Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Tolerance in Transplantation and Autoimmunity (A8)

Organizer(s): Jeffrey A. Bluestone, Abul K. Abbas, Laurence A. Turka and Diane J. Mathis
January 29 - February 3, 2008
Keystone Resort · Keystone, Colorado
Abstract Deadline: October 1, 2007
Late Abstract Deadline: November 1, 2007
Scholarship Deadline: October 1, 2007
Early Registration Deadline: December 3, 2007

Sponsored by Novo Nordisk A/S

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This meeting took place in the 2008 season.

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Summary of Meeting
The past 40 years has seen enormous progress in the treatment of organ transplantation and autoimmunity. However, with the modern era of immunosuppression, significant problems remain including strikingly higher rates of cardiovascular disease, opportunistic infection, and malignancy. The ability to induce immune tolerance would solve most of these problems. There has been enormous progress in our understanding of the basic processes of both central and peripheral tolerance. Moreover, the development of novel cell surface, soluble and cellular targets has created new therapeutics. The goals of this meeting will be to present cutting edge basic and clinical tolerance research related to transplantation and autoimmunity. Presentations will focus on both advances in basic understanding of immune tolerance, pre-clinical models of disease as well as far-reaching mechanistic studies devoted to the understanding of diseases and therapeutic interventions. The meeting stands out as bringing both basic science and clinical research experts together to explore the major biological pathways of tolerance at the molecular, cellular, pre-clinical and clinical levels. Thus, the meeting will promote critical interchanges between scientists who study these processes and educate students. The long-term objective is to increase our understanding of basic tenets underlying tolerance, to establish new collaborative research projects between basic and clinical researchers and to excite future scientists in this field of study.

Tuesday, January 29
3:00 - 7:30 PM	Registration	Shavano Peak Foyer
6:30 - 7:30 PM	Refreshments	Shavano Peak Foyer
7:30 - 8:30 PM	Keynote Address	Shavano/Torreys

	Christopher C. Goodnow, Australian National University Multiple Steps to Tolerance and Autoimmunity
Wednesday, January 30
7:00 - 8:00 AM	Breakfast	Crestone/Red Cloud
8:00 - 11:00 AM	Central Tolerance	Shavano/Torreys
	* Philippa C. Marrack, National Jewish Medical and Research Center How the T Cell Repertoire becomes Peptide and MHC Specific

	George S. Eisenbarth, University of Colorado Health Sciences Center Insulin: Tolerance and Intolerance in Type 1 Diabetes of Man and Mouse
	Megan Sykes, Massachusetts General Hospital Clinical Application of Bone Marrow Transplantation in Organ Transplantation
	Mark Anderson, University of California at San Francisco Mechanisms of a Novel Autoimmunity Syndrome caused by a Dominant Mutation in Aire
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM - 1:00 PM	Poster Setup	Crestone/Red Cloud
1:00 - 10:00 PM	Poster Viewing	Crestone/Red Cloud
2:30 - 4:30 PM	Workshop 1	Shavano/Torreys
	* Bruce R. Blazar, University of Minnesota Role of Indoloeamine 2, 3 Dioxygenase and Regulating Alloresponses
	Steven D. Levin, ZymoGenetics, Inc. Identification and Characterization of Vsig9 as an Inhibitory Member of the CD28 Family

