| Sunday, March 1 |
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3:00 - 7:30 PM
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Registration
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Rio Grande D
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6:30 - 7:30 PM
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Refreshments
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Rio Grande A/B/C
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7:30 - 9:30 PM
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Keynote Session
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Bataan
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Maria Jasin,
Memorial Sloan-Kettering Cancer Center
Welcome
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Michael S. Neuberger,
Medical Research Council
Introduction
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Michael Stratton,
Wellcome Trust Sanger Institute
Patterns of Somatic Mutation in Human Cancer Genomes
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Stephen J. Elledge,
Harvard-Partners Center for Genetics and Genomics
Introduction
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Titia de Lange,
Rockefeller University
How Telomeres Protect Chromosome Ends
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| Monday, March 2 |
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7:00 - 8:00 AM
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Breakfast
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Rio Grande A/B/C
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8:00 - 11:15 AM
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Checkpoints
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Bataan
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*
Stephen J. Elledge,
Harvard-Partners Center for Genetics and Genomics
Integrative Approaches for DNA Damage and Cell Cycle Analysis
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Jean J. Gautier,
Columbia University, College of Physicians and Surgeons
Sensing and Repairing a Single DNA Interstrand Crosslink
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Alexander J.R. Bishop,
University of Texas Health Science Center, San Antonio
Short Talk: A Conserved DNA Damage Survival Network
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Simon J. Boulton,
London Research Institute, Clare Hall Laboratories
EMBO Young Investigator Lecture: The Function and Regulation of HCLK2/Tel2 in DNA Damage Checkpoints
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Tanya T. Paull,
University of Texas at Austin
Mre11/Rad50 Complexes and Mechanisms of DNA Double-Strand Break Repair
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R. Scott Williams,
The Scripps Research Institute
Short Talk: Structural Basis for Mre11/Rad50 DNA End Bridging and Nuclease Processing in DNA Double Strand Break Repair
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9:20 - 9:40 AM
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Coffee Break
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Rio Grande C/D
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Rio Grande
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1:00 - 10:00 PM
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Poster Viewing
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Rio Grande
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2:30 - 4:30 PM
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Workshop 1: Checkpoints and Genomic Rearrangements
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Bataan
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Ralph Scully,
Harvard Medical School
Control of Non-Homologous End Joining by Mre11 in Mammalian Cells
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Brendan D. Price,
Dana-Farber Cancer Institute
Histone Methylation Couples DNA Damage Detection to Activation of the Tip60-ATM Signaling Pathway
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Yaron Galanty,
Wellcome Trust/Cancer Research UK Gurdon Institute
SUMO Proteins Promote Responses to DNA Double-Strand Breaks in Mammalian Cells
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John L. Nitiss,
St. Jude Children's Research Hospital
Tdp1, Exo1 and Apn1 Collaborate to Control the Accuracy of Non-Homologous End-Joining in Yeast
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Jeremy M. Stark,
BRI of the City of Hope
Mechanisms of Mammalian Alternative-NHEJ
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Bernard S. Lopez,
CNRS, Centre des Etudes Atomique
Initiation of Alternative NHEJ in Mammalian Cells
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Karina B. Falbo,
University of Texas MD Anderson Cancer Center
Involvement of a Chromatin-Remodeling Complex in the DNA Damage Tolerance Pathways during DNA Replication
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4:30 - 5:00 PM
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Coffee Available
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Rio Grande C/D
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5:00 - 7:15 PM
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DNA Repair and Chromatin
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Bataan
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*
Jiri Lukas,
Danish Cancer Society
Dynamic Organization of Signaling and Repair Machines at Damaged Chromosomes
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Samantha Gail Zeitlin,
University of California, San Diego
Short Talk: The Centromeric H3 Variant CENP-A is Targeted by and Functions in DNA Repair
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Wade Harper,
Harvard Medical School
The Mammalian SLX4 Complex: A Molecular Tool-Kit for DNA Repair
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Geneviève Almouzni,
Centre National de la Recherche Scientifique
Chromatin Assembly Factors and the Challenges of DNA Replication and Repair
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Matthew D. Weitzman,
The Salk Institute
Short Talk: A Viral Ubiquitin Ligase Targets RNF8 and RNF168 to Modulate Histone Ubiquitination and the DNA Damage Response
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Rio Grande
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7:30 - 10:00 PM
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Poster Session 1
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Rio Grande
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| Tuesday, March 3 |
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7:00 - 8:00 AM
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Breakfast
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Rio Grande A/B/C
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8:00 - 11:15 AM
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Double-Strand Break Repair
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Bataan
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*
Lorraine S. Symington,
Columbia University
