| Sunday, February 10 |
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3:00 - 7:30 PM
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Registration
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Zia Concourse
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6:30 - 7:30 PM
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Refreshments
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Pavillion
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7:30 - 7:40 PM
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Brief Introduction to the Meeting
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Jack D. Griffith,
University of North Carolina, Chapel Hill
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7:40 - 8:40 PM
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Keynote Address
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Anasazi Ballroom
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Michael E. O'Donnell,
Rockefeller University
Dynamic Mechanisms at the E. coli Replication Fork
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| Monday, February 11 |
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7:00 - 8:00 AM
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Breakfast
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Eldorado Court
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8:00 - 11:00 AM
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Replication Fork Mechanisms
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Anasazi Ballroom
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*
Peter M. Burgers,
Washington University School of Medicine
Remodeling of the Replication Fork in Response to DNA Damage
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Thomas A. Steitz,
Howard Hughes Medical Institute, Yale University
The Macromolecular Replication Machinery: Structural Insights into the Replisome
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Charles S. McHenry,
University of Colorado, Boulder
Reconstitution of a B. Subtilis Rolling Circle DNA Replication System
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Antoine van Oijen,
Harvard Medical School
Under the Hood of the Replisome: A Single-Molecule View of DNA Replication
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9:20 - 9:40 AM
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Coffee Break
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Pavillion
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11:00 AM - 1:00 PM
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Poster Setup
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Pavillion
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11:00 AM -
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On Own for Lunch
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1:00 - 10:00 PM
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Poster Viewing
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Pavillion
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2:30 - 4:30 PM
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Workshop 1: Origins and Okazaki Fragments
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Anasazi Ballroom
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Nicholas E. Dixon,
University of Wollongong
A Molecular Mousetrap Determines Polarity in Termination of E. coli DNA Replication
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Alan C. Leonard,
Florida Institute of Technology
Two Growth Rate-Dependent Mechanisms for Pre-Replication Complex Assembly in E. coli
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Kenji Keyamura,
Kyushu University
A Novel Initiation-Stimulator DiaA Directly Promotes ATP-DnaA-Specific Initiation Complexes in E. coli
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Smita S. Patel,
UMDNJ-RW Johnson Medical School
Coordination of Helicase, Primase, and Polymerase Activities in DNA Replication
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Samir Hamdan,
Harvard Medical School
Two Molecular Triggers Reset the Bacteriophage T7 Replisome after Okazaki Fragment Synthesis
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Isabel Kurth,
Rockefeller University
Polymerase Collision Release is Mediated by Loss of Multiple Attachment Points to DNA upon Completing each Okazaki Fragment
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Erik Johansson,
Umeå University
The Eukaryotic Leading and Lagging Strand DNA Polymerases are Loaded onto Primer-Ends via Separate Mechanisms but have Comparable Processivity in the Presence of PCNA
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Nina Y. Yao,
Rockefeller University
Mechanism of PCNA Clamp Opening by Replication Factor C
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2:30 - 4:30 PM
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Workshop 2: Chromosomes, Telomeres, and Large Scale Organization
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Zia Ballroom
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David J. Sherratt,
University of Oxford
Independent positioning and action of replication forks in live Esherichia coli
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Kiyoshi Mizuuchi,
NIDDK, National Institutes of Health
P1 Plasmid Partition: Role of ATP-Dependent ParA Conformational Change and DNA Binding Kinetics in DNA Translocation
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Shingo Nozaki,
Nagoya University Graduate School
Subcellular Localization of Escherichia coli DnaA, the Initiator of DNA Replication
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Bhupender Singh,
Uppsala University
Replication Factories in Live Bacteria (E. coli): Localization for Chromosomal, Viral and Plasmid Replication Sites
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Amitabh Nimonkar,
University of California
Single-Molecule Imaging & Biochemical Analysis of Saccharomyces Cerevisiae Encoded Dmc1 & Tid1/Rdh54 Proteins
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Constance Nugent,
University of California, Riverside
Analysis of Telomere Capping Protein Interactions with Polalpha Subunits
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Toru Nakamura,
University of Illinois at Chicago
Cell Cycle Regulation of Fission Yeast Telomere Proteins
