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Dissecting the Vasculature: Function, Molecular Mechanisms and Malfunction (J8)

Organizer(s): Stephanie Wengert Watts, Nancy J. Rusch and William F. Jackson
February 24 - March 1, 2009
Fairmont Hotel Vancouver  ·  Vancouver, British Columbia
Abstract Deadline: October 23, 2008
Late Abstract Deadline: November 25, 2008
Scholarship Deadline: October 23, 2008
Early Registration Deadline: December 29, 2008


Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.


Joint meeting: Complications of Diabetes and Obesity (J7)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).



This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
The goal of this meeting is to present the most current research on the vasculature by breaking down the blood vessel into individual cells (endothelium, smooth muscle and nerve) and examine the function of organelles (nucleus, ER, plasma membrane) within each cell type. This work will be synthesized into the whole blood vessel, and a focus given to vessel dysfunction in hypertension and—as is highlighted by a concurrent meeting—diabetes. Workshops will support young investigators, and techniques specific to studying the vasculature. Attendees should take away an appreciation for the complexity and beauty of the vasculature.

Tuesday, February 24
3:00 - 7:30 PM Registration BC Foyer
6:30 - 7:30 PM Refreshments Pacific Ballroom
7:30 - 8:30 PM Keynote Address (Joint) British Columbia Ballroom
* Ann Marie Schmidt, Columbia University
†,
* William F. Jackson, Michigan State University
Joseph Loscalzo, Brigham and Women's Hospital/Harvard Medical School
Redox Dysregulation in Vascular Disease
Wednesday, February 25
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:00 AM Endothelial Cell Signaling Components
The Endothelial Cell: New Molecules and Markers
British Ballroom
* Jonathan H. Jaggar, University of Tennessee College of Medicine
* Michel Feletou, Institut de Recherches Servier
Brant M. Weinstein, NICHD, National Institutes of Health
Regulation of Developmental Angiogenesis and Lymphangiogenesis
Mark S. Taylor, University of South Alabama College of Medicine
Localized Calcium Signaling in the Endothelium
Lothar A. Blatter, Rush University Chicago
Calcium and NFAT Signaling in Vascular Endothelial Cells
Luisa Iruela-Arispe, University of California, Los Angeles
Intracrine VEGF Signaling in Endothelial Cells
Ralf Koehler, Phillips University Marburg
Short Talk: EDHF-Signaling and Arterial Blood Pressure in Mice Deficient of Endothelial KCa-Channels
Evgenia V. Gerasimovskaya, University of Colorado, Denver
Short Talk: PI3K and RhoA/ROCK Pathways Play a Critical Role in Hypoxia-Induced ATP Exocytosis and ATP-induced Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells
9:20 - 9:40 AM Coffee Break BC Foyer
11:00 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Pacific Ballroom
1:00 - 10:00 PM Poster Viewing Pacific Ballroom
2:30 - 4:30 PM Workshop 1: Techniques (Joint) British Columbia Ballroom
* Karen Lounsbury, University of Vermont
Paul L. Hermonat, University of Arkansas for Medical Sciences
Viral Gene Therapy Targeting the Vasculature
W. Gil Wier, University of Maryland School of Medicine
Techniques for Imaging Signal Transduction in the Vasculature
Lloyd P. Aiello, Joslin Diabetes Center
Designing Clinical Trials - The Fruits of Translational Research
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Endothelial Cell Interactions and Targeting
The Endothelial Cell: New Molecules and Markers
British Ballroom
* Mark S. Taylor, University of South Alabama College of Medicine
* Richard A. Cohen, Boston University School of Medicine
Sarah Y. Yuan, University of California, Davis
Endothelial Junction and Vascular Permeability
Michel Feletou, Institut de Recherches Servier
The Endothelium as a Target for Drug Development
Wolfgang F. Graier, Medical University of Graz
