Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Allergy and Asthma (J1)

Organizer(s): Catherine M. Hawrylowicz, Stephen J. Galli and Bart N. Lambrecht
January 20 - 25, 2009
Keystone Resort · Keystone, Colorado
Abstract Deadline: September 22, 2008
Late Abstract Deadline: October 22, 2008
Scholarship Deadline: September 22, 2008
Early Registration Deadline: November 20, 2008

Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Fibrosis (J2)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Allergic diseases, including asthma, affect up to one third of individuals in the developed world at some time in their lifetime, causing severe loss in the quality of life and a significant healthcare burden. Current treatments are predominantly palliative and there remains an unmet need for improved and novel treatments that provide long-term relief from disease symptoms. At this meeting, clinicians and scientists from both academic and pharmaceutical research environments will discuss: (1) risk factors for disease; (2) innate mechanisms and structural cells involved in the initiation, development and manifestations of disease; (3) effector and regulatory immune mechanisms involved in the allergic process; (4) the relationship between inflammation and structural remodeling in asthma; (5) the improvement of conventional treatments; and (6) novel emerging therapeutic strategies for the control of allergic and asthmatic disease. Opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting “Fibrosis”, which will share a session with this meeting.

Tuesday, January 20
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address	Grays 1-3
	Stephen T. Holgate, Southampton General Hospital Overview of Asthma and Identification of Unmet Clinical Needs
Wednesday, January 21
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Risk Factors, Early Life Events and Innate Mechanisms	Grays 1-3
	* Catherine M. Hawrylowicz, King's College London
	Marsha Wills-Karp, Cincinnati Children's Hospital Medical Center Innate Immune Responses To Allergens
	Patrick G. Holt, University of Western Australia Early Life Events that Influence Allergic Status
	René Teich, Philipps University of Marburg Short Talk: Epigenetic Regulation of Asthma Protection Early in Life by the Non-Pathogenic Microbe Acinetobacter lwoffii F78
	* Scott T. Weiss, Brigham and Women's Hospital Vitamin D and Allergy/Asthma Prevalence
	David B. Lewis, Stanford University Influence of viral infections on the development of asthma: Insights from a murine model of influenza A viral-induced allergen sensitization for allergic pathogenesis and its prevention by vaccination for influenza
	Matthew E. Poynter, University of Vermont Short Talk: Airway Epithelial Activation of NF-ƒÛB is Sufficient to Promote Allergic Sensitization to an Innocuous Inhaled Antigen
9:20 - 9:40 AM	Coffee Break	Longs Paek Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 1: Genes and Gene: Environment Interactions and Innate Immunity	Grays 1-3
	* Marsha Wills-Karp, Cincinnati Children's Hospital Medical Center

	* Donata Vercelli, University of Arizona Epigenetic Signatures of Environmental Exposures
	Ulus Atasoy, University of Missouri Coordinate Posttranscriptional Regulation of Asthma Genes by the RNA Binding Protein HuR

	Annerose Berndt, The Jackson Laboratory Haplotype Association Mapping for Airway Hyper-responsiveness and a Systematic Gene-identification Approach Identifies SERPINB6b
	Jennifer Kearley, MedImmune Chitinase-like Protein BRP-39 is a Critical Mediator of Allergic Sensitization
	Benjamin D. Medoff, DRAI, Massachusetts General Hospital Adiponectin-Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling
	Lisa Cameron, University of Alberta CRTh2+1431G>C is Associated with sIgE to Food Allergens and Allele-specific Transcription Factor Binding

	Sean Saunders, Institute of Molecular Medicine Talk Title to be Announced
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Structural and Resident Cells of the Lung	Grays 1-3
	* Stephen J. Galli, Stanford University

	* Michael J. Holtzman, Washington University New Immune Pathways for Allergy and Asthma
	Hamida Hammad, Ghent University Short Talk: TLR4 Expression on Airway Stromal Cells is Crucial for Innate and Adaptive Immunity to House Dust Mite Allergen
	Maria do Carmo Leite-de-Moraes, CNRS, UMR 8147 NKT Cells in the Lung

