Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Regulatory T Cells (C5)

Organizer(s): Yasmine Belkaid, Fiona M. Powrie, and Shimon Sakaguchi
March 1 - 6, 2009
Keystone Resort · Keystone, Colorado
Abstract Deadline: November 3, 2008
Late Abstract Deadline: December 2, 2008
Scholarship Deadline: November 3, 2008
Early Registration Deadline: January 5, 2009

Sponsored by Novo Nordisk A/S

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This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Immunoregulatory Networks (D5)
April 1 - 6, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Over the past few years Regulatory T cells have taken center stage in the field of immunoregulation. Several types of regulatory T cell have been described on the basis of their origin, generation and mechanism of action, with two main subsets identified: naturally occurring FOXP3+ regulatory T cells and inducible regulatory T cells. All types of regulatory T cell, by virtue of their capacity to control the intensity of effector responses, have been shown to play a major role in the control of immune responses at large. This meeting will highlight recent developments in our understanding of the molecular basis for the differentiation of naturally occurring or inducible regulatory T cells. The second goal is to discuss information on the targets, mechanism of action, recruitment and homeostasis of regulatory T cells. The third goal is to discuss recent advances in our understanding of the conditions favoring the emergence and regulation of these populations and to discuss how these findings are translated in clinical trials.

Sunday, March 1
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address	Grays Peak / Longs Peak
	Alexander Y. Rudensky, Memorial Sloan-Kettering Cancer Center Development and Maintenance of Foxp3+Treg
Monday, March 2
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Molecular Control of Foxp3+Treg	Grays Peak / Longs Peak
	Dan R. Littman, New York University School of Medicine ROR Gamma T, Foxp3, and the Th17 Lineage
	Christophe O. Benoist, Joslin Diabetes Center Treg Genomics
	* Steven F. Ziegler, Benaroya Research Institute Regulation and Role of Foxp3 in Regulatory T Cells
	Jochen Huehn, Experimental Immunology, Helmholtz Centre for Infection Research Epigenetic Control of the Foxp3 Locus in Regulatory T Cells
	Girdhari Lal, Mount Sinai School of Medicine Short Talk: Epigenetic Regulation of Foxp3 Expression in T Cells during Tolerance and Inflammation
	Hozefa S. Bandukwala, Harvard Medical School Short Talk: A Critical Role of Domain-Swapping in FOXP3 for its Induction of Suppressive Potential in T Cells
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 1: Molecular Control	Grays Peak / Longs Peak
	* Shimon Sakaguchi, Institute for Frontier Medical Sciences, Kyoto University
	Chan Wang Lio, Washington University, St. Louis A Two-Step Model of Thymic Regulatory T Cells Development
	Lydia R. Durant, NIAMS, National Institutes of Health STAT3 Promotes Pathogenic T Cell Development in a Mouse Model of Colitis
	Noriko Komatsu, RIKEN Research Center for Allergy and Immunology Heterogeneity of Natural Foxp3+ T Cells: A Committed Regulatory T Cell Lineage and an Committed Minor Subpopulation Retaining Developmental Plasticity
	Alexander Georg Scheffold, Miltenyi Biotec Notch Switches on IL-10 Production and Suppressive Activity in Th1 Cells
	Marc Beyer, University of Bonn Genome-Wide mRNA and miRNA Analysis Reveals Individual miRNA-Based Regulation of the Core Transcriptome Genes in Human Regulatory T Cells

	Marta Monteiro, Instituto de Medicina Molecular Acquisition of Foxp3 Expression and Regulatory Function by Invariant Natural Killer T Cells
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:30 PM	Pathways of Thymic and Peripheral Treg Development	Grays Peak / Longs Peak
	Ludger Klein, University of Munich, Institute for Immunology Determinants of Intrathymic Regulatory T Cell Development
	Harald von Boehmer, Harvard Medical School Prospective Tolerance by Inducing Foxp3+ Treg in Peripheral Lymphoid Tissue
	* Megan K. Levings, University of British Columbia The Role of FOXP3 in the Development and Function of Human T Regulatory Cells
	Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School Role of TGF-beta in Regulating the Balance between Pathogenic and Regulatory T Cells
	Lin Chen, University of Southern California Short Talk: Crystal Structure of the NFAT1:FOXP3: DNA Complex Reveals New Insights into the Function of FOXP3 in Regulatory T Cells
7:30 - 8:30 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 1	Quandary 1-3
Tuesday, March 3
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Inducible Regulatory T Cells	Grays Peak / Longs Peak
	* Anne O'Garra, National Institute for Medical Research IL-10 and Immunoregulation
	Catherine M. Hawrylowicz, King's College London IL-10 Secreting T Regulatory Cells in Allergy and Asthma
	Dragana Jankovic, NIAID, National Institutes of Health Highly Polarized Th1 Cells as Regulatory T Cells
	Wanjun Chen, NIDCR, National Institutes of Health Role of TGF-beta in Induction and Survival of Treg Cells
	Monica Froicu, Yale University Short Talk: Therapeutic Effects of CD45RB Ligation on Experimental Colitis
	Rachel A. Gottschalk, Memorial Sloan Kettering Cancer Center Short Talk: TCR Signal Strength in the Peripheral Conversion to CD4+Foxp3+ Regulatory T Cells in vivo
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 2: Mechanisms	Grays Peak / Longs Peak
	* Fiona M. Powrie, University of Oxford
	Andy Hurwitz, National Cancer Institute, Frederick Prostatic Tumors Induce CD8+ T Cells to Become Suppressor Cells

