Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

The Neurobiology of Pain and Analgesia (C2)

Organizer(s): Clifford J. Woolf, Ardem Patapoutian and Simon Tate
February 22 - 27, 2009
Hilton Santa Fe/Historic Plaza · Santa Fe, New Mexico
Abstract Deadline: October 21, 2008
Late Abstract Deadline: November 21, 2008
Scholarship Deadline: October 21, 2008
Early Registration Deadline: December 22, 2008

Sponsored by Abbott Laboratories and AstraZeneca Pharmaceuticals, L.P.

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2009 season.

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Summary of Meeting
This symposium will highlight the substantial advances made in our understanding of the neurobiology and pathophysiology of pain and the enormous opportunities these present for identifying and exploiting new targets for therapy. Current therapy is largely empirical and is based on suppressing symptoms. The future offers treatment targeted at the specific neural mechanisms responsible. This requires understanding the mechanisms, being able to identify which mechanism operates in which patient, and having pharmacological tools to act on the molecular targets that drive these mechanisms. Furthermore, we need to identify which patient is at risk of developing pain and develop preventative disease-modifying treatments to abort the establishment of pain. This symposium will address how these goals can be achieved by the combined effort of academics and industry.

Sunday, February 22
3:00 - 7:30 PM	Registration	Promenade
6:30 - 7:30 PM	Refreshments	Promenade
7:30 - 9:30 PM	Keynote Session	Mesa A-B
	* Clifford J. Woolf, Massachusetts General Hospital

	Michael J. Detke, MedAvante Research Institute New Treatments for Pain: Starting with the End in Mind – Market, Regulatory, and Development Challenges, and How These Relate to Neurobiology
	Xinzhong Dong, Johns Hopkins University Short Talk: Regulation of TRP Channels by Pirt

	Samer Eid, Merck & Co., Inc. Short Talk: To Feel or not to Feel - Targeting the Heat Sensor TRPV1 for Pain Treatment
Monday, February 23
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Nociceptor Transduction and Plasticity	Mesa A-B
	* Ardem Patapoutian, The Scripps Research Institute
	Jon Levine, University of California, San Francisco Kinases - Nociceptors Pain Switches
	Peter McNaughton, University of Cambridge Sensitization in Nociceptors
	David Shelton, Rinat Laboratories, Pfizer Global Research and Development NGF and Anti-NGF: The Ying and Yang of Pain
	Stephen B. McMahon, King's College London Nociceptor Mechano-Sensitisation Induced by UVB Irradiation in Human and Rodent Skin
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Mesa C
1:00 - 10:00 PM	Poster Viewing	Mesa C
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	TRP Channels	Mesa A-B
	* Stephen B. McMahon, King's College London
	Ardem Patapoutian, The Scripps Research Institute Molecular Mechanisms of Thermosensation
	David Julius, University of California, San Francisco From Peppers to Peppermints: Natural Products as Probes of the Pain Pathway
	Magdalene Moran, Hydra Biosciences TRPs as Analgesic Drug Targets
	Cheryl L. Stucky, Medical College of Wisconsin Short Talk: TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons via Neuronal and Keratinocyte Expression
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa
7:30 - 10:00 PM	Poster Session 1	Mesa C
Tuesday, February 24
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Synaptic Plasticity	Mesa A-B
	* David Julius, University of California, San Francisco
	Robert W. Gereau, Washington University Pain Center Postsynaptic Mechanisms of Plasticity in Dorsal Horn Neurons
	Sandra Garraway, Texas A & M Activation of Neuronal ERK2 is Required for Inflammation-Induced Pain
	Frank Porreca, University of Arizona Modulating Descending Modulation
	Hans Ulrich Zeilhofer, University of Zurich GABA-A Receptor Subunit-Specific Analgesia
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Mesa C
1:00 - 10:00 PM	Poster Viewing	Mesa C
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Sodium and Calcium Channels	Mesa A-B
	* Prisca Honore, Abbott Laboratories
	Peter W. Reeh, University of Erlangen - Nurnberg Nociceptor Sodium Channels – Few but Decisive


	Alex Binshtok, Harvard Medical School Interleukin 1beta and Sodium Channels - From Slow Inactivation to Fast Nociception
	Diane Lipscombe, Brown University Nociceptors Modulate Calcium Channel Activity by Alternative Splicing.
	Sarah E. Canetta, Columbia University Short Talk: Type III Nrg1-erbB Signaling Affects Peripheral Nociception
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa
7:30 - 10:00 PM	Poster Session 2	Mesa C
Wednesday, February 25
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Discovering Pain Targets	Mesa A-B
	* Simon Tate, GlaxoSmithKline
	Clifford J. Woolf, Massachusetts General Hospital Finding Novel Analgesic Targets
	Qiufu Ma, Dana Farber Cancer Institute Regulation of Nociceptor Phenotype and Pain Behavior
	Benjamin F. Cravatt III, The Scripps Research Institute Modulating Pain by Blockade of Endocannabinoid Metabolism
	Gary R. Lewin, Max-Delbruck Center for Molecular Medicine Mechanostransducers as Targets for Pain Therapy
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Pain Circuits	Mesa A-B

	* Gary R. Lewin, Max-Delbruck Center for Molecular Medicine
	Mark Zylka, University of North Carolina Biochemical Modulation of Nociceptive Circuits
	Allan I. Basbaum, University of California, San Francisco Behaviorally Relevant Specificity of Nociceptors and Their Differential Regulation via mu and delta Opioid Receptors
	Joyce A. DeLeo, Dartmouth Medical School Glial-Neuronal Circuits
	Sarah Ross, Harvard Medical School Short Talk: Bhlhb5 Is Critical for the Formation of Nociceptive Circuits in the Developing Spinal Cord
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa
Thursday, February 26
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Validating Pain Targets and Developing Analgesics	Mesa A-B
	* Allan I. Basbaum, University of California, San Francisco
	Simon Tate, GlaxoSmithKline Progressing Pain Targets: A Focus on in vitro Screening
	Rohini Kuner, University of Heidelberg Target Validation using Genetically Modified Mice
	Prisca Honore, Abbott Laboratories Pharmacological Validation for Analgesia Targets
	Kenneth M. Verburg, Pfizer Inc. Pain Therapeutics: Focus on Development
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Promenade
5:00 - 7:00 PM	Pain Genetics	Mesa A-B

	* Peter W. Reeh, University of Erlangen - Nurnberg

	Annemieke Kavelaars, University Medical Center Utrecht Short Talk: GRK2 Deficiency Prolongs PGE2-Induced Hyperalgesia via a Switch in Signaling from PKA to ERK
	Michele Hummel, Wyeth Research Short Talk: Corticotropin Releasing Factor1 Receptors Mediate Inflammatory- and Neuropathic-Like Pain
	Achim Schmidtko, University of Frankfurt Short Talk: Reduced Inflammatory and Neuropathic Pain in Mice Lacking Nitric Oxide-Sensitive Guanylyl Cyclase

	Jeff S. Mogil, McGill University Genetics of Pain in the Laboratory Mouse
	Luda Diatchenko, University of North Carolina School of Dentistry Expansion of the Human mu-Opioid Receptor Gene Locus: Novel Functional Variants
7:00 - 7:15 PM	Concluding Remarks	Mesa A-B
	Clifford J. Woolf, Massachusetts General Hospital
	Simon Tate, GlaxoSmithKline
	Ardem Patapoutian, The Scripps Research Institute
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Mesa A-B
8:00 - 11:00 PM	Entertainment	Mesa A-B
Friday, February 27
	Departure

*Session Chair †Speaker invited, not yet responded.