Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Cell Death and Cellular Senescence (J8)

Organizer(s): Jacqueline A. Lees, Sally A. Kornbluth and Gerard I. Evan
February 7 - 12, 2008
Beaver Run Resort · Breckenridge, Colorado
Abstract Deadline: October 8, 2007
Late Abstract Deadline: November 7, 2007
Scholarship Deadline: October 8, 2007
Early Registration Deadline: December 10, 2007

Supported by the Director's Fund

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Joint meeting: Cell Death in the Immune System (J7)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Cell death is known to play a critical role in both normal development and human disease. We have a good understanding of the proteins that constitute the apoptotic machinery as well as the signaling pathways that regulate this process. Many of these regulatory proteins can also induce cellular senescence, a state of irreversible cell arrest. After some initial speculation that cellular senescence might be primarily a phenomenon of cultured cells, there is now unequivocal evidence that cellular senescence occurs in vivo in response to both telomere erosion and oncogenic activation and, furthermore, that this plays a key role in tissue maintenance and tumor suppression. This meeting will explore the fundamental mechanisms that control cell death and cellular senescence and discuss how each of these processes impact both normal development and tumor suppression. To achieve this goal, the meeting assembles a broad spectrum of speakers whose interests span a variety of model organisms. The Keynote Speaker, Craig Thompson, will discuss the relationship between metabolic status and cell survival. This meeting will be held in conjunction with “Cell Death in the Immune System”. Joint sessions will include the core apoptotic machinery, cell death and cellular homeostasis, signaling and apoptosis, and autophagy, inflammation and apoptosis.

Thursday, February 7
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 9:30 PM	Keynote Session (Joint)	Colorado Ballroom
	* Douglas R. Green, St. Jude Children's Research Hospital
	* Jacqueline A. Lees, Massachusetts Institute of Technology
	Craig B. Thompson, Abramson Family Cancer Center and Research Institute, University of Pennsylvania Anergy and Apoptosis Represent Alternative Cellular Responses to Bioenergetic Stress
	Jürg Tschopp, University of Lausanne Inflammatory Caspases
Friday, February 8
7:00 - 8:00 AM	Breakfast	Summit Gallery
8:00 - 11:00 AM	Cell Death and Cellular Homeostasis (Joint)	Colorado Ballroom
	* Sally A. Kornbluth, Duke University Medical Center
	Jacqueline A. Lees, Massachusetts Institute of Technology The Role of Bmi1 in Tumorigenesis
	Gerard I. Evan, University of California, San Francisco Intrinsic Tumor Suppression

	Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research Mechanism of Immunopathology Induced by TNFalpha or Fas Ligand
	Vishva M. Dixit, Genentech, Inc. Targeting the IAPs
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Breckenridge Ballroom
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Regulation of Apoptosis (Joint)	Colorado Ballroom
	* J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine
	Stephen W. Fesik, Vanderbilt University School of Medicine Bcl-2 Family Inhibitors for the Treatment of Cancer
	Michael Karin, University of California, San Diego NF-kB has Important Antiapoptotic Functions, a Negative Regulator of Caspase 1

	Nika N. Danial, Dana Farber Cancer Institute A Phospho-BAD BH3 Helix Selectively Activates Glucose Metabolism
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 1	Breckenridge Ballroom
Saturday, February 9
7:00 - 8:00 AM	Breakfast	Colorado Ballroom
8:00 - 11:00 AM	Apoptosis Pathways in Model Organisms	Peaks 1-4
	* Joan S. Brugge, Harvard Medical School
	Kristin White, Harvard Medical School Regulation of Neural Stem Cell Apoptosis in Drosophila
	John M. Abrams, University of Texas Southwestern Medical Center The Drosophila p53 regulatory network
	David W. Andrews, McMaster University Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax
	J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine Conserved Mitochondrial Regulators of Cell Death