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Manolis Papamichos-Chronakis,
University of Massachusetts Medical School
The INO80 Chromatin Remodeling Enzyme Regulates Replisome Function and Stability
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4:30 - 5:00 PM
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Coffee Available
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Pavillion
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5:00 - 7:00 PM
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Replication and Recombination at Telomeres
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Anasazi Ballroom
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*
Jack D. Griffith,
University of North Carolina, Chapel Hill
T-Loops and T-Circles in the Replication of Telomeres
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Julia Cooper,
London Research Institute
Disentangling Chromosome Ends: The Outcome of Replication Fork Stalling at Telomeres is Dictated by Sumoylation of RecQ Helicase
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Susan M. Bailey,
Colorado State University
Telomere Dynamics and Premature Aging
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pavillion
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7:30 - 10:00 PM
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Poster Session 1
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Pavillion
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| Tuesday, February 12 |
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7:00 - 8:00 AM
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Breakfast
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Eldorado Court
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7:00 - 8:00 AM
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Poster Setup
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Pavillion
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8:00 - 11:00 AM
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Assembling Initiation Complexes - Replication Origins and Cell Cycle Control
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Anasazi Ballroom
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*
Jerard Hurwitz,
Memorial Sloan-Kettering Cancer Center
Initiation of Replication
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Louise T. Chow,
University of Alabama at Birmingham
Regulation of Human Papillomavirus DNA Replication
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Bruce W. Stillman,
Cold Spring Harbor Laboratory
Control of the Chromosome Cycle in Human Cells by the Origin Recognition Complex
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John F.X. Diffley,
Cancer Research UK London Research Institute
Regulation of Replication Origin Activation during the Cell Cycle and in Response to DNA Damage
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9:20 - 9:40 AM
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Coffee Break
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Pavillion
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11:00 AM - 12:00 PM
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Lunch
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Pavillion
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12:00 - 2:30 PM
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Poster Session 2
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Pavillion
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2:30 - 4:30 PM
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Workshop 3: Helicases, Mitochondrial Replication
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Anasazi Ballroom
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Laurie S. Kaguni,
Michigan State University
Modular Architecture and Human Disease Alleles of the Mitochondrial Replicative DNA Helicase
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Amy Marion Branagan,
University of Vermont
Intermediates in Gp59-Mediated Helicase Loading at the T4 DNA Replication Fork
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Ajit Kumar Satapathy,
Harvard Medical School
Nucleotide and Metal Cofactor Specificity in Bacteriophage T7 Helicase
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Whitney Yin,
University of Texas, Austin
Crystal Structure of Human Miochondrial DNA Polymerase Holoenzyme
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Robert A. Sclafani,
University of Colorado Denver
Structure-Function Analysis of DNA Binding Domains in Mcm DNA Helicases
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Matthew L. Bochman,
University of Pittsburgh
Involvement of an ATP-Dependent “Gate” in MCM2-7 Helicase Activity
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Megan Davey,
University of Western Ontario
A Ringmaker Mechanism for Loading MCMs onto DNA
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Jaya G. Yodh,
University of Illinois at Urbana-Champaign
Single Molecule Analysis of DNA Unwinding by Human Bloom Helicase
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2:30 - 4:30 PM
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Workshop 4: Recombination and Repair in Yeast and Prokaryotes
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Zia Ballroom
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Johannes C. Walter,
Harvard Medical School
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Chrystelle Maric Antoinat,
Institut Andre Lwoff
X-Shaped Post-Replicative Joint DNA Molecules Contain Ribonucleotides
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Francesca Storici,
Georgia Institute of Technology
RNA-Templated DNA Repair
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Benedicte Michel,
CNRS
Ruva Mutants that Resolve Holliday Junctions but do not Revert Replication Forks
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Kent W. Mouw,
University of Chicago
Architecture of a Serine Recombinase – DNA Regulatory Complex
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Yasuto Murayama,
Yokohama City University
Fission Yeast Rhp51 Recombinase Promotes DNA Four-Strand Exchange Reaction in vitro
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Sapna Das-Bradoo,
University of Minnesota
How do Cells Sense DNA Damage “Behind” the Fork?
