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Molecular Basis for Biological Membrane Organization (A2)

Organizer(s): Kai Simons, Ira Mellman and Petra Schwille
January 12 - 17, 2008
Big Sky Resort  ·  Big Sky, Montana
Abstract Deadline: September 12, 2007
Late Abstract Deadline: October 15, 2007
Scholarship Deadline: September 12, 2007
Early Registration Deadline: November 12, 2007


Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.



This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
The organization of cell membranes is a hot topic and the field is characterized by controversies regarding how proteins and lipids interact and how membranes become compartmentalized to form platforms that function in signaling, trafficking and cell polarization. Lipids and membranes are central to understanding the pathogenesis of important diseases such as atherosclerosis, Alzheimer’s Disease, AIDS, and influenza. Major questions revolve around how lipids interact with other lipids and, most importantly, how proteins and lipids interact. The goal of this meeting is to bring together scientists from biochemistry, structural biology, lipidomics, molecular cell biology and biomedicine to discuss major issues in the field. The multidisciplinary character of the meeting will promote discussion and the program is designed to stimulate exchange among investigators who would not otherwise interact.

Saturday, January 12
3:00 - 7:30 PM Registration Lower Atrium
6:30 - 7:30 PM Refreshments Lower Atrium
7:30 - 8:30 PM Keynote Address Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics
Michael S. Brown, University of Texas Southwestern Medical Center
The SREBP Pathway for Membrane Cholesterol Homeostasis
Sunday, January 13
7:00 - 8:00 AM Breakfast Jefferson / Madison
8:00 - 11:00 AM Membrane Proteins Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics
Harvey T. McMahon, MRC Laboratory of Molecular Biology
Structural Biology of Cell Membrane Bending
Margaret Kielian, Albert Einstein College of Medicine
Virus-Membrane Fusion: Mechanisms and Lipid Interactions of Class II Fusion Proteins.
Michael F. Summers, University of Maryland Baltimore County and HHMI
Structural Basis for Membrane Targeting by the HIV-1 Gag Protein
Shinya Yoshikawa, University of Hyogo
Lipid-Protein Interactions in Cytochrome c Oxidase
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 1:00 PM Poster Setup Jefferson / Madison
1:00 - 10:00 PM Poster Viewing Jefferson / Madison
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Membrane Dynamics Gallatin
* Petra Schwille, Institute of Biophysics
Pietro V. De Camilli, Yale University School of Medicine
Role of Dynamin in Membrane Fission
Patricia Bassereau, Institut Curie
Membrane Nanotubes and Intracellular Traffic
Cameron Scott, University of Geneva
Short Talk: Lumenal Ion Composition and Endosomal Membrane Dynamics
Enrico Gratton, University of Illinois at Urbana Champaign
Short Talk: Detecting Membrane Transient Zones Using Scanning Fluctuation Correlation Spectroscopy
7:15 - 8:15 PM Social Hour w/ Lite Bites Jefferson / Madison
7:30 - 10:00 PM Poster Session 1 Jefferson / Madison
Monday, January 14
7:00 - 8:00 AM Breakfast Jefferson / Madison
8:00 - 11:00 AM Membrane Phases Gallatin
* Petra Schwille, Institute of Biophysics
Gerald Feigenson, Cornell University
Phase Diagrams as Models for Plasma Membranes
Sarah Keller, University of Washington
Domain Formation in Asymmetric Model Bilayers
Tobias Baumgart, University of Pennsylvania
Of Domains and Boundaries: Phase Behavior and Partitioning in Biomembrane Models
Satyajit Mayor, National Centre for Biological Sciences
Active Membrane Organization in Living Cells
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 1:00 PM Poster Setup Jefferson / Madison
1:00 - 10:00 PM Poster Viewing Jefferson / Madison
2:30 - 4:30 PM Workshop 1: Molecular Basis for Domains within Membranes Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics
Peter Mayinger, Oregon Health and Science University
Lipid Phosphatases Establish Spatially and Functionally Distinct Regions within the Golgi
Robin Klemm, Max Planck Institute of Molecular Cell Biology and Genetics
A Role for Lipid Rafts in Protein Sorting and Vesicle Formation at the trans Golgi Network
Jen Liou, Stanford University
Dynamic Contact Formation of the Endoplasmic Reticulum and the Plasma Membrane during Store-Operated Ca2+ Entry
Ritva Tikkanen, University Clinic of Frankfurt
Lymphocyte Raft Protein Reggie-2/Flotillin-1 Directly Interacts with HIV-1 Gag Protein and Plays a Role in Virus Assembly and Release
Angela Wandinger-Ness, University of New Mexico
Sorting Out The Ciliary Transport Puzzle: Small GTPases and Renal Cystic Disease
