Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Inflammation, Microenvironment and Cancer (D2)

Organizer(s): Michael Karin and Mina J. Bissell
March 30 - April 4, 2008
Snowbird Resort · Snowbird, Utah
Abstract Deadline: December 4, 2007
Late Abstract Deadline: January 2, 2008
Scholarship Deadline: December 4, 2007
Early Registration Deadline: January 30, 2008

Part of the Translational Medicine Series, Sponsored by Pfizer Global Research & Development

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
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Summary of Meeting
In recent years it has become increasingly clear that the inflammatory and innate immune system plays a critical role in cancer development and progression. Initial hints for a potential link between infection, inflammation and cancer came from epidemiological studies. However the subsequent proof of a mechanistic link between inflammation and cancer came from studies in mouse models of cancer. Such studies have highlighted the important function of cells of the innate immune system, especially macrophages, in cancer development and progression. In addition such studies provided evidence for the important pro-carcinogenic function of certain inflammatory signal transduction pathways, especially those leading to NF-kappaB activation. However, it is also becoming evident that the adaptive immune system has a considerable impact on tumor development that can be both negative and positive. Undoubtedly, future development of immunotherapeutic approaches to cancer treatment will have to consider all of these factors and manipulate them in a way that will allow more effective tumor elimination. This meeting will consider the different mechanisms and pathways through which inflammation and immunity affect cancer development. In addition, the contribution of other cells in the tumor microenvironments, such as myofibroblasts and cancer stem cells, will be discussed. Presentations will include state-of-the-art animal studies indicating that even potent oncogenes do not lead to cancer without assistance from activated inflammatory cells. In addition to being a fertile area for research and an important source for new ideas in cancer biology, the inflammation and cancer field is likely to provide us with novel therapeutic opportunities. This meeting will therefore be a source of inspiration of basic and translational researchers alike.

Sunday, March 30
3:00 - 7:30 PM	Registration	Ballroom Lobby
6:30 - 7:30 PM	Refreshments	Ballroom Lobby
7:30 - 8:30 PM	Keynote Address	Ballroom 2-3
	Alberto Mantovani, Istituto Clinico Humanitas Inflammation and Cancer: An Intrinsic and an Extrinsic Pathway
Monday, March 31
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	Innate Immunity and Cancer	Ballroom 2-3
	* Jürg Tschopp, University of Lausanne RNA Helicases and HCV

	Laurence Zitvogel, Institut Gustave Roussy The Molecular Bases of the Immunogenicity of Cell Death
	Vishva M. Dixit, Genentech, Inc. Role of cIAP1/2 in the Non-Canonical NF-kappaB Survival Pathway
	Robert D. Schreiber, Washington University School of Medicine Cancer Immunoediting: Distinct Roles for Innate and Adaptive Immunity in Cancer Control and Promotion
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
11:00 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:00 PM	Adaptive Immunity	Ballroom 2-3
	Martin Oft, Merck IL-23 Induces Immune Deviation in Tumors
	* Hans Schreiber, University of Chicago Stromal Cross-Presentation and the Destruction of the Tumor Microenvironment by T Cells
	George C. Prendergast, Lankenau Institute for Medical Research Genetics and Therapeutic Correction of Immune Escape in Cancer
	Matthias R. Ernst, Ludwig Institute for Cancer Research Short Talk: Stat3 and Stat1 Functionally Cooperate in IL-11-Dependent, Inflammation-Associated Gastric Cancer in gp130 Mutant Mice

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 1	Superior/Superior Lobby/Wasatch/Maybird
Tuesday, April 1
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	Microenvironment	Ballroom 2-3

	Claire E. Lewis, University of Sheffield Medical School Activation of the Potent, Pro-Tumour Functions of Macrophages by the Tumour Microenvironment
	Randall S. Johnson, University of California, San Diego Hypoxia
	Shahin Rafii, Weill Cornell Medical College Contribution of Pro-Angiogenic Hematopoietic Cells to Tumor Growth

	* Tak W. Mak, Campbell Family Institute for Breast Cancer Research at PMH, UHN Control of Cell Deaths in Tumour Microenviroment
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
11:00 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:00 PM	Cytokines and Chemokines	Ballroom 2-3
	Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School Targeting Inflammatory Cytokines in the Tumor Microenvironment
	Markus F. Neurath, University of Mainz IL-6 in Chronic Intestinal Inflammation and Colon Cancer
	* Ann Richmond, Vanderbilt University School of Medicine Chemokines and Cancer Biology
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 2	Superior/Superior Lobby/Wasatch/Maybird
Wednesday, April 2
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	Animal Models	Ballroom 2-3
	Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas Ras Oncogenes, Inflammation and Pancreatic Cancer
	* Dafna Bar-Sagi, New York University School of Medicine Chronic Inflammation and the Pathogenesis of Pancreatic Cancer
	Lisa M. Coussens, University of California, San Francisco Polarized Immune Responses Differentially Regulate Cancer Development
	Eli Pikarsky, Hadassah, Hebrew University Medical Center Short Talk: Molecular Mechanisms for Liver Tumor Inhibition by non Steroidal Anti- Inflammatory Drugs
	Michael Karin, University of California, San Diego Inflammatory Processes in Metastatic Progression
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
11:00 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Wasatch/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Wasatch/Maybird
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:00 PM	Bacteria Viruses Tissue Injury	Ballroom 2-3
	James G. Fox, Massachusetts Institute of Technology Helicobacters, Chronic Inflammation and Cancer
	Timothy Cragin Wang, Irving Cancer Research Center, Columbia University Gastric Cancer

	* Erwin F. Wagner, Spanish National Cancer Research Centre AP-1(Fos/Jun) in Inflammation and Cancer Development
	Xin-Yuan Fu, National University of Singapore Short Talk: Stats and Inflammation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Wasatch/Maybird
7:30 - 10:00 PM	Poster Session 3	Superior/Superior Lobby/Wasatch/Maybird
Thursday, April 3
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	Fibroblasts and Stem Cells	Ballroom 2-3

	Nancy J. Boudreau, University of California, San Francisco The Role of Microenvironment in Breast Cancer and Mammary Cell Fate
	Kornelia Polyak, Dana-Farber Cancer Institute Regulation of in Situ to Invasive Carcinoma Transition

	Judith Campisi, Buck Institute for Age Research The Pro-Inflammatory and Pro-Carcinogenic Senescent Microenvironment
	Harold L. Moses, Vanderbilt University TGF-beta and Metastasis
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:15 PM	Therapeutics	Ballroom 2-3

	Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM) Targeting Host Stromal Microenvironment in Developing New Cancer Therapies


	Roya Khosravi-Far, Harvard Medical School, Beth Israel Deaconess Medical Center A Novel Connection between the Bcr-Abl and the Forkhead Family of Tumor Suppressors
	Douglas Hanahan, ISREC Short Talk: Distinctive Pro-Angiogenic Roles by Cancer-Associated Fibroblasts and Inflammatory Macrophages in the Neoplasctic Cell Enveronment.
	* David A. Cheresh, University of California, San Diego Raf Kinase as Target for Tumor Growth and Angiogenesis
	George C. Prendergast, Lankenau Institute for Medical Research Genetics and Therapeutic Correction of Immune Escape in Cancer
8:00 - 9:00 PM	Social Hour w/ Lite Bites	Ballroom 2-3
8:00 - 11:00 PM	Entertainment	Ballroom 2-3
Friday, April 4
	Departure

*Session Chair †Speaker invited, not yet responded.