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Complex Traits: Biologic and Therapeutic Insights (C4)

Organizer(s): Trudy F.C. Mackay, Lon Cardon and David R. Cox
February 29 - March 5, 2008
Eldorado Hotel & Spa  ·  Santa Fe, New Mexico
Abstract Deadline: October 30, 2007
Late Abstract Deadline: November 29, 2007
Scholarship Deadline: October 30, 2007
Early Registration Deadline: December 31, 2007


Supported by the Director's Fund



This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Most phenotypic variation in populations, including variation in susceptibility to common human diseases, is attributable to segregating alleles of multiple genes, whose expression is dependent on the environment. Rapidly increasing knowledge about variation in genome sequence and gene expression will facilitate understanding the relationships of genotype to complex phenotypes and the evolutionary mechanisms shaping variation for complex traits, in humans and model organisms. Major questions to be solved regarding the genetic architecture of complex traits include the following: (1) the relative prevalence of common and rare variants; (2) whether causal variation is typically regulatory or structural; (3) how many segregating alleles affect any given trait and their pleiotropic effects on other traits; and (4) the extent to which allelic effects depend on other segregating alleles and the environment. This meeting aims to address these questions by bringing together investigators from population and quantitative genetics, genomics, and with expertise in model systems and humans.

Friday, February 29
3:00 - 7:30 PM Registration Zia Concourse
6:30 - 7:30 PM Refreshments Sunset Room
7:30 - 8:30 PM Keynote Address Anasazi Ballroom
* Trudy F.C. Mackay, North Carolina State University
Michael Lynch, Indiana University
Spontaneous Mutation, Complex Traits and Evolution
Saturday, March 1
7:00 - 8:00 AM Breakfast Eldorado Court
8:00 - 11:00 AM The Spectrum of Genetic Variation Anasazi Ballroom
Charles H. Langley, University of California, Davis
Polymorphism and Divergence across the Drosophila melanogaster Genome
Detlef Weigel, Max Planck Institute for Developmental Biology
Whole-Genome Variation and its Impact on Reproductive Isolation in Arabidopsis thaliana
Eleazar Eskin, University of Calfornia, Los Angeles
A Sequence-Based Variation Map of 8.27 million SNPs in Inbred Mouse Strains
* Peter Donnelly, University of Oxford
Human Genetic Variation and Disease Susceptibility
Richard M. Durbin, Wellcome Trust Sanger Institute
Short Talk: Whole Genome Sequence Variation in 70 Saccharomyces Strains
9:20 - 9:40 AM Coffee Break Zia Concourse
11:00 AM - 1:00 PM Poster Setup Sunset Room
1:00 - 10:00 PM Poster Viewing Sunset Room
4:30 - 5:00 PM Coffee Available Zia Concourse
5:00 - 7:00 PM Genetic Variation and Evolution Anasazi Ballroom
Adam Eyre-Walker, University of Sussex
Inferring the Effects of Mutations from DNA Sequence Data
Daniel L. Hartl, Harvard University
Therapeutic Insights from Yeast: Plasticity, Pleiotropy, and Mutability in the Transcriptome
* Sarah A. Tishkoff, University of Pennsylvania
Genotypic and Phenotypic Variation in Africa
James P. Noonan, Yale University School of Medicine
Short Talk: Functional Insights into the Role of Gene Regulatory Change in Human Evolution
7:00 - 8:00 PM Social Hour w/ Lite Bites Eldorado Court/Sunset Room
7:30 - 10:00 PM Poster Session 1 Sunset Room
Sunday, March 2
7:00 - 8:00 AM Breakfast Eldorado Court
8:00 - 11:00 AM The Genetic Architecture of Gene Expression Anasazi Ballroom
Ritsert C. Jansen, University of Groningen
Statistical Challenges for Genetical Genomics
* Leonid Kruglyak, Princeton University
Genetic Architecture of Gene Expression in Yeast
Eric Schadt, Pacific Biosciences
Mapping the Genetic Architecture of Gene Expression in Mouse and Human Populations
Vivian Cheung, University of Pennsylvania
Genetics of Natural Variation in Human Gene Expression
Jan Veldink, University Medical Center Utrecht
Short Talk: Differential Expression of Gene Networks in Peripheral Blood of Sporadic Amyotrophic Lateral Sclerosis (ALS) Patients Reveals Molecular Heterogeneity of the Disease
9:20 - 9:40 AM Coffee Break Zia Concourse
11:00 AM - 1:00 PM Poster Setup Sunset Room
1:00 - 10:00 PM Poster Viewing Sunset Room
1:30 - 2:30 PM Editor's Roundtable Anasazi Ballroom
2:30 - 4:30 PM Workshop: Short Talks Selected from Abstracts Anasazi Ballroom
* Trudy F.C. Mackay, North Carolina State University
Michael N. Weedon, Peninsula Medical School
Genome Wide Association Analysis Identifies 20 loci that Influence Adult Height
Laurens Basten Snoek, Wageningen University and Research Centre
The Genetic Architecture of Life-History Variation
Cristen J. Willer, University of Michigan