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Membrane Cytoskeleton Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics
Ira Mellman, Genentech, Inc.
Pekka Lappalainen, University of Helsinki
Regulation of the Actin Cytoskeleton and Plasma Membrane Dynamics by MIM/ABBA Family Proteins
Anthony P. Bretscher, Cornell University
Regulation of the Cell Cortex by ERM and their Association Proteins
Tatyana Svitkina, University of Pennsylvania
Membranes on the Move
Chiara Zurzolo, Pasteur Institute
Short Talk: Prions Hi-Jack TNTs for Intracellular Transfer
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson / Madison
7:30 - 10:00 PM Poster Session 2 Jefferson / Madison
Tuesday, January 15
7:00 - 8:00 AM Breakfast Jefferson / Madison
8:00 - 11:00 AM Membrane Signaling Gallatin
* Ira Mellman, Genentech, Inc.
Gillian Griffiths, Cambridge Institute for Medical Research - Wellcome Trust
Secretory Lysosome
Mark M. Davis, Stanford University
T-Cell Receptor Signaling
Jay T. Groves, University of California, Berkeley
Membrane Spatial Organization and the Mechanics of T Cell Receptor Signaling
Katharina Gaus, University of New South Wales
Functional Implications of Membrane Condensation for T Cell Activation
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 1:00 PM Poster Setup Jefferson / Madison
1:00 - 10:00 PM Poster Viewing Jefferson / Madison
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Lipids and Fusion Gallatin
* Petra Schwille, Institute of Biophysics
Andrej Shevchenko, Max Planck Institute
Toward Comprehensive Profiling of Membrane Lipidomes
Peter Kasson, Stanford University
Short Talk: Simulating Vesicle Fusion: Effects of Membrane Composition, Curvature, and Lipid Ordering
Leonid V. Chernomordik, National Institute of Child Health and Human Development
Protein-Lipid Interplay in Membrane Fusion
Martin W. Hetzer, The Salk Institute
Short Talk: Nuclear Envelope Formation by Chromatin-Mediated Reorganization of the Endoplasmic Reticulum
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson / Madison
7:30 - 10:00 PM Poster Session 3 Jefferson / Madison
Wednesday, January 16
7:00 - 8:00 AM Breakfast Jefferson / Madison
8:00 - 11:00 AM Membrane Morphogenesis Gallatin
* Kai Simons, Max Planck Institute of Molecular Cell Biology and Genetics
Tom A. Rapoport, Harvard University Medical School
How the ER Gets into Shape
Walther Mothes, Yale University School of Medicine
Cell-to-Cell Transmission of Retroviruses via Filopodial Bridges
Daniel M. Davis, Imperial College London
Membrane Nanotubes in Human T Cell Biology
Peter K. Jackson, Genentech, Inc.
Biogenesis and Function of the Primary Cilium
Ruth Kroschewski†, Swiss Federal Institute of Technology
Short Talk:
9:20 - 9:40 AM Coffee Break Lower Atrium
2:30 - 4:30 PM Workshop 2: New Technologies for Addressing Challenges in Studies of Biological Membranes Gallatin
* Ira Mellman, Genentech, Inc.
Tristan S. Ursell, California Institute of Technology
Dynamic Morphologies and Coalescence of Lipid Domains
Inhee Chung, Genentech Incorporated
Reversible Dimerization of Single Epidermal Growth Factor Receptor and its Spatial Heterogeneity in Live A431 Cell
Suliana Manley, National Institutes of Health
Live Cell Photoactivated Localization Microscopy (PALM) for the Spatio-Temporal Mapping of Single Molecule Diffusion in the Plasma Membrane
Dimitrios Stamou, Bio-Nanotechnology Laboratory
How BAR Domains and Amphipathic Helixes Recognize Membrane Curvature: A High-Throughput Single Vesicle Study
Xavier Michalet, University of California, Los Angeles
Single-Molecule Tracking of GPI-Anchored Protein Using Quantum Dots Shows Dynamic Partitioning In and Out of GM1 and Cholesterol-Rich Domains in the Plasma Membrane of Live Cells
Salvatore Chiantia, MPI-CBG
Role of Ceramide Domains in Membrane Protein Organization Investigated by Simultaneous FCS and AFM
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Membrane Sorting and Vesicle Formation Gallatin
* Ira Mellman, Genentech, Inc.
Marino Zerial, Max Planck Institute of Molecular Cell Biology and Genetics
Genome-Wide Survey of Endocytosis by Quantitative Multi-Parametric Image Analysis
Ari Helenius, ETH Zurich
Endocytic Pathways of Virus Entry
Sandra L. Schmid, The Scripps Research Institute
Role of Dynamin in Clathrin-Mediated Endocytosis
Jason A. Mears, NIDDK, National Institutes of Health
Short Talk: Structural Analysis of Dynamin Family Members Offers Insight into Membrane Fission
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson / Madison
8:00 - 11:00 PM Entertainment Jefferson / Madison
Thursday, January 17
Departure
*Session Chair   †Speaker invited, not yet responded.



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