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Epigenetics, Development and Human Disease (A1)

Organizer(s): Anne Ferguson-Smith and Steven Henikoff
January 5 - 10, 2009
Beaver Run Resort  ·  Breckenridge, Colorado
Abstract Deadline: September 15, 2008
Late Abstract Deadline: October 8, 2008
Scholarship Deadline: September 15, 2008
Early Registration Deadline: November 5, 2008


Supported by the Directors' Fund



This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
This meeting aims to provide a stimulating forum for exploring the epigenetic control of genome function illustrated through the regulation of a variety of biological processes in a range of model organisms. The role of factors influencing chromatin organization and chromosome architecture, and the dynamic changes in epigenetic state that regulate development, are two well-established but fast-moving areas that will be covered. The dynamic nature of epigenetic states renders them both adaptable and vulnerable; this will be explored in sessions considering the influence of the environment on epigenetic control, and the causes and consequences of epigenetic change in disease. We anticipate that the data presented will allow evolutionary insights and functional comparison of epigenetic mechanisms in different organisms and systems, resulting in the integration of ideas to generate new concepts and a deeper understanding in this field.

Monday, January 5
3:00 - 7:30 PM Registration Foyer
6:30 - 7:30 PM Refreshments Foyer
7:30 - 8:30 PM Keynote Address Colorado Ballroom
Anne Ferguson-Smith, University of Cambridge
Opening and Welcoming Greeting
* Steven Henikoff, Fred Hutchinson Cancer Research Center
Huntington F. Willard, Duke University
Epigenetics in Complex Genomes: What's the Genome Do?
8:30 - 9:30 PM Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.
Colorado Ballroom
Tuesday, January 6
7:00 - 8:00 AM Breakfast Summit Gallery
8:00 - 11:15 AM Chromatin Dynamics Colorado Ballroom
* Barbara J. Meyer, University of California, Berkeley
Bradley R. Cairns, Huntsman Cancer Institute, University of Utah
DNA Methylation Dynamics in Zebrafish Embryos
Steven Henikoff, Fred Hutchinson Cancer Research Center
Histone Variants and Chromatin Dynamics
Jessica K. Tyler, University of Colorado Health Sciences Center
Novel Roles for Core Histone Acetylation on H3 lysine 56 in Longevity and Tumorigenesis
Geneviève Almouzni, Centre National de la Recherche Scientifique
During Cell Cycle - Challenges of DNA Replication and Repair
Petra Hajkova, Wellcome Trust, Cancer Research UK
Short Talk: Mechanistic Aspects of DNA Demethylation in Mouse Development
Craig S. Pikaard, Washington University
Short Talk: Plant RNA Polymerases IV and V: Subunit Structures and Modes of Action in RNA-Directed DNA Methylation
9:20 - 9:40 AM Coffee Break Foyer
11:15 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Breckenridge Ballroom
1:00 - 10:00 PM Poster Viewing Breckenridge Ballroom
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Functional Organization of the Nucleus Colorado Ballroom
* Amanda G. Fisher, Imperial College London
Jeannie T. Lee, Massachusetts General Hospital
Imprinted X Chromosome Inactivation
Gary Karpen, Lawrence Berkeley National Lab, University of California, Berkeley
DNA Repair in Heterochromatin
Peter Fraser, Babraham Institute
The Role of the Air Non-Coding RNA in Gene Silencing
Jane A. Skok, New York University School of Medicine
Short Talk: Recombinase-Dependent Homologous Pairing of Ig Alleles: A Novel Regulatory Aspect of Allelic Exclusion
7:00 - 8:00 PM Social Hour w/ Lite Bites Breckenridge Ballroom
7:30 - 10:00 PM Poster Session 1 Breckenridge Ballroom
Wednesday, January 7
7:00 - 8:00 AM Breakfast Summit Gallery
8:00 - 11:15 AM Long-Range Epigenetic Control during Development Colorado Ballroom
* Geneviève Almouzni, Centre National de la Recherche Scientifique
William G. Kelly, Emory University
Chromatin Remodeling and Erasure during C. elegans Germline Specification
Vincenzo Pirrotta, Rutgers University
Alternative Chromatin States of Polycomb Target Genes
Barbara J. Meyer, University of California, Berkeley
Targeting X-Chromosome Repression
Asifa Akhtar, European Molecular Biology Laboratory
Dosage Compensation
Sam Schoenmakers, Erasmus MC - University Medical Center
Short Talk: Meiotic Sex Chromosome Inactivation in the Female Germline
Patrick J.E.C. Wijchers, Medical Research Council, Clinical Sciences Centre
Short Talk: Sexual Dimorphisms in Mammals
