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Signaling Pathways in Cancer and Development (C6)

Organizer(s): Juan Carlos Izpisúa Belmonte and Geoffrey M. Wahl
March 24 - 29, 2008
Sheraton Steamboat Resort  ·  Steamboat Springs, Colorado
Abstract Deadline: November 26, 2007
Late Abstract Deadline: December 26, 2007
Scholarship Deadline: November 26, 2007
Early Registration Deadline: January 25, 2008


Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.



This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Our views of how cancer arises are changing dramatically. While cancer was originally thought to be a cell autonomous process, we now realize that cancers comprise aberrant organs, in which cell:cell, and cell:matrix interactions are critical. Furthermore, it now seems likely that not all cells within a tumor mass are, in fact, tumorigenic. Rather, specialized cells, that resemble tissue stem cells in some of their properties, may be responsible for tumor formation. Finally, the signaling pathways involved in normal development and in cancer have long been known to be similar. Studies over the past several years have given insight into how these pathways work, and how they can be manipulated for therapeutic benefit. Given all these links between cancer formation and development, and the potential applications to new treatment strategies, this conference has been developed to link these two important, rapidly evolving, and exciting areas.

Monday, March 24
3:00 - 7:30 PM Registration Foyer
6:30 - 7:30 PM Refreshments Foyer
7:30 - 8:30 PM Keynote Address Storm Peak/Mt. Werner
Hans C. Clevers, Hubrecht Institute
The Wnt Target Gene Lgr5, a Marker for Adult Stem Cells in Multiple Tissues
Tuesday, March 25
7:00 - 8:00 AM Breakfast Sunshine/Rainbow/Twilight
8:00 - 11:00 AM Enabling Technologies and Treatment Storm Peak/Mt. Werner
* Shinya Yamanaka, Center for iPS Cell Research and Application (CiRA), Kyoto University
Generation of iPS Cells from Adult Human Fibroblasts
Angel Raya, Center of Regenerative Medicine
Generation of Patient-Specific iPS Cells
Marius Wernig, Stanford School of Medicine
Short Talk: Direct Reprogramming of Mouse Fibroblasts and Therapeutic Applicability
Christopher L. Murriel, Genentech, Inc.
Short Talk: The use of a Dual Function Single Lentiviral Vector System for Cre/Lox Mediated Gene Recombination and Inducible Gene Silencing in vivo
Gerald Pao, The Salk Institute
Short Talk: Use of Lentiviral Vectors in Human Stem Cell Biology
9:20 - 9:40 AM Coffee Break Foyer
11:00 AM - 1:00 PM Poster Setup Sunshine
1:00 - 10:00 PM Poster Viewing Sunshine
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 6:50 PM Wnt Signaling in Development and Cancer Storm Peak/Mt. Werner
* Elaine Fuchs, HHMI/Rockefeller University
Wnt Signaling, Stem Cell Activation and Cancer in Skin
Roeland Nusse, Stanford University
Wnt Signaling during Development and Tissue Regeneration
Randall T. Moon, University of Washington School of Medicine
Wnt Signaling during Development and Cancer
6:50 - 7:30 PM Stem Cells: A Potential Common Link Between Development and Cancer Storm Peak/ Mt. Werner
Irving L. Weissman, Stanford University
Normal and Neoplastic Stem Cells
7:30 - 8:30 PM Social Hour w/ Lite Bites Sunshine
7:30 - 10:00 PM Poster Session 1 Sunshine
Wednesday, March 26
7:00 - 8:00 AM Breakfast Sunshine/Rainbow/Twilight
8:00 - 11:00 AM Adult Stem Cells Storm Peak/Mt. Werner
* Fiona M. Watt, CRUK Cambridge Research Institute
Epidermal Stem Cells and Cancer
Leonard I. Zon, Children's Hospital, Boston
Genetic Interaction between PGE2 and Wnt Signaling in Stem Cell Formation and Organ Regeneration
Connie J. Eaves, British Columbia Cancer Agency
Mammary Epithelial Stem Cells
Helen M. Blau, Stanford University
Adult Stem Cell Behavior In Bioengineered Niches
Hao Chang, University of Texas M. D. Anderson Cancer Center
Short Talk: Misregulated beta-catenin signaling causes Sertoli cell tumor development
9:20 - 9:40 AM Coffee Break Foyer
11:00 AM - 1:00 PM Poster Setup Sunshine
1:00 - 10:00 PM Poster Viewing Sunshine
