Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Molecular Control of Adipogenesis and Obesity (X3)

Organizer(s): Ormond A. MacDougald and Evan D. Rosen
February 19 - 24, 2008
Fairmont Banff Springs · Banff, Alberta
Abstract Deadline: October 22, 2007
Late Abstract Deadline: November 20, 2007
Scholarship Deadline: October 22, 2007
Early Registration Deadline: December 19, 2007

Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Neuronal Mechanisms Controlling Food Intake, Glucose Metabolism and Body Weight (X4)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2008 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Obesity (J2)
January 12 - 17, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The worldwide epidemic in obesity has brought with it dramatic increases in the prevalence of co-morbid, chronic conditions including insulin resistance and type 2 diabetes. To further our understanding of the molecular control of adipogenesis and obesity, this meeting will focus on several rapidly developing and important areas. These include novel transcriptional regulators of adipogenesis, the adipocyte lipid droplet as an organelle, mechanisms of insulin-resistance, relationships between white adipocytes and alternative mesenchymal cell fates, and genetic contributions to energy balance in humans and model organisms. Cutting edge research in these areas will improve our understanding of mechanisms by which precursor cells develop into adipocytes, and how excess adipose tissue leads to diseases such as diabetes. Our goal is to attract researchers from around the world to participate in an interactive meeting on these physiological and pathological aspects of adipose tissue biology.

Tuesday, February 19
3:00 - 7:30 PM	Registration	Van Horne Ballroom Foyer
6:30 - 7:30 PM	Refreshments	Van Horne Ballroom Foyer
7:30 - 9:30 PM	Keynote Session (Joint)	Van Horne Ballroom
	* Michael W. Schwartz, University of Washington/Harborview Medical Center and
	* Ormond A. MacDougald, University of Michigan Opening Remarks

	Charles S. Zuker, University of California, San Diego The Emerging Biology of Taste Perception
	Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School Genome Screens for Fat Storage Genes in C. elegans
Wednesday, February 20
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:15 AM	Interactions between Brain and Periphery I (Joint)	Van Horne Ballroom
	* Stephen O'Rahilly, University of Cambridge
	Masato Kasuga, Kobe University Graduate School of Medicine Role of IL-6/STAT3 in Insulin Action
	Bruce M. Spiegelman, Harvard Medical School Transcriptional Control of Brown Fat Determination by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors

	Nadine Cybulski, Biozentrum, University of Basel and
	Pazit Polak, Biozentrum, University of Basel Short Talk: mTOR Signaling in Adipose Tissue Controls Body Metabolism
	Jeffrey M. Friedman, Rockefeller University Neuronal Integration of Humoral Signals Controlling Energy Balance
	Morris F. White, Children's Hospital Boston IRS Proteins, Metabolism and Longevity
	Su Gao, University of Alberta Short Talk: The Role of Malonyl-CoA and Long-chain Fatty Acyl-CoA in Mediating Leptin’s Anorectic Signaling in Specific Hypothalamic Nuclei
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:15 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
11:15 AM -	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:00 PM	Lower Organisms as Models of Lipid Homeostasis	Van Horne Ballroom AB
	* Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University
	Jonathan M. Graff, University of Texas Southwestern Medical Center Hedgehog Signaling and Mesenchymal Cell Fate
	Anders M. Näär, Massachusetts General Hospital SREBP and Lipid Metabolism in C. elegans

