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Angiogenesis and Lymphangiogenesis in Cancer (A2)

Organizer(s): Lee M. Ellis and Luisa Iruela-Arispe
January 6 - 11, 2009
Big Sky Resort  ·  Big Sky, Montana
Abstract Deadline: September 15, 2008
Late Abstract Deadline: October 9, 2008
Scholarship Deadline: September 15, 2008
Early Registration Deadline: November 6, 2008


Sponsored by Genentech BioOncology, ImClone Systems Corporation and sanofi-aventis



This meeting took place in the 2009 season.

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Summary of Meeting
A concrete understanding of the mechanisms that regulate tumor angiogenesis has led to advances in the clinic; however multiple challenges remain. First, not all tumors or tumor types respond equally well to anti-VEGF therapy. And for those that do, many, if not all, eventually become refractory to anti-VEGF therapies. It is essential to understand the various factors that lead to the development and function of the neovascular network in tumors in order to improve therapies and identify predictive markers. In addition, understanding basic mechanisms of angiogenesis will lead to insights into other diseases where neovascularization is an important factor in the progression or resolution of the pathology. This symposium will provide a forum to discuss the current status of anti-angiogenic therapy, new insights into the molecular and morphologic abnormalities of the tumor vascular network, methods to investigate mechanisms of angiogenesis, the relationship of the tumor microenvironment to vascular and tumor stem cells, and elucidation of recently discovered mediators of angiogenesis.