9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Breckenridge Ballroom
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Apoptosis Pathways in Vertebrates	Peaks 1-4
	* Laura D. Attardi, Stanford University School of Medicine
	Joan S. Brugge, Harvard Medical School Entosis: Suicide/Murder of Homeless Cells
	Kay F. Macleod, University of Chicago Short Talk: Regulation of Mitochondrial Integrity and Non-Apoptotic Cell Death by BNIP3 and Tumor Progression
	Linda Z. Penn, Ontario Cancer Institute Short Talk: Cul7 a Novel Antiapoptotic Oncogene
	Guillermina Lozano, University of Texas MD Anderson Cancer Center The Mdm2/Mdm4 Complex: A Rheostat for p53 Activity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 2	Breckenridge Ballroom
Sunday, February 10
7:00 - 8:00 AM	Breakfast	Colorado Ballroom
8:00 - 11:00 AM	Signaling Pathways, Cell Death and Senescence	Peaks 1-4


	* Scott W. Lowe, Cold Spring Harbor Laboratory Dissecting Tumor Suppressor Gene Networks In Vivo

	Jeffrey C. Rathmell, Duke University Metabolism and Cell Death
	Aimee L. Edinger, University of California, Irvine Short Talk: Nutrient Transporter Down-Regulation Contributes to the Induction of Cell Death by Ceramide
	Laura D. Attardi, Stanford University School of Medicine Dissecting P53 Function using Knock-in Mice
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Breckenridge Ballroom
1:00 - 10:00 PM	Poster Viewing	Breckenridge Ballroom
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Telomeres and Senescence	Peaks 1-4
	* Guillermina Lozano, University of Texas MD Anderson Cancer Center

	Steven Artandi, Stanford University Telomerase in Stem Cells and Cancer
	Chunying Du, Stowers Institute for Medical Research Short Talk: Bruce, an Inhibitor of Spoptosis and Role in DNA Damage Resistance to Suppress Tumor Development
	Murray O. Robinson, AVEO Pharmaceuticals Human in Mouse Tissue Transgenic Breast Tomors: Dissecting Genetic Requirements for Tumorigenesis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
7:30 - 10:00 PM	Poster Session 3	Breckenridge Ballroom
Monday, February 11
7:00 - 8:00 AM	Breakfast	Colorado Ballroom
8:00 - 11:00 AM	Signaling and Apoptosis (Joint)	Colorado Ballroom
	* Gerard I. Evan, University of California, San Francisco
	Douglas R. Green, St. Jude Children's Research Hospital Matters of Life and Death; Mitochondria, ER and the Greasy Road to Apoptosis
	Sally A. Kornbluth, Duke University Medical Center Apoptosome Regulation in Cancer a Point of Resistance to Chemotherapy
	Guy S. Salvesen, Burnham Institute for Medical Research Caspase Pathways
	Huseyin Mehmet, Merck Research Laboratories Caspase-12 in Inflammation, Association with Sepsis and Neonatal Brain Injury
	Xiaodong Wang, University of Texas Southwestern Medical Center Short Talk: CAS/PHAP/Hsp70 Promote Nucleotide Exchange on Apaf-1 and Block Cytochrome C Induced Apaf-1 Aggregation
9:20 - 9:40 AM	Coffee Break	Foyer
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Autophagy, Inflammation and Apoptosis (Joint)	Colorado Ballroom
	* Christian Münz, University of Zurich
	Herbert (Skip) W. Virgin IV, Washington University School of Medicine Role of Autophagy Genes ATG5 and ATG16L1 in Immunity and Inflammation

	Eileen P. White, Rutgers University Role of Autophagy in Cancer and Therapy
	Lisa M. Coussens, University of California, San Francisco Inflammation and Cancer: Organ-Specific Regulation of Cancer Development
	You-Wen He, Duke University Medical Center Short Talk: Autophagy in T Lymphocytes
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Breckenridge Ballroom
8:00 - 11:00 PM	End of Meeting Reception and Entertainment Supported in part by Merck & Co., Inc.	Breckenridge Ballroom
Tuesday, February 12
	Departure

*Session Chair †Speaker invited, not yet responded.