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:15 PM Proliferation, Aging and Cancer Storm Peak/Mt. Werner
* Margaret T. Fuller, Stanford University
Regulation of Proliferation and Differentiation in Adult Stem Cell Lineages
Leanne Jones, The Salk Institute for Biological Studies
Aging-Related Changes to Stem Cells and the Stem Cell Niche
Brigid L.M. Hogan, Duke University Medical Center
Stem/Progenitor Cells in Lung Development, Homeostasis, and Repair
Ignacio Flores, Spanish National Cancer Research Centre (CNIO)
Telomerase Regulation and Stem Cell Behavior
Tatjana Piotrowski, University of Utah
Short Talk: Interactions between beta-Catenin and Fgf Signaling Regulate Directional Migration of Groups of Cells
7:15 - 8:15 PM Social Hour w/ Lite Bites Sunshine
7:30 - 10:00 PM Poster Session 2 Sunshine
Thursday, March 27
7:00 - 8:00 AM Breakfast Sunshine/Rainbow/Twilight
8:00 - 10:50 AM Organogenesis and Cancer Storm Peak/Mt. Werner
* Catriona H.M. Jamieson, University of California, San Diego
The Molecular Evolution of Leukemia Stem Cells
Frank McKeon, Harvard Medical School
TAp63 and the Female Germline
Bruce A. Edgar, Zentrum für Molekulare Biologie University of Heidelberg
Homeostatic Growth Mediated by Intestinal Stem Cells in Adult Drosophila
Duojia D.J. Pan, Johns Hopkins University School of Medicine
The Hippo Signaling Pathway in Organ Size-Control and Cancer
Nicolas Di-Poi, University of Geneva
Short Talk: Distinct Roles for Hoxd Genes in Metanephric Kidney Development
10:50 - 11:30 AM Enabling Technologies and Treatment Storm Peak/Mt. Werner
David T. Scadden, MGH/Harvard University
Title to be Determined
9:20 - 9:40 AM Coffee Break Foyer
11:30 AM - 1:00 PM Poster Setup Sunshine
1:00 - 10:00 PM Poster Viewing Sunshine
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:15 PM Hedgehog Signaling in Development and Cancer
Philip A. Beachy, Stanford University
Hedgehog Signaling during Cancer Growth
* Matthew P. Scott, Stanford University
Communicating with Hedgehogs
Norbert Perrimon, Harvard Medical School
Genetic Analysis of Growth and Homeostasis
William Matsui, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Short Talk: Hedgehog Signaling, Self-Renewal and Cancer Stem Cells
Uda Ho, Queensland Institute of Medical Research
Short Talk: Hedgehog Signaling in Lung Development
7:15 - 8:15 PM Social Hour w/ Lite Bites Sunshine
7:30 - 10:00 PM Poster Session 3 Sunshine
Friday, March 28
7:00 - 8:00 AM Breakfast Sunshine/Rainbow/Twilight
8:00 - 11:00 AM Stem Cell Renewal Mechanisms Storm Peak/Mt. Werner
* Austin G. Smith, University of Cambridge
The Ground State of Pluripotency
Sheng Ding, The Scripps Research Institute
A Chemical Approach to Pluripotency and Reprogramming
Kathrin Plath, University of California, Los Angeles
In vitro Reprogramming of Human and Murine Somatic Cells to an Embryonic State
Konrad Hochedlinger, Massachusetts General Hospital
Global Epigenetic Reprogramming by Defined Transcription Factors
Thomas P. Zwaka, Baylor College of Medicine
Short Talk: Ronin Is Essential for Embryogenesis and the Pluri-Potency of Mouse ES Cells and Acts Independently of Canonical Pathways
9:20 - 9:40 AM Coffee Break Foyer
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Stem Cells: A Potential Common Link Between Development and Cancer Storm Peak/ Mt. Werner
* Sean J. Morrison, HHMI/University of Michigan
The Loss of Nf1 Transiently Promotes Self-Renewal but not Tumorigenesis by Neural Crest Stem Cells
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research
The Role of Pro-survival Bcl-2 Family Members in Tumour Development and Sustaining Tumour Growth
Maikel P. Peppelenbosch, University Medical Center, Groningen
Louis Vermeulen, Academic Medical Center
Short Talk: Single Cell Cloning of Colon Cancer Stem Cells Reveals Multi-Lineage Differentiation Capacity
7:00 - 8:00 PM Social Hour w/ Lite Bites Sunshine
8:00 - 11:00 PM Entertainment Sunshine
Saturday, March 29
Departure
*Session Chair   †Speaker invited, not yet responded.



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