Genome-Wide Association Scans Identify Novel Loci That Influence Lipid Levels and Risk of Coronary Artery Disease
Michael Olivier, Medical College of Wisconsin
Complete Dissection of a QTL Identifies Five Novel Genes Responsible for Altered Lipid Levels in the Metabolic Syndrome
Hyun Seok Kim, Washington University
A Systematic Screen for Genes Contributing to Quantitative Traits in Yeast using Quantitative non-Complementation
Yi Jia, Iowa State University
Genetic Control of the Transcription of Natural Antisense Transcripts (NATs) in Maize
Yurii S. Aulchenko, Erasmus MC Rotterdam
Comparison of Methods for Genome-Wide Quantitative Trait Association Analysis in Related Individuals
Ana-Teresa Maia, CRUK-Cambridge Research Institute
New Approach to Study Susceptibility to Breast Cancer: Allelic Variation of Gene Expression Analysis
4:30 - 5:00 PM Coffee Available Zia Concourse
5:00 - 7:00 PM The Genetic Architecture of Complex Traits: Lessons from Model Organisms Anasazi Ballroom
* Trudy F.C. Mackay, North Carolina State University
Genetic Analysis of Complex Traits in Drosophila
Ronald W. Davis, Stanford University
Chemical and Complex Genetics in Yeast
Beverly Paigen, The Jackson Laboratory
Genetic Dissection of Mouse Complex Traits
Bart M.G. Smits, University of Wisconsin - Madison
Short Talk: Characterization of Mcs5a, a non-Coding Breast Cancer Susceptibility Locus
7:00 - 8:00 PM Social Hour w/ Lite Bites Eldorado Court/Sunset Room
7:30 - 10:00 PM Poster Session 2 Sunset Room
Monday, March 3
7:00 - 8:00 AM Breakfast Eldorado Court
8:00 - 11:00 AM Human Complex Traits: Progress and Prospects Anasazi Ballroom
P. Eline Slagboom, Leiden University Medical Centre
Genetic and Biomarker Studies for Human Longevity
* Carole Ober, University of Chicago
Genome-Wide Association Studies in a Founder Population
Gilles Thomas, NCI - National Institutes of Health
Genome-Wide Association Studies in Breast and Prostate Cancer: Cancer Genetic Markers of Susceptibility (CGEMS).
Adnan Derti, Harvard Medical School
Short Talk: Assessing Excess Epistasis Among Functionally Related Human Genes
9:20 - 9:40 AM Coffee Break Zia Concourse
4:30 - 5:00 PM Coffee Available Zia Concourse
5:00 - 6:40 PM Whole Genome Association Studies Anasazi Ballroom
* David R. Cox, Perlegen Sciences, Inc.
Common Human DNA Variation and Complex Human Traits: Success Stories
Teri Manolio, National Institutes of Health
Collaboration and Data Sharing in the Genetic Association Information Network
Richard Spielman, University of Pennsylvania
Short Talk: Monozygotic Twins Reveal Germ-line Contribution to Allelic Expression Differences
Minerva M. Carrasquillo, Mayo Clinic
Short Talk: Genome-Wide Association Scan for Late Onset Alzheimer’s Disease (LOAD)
6:40 - 7:15 PM Roundtable: Whole Genome Scans in Non-Academic Medicine Anasazi Ballroom
* David R. Cox, Perlegen Sciences, Inc.
Kári Stefánsson, deCode Genetics
Prospects for Whole Genome Analysis for Individualized Medicine in the Real World
7:00 PM - On Own for Dinner
Tuesday, March 4
7:00 - 8:00 AM Breakfast Eldorado Court
8:00 - 11:00 AM Behavioral Genetics and Genomics Anasazi Ballroom
* Robert R.H. Anholt, North Carolina State University
Genetic Architecture of Complex Behavior in Drosophila
Emmanuel Mignot, Stanford University
Molecular Studies in Narcolepsy and Hypersomnia
Kári Stefánsson, deCode Genetics
Genetic of Common Diseases
Hans A. Hofmann, University of Texas at Austin
Genes, Hormones and Brains: A Genomic Analysis of Social Behavior
Susan T. Harbison, North Carolina State University
Short Talk: Identification of Co-Regulated Genetic Networks Contributing to Naturally Occurring Genetic Variation in Drosophila Sleep
9:20 - 9:40 AM Coffee Break Zia Concourse
4:30 - 5:00 PM Coffee Available Zia Concourse
5:00 - 7:00 PM Epigenetics and Genomic Rearrangement Anasazi Ballroom
* James R. Lupski, Baylor College of Medicine
Genomic Rearrangements and Gene Copy Number Variation as a Cause for Complex Traits
Andrew Chess, Massachusetts General Hospital
Epigenetic Mechanisms of Gene Regulationand Their Impact on Complex Traits
Iuliana Ionita, Harvard University
Short Talk: On the Analysis of Copy-Number Variations (CNVs) in Genome-Wide Association Studies: A Translation of the Family-Based Association Test (FBAT) Approach
Dana C. Crawford, Vanderbilt University
Short Talk: APOA1/C3/A4/A5 Gene Cluster SNPs and their Interaction with Dietary Intake are Associated with Triglyceride Levels in the Third National Health and Nutrition Examination Survey
Dana Pe'er, Columbia University
Short Talk: On the Complexity of the Growth Phenotype
7:00 - 8:00 PM Social Hour w/ Lite Bites Eldorado Court/Sunset Room
8:00 - 11:00 PM Entertainment Eldorado Court/Sunset Room
Wednesday, March 5
Departure
*Session Chair   †Speaker invited, not yet responded.



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