Resection and DNA Synthesis during Double-Strand Break Repair
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James E. Haber,
Brandeis University
Genome Stability and Instability through Homologous Recombination
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Toyoko Tsukuda,
School of Medicine, University of New Mexico
Short Talk: Chromatin Remodeling during DNA Double-Strand Break (DSB) Repair by Homologous Recombination (HR)
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Stephen C. West,
Cancer Research UK
Identification of Holliday Junction Resolvases from Yeast and Human Cells
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Maria Jasin,
Memorial Sloan-Kettering Cancer Center
Double-Strand Break Repair in Mammalian Cells and the Role of BRCA2
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Emmanuelle Passegué,
University of California, San Francisco
Short Talk: Differential DNA Repair in Hematopoietic Stem Cells and Myeloid Progenitors
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9:20 - 9:40 AM
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Coffee Break
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Rio Grande C/D
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11:00 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Rio Grande
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1:00 - 10:00 PM
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Poster Viewing
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Rio Grande
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2:30 - 4:30 PM
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Workshop 2: Mechanisms of Repair and Replication
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Bataan
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*
Anindya Dutta,
University of Virginia
RNAi Screens Identify Genes Important for Genetic Stability in Human Cells
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Bik K. Tye,
Cornell University
A Defective MCM Helicase Predisposes Yeast to Aneuploidy and Accelerated Proliferation Independently
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Judith L. Campbell,
California Institute of Technology
Interplay between Mre11 Nuclease and Dna2 Helicase/Nuclease in DSB Repair and at Telomeres
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Gregory Ira,
Baylor College of Medicine
Resection of DNA Double Strand Breaks in Budding Yeast
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Hannah L. Klein,
New York University
Regulating Rad51 Recombinase through DNA Helicases and SWI2-like Proteins
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Dipanjan Chowdhury,
Dana Farber Cancer Institute, Harvard Medical School
miR-24-Mediated Down-Regulation of H2AX Suppresses DNA Repair in Terminally Differentiated Cells
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4:30 - 5:00 PM
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Coffee Available
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Rio Grande C/D
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5:00 - 7:15 PM
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Replication and Genomic Stability
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Bataan
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Marco F. Foiani,
Instituto FIRC di Oncologia Molecolare
Topological Transitions at Replicating Chromosomes
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Kyungjae Myung,
NHGRI, National Institutes of Health
Short Talk: Human ELG1 Regulates the Level of Monoubiquitinated PCNA through Interactions with PCNA and USP1
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Vincenzo Costanzo,
London Research Institute, Clare Hall Laboratories
EMBO Young Investigator Lecture: Maintaining Genome Stability during DNA Replication in Vertebrate Organisms
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Karlene A. Cimprich,
Stanford University
Mechanisms for Maintaining Genome Stability at the Replication Fork
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Carol E. Bansbach,
Vanderbilt University
Short Talk: A Functional Genomic Screen Identifies a Novel Replication Stress Protein
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Rio Grande
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7:30 - 10:00 PM
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Poster Session 2
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Rio Grande
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| Wednesday, March 4 |
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7:00 - 8:00 AM
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Breakfast
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Rio Grande A/B/C
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8:00 - 11:15 AM
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Genomic Instability and the Immune System
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Bataan
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Michael R. Lieber,
University of Southern California
Mechanisms of DNA Breakage and NHEJ in Human Chromosomal Translocations
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*
Michael S. Neuberger,
Medical Research Council
DNA Deaminases in Immunity
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Jayanta Chaudhuri,
Memorial Sloan Kettering Cancer Center
Short Talk: Specific Recruitment of Protein Kinase A to the Immunoglobulin Locus Regulates Class Switch Recombination
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Frederick W. Alt,
HHMI, Children's Hospital and Immune Disease Institute, Boston
DNA Double Strand Breaks, Translocations and Lymphoma
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Davide F. Robbiani,
Rockefeller University
Short Talk: Activation Induced Cytidine Deaminase is Required for the Breaks in c-myc that Lead to c-myc/IgH Chromosome Translocations
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Alberto Martin,
University of Toronto
Short Talk: Msh2-Deficient Emu c-myc Mice Rapidly Succumb to Pro B Cell Lymphoma
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9:20 - 9:40 AM
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Coffee Break
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Rio Grande C/D
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Rio Grande
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1:00 - 10:00 PM
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Poster Viewing
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Rio Grande
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2:30 - 4:30 PM
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Workshop 3: DNA Repair: Part 1 - Cancer, Part 2 - The Immune System
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Bataan
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*
David O. Ferguson,
University of Michigan
Roles of the Mre11 Nuclease in DNA Repair and Lymphocyte Development
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Kevin D. Mills,
The Jackson Laboratory
Replication, Recombination, and DNA Repair: The 3 R's are Required in Lymphocytes