	Elizabeth C. Nowak, Dartmouth Medical School Specific DC Subsets and Co-Stimulatory/Inhibitory Molecules Regulate Conversion of Naïve CD4+ T Cells to Foxp3+ Regulatory T Cells
	Greg M. Delgoffe, Johns Hopkins University School of Medicine Identification of mTOR as a Central Regulator in Adaptive Effector versus Regulatory T Cell Lineage Development
	Girdhari Lal, Mount Sinai School of Medicine Epigenetic Regulation of Foxp3 Expression and Efficient Generation of Regulatory CD4+ T Cells from Peripheral Naïve CD4+CD25- T Cells
	Allison L. Bayer, University of Miami School of Medicine IL-2R and IL-7R Signaling Normally Functions during Thymic Development of CD4+CD25+Foxp3+ Regulatory Cells
	* Hugh Auchincloss, NIAID, National Institutes of Health
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:00 PM	Biochemical Pathways of Tolerance	Shavano/Torreys
	Anjana Rao, Harvard Medical School Thoughts on Treg and Th17 Differentiation and Function
	* Diane J. Mathis, Harvard Medical School CD4, CD25, Foxp3 and Tregs Regulate Diabetes Progression in NOD Mice
	Andrew C. Chan, Genentech, Inc. Cellular Polarity in Tcell Biology
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Crestone/Red Cloud
7:30 - 10:00 PM	Poster Session 1	Crestone/Red Cloud
Thursday, January 31
7:00 - 8:00 AM	Breakfast	Crestone/Red Cloud
8:00 - 11:00 AM	Co-Stimulatory and Inhibitory Receptors and Cytokines	Shavano/Torreys
	Arlene H. Sharpe, Harvard Medical School PD-L1:PD-1 and PD-L1:B7-1 Interactions and T Cell Tolerance
	Flavio G. Vincenti, University of California, San Francisco Costimulation Blockade with Belatacept in Renal Transplantation
	* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School TIM Family of Genes: Role in T Cell Differentiation, Autoimmunity and Tolerance

	Christian P. Larsen, Emory University School of Medicine Determinants of Transplantation Tolerance Induction
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM - 1:00 PM	Poster Setup	Crestone/Red Cloud
1:00 - 10:00 PM	Poster Viewing	Crestone/Red Cloud
2:30 - 4:30 PM	Workshop 2: Drug Discovery and Therapeutic Intervention	Shavano/Torreys
	* Jeffrey L. Browning, Biogen Idec, Inc. BioGen/IDEC
	Paul Anthony Blair, University College London Suppressive Effect of Regulatory B Cells in Experimental Lupus: Translation to Systemic Lupus Erythematosus

	Joseph M. Dal Porto, Roche Palo Alto LLC Immunomodulation of B Cell Activation via Non-Depleting, Therapeutic Intervention of the CD19 Co-Receptor
	Barbara Metzler, Novartis Institutes for BioMedical Research Homeostatic Tuning of FoxP3+CD4 T Cell Populations under Continuous Exposure to FTY720
	Andrew T. Miller, Genomics Institute of the Novartis Research Foundation ITPKb is a Negative Regulator of B Cell Tolerance via Inhibition of Store-Operated Calcium Channels
	Mark R. Rigby, Emory University Costimulation Antagonists Result in Abortive Activation of Antigen-Stimulated T Cells


	Anne De Groot, Brown University A Novel Model of IVIG Immunosuppression: Activation of Natural Regulatory T cells by IgG-Derived Peptides
	* David W. Scott, University of Maryland School of Medicine Peptide-IgG Transduced B Cells that Activated via TLR4 and TLR9 have Opposite Effects on Tolerance Induction
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:00 PM	Bioinformatics and Biomarkers in Tolerance	Shavano/Torreys
	* Terry B. Strom, Beth Israel Deaconess Medical Center Gene Expression Profiling to Study Tolerance
	Ken H. Buetow, National Cancer Institute, National Institutes of Health Enabling the Molecular Medicine Revolution through Network-Centric Biomedicine