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Kristina Trenz,
London Research Institute, Clare Hall
Plx1 is Required for Chromosomal DNA Replication under Stressful Conditions
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Audrey Klingele,
University of Wisconsin-Madison
Changes in Gene Expression Related to Acquired Resistance to Radiation Damage
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4:30 - 5:00 PM
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Coffee Available
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Pavillion
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5:00 - 7:00 PM
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Recombination Mechanisms and Chromosome Pairing
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Anasazi Ballroom
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Kirill S. Lobachev,
Georgia Institute of Technology
Mechanisms of Chromosomal Fragility and Genome Rearrangements Mediated by Unstable Repeats
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Eric C. Greene,
Columbia University
Visualizing DNA Repair Proteins in Action
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Camilla Sjögren,
Karolinska Institute
Sister Chromatid Cohesion in Chromosome Segregation and Repair
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7:00 PM -
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On Own for Dinner
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| Wednesday, February 13 |
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7:00 - 8:00 AM
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Breakfast
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Eldorado Court
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8:00 - 11:00 AM
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Architecture of Replication and Recombination Complexes
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Anasazi Ballroom
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Stephen C. West,
Cancer Research UK
Aprataxin — A Proofreader for Abortive DNA Ligation Events
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Johannes C. Walter,
Harvard Medical School
Mechanism of DNA Interstrand Crosslink Repair
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Fred Dyda,
National Institutes of Health
Molecular Mechanism of Asymmetric DNA Transposition
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James M. Berger,
University of California, Berkeley
Molecular Mechanisms for Initiating DNA Replication
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9:20 - 9:40 AM
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Coffee Break
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Pavillion
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11:00 AM - 1:00 PM
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Poster Setup
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Pavillion
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11:00 AM -
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On Own for Lunch
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1:00 - 10:00 PM
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Poster Viewing
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Pavillion
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2:30 - 4:30 PM
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Workshop 5: New Polymerases
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Anasazi Ballroom
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*
Kyungjae Myung,
NHGRI, National Institutes of Health
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Elena Curti,
NICHD, National Institutes of Health
Interplay of E. coli Polymerases during Genome Duplication
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Anne-Marie MacLean McRobbie,
University of St Andrews
Understanding the Interplay between Recombinases, Helicases and DNA Binding Proteins during Homologous Recombination in Archaea
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Danielle L. Daee,
Functional Consequences of Replicative Polymerase Polymorphisms and Cancer-Associated Mutations Modeled in Yeast
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Daniel Kane,
Tufts University
Usage of DNA Polymerase Eta and Zeta in Homologous Recombination and Repair following DNA Damage in Drosophila
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Mitch McVey,
Tufts University
DNA Polymerase Theta Functions in an Alternative Double-Strand Break Repair Pathway in Drosophila Melanogaster
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Nilabja Sikdar,
National Human Genome Research Institute
Human ELG1 Functions to Repair DNA Damage through its Interaction with PCNA and Polymerase eta
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Tina M. Albertson,
University of Washington
Polymerase Delta and Epsilon Proofreading Act in Parallel Pathways to Suppress Spontaneous Mutation and Cancer in Mice
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Garry Dallmann,
University of Colorado
Identification of Small–Molecule Inhibitors of DNA Polymerase III Holoenzyme
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2:30 - 4:30 PM
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Workshop 6: Recombination and Repair in Higher Eukaryotes
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Zia Ballroom
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Richard A. Fishel,
Ohio State University
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Guo-Min Li,
University of Kentucky
Identification of a Novel Mismatch Repair Stimulating Factor involving RFX
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Ling Xia,
Molecular Medicine and Genetics
The Role of Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells
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Martin Kupiec,
Tel Aviv University
Elg1 is Required for Genome Stability
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Renee D. Paulsen,
Stanford University
siRNA Screening for Novel Regulators of Genomic Integrity
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Kirstin Bass,
Mount Sinai School of Medicine
Brc1: Coordinating DNA Repair and Replication
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Bernard S. Lopez†,
CNRS, Centre des Etudes Atomique
PKBalpha/AKT1 Inhibits Homologous Recombination by Cytoplasmic Retention of BRCA1 and Rad51, Mediated by FOXO1a: Impact in Sporadic Breast Cancer
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Mark A. Brenneman,
Rutgers University
DSS1, a BRCA2-Associated Protein, Regulates Homologous Recombinational Repair in Human Cells
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Sandra K. Weller,
University of Connecticut Health Center
HSV-1 inactivates the ATR pathway during infection by sequestration of ATRIP
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4:30 - 5:00 PM
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Coffee Available
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Pavillion
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5:00 - 7:00 PM
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Replication Response to Checkpoints
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Anasazi Ballroom