	Steven F. Ziegler, Benaroya Research Institute TSLP and Allergic Inflammation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 1	Quandary 1-3
Thursday, January 22
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Effector Mechanisms and Cells	Grays 1-3
	* Bart N. Lambrecht, Ghent University
	Sally E. Wenzel, University of Pittsburgh Asthma Phenotypes: Are we Closing the Loop to Pathobiology?
	Stephanie C. Eisenbarth, Yale University The Role of Inflammasomes in Vaccination and Allergic Disease

	Hiroshi Watarai, Riken Research Center for Allergy and Immunology Short Talk: A novel Subset of Mouse NKT Cells Bearing the IL-17 Receptor B Responds to IL-25 and Contributes to Airway Hyperreactivity
	Frances E. Lund, University of Rochester Medical Center CD38: Modulator of the NAD Metabolome and Regulator of Inflammation
	Pierre Bruhns, Institut Pasteur Short Talk: FcgammaRIV as a Murine Equivalent of FcepsilonRI Expressed by Macrophages from Human Atopics in IgE-Induced inflammation
	* K. Frank Austen, Harvard Medical School Leukotrienes as Therapeutic Targets in Asthma
9:20 - 9:40 AM	Coffee Break	Longs Paek Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 2: Intercellular and Intracellular Signaling Mechanisms	Grays 1-3
	* Paul B. Rothman, University of Iowa
	* Bart N. Lambrecht, Ghent University
	Charlotte Andreasen, Yale University TGF-beta1 Production by Alveolar Macrophages is Crucial for Controlling Inflammation in the Lung
	Alison L. Budelsky, Amgen Investigation of the Functional Roles for IL-17A, IL-25, IL-17RA, and IL-17RB in a Mouse Asthma Model
	Jennifer Louten, Schering-Plough Biopharma IL-23 Signaling Negatively Regulates Th2 Responses in Asthma
	Martijn C. Nawijn, University Medical Center Groningen PAR2 Activation Induces Airways Hyperresponsiveness without Loss of Inhalation Tolerance
	Mindy Tsai, Stanford University Thymic Stromal Lymphopoietin (TSLP) Promotes Myeloid Hyperplasia and Overproduction of Immunoglobulins, but not Skin Inflammation, in RabGEF1-deficient Mice
	Nicolas Charles, NIAMS, National Institutes of Health Homeostatic Control of Basophil GATA-3 Expression and TH2 Differentiation by Lyn Kinase
	Wanjun Chen, NIDCR, National Institutes of Health TGF-beta in the Development of CD4+ Foxp3+ Regulatory T Cells and the Regulation of House Dust Mite Induced Asthma
	Nandini Krishnamoorthy, University of Pittsburgh A Critical Role for c-kit on Dendritic Cells in Regulating in T Helper Cell Differentiation and Allergic Asthma
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Immune Regulation	Grays 1-3
	* Steven F. Ziegler, Benaroya Research Institute
	Valerie Julia, INSERM Breast Milk-Mediated Transfer of an Antigen Induces Tolerance and Protection from Allergic Asthma

	* Catherine M. Hawrylowicz, King's College London Regulatory T Cells in Allergy and Asthma: The Role of the Vitamin D Pathway
	Yong-Jun Liu, University of Texas MD Anderson Cancer Center Cross Talk between Epithelial Cells and Dendritic Cells through TSLP/TSLPR in Allergic Inflamation
	Hiromasa Inoue, Kyushu University Short Talk: Pulmonary SOCS1 as a Central Endogenous Inhibitor of Allergic Asthma
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 2	Quandary 1-3
Friday, January 23
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Asthma, Allergy and Tissue Remodeling (Joint)	Longs Peak / Grays Peak
	* Cory M. Hogaboam, University of Michigan
	Jack A. Elias, Yale School of Medicine Insights from Transgenic Models of Lung Fibrosis
	James J. Lee, Mayo Clinic Scottsdale Eosinophils Orchestrate Allergic Pulmonary Responses: Who’s your Daddy Now T Cells!
	John V. Fahy, University of California, San Francisco Short Talk: Plasma Proteins Inhibit Protease-Dependent Degradation of Airway Mucus Plugs in Acute Asthma
	Lauren E. Cohn, Yale University Short Talk: IFN-gamma Modulates Allergic Airway Disease through Effects on the Airway Epithelium
	Hajime Karasuyama, Tokyo Medical and Dental University Short Talk: Basophils Resolve Inflammation through Alternate Activation of Macrophages
	Jean Kim, Johns Hopkins University School of Medicine Short Talk: Involvement of VEGF in Upper Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyposis Subjects
	Stephen J. Galli, Stanford University Mast Cells and Tissue Remodeling
9:20 - 9:40 AM	Coffee Break	Longs Paek Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Lipid Mediators, Proteases and Cytokines in Tissue Remodeling	Grays 1-3
	* Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School
	Clare M. Lloyd, Imperial College London Cytokine Regulation of Allergic Airway Inflammation and Remodeling
	* Juan Rivera, NIAMS, National Institutes of Health Sphingosine-1-Phosphate in Allergy and Asthma