	David A. Hafler, Harvard Medical School Tolerance in Transplantation and Autoimmunity
	Vicki L. Seyfert-Margolis, Immune Tolerance Network Short Talk: New Biomarkers in Immune Tolerance
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Crestone/Red Cloud
7:30 - 10:00 PM	Poster Session 2	Crestone/Red Cloud
Friday, February 1
7:00 - 8:00 AM	Breakfast	Crestone/Red Cloud
8:00 - 11:00 AM	Regulatory Cells to Control Immunity	Shavano/Torreys
	* Jeffrey A. Bluestone, University of California, San Francisco Immune Homeostasis in Autoimmunity
	Alexander Y. Rudensky, Memorial Sloan-Kettering Cancer Center Cell-Mediated Control of Immune Mediated Inflammation
	Herman Waldmann, University of Oxford How is Infectious Tolerance Generated?
	Maria Grazia Roncarolo, San Raffaele Telethon Institute for Gene Therapy In Vitro Expansion and Therapy with Regulatory T Cells
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM - 1:00 PM	Poster Setup	Crestone/Red Cloud
1:00 - 10:00 PM	Poster Viewing	Crestone/Red Cloud
2:30 - 4:30 PM	Workshop 3	Shavano/Torreys
	* Howard L. Weiner, Brigham and Women's Hospital A Dominant Function for Interleukin 27 in Generating Interleukin 10-Producing Anti-Inflammatory T Cells
	Benoit L. Salomon, University Pierre et Marie Curie CD4+ T Cells Limit their Own-Pathogenicity by Activating Regulatory T Cells
	Irene Puga, Albert Einstein College Of Medicine Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells
	Francisco J. Quintana, Harvard Medical School Control of Foxp3 Expression and Treg Generation by AHR
	Masahide Tone, University of Pennsylvania Smad3 and NFAT Cooperate to Induce FoxP3 Expression through its Enhancer
	Gerald J. Prud'homme, St. Michael's Hospital Neuropilin-1 is a Receptor for Latent and Active TGF-beta-1 and Contributes to Regulatory T Cell Activity
	* Ken Shortman, Walter and Eliza Hall Institute of Medical Research Role of Different Thymic Dendritic Cells in the Development of Thymic Tregs
	Qizhi Tang, University of California, San Francisco Amplification of Autoimmune Response through Induction of Dendritic Cell Maturation in Inflamed Tissues
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:00 PM	B Cells in Tolerance and Autoimmunity	Shavano/Torreys
	* Ann Marshak-Rothstein, University of Massachusetts Medical School Dissecting the Autoantibody Response
	Mark J. Shlomchik, Yale University School of Medicine Activation and Regulation of Autoreactive B Cells: T Cells, Tolls, and Tolerance
	John C. Cambier, University of Colorado Denver Health Sciences Center Chronic Transduction of Biased Inhibitory Signals Maintains the Antigen Unresponsiveness of Anergic B Cells
	E. William St. Clair, Duke University Medical Center Short Talk: B Cells as Therapeutic Targets for Human Autoimmunity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Crestone/Red Cloud
7:30 - 10:00 PM	Poster Session 3	Crestone/Red Cloud
Saturday, February 2
7:00 - 8:00 AM	Breakfast	Crestone/Red Cloud
8:00 - 11:00 AM	Balancing Effector and Regulatory T Cells in Immunity and Disease	Shavano/Torreys
	* Abul K. Abbas, University of California, San Francisco Development of Autoagressive and Protective T Cell Responses to a Systemic Antigen
	Brigitta Stockinger, National Institute for Medical Research Context Matters - Regulation of Th17 Responses

	Kathryn J. Wood, University of Oxford Transplantation Tolerance in the Clinic
	Andrew D. Wells, University of Pennsylvania Short Talk: Foxp3 and Ikaros: Partners in Regulatory T Cell Function
	Dario A.A. Vignali, St. Jude Children's Research Hospital Short Talk: Interleukin-35: A Novel Cytokine that Mediates Regulatory T Cell Function
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:00 PM	Innate Immunity in Autoimmune Disease, Transplantation and Allergic Diseases	Shavano/Torreys
	* Laurence A. Turka, Beth Israel Deaconess/Harvard Expression and Function of MyD88 and TLRs on T Cells
	Robert L. Coffman, Dynavax Technologies TLR Interventions in Allergy
	Alberto Sanchez-Fueyo, Hospital Clinic Barcelona Short Talk: Identification of Operationally Tolerant Liver Transplant Recipients
	Wayne W. Hancock, Children's Hospital of Philadelphia Exploiting Epigenetic Mechanisms to Prevent and Cure Autoimmunity and Transplant Rejection
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Crestone/Red Cloud
8:00 - 11:00 PM	Entertainment	Crestone/Red Cloud
Sunday, February 3
	Departure

*Session Chair †Speaker invited, not yet responded.