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JoAnn Sekiguchi,
University of Michigan
Dysfunctional Artemis Nuclease Activity Leads to Partial Immunodeficiency, Genome Instability and Tumorigenesis
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Bernardo Reina-San-Martin,
IGBMC
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Jean Pierre de Villartay,
INSERM U768
Reduced Immunoglobulin Class Switch Recombination in the Absence of Artemis
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Kefei Yu,
Michigan State University
Class Switch Recombination in NHEJ-Deficient B Cells
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4:30 - 5:00 PM
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Coffee Available
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Rio Grande C/D
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5:00 - 7:00 PM
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Cancer and DNA Repair Defects
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Bataan
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*
John H.J. Petrini,
Memorial Sloan-Kettering Cancer Center
Genetic Analysis of Chromosome Break Metabolism
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Lee Zou,
Harvard Medical School
Short Talk: Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
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Jos Jonkers,
Netherlands Cancer Institute
Targeting Double-Strand Break Repair Defects in Conditional Mouse Models of BRCA-Associated Breast Cancer
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Thomas Ludwig,
Columbia University
Short Talk: The E3 Ligase Activity of BRCA1 is Not Essential for Mammalian Cell Viability or Homology-Directed Repair of Double-Strand DNA Breaks
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Hai Jiang,
Massachusetts Institute of Technology
Short Talk: The ATM-Chk2 Signaling Network Controls Alternative Cell Fates after Chemotherapy, Based on a p53 Binary Switch
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Rio Grande
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7:30 - 10:00 PM
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Poster Session 3
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Rio Grande
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| Thursday, March 5 |
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7:00 - 8:00 AM
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Breakfast
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Rio Grande A/B/C
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8:00 - 11:15 AM
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Genetic Variation
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Bataan
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*
Neil Hunter,
University of California, Davis
Implementing a Crossover Outcome during Meiotic Recombination
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Scott Keeney,
Memorial Sloan-Kettering Cancer Center
Molecular Cartography: Mapping the Landscape of Meiotic Double-Strand Break Distributions
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Jennifer Fung,
University of California, San Francisco
Short Talk: Global Analysis of Meiotic Crossover Control
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James R. Lupski,
Baylor College of Medicine
Two is Fine, Three is a Crowd, and One Often does not Satisfy - Getting the Gene Dosage Correct in the Nervous System
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Matthew Hurles,
Wellcome Trust Sanger Institute
Germline Structural Variation: Maps, Mechanisms and Disease
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Adam Shlien,
Hospital for Sick Children
Short Talk: Contribution of Constitutional DNA Copy Number Variation to the Li-Fraumeni Cancer Predisposition Syndrome and it’s Associated Tumors
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9:20 - 9:40 AM
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Coffee Break
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Rio Grande C/D
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11:15 AM -
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On Own for Lunch
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2:30 - 4:30 PM
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Workshop 4: Genetic Variation and Meiosis
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Bataan
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*
Bernard de Massy,
Institut de Génétique Humaine
Genome Wide Control of the Distribution of Meiotic Recombination in Mice
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Philippe R. Bois,
The Scripps Research Institute - Scripps Florida
Regulation of Mouse Recombination Hotspots
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Petko M. Petkov,
The Jackson Laboratory
Recombination Landscape, Genetic Background and Genes Regulating Hotspot Activity
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Eugenio Mancera,
European Molecular Biology Laboratories
High-Resolution Mapping of Crossovers and Noncrossovers in the Yeast Genome
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Catherine H. Freudenreich,
Tufts University
Replication Fork Restart and Checkpoint Responses at Structure-Forming CAG/CTG Trinucleotide Repeats
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Kirill S. Lobachev,
Georgia Institute of Technology
Role of Post-Replication Repair Pathway in Cruciform Resolution in Yeast
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4:30 - 5:00 PM
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Coffee Available
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Rio Grande C/D
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5:00 - 7:15 PM
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Sequence Elements and Genomic Instability
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Bataan
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John V. Moran,
University of Michigan Medical School
Studies of a Human Transposable Element
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Prescott Deininger,
Tulane University
Mobile Elements, Double-Strand DNA Breaks, and the Cellular Response
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Beverly S. Emanuel,
University of Pennsylvania, Children's Hospital of Philadelphia
The Role of Palindromic Sequences in 22q11 Rearrangements
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Susanna Maxwell Lewis,
Harvard Medical School
Three Mechanisms for Palindrome-Associated Breaks Acquired in vivo
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Rio Grande
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8:15 - 11:00 PM
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Entertainment
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Rio Grande
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| Friday, March 6 |
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Departure
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