| Tuesday, January 20 |
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3:00 - 7:30 PM
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Registration
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Longs Peak Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 8:30 PM
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Keynote Address
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Longs Peak
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Harry C. Dietz,
Johns Hopkins University School of Medicine
TGF-beta, Microfibrils and Connective Tissue Homeostasis
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| Wednesday, January 21 |
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7:00 - 8:00 AM
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Breakfast
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Quandary 1-3
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8:00 - 11:15 AM
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Cellular Basis of Fibrosis: Focus on the Lung
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Longs Peak
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Moisés Selman,
Instituto Nacional de Enfermedades Respiratorias
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David A. Schwartz,
National Jewish Medical and Research Center
Common Variants of MUC5AC and Pulmonary Fibrosis
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Richard P. Phipps,
University of Rochester
Fibroblast Heterogeneity –Impact of Fibroblast Diversity and Differentiation
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Harold A. Chapman,
University of California, San Francisco
Regulation of EMT and Pulmonary Fibrosis by Epithelial Integrins
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Manuela Funke,
Massachusetts General Hospital
Short Talk: Lysophosphatidic Acid Contributes to an Apoptosis Paradox in Lung Fibrosis
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Boris Hinz,
University of Toronto
Myofibroblasts and Mechanical Signal Transduction
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Usamah S. Kayyali,
Tufts Medical Center
Short Talk: MK2 Signaling in Fibroblast Biology and Pulmonary Fibrosis
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Quandary 1-3
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1:00 - 10:00 PM
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Poster Viewing
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Quandary 1-3
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2:30 - 4:30 PM
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Workshop 1: EMT, Plasticity and the Origin of Fibroblasts
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Longs Peak
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Richard H. Gomer,
Rice University
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Robert Lafyatis,
Boston University
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Brandi Nicole Baird,
Brown Foundation Institute of Molecular Medicine
Identification and Characterization of Prospectively Isolated Candidate Stem/Progenitor Cells in the Adult Mouse Lung
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Marianne E. Fairclough,
University of Birmingham
Diversity within Monocyte Derived Stromal Cells
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Darrell Pilling,
Texas A&M University
Th-1 Cytokines Inhibit, and Th-2 Cytokines Promote Fibrocyte Differentiation
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Kirkwood A. Pritchard Jr.,
Medical College of Wisconsin
The Role of Matrix and Mesenchymal Transition in Fibrosis in Tight Skin Mice
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Peter H. S. Sporn,
Northwestern University Feinberg School of Medicine
Epithelial-Mesenchymal Transition in Normal Human Bronchial Epithelial Cells Triggered by TGF-beta1, Eosinophils and Cyclic Mechanical Strain
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Shangxi Liu,
University of Western Ontario
Loss of Beta 1 Integrin in Mouse Fibroblasts Results in Resistance to a bleo model of Skin Sclerodermav
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Gregory deHart,
FibroGen, Inc.
Regulation of Epithelial to Mesenchymal Transition by Connective Tissue Growth Factor
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Liver Fibrosis
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Longs Peak
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*
Thomas A. Wynn,
National Institutes of Health
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Anna Mae Diehl,
Duke University Medical Center
The Cellular Biology and Clinical Spectrum of Liver Fibrosis
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John P. Iredale,
University of Edinburgh
Liver Fibrosis: A Dynamic Model of Inflammation and Repair
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Margaret M. Mentink-Kane,
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Short Talk: Accelerated Liver Fibrosis in the Combined Absence of Interleukin-13 Regulatory Molecules: IL-13 Receptor Alpha 2, IL-10 and IL-12
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Scott L. Friedman,
Mount Sinai School of Medicine
Genetic Determinants of Fibrosis Progression
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Quandary 1-3
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7:30 - 10:00 PM
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Poster Session 1
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Quandary 1-3
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| Thursday, January 22 |
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7:00 - 8:00 AM
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Breakfast
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Quandary 1-3
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8:00 - 11:15 AM
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The Immunology and Cell Biology of Fibrosis
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Longs Peak
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*
John Varga,
Northwestern University, Feinberg School of Medicine
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Thomas A. Wynn,
National Institutes of Health
Targets of IL-13 Signaling in Inflammation and Fibrosis
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Erica Herzog,
Yale University School of Medicine
Short Talk: Profibrotic Monocyte Subsets in Pulmonary Fibrosis
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Rebecca G. Wells,
University of Pennsylvania
Liver Fibrosis: The Intersection of Soluble and Mechanical Factors
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Paul W. Noble,
Duke University
Regulation and Lung Injury and Repair: Toll Like Receptors and Innate Immunity
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Anna P. Lam,
Northwestern University
Short Talk: Activated Canonical Wnt/beta-catenin Signaling Mediates Lung Fibroblast Migration and Proliferation
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Victor J. Thannickal,
University of Alabama at Birminham
Apoptosis and Fibroblast Survival in Fibrogenesis
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Quandary 1-3
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1:00 - 10:00 PM
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Poster Viewing
