Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Nuclear Receptors: Steroid Sisters (Z2)

Organizer(s): Nancy Lynn Weigel, Dean P. Edwards and W. Lee Kraus
March 30 - April 4, 2008
Whistler Conference Centre (meeting only) · Whistler, British Columbia
Abstract Deadline: December 3, 2007
Late Abstract Deadline: January 2, 2008
Scholarship Deadline: December 3, 2007
Early Registration Deadline: January 30, 2008

Supported by the Director's Fund

Joint meeting: Nuclear Receptors: Orphan Brothers (Z1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Steroid receptors are hormone-regulated transcription factors that control a diverse array of physiological processes. Recent studies have (1) revealed new mechanisms by which steroid receptors modulate transcription and activate cell signaling pathways, (2) identified molecules with diverse functions that regulate steroid receptor action, and (3) elucidated roles for steroid receptors in both normal physiological processes and disease states, including cancer. Identification of the specific factors and molecular mechanisms that contribute to the tissue-specific actions and aberrant pathological effects of steroid receptors is critical for developing therapeutic agents. The objective of the meeting is to facilitate interactions between leaders in the field, younger scientists, and trainees to address these questions. Topics covered in this meeting include: (1) receptor structure and function; (2) genome-wide actions; (3) coactivators and corepressors; (4) chromatin remodeling; (5) interactions with cell signaling pathways; (6) novel biological roles for steroid receptors; and (7) steroid hormone actions in cancer.

Sunday, March 30
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 8:30 PM	Keynote Address (Joint)	Sea to Sky Ballroom BC

	* Peter Tontonoz, University of California, Los Angeles
	* Nancy Lynn Weigel, Baylor College of Medicine
	Eric N. Olson, University of Texas Southwestern Medical Center at Dallas A MicroRNA Network that Governs Growth and Thyroid Hormone Responsiveness of the Heart
Monday, March 31
7:00 - 8:00 AM	Breakfast	Lower Level
8:00 - 11:15 AM	Steroid Receptor and Coregulator Structure and Function	Sea to Sky Ballroom C
	* Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign
	Donald P. McDonnell, Duke University Medical Center Nuclear Receptor-Coactivator Interactions as Targets for New Drug Discovery
	Dean P. Edwards, Baylor College of Medicine The Role and Mechanisms of Progesterone Receptor Cross Talk with Signal Transduction Pathways
	J. Wesley Pike, University of Wisconsin-Madison Regulation of Target Genes by The Vitamin D Receptor: Paradigms for Distal Enhancer Control
	Peter E. Wright, The Scripps Research Institute Role of Protein Folding in Coactivator Function
	Martin L. Privalsky, University of California, Davis Short Talk: Selective Impairment of Thyroid Hormone Receptor (TR)beta2 in Resistance to Thyroid Hormone Syndrome: Mutations Associated with Pituitary Resistance Disrupt Cooperative Contacts that Normally Enhance Coactivator Recruitment
	Sebastiaan H. Meijsing, University of California, San Francisco Short Talk: The Binding Site Code: The effect of DNA Binding Site Sequence Variation on Transcriptional Regulation by the Glucocorticoid Receptor
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Foyer/Mountain View/Sea to Sky Ballroom A
11:15 AM -	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Foyer/Mountain View/Sea to Sky Ballroom A
2:30 - 4:30 PM	Workshop 1 - Hot Topics: Cancer/Signaling	Sea to Sky Ballroom C
