Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Innate Immunity: Signaling Mechanisms (X6)

Organizer(s): Luke A.J. O'Neill, Jürg Tschopp and Shizuo Akira
February 24 - 29, 2008
Keystone Resort · Keystone, Colorado
Abstract Deadline: October 29, 2007
Late Abstract Deadline: November 27, 2007
Scholarship Deadline: October 29, 2007
Early Registration Deadline: December 27, 2007

Sponsored by sanofi-aventis

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Joint meeting: NK and NKT Cell Biology (X5)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The past 5 years has seen remarkable progress in our understanding of the molecular basis for innate immunity. New families of receptors have been discovered that sense microbial products, including Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors. In addition, signaling mechanisms activated by these receptor families have been described, with new adapter proteins, protein kinases and transcription factors being found. Breakthroughs in our understanding of signaling mechanisms is a key aspect for this field, with much excitement and insight being generated. This Keystone Symposia meeting will assemble the world’s leading investigators in cell signaling during innate immunity, to present recent data and discuss the importance of signaling in the more general context of innate immunity. We can expect a compelling and informative meeting that will bring together basic researchers in the area but also those more generally interested in leading edge research in innate immunity.

Sunday, February 24
3:00 - 7:30 PM	Registration	Shavano Peak Foyer
6:30 - 7:30 PM	Refreshments	Shavano Peak Foyer
7:30 - 8:30 PM	Keynote Address	Red Cloud/Shavano
	* Luke A.J. O'Neill, Trinity College Dublin
	Michael Karin, University of California, San Diego IKK-NF-kappaB Signaling and the Control of Caspase Activation and Cell Survival
Monday, February 25
7:00 - 8:00 AM	Breakfast	Grays 1/Torreys
8:00 - 11:45 AM	TLR Signaling: Role of Adapters	Red Cloud/Shavano
	Ruslan M. Medzhitov, Yale University School of Medicine Cell Biology of TLR Signal Transduction
	* Luke A.J. O'Neill, Trinity College Dublin Novel Regulators of Toll-like Receptor Signaling
	Kate A. Fitzgerald, University of Massachusetts Medical School Negative Regulation of Innate Immunity

	Alan Aderem, Institute for Systems Biology A Systems Approach to Dissecting Immunity
	Abigail M. Spear, Defence Science and Technology Laboratory Short Talk: Identification and Characterization of Toll/Interleukin-1 Receptor Family Proteins in a Range of Pathogenic Bacteria

9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:15 AM - 1:00 PM	Poster Setup	Grays 1/Torreys
1:00 - 10:00 PM	Poster Viewing	Grays 1/Torreys
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:15 PM	TLR Signaling: Role of Protein Kinases	Red Cloud/Shavano


	Alexander (Sasha) Tarakhovsky, Rockefeller University Essential Role of Histone Lysine Methyltransferase G9a in Innate Antiviral Response
	* Sankar Ghosh, Columbia University TLR-Mediated Signaling to NF-kappaB
	Carla Vanina Rothlin, Yale University Short Talk: TAM Receptors are Pleiotropic Inhibitors of the Innate Immune Response
	Sinead Keating, Trinity College Dublin Short Talk: IRAK-2 Participates in Multiple Toll-Like Receptor Signalling Pathways to NF-kappaB via Activation of TRAF6 Ubiquitination
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Grays 1/Torreys
7:30 - 10:00 PM	Poster Session 1	Grays 1/Torreys
Tuesday, February 26
7:00 - 8:00 AM	Breakfast	Grays 1/Torreys
8:00 - 11:15 AM	NLR Signaling	Red Cloud/Shavano
	* Jürg Tschopp, University of Lausanne The Inflammasomes
	Gabriel Nuñez, University of Michigan Role of NLRs in Innate Immunity and Disease
	Dana Philpott, University of Toronto Title to be Determined

	Mihai G. Netea, Radboud University Nijmegen Medical Centre Short Talk: Monocytes are not Macrophages: One-Hit Versus Two-Hit Stimulation for LPS-Driven Activation of the Human Inflammasome for IL-1beta

	Marie-Cécile Michallet, INSERM U851 Short Talk: Tradd is an Essential Component of the RIG-like Helicases (RLH) Antiviral Pathway

	Chris B. Moore, University of North Carolina at Chapel Hill Short Talk: NLRX1: a Novel Member of the NLR Family which Regulates RLH-Mediated Mitochondrial Antiviral Signaling
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:15 AM - 1:00 PM	Poster Setup	Grays 1/Torreys
1:00 - 10:00 PM	Poster Viewing	Grays 1/Torreys
2:00 - 4:30 PM	Workshop: At the Interface between Innate Immunity and Inflammation	Red Cloud/Shavano
	* Alan Sher, NIAID, National Institutes of Health
	Anna-Marie Fairhurst, University of Texas, Southwestern Medical Center Yaa-Autoimmune Phenotypes are Conferred by an Overexpression of TLR7
	Hsin-Jung Wu, Harvard Medical School Inflammatory Arthritis can be Reined in by CpG-Induced DC-NK Cell Cross Talk
	Sandra M. Sacre, University of Sussex Toll-Like Receptor 8 is a Novel Therapeutic Target for Rheumatoid Arthritis
	Liliana Schaefer, University of Frankfurt The Matrix Component Biglycan as an Endogenous Ligand to Toll-like Receptor-4 and -2 Aggravates Inflammation and Sepsis
	R. William DePaolo, University of Chicago Infectious Tolerance Induced by Yersinia Involves JNK2-Dependent IL-10 Production
	Monica Andrea Delgado Vargas, University of New Mexico Toll Like Receptors Control Autophagy
	Rowan Higgs, Royal College of Surgeons in Ireland The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-beta Gene Transcription by Initiating Proteasomal Degradation of IRF3
	Ashish Banerjee, Walter and Eliza Hall Institute of Medical Research Non-Transcriptional Role of NF-kappaB in Regulating B Cell Survival
	Neal Silverman, University of Massachusetts Medical School Recognition and Signaling in the Drosophila IMD Pathway
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:15 PM	RIG-I-Like Receptors and Viral Sensing	Red Cloud/Shavano
	Takashi Fujita, Institute for Virus Research, Kyoto University Non-Self RNA Sensing Mechanism of RIG-I-Like Helicases and Activation of Antiviral Immune Responses

