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Tumor Suppressors and Stem Cell Biology (C3)

Organizer(s): Sean J. Morrison and Alejandro Sánchez Alvarado
February 24 - 29, 2008
Fairmont Hotel Vancouver  ·  Vancouver, British Columbia
Abstract Deadline: October 24, 2007
Late Abstract Deadline: November 26, 2007
Scholarship Deadline: October 24, 2007
Early Registration Deadline: December 26, 2007


Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

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To receive CME credits, mark the box on the registration form, and pay the additional $50.00.



This meeting took place in the 2008 season.

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Summary of Meeting
Stem cells play key roles in the development, maintenance, and reproduction of all known multicellular organisms. Stem cells operate in a wide variety of biological contexts from homeostasis to regeneration and must be subject to complex and robust regulation. Recent evidence suggests that tumor suppressor mechanisms, originally discovered for their ability to inhibit tumorigenesis, also play widespread roles in the physiological regulation of stem cells. Tumor suppressors play critical roles in the regulation of tissue homeostasis, stem cell self-renewal, regeneration, and aging. This reveals mechanistic links between the regulation of stem cells, and the regulation of cancer cells that could potentially be exploited to target cancer and to enhance regeneration. The dual roles of these mechanisms in stem cell and cancer biology illuminate the evolved balance between the promotion of regeneration and the suppression of cancer.

