| Tuesday, January 15 |
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3:00 - 7:30 PM
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Registration
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BC Foyer
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6:30 - 7:30 PM
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Refreshments
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BC Foyer
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7:30 - 9:30 PM
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Keynote Session (Joint)
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British Columbia Ballroom
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Salvador Moncada,
University College London
Nitric Oxide and Oxygen Homeostasis
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| Wednesday, January 16 |
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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8:00 - 11:00 AM
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Oxygen and Cells
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Columbia Ballroom
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*
Lorenz Poellinger,
Karolinska Institutet
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Sten Lindahl,
Karolinska Institutet
Short Talk: Oxygen Biology: An Historical Perspective
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Peter J. Ratcliffe,
University of Oxford
Protein Hydroxylation and the Cellular Response to Hypoxia
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Paul T. Schumacker,
Northwestern University
Signaling by Mitochondrial Reactive Oxygen Species during Hypoxia
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Edward T.H. Yeh,
University of Texas MD Anderson Cancer Center
Short Talk: SUMO-specific Protease 1 is Essential for Stabilization of HIF-1alpha during Hypoxia
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Bradly G. Wouters,
Ontario Cancer Institute
Short Talk: Hypoxia Inhibits Disulfide Bond Formation and Protein Folding in the Endoplasmic Reticulum
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Walter F. Boron,
Case Western Reserve University
Gas Channels
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Jose Lopez-Barneo,
Hospital Universitario Virgen del Rocío
Facilitated O2 Diffusion and O2 Regulated Ion Channels
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:00 AM - 1:00 PM
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Poster Setup
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Pacific Ballroom
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1:00 - 10:00 PM
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Poster Viewing
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Pacific Ballroom
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2:30 - 4:30 PM
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Workshop 1: Neurophysiological Responses to Hypoxia
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Columbia Ballroom
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*
Jan-Marino Ramirez,
University of Chicago
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Ganesh K. Kumar,
University Of Chicago
ROS Signaling Mediates Intermittent Hypoxia-Induced Neurotransmitter Synthesis Via Post-translational Modifications of Synthesizing Enzymes
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Stephen T. Brown,
McMaster University
Chronic Hypoxia Regulates Genes Important for Metabolism, Packaging, and Secretion of Catecholamines in an Immortalized Adrenomedullary Chromaffin Cell Line
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Alfredo J. Garcia,
University of Chicago
Redox State Modulates the Respiratory Rhythmogenesis in the Pre-Botzinger Complex
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Jay B. Dean,
University of South Florida
Hyperoxia Induces CA1 Hippocampal Redox Stress, Neural Plasticity, and Hyperexcitability in Rat Brain Slices
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Thomas F. Floyd,
University Of Pennsylvania
Impact of Aging Upon Cerebral Hypoxia Sensing of Anemia
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Fei Meng†,
Birmingham University
Hypoxia-induced Calcium Elevation in Human Embryonic Kidney Cells
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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Adaptive Responses to Hypoxia
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Columbia Ballroom
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*
Randall S. Johnson,
University of California, San Diego
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Gregg L. Semenza,
Johns Hopkins University School of Medicine
Role of Hypoxia-Inducible Factor 1 in Oxygen Homeostasis
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Joseph A. Garcia,
University of Texas Southwestern Medical Center
Molecular Mechanisms Underlying HIF-2 Selective Signal Transduction
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John G. Wood,
University of Kansas Medical Center
Short Talk: Microvascular Acclimatization to Hypoxia
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Mircea Ivan,
Tufts-New England Medical Center
Short Talk: A microRNA Component of the Hypoxia Response
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Cynthia M. Beall,
Case Western Reserve University
Contrasting Adaptations to Hypoxia by Andean, Tibetan and East African Populations
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pacific Ballroom
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7:30 - 10:00 PM
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Poster Session 1
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Pacific Ballroom
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| Thursday, January 17 |
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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7:00 - 8:00 AM
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Poster Setup
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Pacific Ballroom
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8:00 - 11:00 AM
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Development and Differentiation
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Columbia Ballroom
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*
Peter J. Ratcliffe,
University of Oxford
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Randall S. Johnson,
University of California, San Diego
Tissue-Specific Effects of HIF-1 Loss of Function
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Guo-Hua Fong,
University of Connecticut Health Center
