Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Cardiac Disease: Development, Regeneration, and Repair (D1)

Organizer(s): Michael D. Schneider and Nadia A. Rosenthal
March 15 - 20, 2009
Grove Park Inn · Asheville, North Carolina
Abstract Deadline: November 18, 2008
Late Abstract Deadline: December 15, 2008
Scholarship Deadline: November 18, 2008
Early Registration Deadline: January 15, 2009

Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Cardiovascular Development and Repair (X2)
February 28 - March 5, 2010

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Cardiac muscle death, without numerically equivalent myocyte creation, poses a formidable and inexorable challenge in both acute and chronic forms of heart disease. A regenerative medicine approach to rescue cardiac muscle cell number or instigate heart repair in other ways has moved from the esoteric fringe to the mainstream of both fundamental and patient-based cardiovascular research. However, notwithstanding the encouraging results from phase I and even phase II trials in this realm, the scientific foundations of cardiac repair largely remain to be proven on a basis that is more than empirical. By virtue of its orientation not merely to translation, but at least equally to the enabling sciences within stem cell biology, cardiovascular development, and genetics, this Keystone Symposia meeting addresses a critical unmet need in a high-impact field of current and foreseeable explosive growth.

Sunday, March 15
3:00 - 7:30 PM	Registration	Vanderbilt Registration
6:30 - 7:30 PM	Refreshments	Grand Ballroom B-C
7:30 - 8:30 PM	Keynote Address	Grand Ballroom A

	George Q. Daley, Children's Hospital Boston Reprogramming and Stem Cells in Disease and Development


Monday, March 16
7:00 - 8:00 AM	Breakfast	Grand Ballroom B-C
8:00 - 11:15 AM	Stemness and Cell Fate in Pluripotent Cells	Grand Ballroom A
	* Gordon M. Keller, University Health Network, MaRS Centre Regulation of Cardiovascular Development from Mouse and Human Pluripotent Stem Cells


	Sean M. Wu, Massachusetts General Hospital Turning Skin into Heart: Cardiac Progenitor Cells from Induced Pluripotent Cells

	Cedric Blanpain, Université Libre de Bruxelles Mesp1 and Multipotent Cardiac Progenitor Cells

	Piero Anversa, Brigham and Women's Hospital Myocardial Regeneration
	Michel Pucéat, INSERM Short Talk: Derivation of Early Human Cardiac Progenitors from Embryonic and Induced Pluripotent Stem Cells
	Li Chen, Texas A&M University Health Science Center Institute of Biosciences & Technology Short Talk: Tbx1 Regulates Proliferation and Differentiation of Multipotent Heart Progenitors
9:20 - 9:40 AM	Coffee Break	Grand Ballroom B-C
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Grand Ballroom B-C
1:00 - 10:00 PM	Poster Viewing	Grand Ballroom B-C
4:30 - 5:00 PM	Coffee Available	Grand Ballroom Foyer
5:00 - 7:00 PM	Making Myocardium: Lessons from Organogenesis	Grand Ballroom A
	* Margaret B. Buckingham, Institut Pasteur Cardiac Progenitor Cells of the Second Heart Field
	Jonathan A. Epstein, University of Pennsylvania Jagged1/Notch Signaling and Outflow Tract Development
	Deepak Srivastava, Gladstone Institute of Cardiovascular Disease MicroRNA Regulation of Cardiac Cell Fate and Morphogenesis
	Caroline E. Burns, Massachusetts General Hospital, HMS Short Talk: Cardiac Chamber Morphogenesis is Regulated by the miR143-adducin3 Pathway
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grand Ballroom B-C
7:30 - 10:00 PM	Poster Session 1	Grand Ballroom B-C
Tuesday, March 17
7:00 - 8:00 AM	Breakfast	Grand Ballroom B-C
7:00 - 8:00 AM	Poster Setup	Grand Ballroom B-C
8:00 - 11:15 AM	Cardiopoiesis: Cardiac Muscle Cell Creation by Adult and Embryonic Cells	Grand Ballroom A
	Michael D. Schneider, Imperial College London The Sox17-Hhex-Cer1 Circuit Drives Heart Muscle Cell Creation in Embryonic Stem Cells
	* Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute Cardiac Progenitor Cell Behaviour in Development and Congenital Heart Disease

	Ibrahim J. Domian, Massachusetts General Hospital Assembly of Mature Ventricular Muscle from Embryonic Stem Cell derived Progenitors

