Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

HIV Pathogenesis (X8)

Organizer(s): Steven M. Wolinsky, John P. Moore and Bette T. Korber
March 27 - April 1, 2008
Fairmont Banff Springs · Banff, Alberta
Abstract Deadline: November 28, 2007
Late Abstract Deadline: December 28, 2007
Scholarship Deadline: November 28, 2007
Early Registration Deadline: January 28, 2008

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: HIV Vaccines: Progress and Prospects (X7)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2008 season.

Listed below are current meetings that are similar to this meeting in nature/content:

HIV Evolution, Genomics and Pathogenesis (X7)
March 20 - 25, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Elucidating the molecular mechanisms of HIV infection is essential for the design and development of an effective vaccine and the next generation of antiviral agents. This Keystone Symposia meeting will focus on (1) our understanding of HIV proteins and their functions, (2) host factors used to aid in viral replication, (3) viral genetic diversity and adaptation, and (4) the central role of the destruction of CD4+ T cells in lymphoid tissue to the pathogenesis. The pathogenic mechanisms of HIV infection from transmission through clinical latency, including the means used by the virus to establish infection and propagate in target cells and evade the innate and adaptive host defense mechanisms will be examined. Scientists from diverse disciplines will be brought together with the objective of devising vaccines and other biology-based ways to prevent transmission and progression to AIDS. The meeting will promote further insights into the dynamic interplay between the virus, the host, and its immune response.

Thursday, March 27
3:00 - 7:30 PM	Registration	Van Horne Ballroom Foyer
6:30 - 7:30 PM	Refreshments	Van Horne Ballroom Foyer
7:30 - 9:30 PM	Keynote Session (Joint)	Van Horne Ballroom
	* Steven M. Wolinsky, Northwestern University
	Henry A. Erlich, Roche Molecular Systems HLA Allelic and Haplotypic Diversity and Host Immunity


	* Dan H. Barouch, Beth Israel Deaconess Medical Center
	Lawrence Corey, Fred Hutchinson Cancer Research Center HIV Vaccines: The Way Forward
Friday, March 28
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:00 AM	Biology of Transmission (Joint)	Van Horne Ballroom
	* Steven M. Wolinsky, Northwestern University
	Ashley T. Haase, University of Minnesota Sexual Mucosal Transmission
	Daniel C. Douek, NIAID, National Institutes of Health Immune Events in the HIV-Infected Gut

	Thomas J. Hope, Northwestern University, Feinberg School of Medicine Analysis of the Early Interactions of HIV with Human Cervical Explants and the Rhesus Macaque Female Genital Tract: The First 4 Hours of Virus Exposure
	James Arthos, National Institutes of Health Short Talk: HIV-1 Envelope Binds to and Signals through alpha4beta7 Integrin, the Gut Mucosal Homing Receptor for Peripheral T Cells
	Frank Wegmann, University of Oxford Short Talk: Combining HIV Antigens and Polyanionic Microbicides to Induce High Levels of Mucosal Env-Specific Antibodies
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:00 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
12:00 - 1:30 PM	Hands-on Computer Session on Los Alamos Sequence Database Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.	Beatty/Coleman
	Thomas K. Leitner, Los Alamos National Laboratory
	Bette T. Korber, Los Alamos National Laboratory
2:30 - 4:30 PM	Workshop 1: Pathogenic and Non-Pathogenic Pathways	Van Horne Ballroom AB
	* Cristian Apetrei, University of Pittsburgh Experimentally-Induced Immune Activation in Natural Hosts of SIVs Results in Significant Increases in Viral Replication
	* Genoveffa Franchini, NCI, National Institutes of Health Preferential Loss of Th17 T Cells at Mucosal Sites and Immune Activation Predicts AIDS Progression
	Mirko Paiardini, University of Pennsylvania Th17 Cells in the Gut of Naturally SIV-Infected Sooty Mangabeys

	Satya Dandekar, University of California, Davis Early Onset of Enteropathic Changes in SIV Infection Lead to Impaired IL-17 Orchestrated Gut Mucosal Immune Response Against Salmonella and cause its Systemic Dissemination from the Gut
	Joern E. Schmitz, Beth Israel Deaconess Medical Center Adaptive Immune Responses Appear to Contribute Little to Viral Containment of SIVagm infection in African Green Monkeys

