| Tuesday, March 25 |
|
3:00 - 7:30 PM
|
Registration
|
Grand Foyer
|
|
6:30 - 7:30 PM
|
Refreshments
|
Grand Foyer
|
|
7:30 - 9:30 PM
|
Keynote Session
|
Sea to Sky Ballroom BC
|
|
*
Judy Lieberman,
Harvard Medical School
and
|
|
|
*
Phillip A. Sharp,
Massachusetts Institute of Technology
Introductions
|
|
|
Craig C. Mello,
University of Massachusetts Medical School
Small RNA Pathways and Germline in C. elegans
|
|
|
Gregory J. Hannon,
Cold Spring Harbor Laboratory
Conserved Roles of Small RNAs in Genome Defense
|
|
| Wednesday, March 26 |
|
7:00 - 8:00 AM
|
Breakfast
|
Sea to Sky Ballroom A, Lower Level
|
|
8:00 - 11:00 AM
|
MicroRNAs and Their Targets (Vertebrate). Session Supported by Regulus Therapeutics
|
Sea to Sky Ballroom BC
|
|
David P. Bartel,
Massachusetts Institute of Technology
MicroRNAs and their Targets
|
|
|
Carlo M. Croce,
Ohio State University
MicroRNA Genes and Cancer
|
|
|
|
|
|
Eric N. Olson,
University of Texas Southwestern Medical Center at Dallas
microRNAs Control of Muscle Development and Disease
|
|
|
*
V. Narry Kim,
Seoul National University
lin 28-Mediated Terminal Uridylation of pre-let-7
|
|
|
|
|
|
Joel G. Belasco,
New York University School of Medicine
Short Talk: Importance of Translational Repression and non-Nucleolytic Ago Isoforms for on-Target RNA Interference
|
|
|
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Grand Foyer
|
|
11:00 AM - 1:00 PM
|
Poster Setup
|
Sea to Sky Ballroom A, Foyer
|
|
11:00 AM -
|
On Own for Lunch
|
|
|
1:00 - 10:00 PM
|
Poster Viewing
|
Sea to Sky Ballroom A, Foyer
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Grand Foyer
|
|
5:00 - 7:15 PM
|
MicroRNAs and Their Targets (Plants and Invertebrates). Session Supported by Regulus Therapeutics
|
Sea to Sky Ballroom BC
|
|
*
Victor R. Ambros,
University of Massachusetts
|
|
|
|
|
|
|
|
|
Stephen M. Cohen,
Temasek Life Sciences Laboratory
MicroRNA Functions
|
|
|
|
|
|
|
|
|
Oliver Hobert,
Columbia University Medical Center
The Regulatory Architecture of a miRNA-Controlled 3'UTR
|
|
|
Molly C. Hammell,
University of Massachusetts Medical School
Short Talk: mirWIP: microRNA Target Prediction Based on miRNP Enriched Transcripts
|
|
|
Marcelo A. German,
Dow AgroSciences
Short Talk: Global Identification of miRNA-Target RNA Pairs by Parallel Analysis of RNA Ends (PARE)
|
|
|
Eric C. Lai,
Sloan-Kettering Institute
Short Talk: Biogenesis and Function of Hairpin RNAs
|
|
|
Alla Grishok,
Columbia University Medical Center
Short Talk: Targets of Endogenous RNAi Processes in C. elegans
|
|
|
7:15 - 8:15 PM
|
Social Hour w/ Lite Bites
|
Sea to Sky Ballroom A, Foyer
|
|
7:30 - 10:00 PM
|
Poster Session 1
|
Sea to Sky Ballroom A, Foyer
|
| Thursday, March 27 |
|
7:00 - 8:00 AM
|
Breakfast
|
Sea to Sky Ballroom A, Lower Level
|
|
8:00 - 11:15 AM
|
RNA Interference: Regulation of Transcription
|
Sea to Sky Ballroom BC
|
|
Danesh Moazed,
Harvard Medical School
Role of Non-Coding RNAs in Heterochromatin Assembly
|
|
|
|
|
|
*
Marjori Ann Matzke,
Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences
RNA-Directed DNA Methylation in Arabidopsis
|
|
|
Alexei A. Aravin,
California Institute of Technology
Small RNA Pathways in Mouse Germline
|
|
|
René F. Ketting,
Hubrecht Institute
TRF-Like Terminal Transferases affect RNAi and Chromosome Segregation in C. elegans
|
|
|
Michel A. J. Georges,
University of Liège
Small RNAs and Imprinting
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Grand Foyer
|
|
11:15 AM - 1:00 PM
|
Poster Setup
|
Sea to Sky Ballroom A, Foyer
|
|
11:15 AM -
|
On Own for Lunch
|
|
|
1:00 - 10:00 PM
|
Poster Viewing
|
Sea to Sky Ballroom A, Foyer
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Grand Foyer
|
|
5:00 - 7:00 PM
|
Non-coding RNAs
|
Sea to Sky Ballroom BC
|
|
|
|
|
*
Thomas R. Gingeras,
Cold Spring Harbor Laboratory
Investigations of the Functional Roles of the Pervasive Transcription Observed for Genomes
|
|
|
Gene W. Yeo,
University of California, San Diego
Short Talk: Analysis of Small RNAs in Stem Cell Development
|
|
|
Dinshaw J. Patel,
Memorial Sloan-Kettering Cancer Center
Structural Biology of Riboswitch-Mediated Gene Regulation and Argonaute-Mediated Gene Silencing
|
|
|
|
|
|
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine
Identifying MicroRNAs and Their Targets
|
|
|
7:00 - 8:00 PM
|
Social Hour w/ Lite Bites
|
Sea to Sky Ballroom A, Foyer
|
|
7:30 - 10:00 PM
|
Poster Session 2
|
Sea to Sky Ballroom A, Foyer
|
| Friday, March 28 |
|
7:00 - 8:00 AM
|
Breakfast
|
Sea to Sky Ballroom A, Lower Level
|
|
7:00 - 8:00 AM
|
Poster Setup
|
Sea to Sky Ballroom A, Foyer
|
|
8:00 - 11:00 AM
|
RNA Interference: Newly Emerging Biology
|
Sea to Sky Ballroom BC
|
|
*
Phillip D. Zamore,
University of Massachusetts Medical School
Germline and Somatic Small RNAs
|
|
|
Thomas Tuschl,
Rockefeller University
miRNA Profiling and in Situ Hybridization to Examine Their Cell-Type Specific Expression Patterns
|
|
|
Haifan Lin,
Yale University
Epigenetic Function of Piwi and piRNAs
|
|
|
Phillip A. Sharp,
Massachusetts Institute of Technology
miRNA Silencing by Translational Inhibition and mRNA Degradation
|
|
|
Elisa Izaurralde,
MPI for Developmental Biology
Short Talk: Mechanism of miRNA-Mediated Gene Silencing
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Grand Foyer
|
|
11:00 AM - 12:00 PM
|
Lunch
|
Sea to Sky Ballroom A, Foyer
|
|
12:00 - 2:30 PM
|
Poster Session 3
|
Sea to Sky Ballroom A, Foyer
|
|
2:30 - 4:30 PM
|
Workshop 1: New Approaches to shRNA-Based Screening and Therapy
|
Sea to Sky Ballroom BC
|
|
David E. Root,
Broad Institute
Pooled shRNA Screens for Functional Fingerprinting
|
|
|
Edward Harlow,
Constellation Pharmaceuticals
shRNA Screens to Identify Targets for Cancer Drug Development
|
|
|
Michael T. Hemann,
Massachusetts Institute of Technology
In Vivo Screens to Identify Mechanisms of Drug Resistance
|
|
|
Mark A. Kay,
Stanford University
Functional Evidence for Restricting MicroRNA Targets to the 3' Untranslated Region of mRNAs
|
|
|
*
John J. Rossi,