	Gunnar Pejler, Swedish University of Agricultural Sciences Mast Cell Chymase - A Friend or Foe?
	Cara MM Williams, Wyeth Pharmaceuticals Short Talk: Cytosolic Phospholipase A2alpha Orchestrates Allergic Disease
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 3	Quandary 1-3
Saturday, January 24
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Conventional and Novel Targets for Intervention	Grays 1-3
	* Edith M. Hessel, Dynavax Technologies

	John A. Cidlowski, NIEHS, National Institutes of Health The Glucocorticoid Receptor: One Gene, Many Proteins – New Mechanisms for Tissue Specific Anti-Inflammatory Actions of Glucocorticoids in Health and Disease.
	Marco Conti, University of California, San Francisco Cyclic AMP-Specific Phosphodiesterase Regulation as a Critical Component of the Airway Inflammatory Responses
	Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School Short Talk: Leukotriene E4-Induced Pulmonary Inflammation is Mediated by the P2Y12 Receptor

	Heidi Campos Schilter, Garvan Institute of Medical Research Short Talk: A Role for Fatty Acid Binding Proteins in Airway Immune Responses
	Prescott G. Woodruff, University of California, San Francisco Short Talk: Presence or Absence of IL-13-Driven Inflammation Defines Major Sub-Phenotypes of Asthma
	Monika Vig, BIDMC, Harvard Medical School CRACM1, a Potential Target for Inhibition of Allergic and Inflammatory Disorders

9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
2:30 - 4:30 PM	Workshop 3: Effector Cells and Mechanisms in Asthma	Grays 1-3

	* Stephen J. Galli, Stanford University
	Helen E. Harries, Local Clonal Expansion of IgE Producing B Cells
	Yuzaburo Inoue, Cincinnati Children's Hospital Medical Center Chitinase Family Members Inhibit House Dust Mite-Induced AHR Independently of Enzymatic Activity
	Irene H. Heijink, University Medical Center Groningen House Dust Mite-Promoted Epithelial-to-Mesenchymal Transition in Human Bronchial Epithelium
	Sara Wernersson, Swedish University of Agricultural Sciences Protective Role of mMCP-4 in Allergic Inflammation
	Mayumi Ueta, Kyoto Prefectural University of Medicine PGE Receptor Subtype EP3 Regulates LPR of Allergic Conjunctivitis
	Karin Stebbins, Amira Pharmaceuticals Novel DP2 Receptor Antagonist Decreases Allergic Inflammation

	Antoon J.M. van Oosterhout, University Medical Center Groningen IL-10 Producing CD11c+ Cells in SIT in Mouse Model of Asthma
	Joan M. Cook-Mills, Northwestern University Feinberg School of Medicine Isoforms of Vitamin E have Opposing Immunoregulatory Function in Allergic Inflammation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Immune Intervention	Grays 1-3
	* Yong-Jun Liu, University of Texas MD Anderson Cancer Center
	Edith M. Hessel, Dynavax Technologies Effects of TLR-9 Agonists in Asthma: Moving Towards Long-Lasting Disease Modification

	Lawren C. Wu, Genentech, Inc. Short Talk: Reduction of Serum IgE by Depletion of the IgE B Cell Lineage – a Novel Approach for the Treatment of Allergic Diseases
	Bart N. Lambrecht, Ghent University Targeting Dendritic Cells
	* Anthony J. Coyle, Pfizer Cytokine Antagonists
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
8:00 - 11:00 PM	Entertainment	Quandary 1-3
Sunday, January 25
	Departure

*Session Chair †Speaker invited, not yet responded.