA Palindrome Formation is Nonrandomly Distributed and Associated with Gene Amplification in Cancer

	Shinya Toyokuni, Kyoto University Graduate School of Medicine Short Talk: Chronic Oxidative Stress as a Cause of Genomic Amplification
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:00 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Integrative Genomics	Chamisa Ballroom 1

	Edison T. Liu, Genome Institute of Singapore Systems Integration in Genomic Medicine
	* Thomas R. Gingeras, Cold Spring Harbor Laboratory Lessons Learned from Pervasive Transcription: Possible Reasons and Mechanisms
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 2	Chamisa Ballroom 2
Friday, February 22
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:30 AM	Chromatin	Chamisa Ballroom 1

	Peter Fraser, Babraham Institute Transcription and Genome Organization
	* Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory Large Scale Chromosomal Interactions at the c-Myc Locus Regulated by SATB1
	Bradley E. Bernstein, Massachusetts General Hospital, Harvard Medical School Sequencing the Mammalian Epigenome
	Agate Noer, University of Oslo Short Talk: Modifications of Histone H3 Associated with Senescence and Differentiation of Human Adipose Stem Cells
	Melissa J. Fullwood, Genome Institute of Singapore Short Talk: Whole Genome Chromatin Interaction Analysis using Paired End diTag Sequencing
	Anderly C. Chueh, Murdoch Childrens Research Institute Short Talk: Defining Neocentromere Identity: Role of L1 Retroelements in the Epigenetic Formation of Ectopic Centromere Chromatin
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:15 PM	RNA and Functional Screening	Chamisa Ballroom 1
	* Gregory J. Hannon, Cold Spring Harbor Laboratory Focal Re-Seqencing: A Comparison of Capture Platforms
	Yaniv Erlich, Cold Spring Harbor Laboratory Short Talk: Improving Solexa Base Calling
	René Bernards, Netherlands Cancer Institute Biomarkers of Resistance to Cancer Therapy Discovered Through Functional Genetic Screens.

	Lili Milani, Uppsala University Short Talk: Allele-Specific Analysis of Gene Expression in Childhood Acute Leukemia by Genome Wide SNP Genotyping
	Sohail F. Tavazoie, Rockefeller University Short Talk: Endogenous Human MicroRNAs that Suppress Breast Cancer Metastasis
	Milan G. Chheda, Massachusetts General Hospital Short Talk: High Throughput RNAi Screen to Identify Genes Required for Stem Cell Phenotype of Glioblastoma Tumor Initiating Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
Saturday, February 23
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:30 AM	Epigenomics	Chamisa Ballroom 1
	* Andrew P. Feinberg, Johns Hopkins University School of Medicine The Epigenetics and Epigenomics of Cancer Etiology
	Tim H.-M. Huang, Ohio State University Finding and Defining Causes of Epigenetic Gene Silencing in Cancer
	Kornelia Polyak, Dana-Farber Cancer Institute Epigenetically Defined Heterogeneity in Normal and Neoplastic Breast Epithelium
	Susan J. Clark, Garvan Institute of Medical Research DNA Methylation Clusters
	Alayne L. Brown, Stanford University Short Talk: Genome-Wide DNA Methylation Profiling of DNMT-Mutant Cells
	Peter L. Molloy, CSIRO Short Talk: Hypomethylation of Different Repeat Families in Colorectal Cancer
	Kevin L. Gunderson, Illumina, Inc. Short Talk: Infinium® Methylation Profiling of over 27,000 CpG Sites from CCDS Gene Promoters
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Translational Genomics	Chamisa Ballroom 1

	Siavash K. Kurdistani, University of California, Los Angeles Epigenetic Reprogramming for Oncogenic Transformation
	* Tomas Ekström, Karolinska Institutet Human Cytomegalovirus and its Association with Epigenetic Alterations

	Jesse S. Boehm, Broad Institute Short Talk: Integrating Functional and Structural Cancer Genomics to Identify Drug Targets
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
8:00 - 11:00 PM	Entertainment	Chamisa Ballroom 2
Sunday, February 24
	Departure

*Session Chair †Speaker invited, not yet responded.