	Thaidra A. Gaufin, Tulane National Primate Research Center Humoral Immune Responses have Little Impact on Controlling Viremia during SIVagm Infection of African Green Monkeys (AGMs)
	Andre Durudas, Seattle Biomedical Research Institute Tissue Specific Inflammatory Responses are Associated with Disease Outcome Following Oral SIV Transmission
	S. Rochelle Mikkelsen, North Carolina State University Transient Depletion of CD4+CD25+ Regulatory T Cells in Cats Chronically Infected with Feline Immunodeficiency Virus Improves Anti-Viral and Novel Immune Responses

4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:15 PM	Host and Viral Genetics	Van Horne Ballroom AB
	* Bette T. Korber, Los Alamos National Laboratory
	Sunil K. Ahuja, University of Texas Health Science Center Host Factors and Pathogenesis
	Mary Carrington, NCI, National Institutes of Health The Influence of HLA Class I and KIR on HIV-1 Disease
	Beatrice H. Hahn, University of Alabama at Birmingham HIV-1 Transmission and Early Viral Evolution

	Christine M. Rousseau, University of Washington Short Talk: HLA-Driven Evolution of HIV-1 Subtype C: Immune Escape and Viral Fitness Costs
	Athe M.N. Tsibris, Massachusetts General Hospital Short Talk: V3 Loop Sequence Dynamics in Subjects Failing CCR5 Antagonist Therapy
7:15 - 8:15 PM	Social Hour w/ Lite Bites	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 1	New Brunswick, Alberta, Cascade
Saturday, March 29
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:00 AM	Intracellular Events	Van Horne Ballroom AB
	* Robert W. Doms, University of Pennsylvania School of Medicine HIV Entry and its Inhibition
	Katherine A. Jones, The Salk Institute Transcription Elongation by HIV-1 Tat Links to Histone Methylation
	Frederic D. Bushman, University of Pennsylvania School of Medicine Retroviral DNA Integration: Mechanism and Consequences
	Daria J. Hazuda, Merck Research Laboratories Inhibitors of HIV-1 Integrase: Lessons from the Analysis of Resistance Derived in vivo and in vitro
	Eiji Morita, University of Utah Short Talk: Identification of ESCRT-I Binding Factors Required for Efficient HIV-1 Release
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:15 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
12:00 - 1:30 PM	Hands-on Computer Session on Los Alamos Sequence/Immunology Databases Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.	Beatty/Coleman
	Thomas K. Leitner, Los Alamos National Laboratory
	Bette T. Korber, Los Alamos National Laboratory
2:30 - 4:30 PM	Workshop 2: Aspects of Progression
	* Bette T. Korber, Los Alamos National Laboratory
	Jason Ho, NIAID, National Institutes of Health HIV-Specific B Cells Are Enriched in a Dysfunctional Tissue-like Memory B-Cell Compartment in HIV-Infected Viremic Individuals
	David M. Kuhrt, University of Pittsburgh Phenotypic Perturbation of the B Cell Compartment During Acute Simian Immunodeficiency Virus Infection

	* Jason M. Brenchley, NIAID, National Institutes of Health Th17 Cells are Preferentially Depleted from GI Tract, but not BAL or Blood, of HIV-Infected Individuals
	Pratip K. Chattopadhyay, National Institutes of Health Does T-Cell Function during Acute/Early HIV Predict Outcome?
	Peter W. Hunt, University of California, San Francisco Inflammatory Consequences of Viral Control in HIV-infected Patients with Undetectable Plasma HIV RNA Levels in the Absence of Therapy
	Paul de Bakker, Brigham and Women's Hospital A Genome-Wide Association Study in HIV Elite Controllers to Identify Host Genetic Factors that Influence Viral Control in the Absence of Anti-Retroviral Therapy
4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:15 PM	Restriction Factors	Van Horne Ballroom AB