	Robert N. Barker, University of Aberdeen A New Role for Soluble CTLA-4 as a Potent Inhibitory Mediator Secreted by Antigen Stimulated CD4+ Regulatory T Cells
	Derese Getnet, Johns Hopkins School of Medicine A Role for Helios in Induced Regulatory T Cells
	Ashley E. Martin, University of California, San Francisco Regulatory T Cells Impede Autoimmune Diabetes by Modulating Dendritic Cell Maturation in Inflamed Islets
	Ann Lauren Jagger, University of Georgia CD4+CD25+Foxp3+ Regulatory T Cells Cooperate with CD4+CD25- Effector T Cells to Restore Immune Homeostasis
	Carla M. Cuda, University of Florida Pbx1 Plays a Role in Controlling the Level of Tregs in the Periphery
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Local Control by Treg	Grays Peak / Longs Peak
	Fiona M. Powrie, University of Oxford Immune Regulation in the Gut
	* Juan J. Lafaille, New York University School of Medicine Control of Gut Homeostasis by Induced Treg
	Rachel R. Caspi, NEI, National Institutes of Health Immune Privilege, Tregs and Autoimmunity

7:15 - 8:15 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 2	Quandary 1-3
Wednesday, March 4
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Treg in Infectious Diseases/Hygiene Hypothesis	Grays Peak / Longs Peak
	Yasmine Belkaid, NIAID, National Institutes of Health Plasticity of Regulatory T Cells during Infections
	* Richard M. Maizels, University of Edinburgh Treg Induced by Helminths
	Craig L. Maynard, University of Alabama at Birmingham Short Talk: Contrasting Roles for All-Trans Retinoic Acid in TGF-beta-Mediated Induction of Foxp3 and Il10 Genes in Developing Regulatory T Cells
	Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard Immune Regulation of HIV Infection
	Eleanor M. Riley, London School of Hygiene and Tropical Medicine T Cell-Mediated Immunoregulation during Human and Murine Malaria Infections

9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 3: Targets	Grays Peak / Longs Peak
	* Yasmine Belkaid, NIAID, National Institutes of Health
	Linda Wammes, Leiden University Medical Center Helminth Infections Induce Spill-Over Suppression by Foxp3+ Regulatory T Cells in Rural Indonesia
	Eva Bjur, McGill University Control of Anti-Tumor Immunity by CD4+FOXP3+ Regulatory T Cells in Tumor Microenvironments
	Fulvia Vascotto, Harvard Medical School Role of Treg during NK Cell Mediated CHS Response
	Jason A. Chesney, University of Louisville Transient Treg Depletion Causes Regression of Metastases in Stage IV Melanoma Patients
	Markus Kleinewietfeld, Max Delbrueck Center for Molecular Medicine ‘Untouched’ Human Foxp3+ Treg for Clinical Therapies
	Hongbo Chi, St. Jude Children's Research Hospital A Mechanism for the Reversal of Regulatory T Cell Activity to Facilitate Lymphocyte Priming
	Mark Claassen, Erasmus MC - University Medical Center Rotterdam Role of Multiple Human Regulatory T Cell Populations in Controlling Peripheral Blood and Liver Immunity to Hepatitis C Virus Infections
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Targets and Mechanisms of Suppression	Grays Peak / Longs Peak
	Shimon Sakaguchi, Institute for Frontier Medical Sciences, Kyoto University Construction of Treg without Foxp3: Key Roles of CTLA-4 and IL-2
	* Ethan M. Shevach, NIAID, National Institutes of Health Control of Immune Responses by Natural and Adaptive Regulatory T Cells

	Dario A.A. Vignali, St. Jude Children's Research Hospital The Mechanism of Regulatory T Cell Function

	Olaf Rötzschke, Singapore Immunology Network (SIgN) Effector/Memory Treg Cells (TREM): Extracellular ATP and Immune Suppression
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 3	Quandary 1-3
Thursday, March 5
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Treg Homeostasis and Survival	Grays Peak / Longs Peak

	Talal A. Chatila, University of California, Los Angeles Dual Requirement for Natural and Induced Regulatory T Cells in Peripheral Tolerance
	Daniel Campbell, Benaroya Research Institute T-bet Controls Regulatory T Cell Homeostasis and Function during Type-1 Inflammation
	* Arne N. Akbar, University College London The Kinetics of CD4+Foxp3+ T Cell Accumulation during a Human Cutaneous Antigen-Specific Memory Response in vivo
	Benoit L. Salomon, University Pierre et Marie Curie Short Talk: Effector T Cells Limit Their Own-Pathogenicity by Activating Regulatory T Cells
	Michael A. Farrar, University of Minnesota Short Talk: Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire
	Soyoung Oh, University of Pennsylvania Short Talk: Effect of TCR Specificity on the in vivo Function of CD4+CD25+ Regulatory T Cells in an Autoimmune Setting
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Treg Antigen Specificity/ Treg Homeostasis and Survival	Grays Peak / Longs Peak
	* Kingston H. G. Mills, Trinity College Dublin Immunotherapeutic Approaches Based on Manipulating Treg versus Th17 Cells
	Maria Grazia Roncarolo, San Raffaele Telethon Institute for Gene Therapy Therapeutic Aspects of Naturally Occurring and Adaptive Regulatory T Cells
	Matthias Edinger, University Hospital Regensburg Treg Cells in Allogeneic Stem Cell Transplantation

	Samantha Bailey-Bucktrout, UCSF Medical School Short Talk: T Regulatory Cell Instability Generates Pathogenic Memory T Cells in vivo
	Clare M. Baecher-Allan, Brigham and Women's Hospital, Harvard Medical School Short Talk: Differential Suppression by Human Treg Subsets and the Role of Granzyme B
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Quandary 1-3
8:00 - 11:00 PM	Entertainment	Quandary 1-3
Friday, March 6
	Departure

*Session Chair †Speaker invited, not yet responded.