	Mark Mercola, Burnham Institute for Medical Research A Chemical Genomics Strategy for Generating Cardiac Myocytes
	Michael Kühl, Ulm University Short Talk: DM-GRASP/ALCAM/CD166 in Cardiogenesis of Xenopus
	Frank L. Conlon, University of North Carolina Chapel Hill Short Talk: CASTOR Is Required for the Differentiation of Cardiomyocyte Progenitors at the Ventral Midline
9:20 - 9:40 AM	Coffee Break	Grand Ballroom B-C
11:00 AM - 12:00 PM	Lunch	Grand Ballroom B-C
12:00 - 2:30 PM	Poster Session 2	Grand Ballroom B-C
2:30 - 4:30 PM	Workshop 1: Human ES Cell Update	Grand Ballroom A
	Joseph Gold, Geron Corporation Large-Scale Generation and Characterization of hESC-Derived Cardiomyocytes for Cell Therapy
	* Lior Gepstein, Technion-Israel Institute of Technology Myocardial Regeneration Using Human Embryonic Stem Cells
	Wei-Zhong Zhu, University of Washington Induction of Human Embryonic Stem Cell Derived Cardiac Pacemaker Cells by Neuregulin Blockade
4:30 - 5:00 PM	Coffee Available	Grand Ballroom Foyer
5:00 - 7:00 PM	Injury and Inflammation in Muscle Regeneration	Grand Ballroom A
	Nadia A. Rosenthal, European Molecular Biology Laboratory Enhancing Cardiac Regeneration
	Kenneth Poss, Duke University Medical Center Mechanisms of Cardiac Regeneration in Zebrafish
	* Elizabeth M. McNally, University of Chicago Regeneration and Repair in Muscle
	Santhosh Kumar Ghadge, Max-Delbruck Center for Molecular Medicine Short Talk: Impaired Cardiac Function in Cardiomyocyte Specific SDF-1/CXCL12 Knockout Mice
7:00 PM -	On Own for Dinner
Wednesday, March 18
7:00 - 8:00 AM	Breakfast	Grand Ballroom B-C
8:00 - 11:15 AM	Vasculogenesis and Angiogenesis: Developmental Insights and Therapeutic Targets	Grand Ballroom A
	Robert J. Schwartz, Texas A&M University Health Science Center The sumoylation Pathway: A Global Regulator of Cardiac Development
	Mary Dickinson, Baylor College of Medicine Form Follows Flow: Where Biomechanics and Genetics Meet
	Paul R. Riley, University College London Epicardium-Derived Progenitors: A Source of Neovascular Repair of the Injured Adult Heart

	* Brian L. Black, University of California, San Francisco A Combinatorial Transcriptional Code for Endothelial Development
	Kimberly R. Cordes, Gladstone Institute Short Talk: miR-143/145 Regulates Smooth Muscle Cell Fate
	Marc Tjwa, University of Frankfurt, Center for Molecular Medicine Short Talk: Mobilization of Bone Marrow Progenitors by Ischemic Tissues Requires an Interplay between Hematopoietic Cytokines and Placental Growth Factor (PlGF)
9:20 - 9:40 AM	Coffee Break	Grand Ballroom B-C
11:15 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Grand Ballroom B-C
1:00 - 10:00 PM	Poster Viewing	Grand Ballroom B-C
3:30 - 4:30 PM	Workshop 2: 'The Vision Thing:' Imaging Sciences and Cell Tracking for Cardiac Repair	Grand Ballroom A
	Karl H. Schuleri, Johns Hopkins Hospital Tomographic Imaging Applications for Myocardial Phenotyping in Cardiac Stem Cell Therapy

	Joseph C. Wu, Stanford University Molecular Imaging of hESC Biology
4:30 - 5:00 PM	Coffee Available	Grand Ballroom Foyer
5:00 - 7:00 PM	Myocyte Death and Dysfunction in Heart Failure	Grand Ballroom A
	Richard N. Kitsis, Albert Einstein College of Medicine Mechanisms of Cell Death in Human Disease

	Jonathan G. Seidman, Harvard Medical School Mechanisms and Modifiers of the Hereditary Cardiomyopathies
	* Eric N. Olson, University of Texas Southwestern Medical Center The Molecular Logic of Cardiac Development and Disease
	Ching-Pin Chang, Stanford University Short Talk: Control of Cardiac Growth, Differentiation and Hypertrophy by the BAF Complex
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grand Ballroom B-C
7:30 - 10:00 PM	Poster Session 3	Grand Ballroom B-C
Thursday, March 19
7:00 - 8:00 AM	Breakfast	Grand Ballroom B-C
8:00 - 11:15 AM	Cardiac Repair in Human Trials: The Half-Full Cup?	Grand Ballroom A
	Andreas M. Zeiher, University Frankfurt Bone Marrow for Cardiac Repair: Molecular Insights and Clinical Deployment
	Douglas W. Losordo, Northwestern University Feinberg School of Medicine Targeting the Microvasculature for Ischemic Tissue Repair
	Joshua M. Hare, University of Miami Miller School of Medicine Mechanisms of Action and Clinical Utility of Mesenchymal Stem Cells to Treat Ischemic Cardiomyopathy

	Robert D. Simari, Mayo Clinic Bone Marrow and The Heart: Opportunities for Discovery
	* Stefanie Dimmeler, University of Frankfurt Control of Angiogenesis by microRNA
9:20 - 9:40 AM	Coffee Break	Grand Ballroom B-C
11:15 AM -	On Own for Lunch
2:30 - 4:30 PM	Workshop 3: Alternative Visions of the Therapeutic Landscape: Tissue Engineering, Stem Cell Mobilization, and Stem Cell Proteins	Grand Ballroom A
	* Victor J. Dzau, Duke University Medical Center Paracrine Mediators of Stem Cell Reparative Action
	Doris A. Taylor, University of Minnesota The Power of Engineering Organs: When Cells aren't Enough
	Sara M. Rankin, Imperial College School of Medicine Progress Toward Selective Stem Cell Mobilization
4:30 - 5:00 PM	Coffee Available	Grand Ballroom Foyer
5:00 - 7:00 PM	'Get with the System:' How Systems Biology is Transforming Biomedicine	Grand Ballroom A
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grand Ballroom B-C
8:00 - 11:00 PM	Entertainment	Grand Ballroom B-C
Friday, March 20
	Departure

*Session Chair †Speaker invited, not yet responded.