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*
Stephen P. Bell,
Massachusetts Institute of Technology
DDK Targets Mcm 2-7 Proteins in the Pre-RC
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Marco F. Foiani,
Instituto FIRC di Oncologia Molecolare
Pathways Controlling Replication Fork Stability
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Karlene A. Cimprich,
Stanford University
Mechanisms for Maintaining Genome Stability at the Replication Fork
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pavillion
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7:30 - 10:00 PM
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Poster Session 3
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Pavillion
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| Thursday, February 14 |
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7:00 - 8:00 AM
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Breakfast
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Eldorado Court
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8:00 - 11:00 AM
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Genome Stability and DNA Repair, Alternative Polymerases, DSB Repair
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Anasazi Ballroom
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Richard D. Kolodner,
Ludwig Institute for Cancer Research
Identification of Pathways that Prevent Genome Instability
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Lorena S. Beese,
Duke University
Human mutS alpha DNA Lesion Recognition Complex
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Roger Woodgate,
National Institutes of Health
Y-Family Polymerases and Their Role in the Translesion Synthesis of Alkylation Damage
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Jan Karlseder,
The Salk Institute
C. elegans Telomeres Contain both G-Strand and C-Strand Overhangs that are Bound by Distinct Telomere-Binding Proteins
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9:20 - 9:40 AM
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Coffee Break
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Pavillion
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11:00 AM -
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On Own for Lunch
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2:30 - 4:30 PM
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Workshop 7: Fork Stalling And Structure of Fork Complexes
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Anasazi Ballroom
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*
Xiaojiang S. Chen,
University of Southern California
The Hexameric Structure of a DnaB-Family Replicative Helicase and its Functional Interplay with Primase
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Sharmistha Ghosh,
Harvard Medical School
Escherichia Coli Thioredoxin Interacts wiht the Thioredoxin Binding Domain of Bacteriophage T7 DNA Polymerase and with Helicase/Primase at the Replication Fork
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Iben Bach Bentsen,
Aarhus University
Identification of Protein Factors Required during Stalled Replication at a Protein-DNA Barrier
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Hong Yan,
Fox Chase Cancer Center
Biochemical Analysis of Replication Fork Stall and Restart at a Defined Lesion in Xenopus Nucleoplasmic Extracts
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Chiara Indiani,
Rockefeller University, Hughes Medical Institute
Programmed Slowing of the Replication Fork in Response to DNA Damage
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Kieran Emptage,
University of Newcastle
Archaeal Family B DNA Polymerase Stalling, Protection and Interaction with PCNA at Deaminated Bases
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Yu-Hao Paul Chang,
University of Southern California
Crystal Structure of the GINS Complex and Functional Insights into its Role in DNA Replication
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Roxana Georgescu,
Rockefeller University
Structure of a Sliding Clamp on DNA
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2:30 - 4:30 PM
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Workshop 8: VDJ, End Joining and Transposition
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Zia Ballroom
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Ronald Chalmers,
University of Nottingham Medical School
Base-Flipping Dynamics in V(D)J Recombination
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Mick G. Chandler,
Centre National de la Recherche Scientifique
Transposition of the Novel Insertion Sequence IS608: Biochemistry and Assimilation into the Cell Cycle
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Hiroshi Nakai,
Georgetown University Medical Center
Effect of Translation Factor IF2-2 at the Interface of Recombination and Replication for Bacteriophage MU Transposition
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Patrick C. Swanson,
Creighton University
Evidence for Long Range RAG1/2 Interactions with Coding Sequences in Discrete V(D)J Initiation Complexes Assembled on Coupled Cleavage Substrates
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Adam G. W. Matthews,
Massachusetts Institute of Technology
RAG2 PHD Finger Couples Histone H3 Lysine 4 Trimethylation with V(D)J Recombination
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Lisa Postow,
Rockefeller University
Ubiquitin-Mediated Removal of Ku80 from DNA Breaks
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John R. Lydeard,
Brandeis University
Break-Induced Replication Requires both the Leading and Lagging Strand Replication Machinery
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Jennifer A. Cobb,
University of Calgary
The Mre11 Complex and S Phase: Maintaining the Replisome during Fork Stalling
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4:30 - 5:00 PM
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Coffee Available
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Pavillion
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5:00 - 7:00 PM
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Replication Stalling and Restart
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Anasazi Ballroom
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*
Kenneth J. Marians,
Memorial Sloan-Kettering Cancer Center
Mechanisms of Replication Fork Reactivation
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Karim Labib,
University of Manchester
Regulating the Progression of Eukaryotic DNA Replication Forks
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James E. Haber,
Brandeis University
Break Induced-Replication and the Recombination Execution Checkpoint
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Pavillion
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8:00 - 11:00 PM
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Entertainment
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Pavillion
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| Friday, February 15 |
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Departure
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