Endothelial Mitochondria as Key Players for Endothelial Cell Function and Dysfunction
Caroline Cheng, Erasmus Medical Center
Short Talk: Functional Analysis of a Newly Identified Regulator of New Vessel Formation “EGIP”
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
7:30 - 10:00 PM Poster Session 1 Pacific Ballroom
Thursday, February 26
7:00 - 8:00 AM Breakfast Pacific Ballroom
7:00 - 8:00 AM Poster Setup Pacific Ballroom
8:00 - 11:15 AM Vascular Smooth Muscle Cell Components and Communicators
Vascular Smooth Muscle Cell Dissection: From Birth to Function
British Ballroom
* Keshari Thakali, Univ of Arkansas for Medical Sciences
* Julian H. Lombard, Medical College of Wisconsin
Mark W. Majesky, University of North Carolina at Chapel Hill
Developmental Origins of Coronary Smooth Muscle
Jonathan H. Jaggar, University of Tennessee College of Medicine
Mitochondrial Regulation of Arterial Calcium Signaling and Diameter
William F. Jackson, Michigan State University
Vascular Ion Channels: Will the Key Players Please Stand Up?
Karen Lounsbury, University of Vermont
Phenotype Switching in Vascular Smooth Muscle Cells: A Complex Interaction between Transcription Factors
Prasad V.G Katakam, Wake Forest University Health Sciences
Short Talk: Impaired Mitochondria Dependent Vasodilation in Cerebral Arteries of Zucker Obese Rats with Insulin Resistance
Magdalena M. Szewczyk, McMaster University
Short Talk: Inhibitors Bioengineered to Inhibit Different Isoforms of Plasma Membrane Ca2+ Pumps in Vascular Smooth Muscle and Endothelium
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - 12:00 PM Lunch Pacific Ballroom
12:00 - 2:30 PM Poster Session 2 Pacific Ballroom
2:30 - 4:30 PM Workshop 2: Funding for the Young Cardiovascular and Diabetes Investigator (Joint) British Columbia Ballroom
* Ann Marie Schmidt, Columbia University
* Nancy J. Rusch, University of Arkansas for Medical Sciences
Cristina Rabadan-Diehl, The National Institutes of Health
Ronald Kohanski, The National Institutes of Health
Teresa Jones, The National Institutes of Health, USA
R. Clinton Webb, American Heart Association
Barbara A. Araneo, Juvenile Diabetes Research Foundation
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM New Insights into Mechanisms of Vascular Contraction
Vascular Smooth Muscle Cell Dissection: From Birth to Function
British Ballroom
* Lothar A. Blatter, Rush University Chicago
* Frank Chip Brosius III, University of Michigan
Richard J. Paul, University of Cincinnati College of Medicine
It’s Not Just [Ca2+]i Anymore or Rho, ROS and Hypoxic Vasorelaxation
R. Clinton Webb, Medical College of Georgia
New Insights into Mechanisms of Vascular Contraction: STIM-1/Orai-1 Pathway and Vascular Dysfunction
W. Gil Wier, University of Maryland School of Medicine
Genetically Encoded FRET-Based Sensors Allow Visualization of Signal Transduction in Individual Cells of Intact Arteries
Zachary P. Neeb, Indiana University School of Medicine
Short Talk: Store-Operated Ca2+ Influx in Coronary Smooth Muscle Cells Predicts Coronary Atherosclerosis in the Metabolic Syndrome
7:00 PM - On Own for Dinner
Friday, February 27
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:15 AM Influences of Neighboring Cells on Vascular Smooth Muscle Function
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
British Ballroom
* William F. Jackson, Michigan State University
* David Robertson, Vanderbilt University Medical Center
Jessica Andrea Filosa, Medical College of Georgia
Interpreting the Communication between Cerebral Microvessels and Astrocytes in the Brain
Ronald J. Korthuis, University of Missouri
Postischemic Arteriolar Dysfunction is Dependent on Venular Leukocyte Adhesion and Mast Cells: Role of Cell-Cell Communication
Brant Isakson, University of Virginia
Coordinated Function of Endothelial and Vascular Smooth Muscle Cells
Gregory Fink, Michigan State University