	Paula M. Pitha-Rowe, Johns Hopkins University The Role of IRF-5 in the Innate Antiviral and Inflammatory Response

	* Shizuo Akira, Osaka University TLR- and RLR-Dependent Anti-Viral Responses
	Hiroyuki Oshiumi, Hokkaido University Short Talk: Riplet: A Novel RING Finger Protein that Activates RIG-I
	Shohei Koyama, Research Institute for Microbial Diseases Short Talk: Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Grays 1/Torreys
7:30 - 10:00 PM	Poster Session 2	Grays 1/Torreys
Wednesday, February 27
7:00 - 8:00 AM	Breakfast	Grays 1/Torreys
8:00 - 11:00 AM	Genetic Variation in Signaling Molecules in Innate Immunity	Red Cloud/Shavano

	* Jenny P. Ting, University of North Carolina at Chapel Hill NLRs at the Intersection of Death and Immunity
	Jean-Laurent Casanova, Rockefeller University A Genetic Dissection of Immunity to Infection in natura
	Warren Strober, National Institutes of Health The Molecular Basis of NOD2 Susceptibility Mutations in Crohn’s Disease
	Jennifer A. Greene, Case Western Reserve University Short Talk: A 22bp Deletion Polymorphism in the 5’ Untranslated Region of the TLR2 Gene is Associated with Protection from Cerebral Malaria

	Richard I. Tapping, University of Illinois Short Talk: A Common Polymorphism Impairs Cell Surface Trafficking and Functional Responses of TLR1 but Protects Against Leprosy
	Gordon D. Brown, University of Aberdeen
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
11:00 AM - 1:00 PM	Poster Setup	Grays 1/Torreys
1:00 - 10:00 PM	Poster Viewing	Grays 1/Torreys
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:15 PM	Signaling: Biophysical and Structural Aspects	Red Cloud/Shavano
	* Nick Gay, University of Cambridge Molecular Mechanism of Signal Transduction by the Toll and Toll-Like Receptors
	Douglas Golenbock, University of Massachusetts Medical School How TLRs Achieve an Active State: Implications for Disease

	Joshua N. Leonard, National Institutes of Health, National Cancer Institute The Signaling Complex of TLR3
	James M. Elliott, Genentech Short Talk: Crystal Structure of Procaspase-1 and its Implications for Activation
	Clare E. Bryant, University of Cambridge Short Talk: Elucidation of the MD-2/TLR4 Interface Required for Signalling by Lipid IVa
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Grays 1/Torreys
7:30 - 10:00 PM	Poster Session 3	Grays 1/Torreys
Thursday, February 28
7:00 - 8:00 AM	Breakfast	Grays 1/Torreys
8:00 - 11:15 AM	Drug Targets in Innate Signaling	Red Cloud/Shavano
	* Anthony J. Coyle, Pfizer Danger Signals and Interferons in Autoimmune Disease

	Mary Collins, Wyeth Research IL-22: A Th17 cytokine contributes to chronic inflammation
	Anthony M. Manning, Biogen Idec Drug Discovery Targeting MAP Kinases: From Innate Immunity to Clinical Benefit


	Jie-Oh Lee, Korea Advanced Institute of Science and Technology Ligand Recognition by the TLR Complexes
	Lani R. San Mateo, Centocor Research and Development Short Talk: Down Modulation of Human TLR3 Function by a Monoclonal Antibody

	Karen Colbjørn Larsen, University of Oxford Short Talk: Combining TLR Signaling Molecules as Vaccine Adjuvants
9:20 - 9:40 AM	Coffee Break	Shavano Peak Foyer
4:30 - 5:00 PM	Coffee Available	Shavano Peak Foyer
5:00 - 7:15 PM	Pathogen Manipulation of Signaling and Immunomodulation	Red Cloud/Shavano
	* Andrew G. Bowie, Trinity College Dublin Insights into Innate Immune Signaling Afforded by Viral Evasion and Subversion
	Anne O'Garra, National Institute for Medical Research Regulation of IL-10 Expression in Dendritic Cells and Macrophages and Implications for Regulation of the Immune Response to Pathogens
	David E. Levy, New York University School of Medicine Transcriptional and Post-Transcriptional Regulation of Gene Expression in the IFN Innate Immune Response
	Tsukasa Seya, Graduate School of Medicine, Hokkaido University Functional Evolution of the TRIF/TLCAM-1 Pathway
	Amanda Mercedes Jamieson, Yale University School of Medicine Short Talk: Modulation of the Innate Immune Response to Bacteria by Viral Infection
7:15 PM -	Concluding Remarks
	* Luke A.J. O'Neill, Trinity College Dublin
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Grays 1/Torreys
8:00 - 11:00 PM	Entertainment	Grays 1/Torreys
Friday, February 29
	Departure

*Session Chair †Speaker invited, not yet responded.