Sunday, February 24
3:00 - 7:30 PM Registration BC Foyer
6:30 - 7:30 PM Refreshments BC Foyer
7:30 - 8:30 PM Keynote Address British Columbia Ballroom
Charles J. Sherr, St. Jude Children's Research Hospital
Tumor Suppressors (RB, p53 INK4 genes, & ARF): On the Road to Immortality
Monday, February 25
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:15 AM Tumor Suppressors and the Evolution of Stem Cells British Columbia Ballroom
Andrea I. McClatchey, Massachusetts General Hospital
Membrane Organization in Tissue Homeostasis and Tumorigenesis
Gad Shaulsky, Baylor College of Medicine
Cell Competition, Stem Cells and the Evolution of Sociality
Yukiko M. Yamashita, University of Michigan, Ann Arbor
Asymmetric Stem Cell Division during Tissue Homeostasis and Aging
* Alejandro Sánchez Alvarado, HHMI / University of Utah School of Medicine
Stem Cells and their Regulation in the Planarian Schmidtea Mediterranea
Bret Pearson, University of Utah
Short Talk: Adult Stem Cells and Tumorigenesis in the Freshwater Planarian
Junlin Qi, University of Washington, Seattle
Short Talk: microRNA-195 Regulates Human Embryonic Stem Cell Division
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - 1:00 PM Poster Setup Pacific Ballroom
11:15 AM - On Own for Lunch
1:00 - 10:00 PM Poster Viewing Pacific Ballroom
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Epigenetic Regulation of Stem Cells British Columbia Ballroom
Megan F. Cole, Massachusetts Institute of Technology
Connecting Signaling to the Core Regulatory Circuitry of Embryonic Stem Cells
Patrick M.P. Viatour, Stanford University
Short Talk: Hematopoietic Stem Cell Quiescence is maintained by Compound Contributions of the Retinoblastoma Gene Family
Valerie M. Renault, Stanford Medical School - Stanford University
Short Talk: The Role of FoxO Transcription Factors in the Maintenance of Neural Stem Cells during Aging
Iannis Aifantis, HHMI/New York University School of Medicine
Short Talk: The E3 Ligase Fbw7, a T-ALL Tumor Suppressor, is a Novel Regulator of Hematopoietic Stem Cell Self-Renewal
Emmanuelle Passegué, University of California, San Francisco
Short Talk: Regulation of Hematopoietic Stem Cell Functions by JunB
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
7:30 - 10:00 PM Poster Session 1
Tuesday, February 26
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:15 AM Tumor Suppressors and the Environmental Control of Stem Cells British Columbia Ballroom
Ruth Lehmann, New York University School of Medicine
The Niche and Germline Homeostasis
* David T. Scadden, MGH/Harvard University
Hematopoietic Stem Cell Niche
Judith E. Kimble, University of Wisconsin-Madison
Germline Stem Cells and their Niche in C. elegans
Linheng Li, Stowers Institute for Medical Research
Stem Cells, Niches, and Zones
Maria Sol Flaherty, New York University School of Medicine
Short Talk: A Novel BTB-Domain Protein Regulates Stem Cell Self-Renewal Downstream of JAK/STAT Signaling in the Drosophila Testis
Vivienne I. Rebel, University of Texas Health Science Center
Short Talk: CBP+/- Mice Develop Myelodysplasia and Hhypersensitivity to gamma Radiation with Age
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - 1:00 PM Poster Setup Pacific Ballroom
11:15 AM - On Own for Lunch
1:00 - 10:00 PM Poster Viewing Pacific Ballroom
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Physiological Function of Tumor Suppressors British Columbia Ballroom
* Scott W. Lowe, Cold Spring Harbor Laboratory
Dissecting Tumor Suppressor Gene Networks in Vivo
Tian Xu, Yale University School of Medicine
Immune Response of Blood Cells to Tumors in Drosophila
Ihor R. Lemischka, Mount Sinai School of Medicine
Mechanisms Regulating Stem Cell Fate
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
7:30 - 10:00 PM Poster Session 2 Pacific Ballroom
Wednesday, February 27
7:00 - 8:00 AM Breakfast Pacific Ballroom
7:00 - 8:00 AM Poster Setup Pacific Ballroom
8:00 - 11:15 AM Stem Cell Self-Renewal British Columbia Ballroom
* Stuart H. Orkin, Dana-Farber Cancer Institute
Lineage Determination in the Hematopoietic System
Guy Sauvageau, IRIC/Université de Montréal
Bmi1 Integrates Multiple Pathways in Hematopoietic Stem Cell Regulation
Cheng-Yu Lee, University of Michigan
Regulation of Neuroblast Self-Renewal in Drosophila
Fiona Doetsch, Columbia University
MicroRNA Regulation of Adult Neural Stem Cells
Janel E. Le Belle, University of California, Los Angeles
Short Talk: Deletion and Inactivation of the Tumor Suppressors TSC and PTEN Influence Neural Stem Cell Self-Renewal and Neurogenesis
Susumu Goyama, University of Tokyo
Short Talk: Evi-1 is a Critical Regulator for Hematopoietic Stem Cells and Leukemic Cells
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - 12:15 PM Lunch Pacific Ballroom
12:00 - 2:30 PM Poster Session 3 Pacific Ballroom
2:30 - 3:00 PM Coffee Available Pacific Foyer
3:00 - 5:00 PM Stem Cells and Cancer Pacific Ballroom
Luis F. Parada, University of Texas Southwestern Medical Center
Title to be Determined
John E. Dick, Toronto General Research Institute, University Health Network
Modeling the Human Leukemogenic Process
* Sean J. Morrison, HHMI/University of Michigan
Stem Cell Self-Renewal Versus Cancer Cell Proliferation
On Own for Dinner
Thursday, February 28
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:00 AM Tumor Suppressors and Regeneration British Columbia Ballroom
Peter W. Reddien, Whitehead Institute
Identification of Regeneration and Stem Cell Regulatory Genes in Planaria
Amy J. Wagers, Harvard University
Regulation and Function of Skeletal Muscle Stem Cells
Leanne Jones, The Salk Institute for Biological Studies
Aging-Related Changes to Stem Cells and the Stem Cell Niche
* Irving L. Weissman, Stanford University
Stem Cells and the Origin of Self/Non-Self Recognition
Michael A. Dyer, St. Jude Children's Research Hospital
Short Talk: The Role of the Rb Family in Retinal Development and Retinoblastoma
Christine Karlsson, Lund University
Short Talk: Defining Regulators of Hematopoietic Stem Cell Self-Renewal using RNA Interference in High-throughput Genetic Screens
9:20 - 9:40 AM Coffee Break BC Foyer
11:00 AM - On Own for Lunch
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Stem Cells and Aging British Columbia Ballroom
* Norman E. Sharpless, University of North Carolina School of Medicine
Tumor Suppressors and Aging
Heinrich Jasper, University of Rochester
Stress Signaling, Stem Cells and Aging
Thomas A. Rando, Stanford University School of Medicine
Wnt Signaling Alters Stem Cell Fate in Aged Tissue
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
8:00 - 11:00 PM Entertainment Pacific Ballroom
Friday, February 29
Departure
*Session Chair   †Speaker invited, not yet responded.



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