Beckman Research Institute of the City of Hope
Applying RNAi for the treatment of HIV infection
|
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Grand Foyer
|
|
5:00 - 7:00 PM
|
RNA Interference: Mechanisms and Cell Biology
|
Sea to Sky Ballroom BC
|
|
Matthias W. Hentze,
European Molecular Biology Laboratory
Mechanism of Translational Inhibition by miRNAs
|
|
|
|
|
|
Carl D. Novina,
Dana Farber Cancer Institute
Short Talk: MicroRNA-Targeted mRNAs Contain 40S, but not 60S Components
|
|
|
*
Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research
Role of Dicer in miRNA Pathways and Beyond
|
|
|
Jennifer A. Doudna,
University of California, Berkeley
Mechanisms of Small RNA Processing
|
|
|
7:00 PM -
|
On Own for Dinner
|
|
| Saturday, March 29 |
|
7:00 - 8:00 AM
|
Breakfast
|
Sea to Sky Ballroom A, Lower Level
|
|
7:00 - 8:00 AM
|
Poster Setup
|
Sea to Sky Ballroom A, Foyer
|
|
8:00 - 11:00 AM
|
RNAi-Based Screening
|
Sea to Sky Ballroom BC
|
|
*
Gary B. Ruvkun,
Massachusetts General Hospital, Harvard Medical School
The Protein Coding Cofactors of miRNAs and siRNAs
|
|
|
Anjana Rao,
Harvard Medical School
RNAi Screen for Mammalian Biology and a Bit About Eri-1
|
|
|
Reuven Agami,
Netherlands Cancer Institute
Dead End 1 Blocks microRNA Access to Target mRNA
|
|
|
|
|
|
Scott M. Hammond,
University of North Carolina at Chapel Hill
Regulation of microRNA Biogenesis by Lin-28
|
|
|
9:20 - 9:40 AM
|
Coffee Break
|
Grand Foyer
|
|
11:00 AM - 12:00 PM
|
Lunch
|
Sea to Sky Ballroom A, Foyer
|
|
12:00 - 2:30 PM
|
Poster Session 4
|
Sea to Sky Ballroom A, Foyer
|
|
2:30 - 4:30 PM
|
Workshop 2: Translating RNAi
|
Sea to Sky Ballroom BC
|
|
Lee Lim,
Rosetta Inpharmatics LLC
Using Profiling to Study miRNAs
|
|
|
|
|
|
Muthiah Manoharan,
Alnylam Pharmaceuticals, Inc.
Cellular Delivery of siRNAs and Antagomirs Using Chemical
Conjugation and Complexation Strategies
|
|
|
*
C. Frank Bennett,
ISIS Pharmaceuticals, Inc.
Therapeutic Approaches for Modulating Gene Expression Utilizing Single Stranded Oligonucleotides
|
|
|
|
|
|
David L. Lewis,
Roche Madison Inc.
Dynamic PolyConjugates: A Rationally Designed, Modular Platform for Systemic siRNA Delivery
|
|
|
|
|
|
Fumitaka Takeshita,
National Cancer Center Research Institute
Systemic microRNA Therapy for Cancer Metastasis
|
|
|
4:30 - 5:00 PM
|
Coffee Available
|
Grand Foyer
|
|
5:00 - 7:00 PM
|
RNAi-Based Therapy
|
Sea to Sky Ballroom BC
|
|
*
Beverly L. Davidson,
University of Iowa
RNAi and Neurodegenerative Diseases
|
|
|
Judy Lieberman,
Harvard Medical School
Silent Treatment for Cancer
|
|
|
Markus Stoffel,
Institut f. Molekulare Systembiologie
Molecular Mechanisms of Cellular Uptake of Cholesterol-Conjugated RNAs
|
|
|
|
|
|
Morten Lindow,
Santaris Pharma
Short Talk: LNA-Mediated microRNA Silencing in non-Human Primates
|
|
|
7:00 - 8:00 PM
|
Social Hour w/ Lite Bites
|
Sea to Sky Ballroom A, Foyer
|
|
8:00 - 11:00 PM
|
Entertainment
|
Sea to Sky Ballroom A, Foyer
|
| Sunday, March 30 |
|
|
Departure
|
|
