Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Islet and Beta Cell Development and Transplantation (Z4)

Organizer(s): Chris Wright, Helena Edlund, David M. Harlan and Ray MacDonald
April 6 - 11, 2008
Snowbird Resort · Snowbird, Utah
Abstract Deadline: December 6, 2007
Late Abstract Deadline: January 9, 2008
Scholarship Deadline: December 6, 2007
Early Registration Deadline: February 6, 2008

Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Islet and Beta Cell Biology (Z3)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
This meeting presents an integrated program on pancreatic islet developmental biology, islet transplantation, and immunity. It is designed to interdigitate with and to augment the companion parallel conference “Islet and Beta-Cell Biology”. The meeting will encompass pioneering science in several disciplines, including development, regeneration, stem cells, transcription factors, transplantation, cell biology, gene regulation, immunity, and diabetes. Islet transplantation as an emergent therapy for diabetes is severely hampered by an insufficient islet supply, gradually decreasing islet function post-transplantation, and by toxic immuno-suppression. Understanding the rules that guide pancreas development in vivo will promote methods to generate new islets from adult or embryonic stem cells, and yet our knowledge remains inadequate as it pertains to the mechanisms controlling normal islet development and function, or of the maintenance of the islet cell differentiated state, survival, and physiological function after transplantation. Similarly, the means elude us to safely, effectively, and reliably prevent recurrent immune attack on the transplanted islets. The meeting program focuses on these challenges by covering the most recent progress in these rapidly moving fields and discussing strategies to overcome major obstacles. The meeting builds upon the extremely strong foundation laid by the 2006 Keystone meeting on “Pancreatic Islets”, which very effectively brought together the fields of islet transplantation and basic pancreatic development. A most important aspect of the meeting will be the instructions given to the speakers to identify specific caveats and problems with the current state of research, to define short and long term goals for the field and, moreover, to orient their presentation in a manner that maximizes accessibility to attendees from the other research areas.

Objectives
Upon completion of this conference, participants should be able to:

To explain our current understanding of the molecular mechanisms regulating pancreatic islet development.
To describe the current state and challenges facing pancreatic islet transplantation.
To identify the future connections that will be made between transplantation, immunology, and developmental biology.

Sunday, April 6
3:00 - 7:30 PM	Registration	Ballroom Lobby
6:30 - 7:30 PM	Refreshments	Ballroom Lobby
7:30 - 9:30 PM	Keynote Session (Joint)	Ballroom 2-3
	* Chris Wright, Vanderbilt University Medical Center
	* Christopher B. Newgard, Duke University Medical Center
	Mark A. Magnuson, Vanderbilt School of Medicine Beta Cells, Technology Convergence and Team Science

	Andrew Hattersley, Peninsula Medical School What can Genetics Teach us about the Beta-Cell?
Monday, April 7
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	Stem Cells and Optimization of Beta Cell Function to Transplantation (Joint)	Ballroom 2-3
	* Chris Wright, Vanderbilt University Medical Center
	* Christopher B. Newgard, Duke University Medical Center
	Frances M. Ashcroft, Henry Wellcome Centre for Gene Function, University of Oxford Ion Channels and Diabetes
	Claes B. Wollheim, University of Geneva Medical Centre Integration of Beta-Cell Transcription and Metabolic Regulation
	Klaus H. Kaestner, University of Pennsylvania School of Medicine Using Functional Genomics to Identify Targets for Beta-Cell Expansion
	Douglas A. Melton, Harvard University Making Beta Cells
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
11:00 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Maybird/Wasatch
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Maybird/Wasatch
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:00 PM	Understanding and Controlling Autoimmunity	Ballroom 3
	* David M. Harlan, National Institutes of Health, NIDDK
	E. William St. Clair, Duke University Medical Center Targeting B Cells in Autoimmune Disease

	Arlene H. Sharpe, Harvard Medical School PD-L1 for Maintenance of Self-Tolerance
	Thomas W. Kay, St. Vincent's Institute Short Talk: Insulin-Specific T Cells and Islet Inflammation Promote Initiation of Diabetes in IGRP-Specific T Cell Receptor Transgenic Mice
	Shira Y. Perl, National Institutes of Health Short Talk: Novel Techniques Suggest Limited beta Cell Turnover in Adult Humans
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Maybird/Wasatch
7:30 - 10:00 PM	Poster Session 1	Superior/Superior Lobby/Maybird/Wasatch
Tuesday, April 8
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:00 AM	Pancreas Development – Transcription \ Factors	Ballroom 3
	* Harry Heimberg, Vrije Universiteit Brussel
	Ray MacDonald, University of Texas Southwestern Medical Center Transcriptional Control of Early Pancreatic Development
	Lori Sussel, Columbia University Nkx2.2: Transcriptional regulation of pancreatic islet differentiation
	Helena Edlund, Umeå University Signaling and Transcription Factors in the Pancreas
	Chris Wright, Vanderbilt University Medical Center Genetic Studies of PTF1a and PDX1 Function in the Main “Secondary Transition” Phase of Pancreatic Endocrine Cell Derivation
	Victoria E. Prince, University of Chicago Short Talk: Localization of the Pancreatic Progenitor Field is Controlled by Retinoic Acid and Cdx4
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
11:00 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Maybird/Wasatch
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Maybird/Wasatch
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:00 PM	Stem Cells and Pancreatic Islets	Ballroom 3
	* Douglas A. Melton, Harvard University
	Gordon M. Keller, University Health Network, MaRS Centre Induction and Specification of Endoderm from Embryonic Stem Cells
	Markus Grompe, Oregon Health & Science University Characterization and Behavior of Liver and Pancreas Stem Cells
	Maike Sander, University of California, San Diego Transcriptional Regulators of Stem-Cellness