	Kaveh Ashrafi, University of California, San Francisco Energy Regulatory Circuits in C. elegans
	Sean M. Oldham, Burnham Institute for Medical Research Short Talk: Genetic Screen for Regulators of Obesity and Aging Identifies the Nutrient Sensing TOR Pathway
7:00 - 8:00 PM	Social Hour w/ Lite Bites	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 1	New Brunswick, Alberta, Cascade
Thursday, February 21
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
7:00 - 8:00 AM	Poster Setup	New Brunswick, Alberta, Cascade
8:00 - 11:15 AM	Novel Transcriptional Pathways in Adipogenesis	Van Horne Ballroom AB
	* Ormond A. MacDougald, University of Michigan
	Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University Beyond PPARgamma: Searching for Novel Transcriptional Pathways in Adipogenesis
	Karsten Kristiansen, University of Copenhagen The Tumor Suppressors pRB and p53 as Regulators of Adipocyte Differentiation and Function
	Jacqueline M. Stephens, Louisiana State University Short Talk: STAT5A is Adipogenic in vivo and Plays an Important Role in the Regulation of Lipid Metabolism and Insulin Resistance in Adipocytes
	Stephen R. Farmer, Boston University School of Medicine Role of SIRT1 in Regulating PPARg Activity during the Formation and Function of Adipocytes
	Mitchell A. Lazar, University of Pennsylvania School of Medicine Novel Mechanisms Regulating Adipogenesis
	Deborah Clegg, University of Texas Southwestern Medical Center Short Talk: Sexual Dimorphism of Adipose Tissues
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:15 AM - 12:00 PM	Lunch	New Brunswick, Alberta, Cascade
12:00 - 2:30 PM	Poster Session 2	New Brunswick, Alberta, Cascade
2:30 - 4:30 PM	Workshop 1: Hot Topics	Van Horne Ballroom AB
	Robert A. Koza, Pennington Biomedical Research Center Evaluation of Mesoderm Specific Transcript as an Epigenetic Target for Diet-Induced Obesity in Mice
	* Jacob E. Friedman†, University of Colorado Denver
	Christoph Buettner, Mount Sinai School of Medicine Leptin Controls Adipose Tissue Endocannabinoid Levels and Lipogenesis through Hypothalamic Pathways that are Independent of STAT3 Signaling
	Alexander Banks, Harvard Medical School Energy Conservation Phenotypes in SirT1 Gain-of-Function Mice
	Yasunori Aizawa, Tokyo Institute of Technology Noncoding “Long” RNAs in the Signaling Networks behind hMSC Differentiation
	Philippe Boucher, UMR CNRS 7213, University of Strasbourg Control of Adipogenesis and Fatty Acid Metabolism by LRP1
	Annette Schürmann, German Institute of Human Nutrition Potsdam-Rehbruekce Adipose-Specific Deletion of the Ras-homologous GTPase Arfrp1 Leads to Suppression of Triglyceride Storage
	Bradley K. Yoder, University of Alabama, Birmingham Ciliary Dysfunction and Altered Energy Homeostasis
4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:00 PM	Adipocytes and Inflammation	Van Horne Ballroom AB
	* Karen Reue, University of California, Los Angeles
	Philipp E. Scherer, University of Texas Southwestern Medical Center at Dallas Adipose Tissue and Acute Phase Response
	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center Metabolic Benefits of Interventions Targeting Proinflammatory Pathways

	Haiming Cao, Harvard School of Public Health
	Jun Wada, Okayama University Graduate School of Medicine Short Talk: Effects of Vaspin on Inflammatory and Metabolic Responses in Obesity
7:00 PM -	On Own for Dinner
Friday, February 22
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:30 AM	Adipocytes from the Inside Out	Van Horne Ballroom AB
	* Stephen R. Farmer, Boston University School of Medicine
	Dawn L. Brasaemle, Rutgers University Molecular Aspects of Lipid Droplet Biology
	Karen Reue, University of California, Los Angeles The Lipin Protein Family: Roles in Adipogenesis and Triglyceride Biosynthesis