9:20 - 9:40 AM Coffee Break Foyer
11:15 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Breckenridge Ballroom
1:00 - 10:00 PM Poster Viewing Breckenridge Ballroom
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Integrated Epigenetic Mechanisms Colorado Ballroom
* William G. Kelly, Emory University
Robert Martienssen, Cold Spring Harbor Laboratory
Copying and Reprogramming of Heterochromatin with RNAi
Jonathan I. Gent, Stanford University
Short Talk: A Small RNA Mediated, Paternal Contribution to C. elegans Embryogenesis?
Steven E. Jacobsen, HHMI/University of California, Los Angeles
DNA Methylation in Arabidopsis
Timothy H. Bestor, Columbia University College of Physicians and Surgeons
Interactions between DNA Methylation and Histone Modifications in Mammals
7:00 - 8:00 PM Social Hour w/ Lite Bites Breckenridge Ballroom
7:30 - 10:00 PM Poster Session 2 Breckenridge Ballroom
Thursday, January 8
7:00 - 8:00 AM Breakfast Summit Gallery
8:00 - 11:00 AM Parental Origin-Specific Epigenetic Processes Colorado Ballroom
* Timothy H. Bestor, Columbia University College of Physicians and Surgeons
James Turner, National Institute of Medical Research
Meiotic Silencing in Mammals
Sundeep Kalantry, University of North Carolina, Chapel Hill
Short Talk: Evolution of Xist-Requirement in the Initiation of Mouse Imprinted X-Chromosome Inactivation
Robert L. Fischer, University of California, Berkeley
Imprinting in Plants
Wolf Reik, Babraham Institute
Epigenetic Regulation of Imprinting, Reprogramming, and Lineage Commitment in Mammalian Development
Urszula Brykczynska, Friedrich Miescher Institute
Short talk: Transmission of Methylated Histones with Modifications Specific Genomic Localization by Human Spermatozoa
Nico Ruf, Babraham Institute
Short Talk: Transcription is Required for Establishment of Germline Methylation Marks at Imprinted Genes
9:20 - 9:40 AM Coffee Break Foyer
11:00 AM - On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Breckenridge Ballroom
1:00 - 10:00 PM Poster Viewing Breckenridge Ballroom
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Environmental Modulation of Epigenetic States Colorado Ballroom
* Michael Meaney, McGill University
†,
Paul D. Soloway, Cornell University
Antagonism Between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus
E. Jean Finnegan, CSIRO Plant Industry
Epigenetic Determinants of an Environmental Response
Jay C. Dunlap, Dartmouth Medical School
Short Talk: DNA Methylation, the frq Antisense Transcript qrf, and the ATP-Dependent Chromatin-Remodeling Enzyme CHD2: Roles in the Epigenetic Transfer of Circadian Time
Frédéric L. Chédin, University of California, Davis
Short talk: The DNMT3L Protein Interacts with Multiple Nucleosomal Components to Guide de novo Methylation
7:00 - 8:00 PM Social Hour w/ Lite Bites Breckenridge Ballroom
7:30 - 10:00 PM Poster Session 3 Breckenridge Ballroom
Friday, January 9
7:00 - 8:00 AM Breakfast Summit Gallery
8:00 - 11:15 AM Vertebrate Developmental Epigenetics Colorado Ballroom
* Wolf Reik, Babraham Institute
Amanda G. Fisher, Imperial College London
Epigenetic Regulators of Pluripotency
Matthias Merkenschlager, Imperial College London
Cohesins in Gene Regulation and Genome Organisation
Gerald R. Crabtree, Stanford University
Understanding the Words of Chromatin Remodeling
Michael Meaney, McGill University
Epigenetic Programming of Behavior and Physiology
Simon C. Biddie, University of Bristol
Short Talk: Cell-Specific Interactions of the Glucocorticoid Receptor with Chromatin
Qiaoning Guan, University of California, Berkeley
Short Talk: Nutritional Epigenomics in Yeasts and Human
9:20 - 9:40 AM Coffee Break Foyer
11:15 AM - On Own for Lunch
4:30 - 5:00 PM Coffee Available Foyer
5:00 - 7:00 PM Epigenetic Mechanisms of Disease Colorado Ballroom
* E. Jean Finnegan, CSIRO Plant Industry
Arthur L. Beaudet, Baylor College of Medicine
The Role of Epigenetics in Neurobehavioral Disorders
Kristian Helin, University of Copenhagen
Histone Methylation at the Center of Cellular Differentiation and Disease
Andrew G. Clark, Cornell University
Short Talk: Transcriptome-Wide Identification of Novel Imprinted Genes in Neonatal Mouse Brain
Andrew Chess, Massachusetts General Hospital
Genome-Wide Allele-Specific Epigenomic Analyses
7:00 - 8:00 PM Social Hour w/ Lite Bites Breckenridge Ballroom
8:00 - 11:00 PM Entertainment Breckenridge Ballroom
Saturday, January 10
Departure
*Session Chair   †Speaker invited, not yet responded.



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