Tuesday, January 6
3:00 - 7:30 PM Registration Lower Atrium
6:30 - 7:30 PM Refreshments Lower Atrium
7:30 - 8:30 PM Keynote Lecture Gallatin
* Lee M. Ellis, University of Texas MD Anderson Cancer Center
* Luisa Iruela-Arispe, University of California, Los Angeles
Peter F. Carmeliet, University of Leuven
Angiogenesis in Cancer
Wednesday, January 7
7:00 - 8:00 AM Breakfast Jefferson/Madison
8:00 - 11:00 AM Current Clinical Status of Anti-Angiogenic Therapy for Cancer Gallatin
* Lee M. Ellis, University of Texas MD Anderson Cancer Center
Anti-VEGF Therapy: Successes and Failures in the Clinic
Axel Grothey, Mayo Clinic College of Medicine
Clinical Toxicities of Anti-VEGF Therapy - Focus on Bevacizumab
John V. Heymach, University of Texas MD Anderson Cancer Center
Circulating Endothelial Precursors as Surrogate Markers of Activity of Anti-VEGF Therapy
Emile E. Voest, University Medical Center Utrecht
Short Talk: Kinetics of Endothelial (Progenitor) Cell Release from the Bone Marrow in Patients Receiving Chemotherapy Predicts Response and Survival
Mark A. Rosen, University of Pennsylvania
Non-Invasive Imaging of the Tumor Vascular Phenotype in Humans Undergoing Anti-Vascular and Anti-Angiogenic Therapies
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 5:00 PM On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Jefferson/Madison
1:00 - 10:00 PM Poster Viewing Jefferson/Madison
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Abnormalities of the Tumor Microvascular Network Gallatin
* Luisa Iruela-Arispe, University of California, Los Angeles
Laura E. Benjamin, Beth Israel Deaconess Medical Center
Akt Signaling in the Tumor Microenvironment
David A. Cheresh, University of California, San Diego
A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation
Ombretta Salvucci, National Cancer Institute, National Institutes of Health
Short Talk: Requirement for EphrinB Activation in Mural Cells Association with Endothelial Cells during New Vessel Formation
Robert S. Kerbel, Sunnybrook Health Sciences Centre
Rapid Systemic Induction of Proangiogenic/Vasculogenic Factors by Chemotherapy or Antiangiogenic Drugs: Implications for Tumor Progression and Response to Therapy
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Madison
7:30 - 10:00 PM Poster Session 1 Jefferson/Madison
Thursday, January 8
7:00 - 8:00 AM Breakfast Jefferson/Madison
8:00 - 11:00 AM Tumor Angiogenesis, Inflammation and the Microenvironment Gallatin
* Laura E. Benjamin, Beth Israel Deaconess Medical Center
Luisa Iruela-Arispe, University of California, Los Angeles
Intracrine VEGF Signaling and Tumor Growth
Raymond N. DuBois, University of Texas MD Anderson Cancer Center
Inflammatory Mediators and Tumor Progression
Kristian Pietras, Karolinska Institutet
Exploring New Strategies to Target the Pro-Angiogenic Tumor Stroma
Calvin Kuo, Stanford University
Short Talk: Angiogenic Phenotypes of the Egfl7 Locus are Attributable to the Embedded MicroRNA miR-126
J. Silvio Gutkind, National Institutes of Health
Semaphorin-Regulated Signaling Networks and Tumor-Induced Angiogenesis
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 5:00 PM On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Jefferson/Madison
1:00 - 10:00 PM Poster Viewing Jefferson/Madison
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Vascular Stem and Progenitor Cells Gallatin
* Robert S. Kerbel, Sunnybrook Health Sciences Centre
Richard J. Gilberston, St Jude Children's Research Hospital
The Perivascular Niche for Tumor Stem Cells
Robert Benezra, Memorial Sloan-Kettering Cancer Center
Id Proteins and Vascular Mobilization
Avner Adini, Children's Hospital, Boston
Short Talk: Prominin-1/CD133, is More than a Marker of Premature Hematopoietic Cells
M. Celeste Simon, University of Pennsylvania
Hypoxia, HIF and Stem Cells
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Madison
7:30 - 10:00 PM Poster Session 2 Jefferson/Madison
Friday, January 9
7:00 - 8:00 AM Breakfast Jefferson/Madison
8:00 - 11:00 AM Tumor Lymphangiogenesis Gallatin
* Robert Benezra, Memorial Sloan-Kettering Cancer Center
Barbara H. Garmy-Susini, University of California, San Diego
Central Requirement for Integrin Signaling in Lymphangiogenesis and Metastasis
Michael J. Detmar, ETH - Zürich
Molecular Control of Lymphangiogenesis
Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre
Collective Invasion and Radioresistance at the Tumor-Vessel Interface
Yusuke Mizukami, Asahikawa Medical College
Short Talk: Hedgehog Signaling Regulates Angiogenesis in Pancreatic Cancer
Tuomas Tammela, University of Helsinki
VEGFR-3 Pathway as a Target to Inhibit Angiogenesis, Lymphangiogenesis and Tumor Metastasis
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 5:00 PM On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Jefferson/Madison
1:00 - 10:00 PM Poster Viewing Jefferson/Madison
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Imaging Angiogenesis: Histopathologic and Non-Invasive Imaging of Live Animals Gallatin
Jan E. Schnitzer, Proteogenomics Research Institute for Systems Medicine (PRISM)
Proteomic Imaging of Tumor Microenvironment and Angiogenesis in vivo for Enhancing Targeted Therapies
Myunghwan Choi, Korea Advanced Institute of Science and Technology
Short Talk: Dynamic Fluorescence Imaging for Multiparametric Measurement of Tumor Vasculature
Lily Wu, University of California, Los Angeles
Functional Molecular Imaging of Prostate Cancer Lymphatic Metastasis
* Donald M. McDonald, University of California, San Francisco
Imaging of Cellular Actions of Angiogenesis Inhibitors
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Madison
7:30 - 10:00 PM Poster Session 3 Jefferson/Madison
Saturday, January 10
7:00 - 8:00 AM Breakfast Jefferson/Madison
8:00 - 11:00 AM Emerging Targets and Endothelial Cell Biology Gallatin
* Gregory D. Plowman, Genentech
Richard O. Hynes, Massachusetts Institute of Technology
Cell-Matrix Interactions in Vascular Development
Hellmut G. Augustin, German Cancer Research Center (DKFZ) & University of Heidelberg
Angiopoietins and Tie-2
Beverly A. Teicher, Genzyme Corporation
Endosialin/CD248: The Evolution of a Target
Napoleone Ferrara, Genentech, Inc.
Myeloid Dependent Tumor Angiogenesis and Bv8
9:20 - 9:40 AM Coffee Break Lower Atrium
11:00 AM - 5:00 PM On Own for Lunch
4:30 - 5:00 PM Coffee Available Lower Atrium
5:00 - 7:00 PM Notch Signaling Gallatin
* Jan K. Kitajewski, Columbia University
Notch Signaling in Tumor Angiogenesis
Nicholas W. Gale, Regeneron Pharmaceuticals Inc.
Targeting Tumor Microvasculature via the VEGF and Delta/Notch Pathways
Ji-Liang Li, Weatherall Institute of Molecular Medicine, University of Oxford
Short Talk: DLL4 Enhances Tumour Growth and Mediates Tumour Resistance to Anti-VEGF Therapy in vivo
Gregory D. Plowman, Genentech
Contrasting Roles of VEGF and DLL4 in Vascular Biology
7:00 - 8:00 PM Social Hour w/ Lite Bites Jefferson/Madison
8:00 - 11:00 PM Entertainment Jefferson/Madison
Sunday, January 11
Departure
*Session Chair   †Speaker invited, not yet responded.



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