	Jackie E. Lee, Geron Corporation Short Talk: Generation of Insulin-Producing Islet-like Clusters from Human Embryonic Stem Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Maybird/Wasatch
7:30 - 10:00 PM	Poster Session 2	Superior/Superior Lobby/Maybird/Wasatch
Wednesday, April 9
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:15 AM	Model Systems for Assessing Beta Cell Replacements	Ballroom 3
	* Ray MacDonald, University of Texas Southwestern Medical Center
	Klaus Ulrich Pechhold, University of Massachusetts Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes
	Alvin C. Powers, Vanderbilt University Imaging Approaches to Follow Beta Cells in Vivo

	Yuval Dor, Hebrew University-Hadassah Medical School Determinants of Pancreatic Beta Cell Regeneration
	Holger Andreas Russ, Sackler School of Medicine Short Talk: Proliferation of Dedifferentiated Adult Human Pancreatic Beta Cells in vitro Revealed by Cell-Lineage Tracing
	Jake A. Kushner, University of Pennsylvania School of Medicine Short Talk: Beta-Cell Regeneration is Severely Restricted with Advanced Age
	E. Edward Baetge, ViaCyte, Inc. In vivo Generation of Glucose-Responsive Insulin-Secreting Cells from Human Embryonic Stem Cell-Derived Pancreatic Endoderm
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
11:15 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Maybird/Wasatch
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Maybird/Wasatch
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:00 PM	Pancreatic Development – Intercellular Signaling	Ballroom 3
	* Maike Sander, University of California, San Diego
	Matthias Hebrok, University of California, San Francisco Wnt and Hedgehog Signaling
	Steven D. Leach, Johns Hopkins University Tails from the Deep: Exocrine Pancreas Differentiation in Mouse and Zebrafish

	Palle Serup, Hagedorn Research Institute Dll1 and Hes1 Regulate Pancreatic Endocrine Differentiation at Distinct Steps
	Ondine Cleaver, University of Texas Southwestern Medical Center Short Talk: Ephrin/Eph Signaling Modulates Pancreatic Development

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Maybird/Wasatch
7:30 - 10:00 PM	Poster Session 3	Superior/Superior Lobby/Maybird/Wasatch
Thursday, April 10
7:00 - 8:00 AM	Breakfast	Golden Cliff/Eagles
8:00 - 11:15 AM	Moving Towards Clinical Application	Ballroom 3
	Kevan C. Herold, Yale University Effects of Immune Modulation on Beta Cells
	David M. Harlan, National Institutes of Health, NIDDK Status of Clinical Trials Testing Beta Cell Regeneration
	* Christian P. Larsen, Emory University School of Medicine Costimulatory Pathway Based Clinical Trials
	Patrik Brundin, Lund University Neural Cell Grafting for Clinical Brain Repair
	Keren Francis, Technion - Israel Institute of Technology Short Talk: Engineering Vascularized Pancreatic Islets In Vitro
	Masahito Matsumoto, Saitama Medical University Short Talk: Regulation of Pancreatic Endocrine Cell Development by Integration between a Growth Factor and Notch Signaling Cascades
9:20 - 9:40 AM	Coffee Break	Ballroom Lobby & Mezzanine
4:30 - 5:00 PM	Coffee Available	Ballroom Lobby & Mezzanine
5:00 - 7:00 PM	Islet Proliferation and Survival	Ballroom 3
	* Helena Edlund, Umeå University
	Marc Y. Donath, University Hospital Basel Islet Inflammation and Treatment of Type 2 Diabetes with the IL-1 Receptor Antagonist
	Harry Heimberg, Vrije Universiteit Brussel Beta Cell Progenitors in Adult Mouse Pancreas
	Seung K. Kim, Stanford University Control of Pancreas Cell Proliferation
	Sonya G. Fonseca, University of Massachusetts Medical School Short Talk: Novel Regulation of ER Stress Signaling in Pancreatic beta-Cells by WFS1
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Maybird/Wasatch
8:00 - 11:00 PM	Entertainment	Ballroom 2-3
Friday, April 11
	Departure

*Session Chair †Speaker invited, not yet responded.