	* Donald P. McDonnell, Duke University Medical Center
	Joyce Slingerland, UM Sylvester Comprehensive Cancer Center Src Promotes Estrogen Dependent ERa Proteolysis in Human Breast Cancer
	Jerome C. Nwachukwu, New York University School of Medicine Roles of the Androgen Receptor Cofactor, ART-27 in Prostate Cancer
	Sudipan Karmakar, Baylor College of Medicine Depletion of SMRT Expression Inhibits the Proliferation of MCF-7 Breast Cancer Cell and Expression of Estrogen Receptor-alpha Target Genes
	Jae-Kyung Myung, British Columbia Cancer Agency Large Scale Analysis of the Phosphoproteome in Response to Rapid Signaling by Androgen
	Muriel Le Romancer, INSERM Regulation of Estrogen Rapid Signaling through Arginine Methylation by PRMT1
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Steroid Receptor Signaling and Dynamics	Sea to Sky Ballroom C
	* Dean P. Edwards, Baylor College of Medicine
	Gordon L. Hager, National Cancer Institute, National Institutes of Health Glucocorticoid Receptor Dynamics and Global Chromatin Structure
	Boris J. Cheskis, Wyeth Research The Role of MNAR in Steroid Receptor Signaling
	Stephen R. Hammes, University of Texas Southwestern Medical Center Extranuclear Steroid Signaling in the Ovary
	Carol A. Lange, University of Minnesota Short Talk: Progesterone Receptor Rapid Signaling Mediates Ser345 Phosphorylation and Tethering to Sp1 Transcription Factors
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grand Foyer/ Mountain View/ Sky Ballroom A
7:30 - 10:00 PM	Poster Session 1	Foyer/Mountain View/Sea to Sky Ballroom A
Tuesday, April 1
7:00 - 8:00 AM	Breakfast	Lower Level
7:00 - 8:00 AM	Poster Setup	Foyer/Mountain View/Sea to Sky Ballroom A
8:00 - 11:15 AM	Steroid Receptors and Chromatin	Sea to Sky Ballroom C
	* Myles Brown, Dana Farber Cancer Institute
	W. Lee Kraus, University of Texas Southwestern Medical Center Transcriptional Regulation by Estrogen Receptors in the Chromatin Environment of the Nucleus
	Trevor K. Archer, NIEHS, National Institutes of Health Regulating Nuclear Receptors with Chromatin
	Karen Elizabeth Knudsen, Thomas Jefferson University, Kimmel Cancer Center Targeting SWI/SNF in Prostate Cancer: Implications for AR Signaling and Regulated Proliferation
	Robert G. Roeder, Rockefeller University Nuclear Receptors, Coactivators, and Chromatin
	Inez Rogatsky, Weill Medical College of Cornell University Short Talk: A GRIP1-Associated SET Domain Methyl Transferase in Glucocorticoid Receptor Target Gene Expression
	Didier Picard, University of Geneva Short Talk: Mechanism of Activation of Unliganded ERalpha by cAMP and its Consequences for Target Gene Selection and Regulation
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 12:00 PM	Lunch	Grand Foyer/Sea to Sky Ballroom A
12:00 - 2:30 PM	Poster Session 2	Foyer/Mountain View/Sea to Sky Ballroom A
2:30 - 4:30 PM	Workshop 2 - Hot Topics: Repression/Regulation of Nuclear Receptor Function	Sea to Sky Ballroom C
	* J. Wesley Pike, University of Wisconsin-Madison
	Ian M. Adcock, National Heart and Lung Institute Glucocorticoid-Mediated Suppression of NF-kappaB-Stimulated TGFbeta1 Expression Requires the Methylase Suv39H1
	Shilpa Chooniedass-Kothari, University of Manitoba The Steroid Receptor RNA Activator Protein (SRAP) Acts as a Transcriptional Repressor
	Peter J. Leedman, Western Australian Institute for Medical Research PACT, TRBP, PKR and Dicer: Novel SRA-binding Coregulators that Modulate Nuclear Receptor Signaling
	Deepa Chotai, Imperial College The Repression of Androgen Receptor Activity by Prohibitin

