Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Complex Lipids in Biology: Signaling, Compartmentalization and Disease (Z4)

Organizer(s): Robert C. Murphy, Julie D. Saba and Michael J.O. Wakelam
April 22 - 27, 2009
Resort at Squaw Creek · Olympic Valley, CA
Abstract Deadline: December 23, 2008
Late Abstract Deadline: January 26, 2009
Scholarship Deadline: December 23, 2008
Early Registration Deadline: February 23, 2009

Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: PI 3-Kinase Signaling in Disease (Z3)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Complex lipids constitute a diverse family of biomolecules of seven general classes that serve essential roles in Biology. For example, lipids include structural phospholipids that form cellular membranes but are also the reservoirs and source of polyunsaturated fatty acids that are signaling mediators. Intense research effort over the past years has substantially changed our understanding of lipid biochemistry and lipid function in cells with the application of new tools and techniques to study these molecules. This meeting will bring together a group of individuals who have the common goal of understanding the role that lipids play in cell biology, physiology and disease processes.

Wednesday, April 22
3:00 - 7:30 PM	Registration	Lobby Alcove
6:30 - 7:30 PM	Refreshments	Sierra Prefunction A,B,C,D
7:30 - 7:45 PM	Welcoming and Introduction	Grand Sierra Ballroom
	Julie D. Saba, Children’s Hospital Oakland Research Institute
7:45 - 8:45 PM	Keynote Address: 50th Anniversary JLR Lecturer	Grand Sierra A
	* Robert C. Murphy, University of Colorado Denver Keynote Introduction and JLR Award
	Takao Shimizu, University of Tokyo Phospholipid Metabolism: Phospholipases and Acyltransferases
Thursday, April 23
7:00 - 8:00 AM	Breakfast	Alpine Ballroom
8:00 - 11:00 AM	Phosphoinositides and Signaling (Joint)	Grand Sierra Ballroom
	* Phillip T. Hawkins, Babraham Institute
	* Michael J.O. Wakelam, Babraham Institute
	Lewis C. Cantley, Harvard Medical School Growth Control by the PI3K/mTOR Pathway
	Len R. Stephens, Babraham Institute Signaling via PI3Ks in Neutrophils