	Felipe Diaz-Griffero, Dana Farber Cancer Institute Blocking Early Events in HIV-1 Infection
	Ruzena Stranska, University of Massachusetts Medical School Short Talk: Heterokaryon Analysis Suggests the Existence of a Dominant Restriction to SIV Infection in Macrophages
	* Michael H. Malim, King's College London School of Medicine APOBEC Proteins and Intrinsic Resistance to HIV Infection
	Stuart J. Neil, King's College London Short Talk: Tetherin, A Novel Antiviral Inhibitpr of Retrovirus Release that is Targeted by the HIV-1 VPU Protein
	Harmit Singh Malik, Fred Hutchinson Cancer Research Center Viral Restriction: Evolutionary Signatures of the Arms-Race between Host and Virus
7:15 - 8:15 PM	Social Hour w/ Lite Bites	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 2	New Brunswick, Alberta, Cascade
Sunday, March 30
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:00 AM	Structure	Van Horne Ballroom AB
	Ian A. Wilson, The Scripps Research Institute HIV Neutralizing Antibody Structures
	Kenneth H. Roux, Florida State University HIV Envelope Glycoproteins
	Sriram Subramaniam, National Institutes of Health Electron Tomography of HIV-1 and SIV: Spike Architecture and Entry Mechanisms
	* Wesley I. Sundquist, University of Utah School of Medicine Retroviral Budding
	Reuben Harris, University of Minnesota Short Talk: Structure of the DNA Deaminase Domain of the HIV-1 Restriction Factor APOBEC3G
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:00 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
2:30 - 4:30 PM	Workshop 3: Mucosal/Innate Immunity and T/B Cell Immunology	Van Horne Ballroom AB
	* Galit Alter, Massachusetts General Hospital
	* John P. Moore, Weill Medical College of Cornell University The Mannose Moieties of gp120 Glycans Suppress the Antibody Response to gp120 in Mice via an MCLR- and IL-10-Dependent Mechanism
	Elias A. Said, Université de Montréal PD-1 Expression in Monocytes: Up-Regulated during HIV Infection and Induces IL10 Production
	Appakkudal Anand, Ohio State University Medical Center HIV-1 Macrophage-Tropic gp120-Induced Migration of Dendritic Cells is Regulated by the Tyrosine Kinase, Pyk2
	Shahin Ranjbar, CBR Institute for Biomedical Research HIV-1 Replication is Differentially Regulated by Different Clinical Strains of Mycobacterium Tuberculosis
	Evan S. Jacobs, University of Medicine and Dentistry in New Jersey PDC Interaction with HIV-Infected Cells Results in Fusion and Loss of Function Leading to the Potential Depletion of PDC in vivo
	Angela Meier, Harvard Medical School, Massachusetts General Hospital Gender Differences in the Activation of pDCs in Response to HIV-1-Encoded TLR7/8 Ligands
	Joseph N. Brown, University of Florida HIV-1 Activates Macrophages Independent of Toll-like Receptors, a Potential Mechanism for Dysregulation of Innate Immunity
4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:00 PM	Viral Control (Joint)	Van Horne Ballroom
	* Dan H. Barouch, Beth Israel Deaconess Medical Center
	Andrew J. McMichael, John Radcliffe Hospital Cellular Immune Responses before and during Early HIV Infection
	Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard Durable Control of HIV Replication

	Douglas D. Richman, University of California, San Diego Neutralizing Antibody in the Control of HIV Infection
	Galit Alter, Massachusetts General Hospital Short Talk: Specific Expansion of Highly Functional KIR+ NK Cells during Acute HIV-1 Infection
7:00 - 8:00 PM	Social Hour w/ Lite Bites	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 3	New Brunswick, Alberta, Cascade
Monday, March 31
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:15 AM	Interface Between Immunology and Vaccine Design (Joint)	Van Horne Ballroom
	* M. Juliana McElrath, Fred Hutchinson Cancer Research Center
	Rafi Ahmed, Emory University School of Medicine CD8 T Cell Memory

	David I. Watkins, University of Wisconsin-Madison The Thorny Issue of Heterologous Challenge
	Bali Pulendran, Emory University Modulating Vaccine Responses with Innate Immunity
	Claire A. Chougnet, Cincinnati Children's Hospital Medical Center Interactions between Regulatory T Cells and HIV: A Complex Balancing Act
	April L. Ferre, University of California, Davis Short Talk: Polyfunctional T-Cells in the Rectal Mucosa of HIV Controllers
	Natalie A. Hutnick, University of Pennsylvania Short Talk: T-Cell Responses in Healthy Adults to Replication Deficient AdHu5 Vector
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
4:30 - 5:00 PM	Coffee Available	Van Horne Ballroom Foyer
5:00 - 7:15 PM	Drugs and Drug Resistance	Van Horne Ballroom AB
	* Jeffrey D. Lifson, SAIC-Frederick, Inc. Lasting Beneficial Consequences of Pharmacological Alteration of Virus/Host Balance in Primary SIV Infection

	Joseph K. Wong, VAMC San Francisco Drug Resistance
	Robin Shattock, St. Georges, University of London New Developments in Design of Effective Microbicides
	Nicoli Nattrass, University of Cape Town The Economics of Drug Delivery
7:15 - 8:15 PM	Social Hour w/ Lite Bites	New Brunswick, Alberta, Cascade
8:00 - 11:00 PM	Entertainment	New Brunswick, Alberta, Cascade
Tuesday, April 1
	Departure

*Session Chair †Speaker invited, not yet responded.