Short Talk: The HIF-Specific Prolyl Hydroxylase PHD2 Protein may be Directly Required in the Vascular Endothelium to Prevent Excessive Angiogenesis in Mice
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Erinn B. Rankin,
Stanford University
Short Talk: Hypoxia-Inducible Factor 2 Regulates VHL Associated Vascular Tumorigenesis and Hepatic Lipid Metabolism In Vivo
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Susan Quaggin,
Samuel Lunenfeld Research Institute
Podocyte-Endothelial Interactions and Angiogenic Factors in the Kidney
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Ellen van Rooijen,
Hubrecht Institute, Developmental Biology and Stem Cell Research
Short Talk: The von Hippel-Lindau Tumor Suppressor Gene Ortholog vhl1 Regulates Zebrafish Hematopoiesis
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Lorenz Poellinger,
Karolinska Institutet
Oxygen-Dependent Regulation of Cellular Differentiation
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M. Celeste Simon,
University of Pennsylvania
Hypoxia and Stem Cells
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:30 AM - 12:30 PM
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Lunch
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Pacific Ballroom
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12:00 - 2:30 PM
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Poster Session 2
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Pacific Ballroom
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2:30 - 4:30 PM
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Workshop 2: Animal Models
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Columbia Ballroom
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*
M. Celeste Simon,
University of Pennsylvania
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Xin Qi,
Stanford University School of Medicine
The Complex of Protein Kinase C delta and c-Abl Communicates Endoplasmic Reticulum Stress to the Mitochondria; an Essential Step in the Subsequent Apoptosis
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Reiko Inagi,
University of Tokyo School of Medicine
Glyoxalase I Overexpression Lowers Oxidative Stress and Ameliorates Renal Ischemia-Reperfusion Injury in the Rat
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Sunghee Cho,
Cornell/Burke Medical Research Institute
Hyperlipidemia Exacerbates Ischemic Brain Injury Via CD36-mediated Foam Cell Formation
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Gail Walkinshaw,
Fibrogen
Novel HIF Prolyl Hydroxylase Inhibitors are Neuroprotective in Both Permanent and Transient Rodent Models of Middle Cerebral Artery Occlusion
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Holger K. Eltzschig,
University of Colorado Denver
Role of HIF-1alpha in A2B Adenosine Receptor-dependent Cardioprotection During Ischemic Preconditioning
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Mikko A. I. Keränen,
University of Helsinki,
Constitutively Expressed Hypoxia-Inducible Factor-1Ą Prevents the Development of Cardiac Allograft Vasculopathy in the Rat
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Cormac T. Taylor,
University College Dublin
The Hydroxylase Inhibitor DMOG is Protective in a Murine Model of Colitis
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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Metabolism
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Columbia Ballroom
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*
Chi Van Dang,
Johns Hopkins University School of Medicine
Oxygen-Dependent Regulation of Glucose Metabolism and Oncogenesis: Interplay between MYC and HIF
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Kathleen A. O'Hagan,
University College Dublin
Short Talk: PGC-1alpha Induced Increase in Oxygen Consumption Leads to Activity of HIF Target Genes
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Julian Aragonés,
Flanders Interuniversity Institute for Biotechnology
Short Talk: PHD1 Deficient Mice Lower Oxygen Consumption by Reprogramming Skeletal Muscle Glucose Metabolism via PPARA Transcription Factor
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Robert T. Abraham,
Pfizer Biopharmaceuticals
Interplay between mTOR Signaling and Autophagy during Metabolic Stress in Human Cancer Cells
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Keith Laderoute,
SRI International
5'-AMP-Activated Protein Kinase (AMPK): Overview and Relevance for Tumor Biology
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7:00 PM -
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On Own for Dinner
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| Friday, January 18 |
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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8:00 - 11:00 AM
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Endothelial Progenitors, Ischemia and Cardiovascular Disease (Joint)
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British Columbia Ballroom
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Mark W. Majesky,
University of North Carolina at Chapel Hill
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Gregg L. Semenza,
Johns Hopkins University School of Medicine
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Eli Keshet,
Hebrew University
Angiogenic- and non-Angiogenic Roles of VEGF in Adult Organs
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Maria B. Grant,
University of Florida
IGF Binding Protein-3 Regulates Hematopoietic Stem Cell and Endothelial Precursor Cell Function During Vascular Development
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Vivek Mittal,
Cold Spring Harbor Laboratory
Bone Marrow-Derived Endothelial Progenitor Cells Regulate the Angiogenic Switch in Tumor Growth and Metastasis
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Stefanie Dimmeler,
University of Frankfurt
Bone Marrow Progenitor Cell Therapy for Myocardial Infarction
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:00 AM - 1:00 PM
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Poster Setup
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Pacific Ballroom
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1:00 - 10:00 PM
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Poster Viewing
|
Pacific Ballroom
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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ROS and Redox
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Columbia Ballroom
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*
Nanduri R. Prabhakar,
University Of Chicago
Responses to Intermittent Hypoxia: Consequences of Altered Red-Ox Homeostasis?