	Beatrice D. Darimont, Merck Research Laboratories Recognition of the Glucocorticoid Receptor by Hsp90
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Analyses of Nuclear Receptor-Dependent Transcription (Joint)	Sea to Sky Ballroom B, C
	* W. Lee Kraus, University of Texas Southwestern Medical Center
	Hendrik G. Stunnenberg, Nijmegen Center for Molecular Life Sciences ChIP-seq Analyses of ER and GR Uncovers an Elaborate Ligand Dependent Interaction Network, the Interactome
	Myles Brown, Dana Farber Cancer Institute Defining the Nuclear Receptor Cistrome
	Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign Integration of Nuclear and Extranuclear Signaling in Global Gene Regulation By Estrogen Receptors
	Edwin Cheung, Genome Institute of Singapore Short Talk: Global Analysis of Estrogen Receptor-Mediated Chromatin Interactions
7:00 PM -	On Own for Dinner
Wednesday, April 2
7:00 - 8:00 AM	Breakfast	Lower Level
8:00 - 11:15 AM	Steroid Receptors and Cancer	Sea to Sky Ballroom C
	* Karen Elizabeth Knudsen, Thomas Jefferson University, Kimmel Cancer Center
	Nancy Lynn Weigel, Baylor College of Medicine Androgen Receptor Action in Prostate Cancer
	Patricia V. Elizalde, Instituto de Biología y Medicina Experimental Progesterone Receptor Signaling in Breast Cancer
	Kathryn B. Horwitz, University of Colorado Health Sciences Center Steroid Hormones and Hormone Dependent Breast Cancer Metastasis
	Rakesh Kumar, University of Texas MD Anderson Cancer Center Estrogen Receptor and Coregulators in Breast Cancer
	Suzanne AW Fuqua, Baylor College of Medicine Short Talk: A Model of Estrogen Receptor (ER) alpha-Positive Breast Cancer Metastasis
	Nicola J. Clegg, Memorial Sloan-Kettering Cancer Center Short Talk: Androgen Receptor Antagonists with a Novel Mechanism of Action
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Foyer/Mountain View/Sea to Sky Ballroom A
11:15 AM -	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Foyer/Mountain View/Sea to Sky Ballroom A
2:30 - 4:30 PM	Workshop 3 - Hot Topics: Chromatin/Transcription	Sea to Sky Ballroom C
	* Trevor K. Archer, NIEHS, National Institutes of Health
	Nina Heldring, Cornell University Molecular Mechanisms of Estrogen Receptor-Mediated Transcription Through the Activating Protein-1-Dependent "Tethering" Pathway
	Mathieu Lupien, Norris Cotton Cancer Center/Dartmouth Medical School FoxA1 Translates Epigenetic Signatures into Enhancer Driven Lineage-Specific Transcription
	Steven K. Nordeen, University of Colorado Health Sciences Center Progesterone Receptor Binds to an Estrogen Response Element, and Antagonizes Estrogen Receptor-Mediated Gene Induction. The Role of DNA as a Functional Ligand
	Raj Kumar, Commonwealth Medical College Effects of Site-Specific Phosphorylation on the Structure and Functions of the Glucocorticoid Receptor AF1 Domain
	Yang Sui Brooks, Medical College of Georgia Alternative Splicing of Nuclear Receptor Coactivator CoAA in Stem Cells
	Martin E. van Royen, Erasmus Medical Center Spatiotemporal Organization of AR intra- and Intermolecular Domain Interactions in Living Cells
	Hong-Wu Chen, University of California, Davis Novel AAA+ ATPase Chromatin Coregulators are Key Integrators of Hormone Signaling and Cell Proliferation Control
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:15 PM	Nuclear Receptor and Coregulator Structure and Function (Joint)	Sea to Sky Ballroom B, C
	* Mitchell A. Lazar, University of Pennsylvania School of Medicine
	Bert W. O'Malley, Baylor College of Medicine Roles of Nuclear Receptor Coactivators in Physiology and Disease.
	Orla M. Conneely, Baylor College of Medicine Orphan Receptors in Cell Growth and Tumorigenesis
	Holly A. Ingraham, University of California, San Francisco Modulating Target Gene Recognition via Sumoylation of SF- 1 (NR5A1) as Revealed by Biochemical and Mouse Mutant
	Fraydoon Rastinejad, University of Virginia Structural Organization of the Intact PPARƒ×-RXR Complex
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Grand Foyer/ Mountain View/ Sky Ballroom A
7:30 - 10:00 PM	Poster Session 3	Foyer/Mountain View/Sea to Sky Ballroom A
Thursday, April 3
7:00 - 8:00 AM	Breakfast	Lower Level
8:00 - 11:15 AM	Steroid Receptor Biology	Sea to Sky Ballroom C
	* Adriana Maggi, University of Milan
	James T. Dalton, GTx, Inc. Therapeutic Promise of Selective Androgen Receptor Modulators (SARMs): Preclinical and Clinical Proof-of-Concept Studies.
	Francesco J. DeMayo, Baylor College of Medicine In Vivo Studies of Progesterone Receptor Action in the Uterus
	Kenneth S. Korach, NIEHS, National Institutes of Health Estrogen Receptor Action in vivo
	Edwin R. Sánchez, University of Toledo College of Medicine Selective Targeting of Steroid Physiology in TPR Protein Ablated Mice
	Inna I. Astapova, Beth Israel Deaconess Medical Center Short Talk: Nuclear CoRepressor (NCoR) Regulates Hepatic Thyroid Hormone Receptor Function In Vivo
	Frank A. Claessens, KULeuven- Faculty of Medicine Short Talk: Loss of Androgen Receptor Binding to Selective Androgen Response Elements causes a Reproductive Phenotype in the Transgenic SPARKI Mice
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Nuclear Receptor Biology (Joint)	Sea to Sky Ballroom B, C
	* Nancy Lynn Weigel, Baylor College of Medicine
	Ronald M. Evans, The Salk Institute PPARs: Bone Up on Metabolism
	Adriana Maggi, University of Milan Estrogen, Nutrition and Fertility
	Bruce M. Spiegelman, Harvard Medical School Transcriptional Control of Brown Fat Determination of Brown Fat Cells by PRDM16: A Co-Regulator of the PGC-1s and Nuclear Receptors
	Ronald N. Margolis, NIDDK, National Institutes of Health Short Talk: The Nuclear Receptor Signaling Atlas (Nursa): A Resource for the NR Community
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grand Foyer/ Mountain View/ Sky Ballroom A
8:00 - 11:00 PM	Entertainment	Foyer/Mountain View/Sea to Sky Ballroom A
Friday, April 4
	Departure

*Session Chair †Speaker invited, not yet responded.