Arteries and Veins: Substrates for Disparate But Integrated Sympathetic Control
Cécile Fligny, INSERM
Short Talk: Are Pericytes Responsible for Renal Interstitial Fibrosis through Transglutaminase-Mediated Collagen Assembly?
Lisa A. Lesniewski, University of Colorado, Boulder
Short Talk: Age-Associated Endothelial Dysfunction is Associated with IKKbeta-Mediated Reductions in FoxO3a Activity and MnSOD Expression
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Vancouver Island Room
1:00 - 10:00 PM Poster Viewing Pacific Ballroom
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Synthesis of the Whole Vessel
Integration of the Vascular Components: The Whole is Greater then the Sum of the Parts
British Ballroom
* Gregory Fink, Michigan State University
* Nancy J. Rusch, University of Arkansas for Medical Sciences
David Robertson, Vanderbilt University Medical Center
Human Phenotypes and Animal Knockout Models of Genetic Autonomic Disorders
Paul L. Hermonat, University of Arkansas for Medical Sciences
Viral Delivery of Therapeutic Genes for Vascular Pathologies
David D. Gutterman, Medical College of Wisconsin
Human Microvascular Function in Disease: Mechanistic Insights
Hema Raina, University of Maryland
Short Talk: Sympathetic Nerve Activity Enhances, and Endothelium Inhibits, the Vasoconstrictor Effect of Low-Dose Ouabain
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
7:30 - 10:00 PM Poster Session 3 Pacific Ballroom
Saturday, February 28
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:15 AM Hypertension and Angiogenesis - Responses to Vascular Injury/Genomics - Disease Models and Human Genomics (Joint)
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
British Columbia Ballroom
* Ronald J. Korthuis, University of Missouri
* Thomas M. Coffman, Duke University Medical Center
Susan Quaggin, Samuel Lunenfeld Research Institute
Angiogenesis and Diabetic Nephropathy
Maria B. Grant, University of Florida
Vascular Repair Strategies for Diabetic Retinopathy- Mobilization and Differentiation of Hematopoietic Stem Cell by IGFBP-3
Geert W. Schmid-Schönbein, University of California, San Diego
A Molecular Mechanism for Blood Pressure Elevation, Type II Diabetes, Immune Suppression and Microvascular Rarefaction in the Spontaneously Hypertensive Rat
Frank Chip Brosius III, University of Michigan
Flipped Signaling: Consequences of Altered Glucose Transporter Expression in Vascular Cells
Julia V. Busik, Michigan State University
Short Talk: Inhibition of Sphingomyelinases Protects from Inflammation, Vascular Degeneration and Neovascularization in Retinopathy Animal Models
David A. Antonetti, Pennsylvania State University
Short Talk: Atypical PKC Inhibitors Block both VEGF and TNF alpha Induced Endothelial Permeability
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - On Own for Lunch
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Mechanisms and Targeted Treatment of Vascular Pathologies: Focus on Hypertension
Mechanisms of Vascular Pathologies: Diabetes and Hypertension
British Ballroom
* R. Clinton Webb, Medical College of Georgia
* David D. Gutterman, Medical College of Wisconsin
Andrea D. Eckhart, Thomas Jefferson University
Novel Mouse Models for Studying Vascular Contributions to Hypertension
Nancy J. Rusch, University of Arkansas for Medical Sciences
Ion Channel Expression and Function in Hypertension
Richard A. Cohen, Boston University School of Medicine
Redox Regulation of SERCA in Diabetic Vascular Disease
Julian H. Lombard, Medical College of Wisconsin
Short Talk: Endothelial Dysfunction and Paradoxical Increase in Vascular Oxidative Stress with Angiotensin II Suppression
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
8:00 - 11:00 PM Entertainment Pacific Ballroom
Sunday, March 1
Departure
*Session Chair   †Speaker invited, not yet responded.



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