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Stephen L. Archer,
University of Chicago Medical Center
Metabolic-Electric Signaling in the Pulmonary Circulation - The Interface Between Oxygen Sensing, Pulmonary Hypertension and Cancer
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Kay F. Macleod,
University of Chicago
Short Talk: Regulation of Mitochondrial Integrity, Autophagy, and Cell Survival by BNIP3
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Patrick van Uden,
Dundee University
Short Talk: NF-kappaB modulates the HIF pathway
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Masayuki Yamamoto,
Tohoku University Graduate School of Medicine
Protective Responses to Oxidant Stress
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pacific Ballroom
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7:30 - 10:00 PM
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Poster Session 3
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Pacific Ballroom
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| Saturday, January 19 |
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7:00 - 8:00 AM
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Breakfast
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Pacific Ballroom
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7:00 - 8:00 AM
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Poster Setup
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8:00 - 11:00 AM
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Cancer
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Columbia Ballroom
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William G. Kaelin Jr.,
Dana Farber Cancer Institute
The VHL Gene: Oxygen Sensing and Cancer
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Poul H.B. Sorensen,
Novelix Pharmaceuticals Inc.
Short Talk: A Novel E3 Ubiquitin Ligase HACE1 Represses HIF-1alpha Accumulation Under Hypoxic Conditions
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Jacques Pouysségur,
University of Nice
Targeting Hypoxia-Induced Tumor Metabolism
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Amato Giaccia,
Stanford University
Hypoxia Induced Gene Expression in Cancer Cells
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Erwin G. Van Meir,
Emory University School of Medicine
Short Talk: KCN1, a Novel HIF Inhibitor Blocks Tumor Growth Through Binding of Plectin-1 and Inhibition of the HSP90 Pathway
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*
Mark W. Dewhirst,
Duke University Medical Center
Exploring Oxidative Stress and HIF-1 in Early Angiogenesis and Response to Radiotherapy and Chemotherapy
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Annamaria Rapisarda,
SAIC-Frederick, Inc.
Short Talk: Antitumor Activity of Antiangiogenic Agents Combined with HIF-1 Inhibitors:
Blocking Hypoxic Dependent Survival Pathways Improves Therapeutic Efficacy
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9:20 - 9:40 AM
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Coffee Break
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BC Foyer
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11:00 AM - 12:00 PM
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Lunch
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11:30 AM - 2:00 PM
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Poster Session 4
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Pacific Ballroom
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2:30 - 4:30 PM
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Workshop 3: Therapeutics
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Columbia Ballroom
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*
Amato Giaccia,
Stanford University
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Joseph R. Marszalek,
Merck Research Laboratories
Using RNAi to Identify Modulators of the HIF Pathway/Hypoxia for Cancer
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Navdeep S. Chandel,
Northwestern University
A Chemical Genomics Screen Highlights the Essential Role of Mitochondria in HIF Regulation
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Natalya A. Smirnova,
Burke Research Medical Institute
High-throughput Screening for HIF Prolyl Hydroxylase Inhibitors
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Stephen John Klaus,
Fibrogen
Induction of Erythropoiesis in Rodents by Novel and Distinct Families of Orally Active HIF Prolyl Hydroxylase Inhibitors
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Sean P. Colgan,
University of Colorado, Denver
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
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Shan Ping Yu,
Emory University School of Medicine
In Vitro Hypoxic Preconditioning of Stem Cells as a Strategy of Promoting Cell Survival and Functional Benefits After Transplantation into the Ischemic Rat Brain
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Periannan Kuppusamy†,
Ohio State University
Oxygen Sensing in Myocardial Stem Cell Therapy
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4:30 - 5:00 PM
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Coffee Available
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BC Foyer
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5:00 - 7:00 PM
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Respiratory Disease
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Columbia Ballroom
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*
Peter A. Robbins,
University of Oxford
Hypoxia and Mechanisms of Cardio-Respiratory Control in Humans
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Larrisa A. Shimoda,
Johns Hopkins School of Medicine
Hypoxic Pulmonary Hypertension
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Michael L. Maitland,
University Of Chicago
Short Talk: Developing the Anti-cancer VEGFR2/Multikinase Inhibitor Sorafenib for Treatment of Human Pulmonary Arterial Hypertension
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Agnes Görlach,
German Heart Center Munich
Short Talk: The Serum- and Glucocorticoid Regulated Kinase-1 is a Novel Regulator of Hypoxia-Inducible Factor 1
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Michail Sitkovsky,
Northeastern University
Iatrogenic Complication Due to Elimination of Hypoxia-driven, Immunosuppressive and Tissue Protecting Adenosinergic Pathway
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pacific Ballroom
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8:00 - 11:00 PM
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Entertainment
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Pacific Ballroom
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| Sunday, January 20 |
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Departure
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