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Quandary 1-3
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2:30 - 4:30 PM
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Workshop 2: Model Systems for Studying Fibrosis
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Longs Peak
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Andrew M. Tager,
Massachusetts General Hospital
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John Westwick†,
Novartis Institutes for Biomedical Research
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Shizhong Bu,
Medical University of South Carolina
DhS1P has a Potent Anti-Fibrotic Effect in Scleroderma Fibroblasts via Modulation of PTEN Levels
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Enrique Brandan,
P. Universidad Católica de Chile
Induction of Fibrosis by Exercise on Dystrophic Muscles: Role of CTGF
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Tomoko Hayashida,
Feinberg School of Medicine, Northwestern University
Lack of beta1 Integrin Enhances TGF-beta Stimulated Type I Collagen Synthesis via Rac1 Mediated ERK Activity that Phosphorylates Smad Linker Region
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Andreas Guenther,
Pulmonary & Critical Care
Role of Defective Surfactant Processing and Transport in Hermansky-Pudlak-Syndrome Associated Interstitial Pneumonia (HPSIP) and Idiopathic Pulmonary Fibrosis (IPF)
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Pura Muñoz Cánoves,
Center for Genomic Regulation
Fibrin-Induced Inflammation Promotes Fibrosis in Muscular Dystrophy
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Joe (Jia-hui) Wang,
King's College London
Antisense Inhibition of Kirsten-Ras Expression Reduces Fibrosis in a Rat Model of Unilateral Ureteric Obstruction
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Renal Fibrosis
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Longs Peak
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*
Michael Zeisberg,
Beth Israel Deaconess Medical Center and Harvard Medical School
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Jeffrey B. Kopp,
National Institutes of Health
Overview of Renal Fibrosis
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Agnes Fogo,
Vanderbilt University Medical Center
Animal Models and the Reversibility of Fibrosis
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Jeremy S. Duffield,
Harvard Medical School
Short Talk: Serum Amyloid P inhibits Renal Fibrosis through an Fc-gamma receptor dependent mechanism.
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H. William Schnaper,
Northwestern University
TGF-beta Signaling in Renal Fibrogenesis
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Jeremy S. Duffield,
Harvard Medical School
Short Talk: Genetic Fate tracing reveal the stromal pericyte not EMT Generates Myofibroblasts in the Obstructive Model of Kidney Fibrosis
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Quandary 1-3
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7:30 - 10:00 PM
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Poster Session 2
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Quandary 1-3
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| Friday, January 23 |
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7:00 - 8:00 AM
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Breakfast
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Quandary 1-3
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8:00 - 11:15 AM
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Asthma, Allergy and Tissue Remodeling (Joint)
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Longs Peak / Grays Peak
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Cory M. Hogaboam,
University of Michigan
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Jack A. Elias,
Yale School of Medicine
Insights from Transgenic Models of Lung Fibrosis
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James J. Lee,
Mayo Clinic Scottsdale
Eosinophils Orchestrate Allergic Pulmonary Responses: Who’s your Daddy Now T Cells!
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John V. Fahy,
University of California, San Francisco
Short Talk: Plasma Proteins Inhibit Protease-Dependent Degradation of Airway Mucus Plugs in Acute Asthma
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Lauren E. Cohn,
Yale University
Short Talk: IFN-gamma Modulates Allergic Airway Disease through Effects on the Airway Epithelium
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Hajime Karasuyama,
Tokyo Medical and Dental University
Short Talk: Basophils Resolve Inflammation through Alternate Activation of Macrophages
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Jean Kim,
Johns Hopkins University School of Medicine
Short Talk: Involvement of VEGF in Upper Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyposis Subjects
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Stephen J. Galli,
Stanford University
Mast Cells and Tissue Remodeling
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Quandary 1-3
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1:00 - 10:00 PM
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Poster Viewing
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Quandary 1-3
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Environmental Cues and Cellular Responses
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Longs Peak
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Rik Derynck,
University of California, San Francisco
TGF-beta Signaling and Epithelial to Mesenchymal Transition
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Florian Rieder,
Lerner Research Institute
Short Talk: Endothelial-to-Mesenchymal Transition of Intestinal Mucosal Microvascular Cells: A Novel Mechanism of Intestinal Fibrosis
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Andrew D. Luster,
Massachusetts General Hospital
Inflammation and Fibrosis - Chemokines, LPA
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Andrew M. Tager,
Massachusetts General Hospital
Grease on the Fire: Chemokine- Lipid cooperation in Fibrosis
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Luisa A. DiPietro,
University of Illinois at Chicago
Scar Formation in the Healing Wound
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Keith C. Olsen,
University of Rochester
Short Talk: Tissue Transglutaminase as a Novel Modulator of and Potential Therapeutic Target in Pulmonary Fibrosis
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Quandary 1-3
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7:30 - 10:00 PM
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Poster Session 3
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Quandary 1-3
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| Saturday, January 24 |
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7:00 - 8:00 AM
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Breakfast
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Quandary 1-3
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8:00 - 11:15 AM
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Novel Therapeutic Targets and Biomarkers
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Longs Peak
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*
Michael Gilman,
Stromedix, Inc.