	Tae-Hwa Chun, University of Michigan Short Talk: Pericellular Collagenenolysis as a Rheostat of Obesity Progression
	Jorge Plutzky, Brigham and Women's Hospital Retinoid Metabolism in Energy Balance
	Joel M. Goodman, University of Texas Southwestern Medical School Lipid Droplet Assembly and Communication in Yeast
	Carole Sztalryd, VAH and University of Maryland School of Medicine Short Talk: Interaction between Lipases and Lipid Droplet Coat Proteins
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:30 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
11:30 AM -	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
2:30 - 4:30 PM	Workshop 2: Molecular Targets and New Therapeutics	Van Horne Ballroom
	* Donald A. McClain, University of Utah School of Medicine

	Alain Baron, Amylin Pharmaceuticals Inc. Integrated Neurohormonal Therapy of Obesity
	Cristina M. Rondinone, Roche RNA Interference: Novel Targets, Unique siRNA Drugs to Treat Metabolic Disorders?

	Tara B. Manion, Pfizer Inc Integration of Gut Hormones, Metabolism and Food Intake

	Anne Reifel Miller, Lilly Research Laboratories The Unexpected Complexity of the AdipoR2-Deficient Mouse Phenotype
	Bei B. Zhang, Merck Research Laboratories Targeting AMPK Activation for the Treatment of Diabetes and Related Metabolic Disorders
	Brad Geddes, Elixir Pharmaceuticals, Inc. Improved Insulin Sensitivity in Ghrelin Receptor Knockout Mice Assessed by Glycemic Clamp Analyses
4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:00 PM	Interactions between Brain and Periphery II (Joint)	Van Horne Ballroom


	Barry E. Levin, VA Medical Center Hypothalamic Integration of Nutrient-Related and Hormonal Inputs Controlling Energy Balance
	* Barbara B. Kahn, Beth Israel Deaconess Medical Center CNS Regulation of Energy Balance and Glucose Metabolism
	Timothy Bartness, Georgia State University Neural Connections between Brain and Adipose Tissue
	Liangyou Rui, University of Michigan Short Talk: Identification of Neuronal SH2B1 as a Key Regulator of Energy Balance and Body Weight
7:00 - 8:00 PM	Social Hour w/ Lite Bites	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 3	New Brunswick, Alberta, Cascade
Saturday, February 23
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:15 AM	Adipocyte Plasticity and Fate Choices	Van Horne Ballroom AB
	* Dawn L. Brasaemle, Rutgers University
	Ormond A. MacDougald, University of Michigan Regulation of Adipocyte Differentiation and Metabolism
	Sven Enerbäck, Göteborg University FOX Transcription Factors in White and Brown Adipose Tissue
	Jan Nedergaard, Stockholm University Short Talk: UCP1 Ablation Induces Obesity and Obliterates Diet-Induced Adrenergic Thermogenesis
	Sheila Collins, Sanford-Burnham Medical Research Institute Kinases and Their Transcription Targets in Adipocyte Cell Fate
	Dwight J. Klemm, University of Colorado Health Sciences Center Bone Marrow-Derived Progenitor Cells Give Rise to a Unique Adipocyte Population in Adipose Tissue
	Barbara Cannon, Stockholm University Short Talk: A Myogenic Gene Expression Signature Establishes that Brown and White Adipocytes Originate from Distinct Cell Lineages
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:00 PM	Genetics of Obesity and Diabetes (Joint)	Van Horne Ballroom
	* Daniel Porte Jr., University of California, San Diego

	Rudolph L. Leibel, Columbia University Genetic Modifiers of Obesity/Diabetes in Mice and Humans
	Stephen O'Rahilly, University of Cambridge Lessons from Human Phenotypes of Obesity and Insulin Resistance

	Joel N. Hirschhorn, Children's Hospital Genomewide Association Studies of Type 2 Diabetes, Obesity and Stature
	David A. Buchner, Case Western Reserve University Short Talk: The Genetic Architecture of Diet-Induced Obesity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	New Brunswick, Alberta, Cascade
8:00 - 11:00 PM	Entertainment	New Brunswick, Alberta, Cascade
Sunday, February 24
	Departure

*Session Chair †Speaker invited, not yet responded.