	Kevan M. Shokat, University of California, San Francisco Discovery of a New Class of mTOR Inhibitors Reveals Rapamycin Resistant Outputs of mTORC1 and mTORC2
	Mark A. Lemmon, University of Pennsylvania School of Medicine Functions of PH Domains and other Phosphoinositide/Phospholipid Binding Domains
9:20 - 9:40 AM	Coffee Break	Sierra Prefunction A,B,C,D
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Alpine Ballroom
1:00 - 10:00 PM	Poster Viewing	Alpine Ballroom
4:30 - 5:00 PM	Coffee Available	Sierra Prefunction A,B,C,D
5:00 - 7:00 PM	Phospholipases and Acyl Transferases	Grand Sierra A
	* H. Alex Brown, Vanderbilt University
	Christina C. Leslie, National Jewish Medical and Research Center Regulation of Cytosolic Phospholipase A2alpha by Phosphorylation and Basic Residues in the Catalytic Domain
	Michael H. Gelb, University of Washington Role of Phospholipases A2 in Eicosanoid Generation
	Michael J.O. Wakelam, Babraham Institute Regulation of Phospholipase D in Normal and Diseased Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Alpine Ballroom
7:30 - 10:00 PM	Poster Session 1	Alpine Ballroom
Friday, April 24
7:00 - 8:00 AM	Breakfast	Alpine Ballroom
8:00 - 11:00 AM	Leukotrienes: New Frontiers	Grand Sierra A
	* Lawrence J. Marnett, Vanderbilt University School of Medicine
	Jilly F. Evans, Amira Pharmaceuticals 5-Lipoxygenase-Activating Protein (FLAP) as a Therapeutic Target
	Marc Peters-Golden, University of Michigan Why Do We Have a 5-Lipoxygenase Pathway? Leukotrienes in Innate Immune Cell Activation
	Robert C. Murphy, University of Colorado Denver Transcellular Biosynthesis of Leukotrienes
	Colin D. Funk, Queen's University Novel Functions for Leukotrienes Based on Cysteinyl Leukotriene 2 Receptor Expression Patterns
9:20 - 9:40 AM	Coffee Break	Sierra Prefunction A,B,C,D
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Alpine Ballroom
1:00 - 10:00 PM	Poster Viewing	Alpine Ballroom
4:30 - 5:00 PM	Coffee Available	Sierra Prefunction A,B,C,D
5:00 - 7:00 PM	Sphingolipid Signaling	Grand Sierra A
	* Sarah Spiegel, Virginia Commonwealth University School of Medicine
	Timothy T. Hla, Weill Medical College of Cornell University S1P Signaling in the Vasculature
	Shaun R. Coughlin, University of California, San Francisco Compartmentalization of S1P Signaling
	Richard L. Proia, National Institutes of Health Sphingosine-1-Phosphate and its Role in Physiology
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Alpine Ballroom
7:30 - 10:00 PM	Poster Session 2	Alpine Ballroom
Saturday, April 25
7:00 - 8:00 AM	Breakfast	Alpine Ballroom
8:00 - 11:00 AM	Ceramides, LysoPA and other Lipid Mediators	Grand Sierra A
	* Julie D. Saba, Children’s Hospital Oakland Research Institute
	Jerold J. Chun, The Scripps Research Institute Lysophospholipid Receptors: Signaling and Disease-Modifying Mechanisms
	Sarah Spiegel, Virginia Commonwealth University School of Medicine Signaling and Compartmentalization of Sphingosine-1-Phosphate
	Teresa M. Dunn, Uniformed Services University of the Health Sciences Serine Palmitoyltransferases - A Family of Heterotrimeric Isozymes?
	Benjamin F. Cravatt III, The Scripps Research Institute Mapping Lipid Signaling Networks by Integrated Proteomics and Metabolomics
9:20 - 9:40 AM	Coffee Break	Sierra Prefunction A,B,C,D
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Alpine Ballroom
1:00 - 10:00 PM	Poster Viewing	Alpine Ballroom
4:30 - 5:00 PM	Coffee Available	Sierra Prefunction A,B,C,D
5:00 - 7:00 PM	Recent Advances in PGH Synthase and 5-Lipoxygenase	Grand Sierra A
	* Takao Shimizu, University of Tokyo
	William L. Smith, University of Michigan Allosteric Regulation of Cyclooxygenases by Fatty Acids and Inhibitors
	Garret A. FitzGerald, University of Pennsylvania Translational Therapeutics of the Arachidonic Acid Cascade
	Frank A. Fitzpatrick, University of Utah Akt Activation by Arachidonic Acid Metabolism
	Tzipora Goldkorn, University of California, Davis Short Talk: nSMase2: Role and Molecular Mechanism in Lung Injury
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Alpine Ballroom
7:30 - 10:00 PM	Poster Session 3	Alpine Ballroom
Sunday, April 26
7:00 - 8:00 AM	Breakfast	Alpine Ballroom
8:00 - 11:00 AM	Phospholipases, Kinases and Signaling Systems	Grand Sierra A
	* Christina C. Leslie, National Jewish Medical and Research Center
	Michael A. Frohman, Stony Brook University Regulation of Exocytosis, Cell Shape and Movement, and Mitochondrial Fusion by Lipid Signaling Pathways
	H. Alex Brown, Vanderbilt University Phospholipase D Signaling Pathways and Inhibitors
	Ana Olivera, NIAMS, National Institutes of Health Sphingosine-1-Phosphate, a Determinant of Mast Cell Responsiveness
	Julie D. Saba, Children’s Hospital Oakland Research Institute Sphingadienes Inhibit AKT-Dependent Signaling and Prevent Intestinal Tumorigenesis
9:20 - 9:40 AM	Coffee Break	Sierra Prefunction A,B,C,D
11:00 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Sierra Prefunction A,B,C,D
5:00 - 7:00 PM	Emerging Nexi	Grand Sierra A
	* Robert C. Murphy, University of Colorado Denver

	Lawrence J. Marnett, Vanderbilt University School of Medicine Identification of Lipid-Protein Covalent Adducts and the Cellular Consequences of their Formation
	Suzanne E. Barbour, Virginia Commonwealth University Regulation of Lipoprotein-Associated PLA2/ PAF-AH by Oxidized Phospholipids
	Atsuo Kawahara, Kyoto University The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Alpine Ballroom
8:00 - 11:00 PM	Entertainment	Alpine Ballroom
Monday, April 27
	Departure

*Session Chair †Speaker invited, not yet responded.