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Howard Y. Chang,
Stanford University
Genomic Encoding of Fibroblast Positional Identities: Implications for Fibrosis
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Roland M. duBois,
National Jewish Health
Genetics of Diffuse Lung Fibrosis: Lessons Learned
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Shelia M. Violette,
Stromedix
Therapeutic Potential of a Function Blocking alphavbeta6 Antibody in Fibrosis and Oncology: Transition from Research to Clinic Development
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Scott M. Lonning,
Genzyme Corporation
Prospects and Challenges of TGFbeta Neutralization for the Treatment of Pathologic Fibrosis
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Francesco Del Galdo,
Thomas Jefferson University
Short Talk: Quantitative Assessment of Tissue Fibrosis in Skin Biopsies from Patients with Systemic Sclerosis Employing Confocal Laser Scanning Microscopy (CLSM). An Objective Outcome Measure for Clinical Trials
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Kusum V. Pandit,
University of Pittsburgh
Short Talk: MicroRNAs in Lung Fibrosis
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch
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2:30 - 4:30 PM
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Workshop 3: Therapeutic Targets and Biomarkers
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Longs Peak
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Shelia M. Violette,
Stromedix
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April A. Cox,
Array Biopharma
Preclinical Efficacy of a PDGFR inhibitor, ARRY-768, in a Rat Model of Gadolinium-Induced Fibrosis
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Francesco Del Galdo,
Thomas Jefferson University
A Pattern of Shared Alterations in the Secretome of Dermal Fibroblasts from Systemic Sclerosis and Nephrogenic Systemic Fibrosis: A Biomarker Signature for Fibrotic Diseases
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Qihe Xu,
King's College London School of Medicine
Discovery of Herbal Compounds with in vitro Anti-Fibrotic Activities
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Jadranka Milosevic,
Simmons Center for Interstitial Lung Disease
The Role of miR-154 microRNA Family in IPF
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Jennifer L. Sargent,
Dartmouth Medical School
Overlapping and Distinct Gene Targets of TGFbeta, IL13 and IL4 in Dermal Fibroblasts are Expressed in Distinct Molecular Subsets of Systemic Sclerosis
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Timothy W. Schacker,
University of Minnesota
Lymph Node Fibrosis Is A Significant Factor In HIV Pathogenesis And Limits Immune Reconstitution Despite Antiretroviral Therapy Suppression of Viral Replication
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Oscar O. Braun,
University of California San Diego
Cyclic AMP can Both Block and Reverse the Fibrotic Phenotype of Cardiac Fibroblasts
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Guofei Zhou,
Northwestern University
Elevated von Hippel-Lindau Protein Expression in Fibrotic Lungs and Its Role in Fibrogenesis
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Novel Therapies
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Longs Peak
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*
Scott M. Lonning,
Genzyme Corporation
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Bruce N. Cronstein,
New York University School of Medicine
Venegeance is Mine. Adenosine, a Retaliatory Metabolite
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Mark L. Lupher Jr.,
Promedior
Regulating Fibrosis with the Natural Innate Response Modifier, SAP
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Claire L. Emson,
KineMed, Inc.
Measurement of Collagen Synthesis by Heavy Water Labeling and its Application for Indentifying Anti-Fibrotic Therapies
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Ruchi Bansal,
University of Groningen
Short Talk: A Mimetic Peptide of Interferon gamma (IFNgamma) as a Novel Anti-Fibrotic Agent
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Quandary 1-3
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8:00 - 11:00 PM
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Entertainment
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Quandary 1-3
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| Sunday, January 25 |
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Departure
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