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B Cells in Context (C3)

Organizer(s): Ann Marshak-Rothstein, Michael P. Cancro and Mark S. Schlissel
February 24 - March 1, 2009
Taos Convention Center (meeting only)  ·  Taos, New Mexico
Abstract Deadline: October 22, 2008
Late Abstract Deadline: November 25, 2008
Scholarship Deadline: October 22, 2008
Early Registration Deadline: December 29, 2008


Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.



This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
B lymphocytes play critical roles in immune responses by producing antibodies that eliminate pathogens, presenting antigens to T cells and secreting regulatory cytokines. B cells develop from hematopoietic precursors through stochastic and directed molecular events that include DNA rearrangements, epigenetic changes, and transcriptional regulation. Further differentiation is controlled by environmental factors that include interactions with hematopoietic and non-hematopoietic cells, pathogenic and non-pathogenic microorganisms, and a broad range of cytokines and chemokines. The B cell receptor repertoire is purged of self-specificity at multiple checkpoints prior to entrance into primary or memory pools. Failures in these processes can lead to autoimmune disease and lymphoid malignancy. These events involve highly choreographed cell-cell interactions and migratory behaviors. The goal of this meeting will be to ask how the various B cell microenvironments regulate the molecular events that determine B cell fate and function, and to explore how manipulation of the microenvironment can impact the immune response, autoimmunity, transformation and vaccine development.

Tuesday, February 24
3:00 - 7:30 PM Registration Rio Grande D
6:30 - 7:30 PM Refreshments Rio Grande
7:30 - 8:30 PM Keynote Address Bataan
Klaus Rajewsky, PCMM, Children's Hospital Boston, Immune Disease Institute
Signaling Life and Lifestyle through the BCR
Wednesday, February 25
7:00 - 8:00 AM Breakfast Rio Grande
8:00 - 11:15 AM Lineage Commitment and BCR Generation Bataan
Harinder Singh, University of Chicago
A Recurring Gene Regulatory Network that Orchestrates Myeloid Versus B Cell Fate Choice
Christian Kosan, Institut de Recherches Cliniques de Montréal (IRCM)
Short Talk: The POZ Domain Transcription Factor Miz-1 (Zbtb17) is Required for B Cell Lineage Commitment and Indispensable for the Formation of Mature Follicular B Cells
Hassan Jumaa, Max Planck Institute for Immunobiology
Role of the Pre-BCR and BCR in Early B Cell Development
Marjorie A. Oettinger, Massachusetts General Hospital
RAG2 Links Histone Methylation and VDJ Recombination
David G. Schatz, Yale University School of Medicine
Short Talk: Focal Binding of RAG1 and RAG2 to Antigen Receptor loci Defines V(D)J "Recombination Centers"
* Mark S. Schlissel, University of California, Berkeley
A Role for NF-kB in Receptor Editing
9:20 - 9:40 AM Coffee Break Rio Grande B/C
11:15 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Rio Grande
1:00 - 10:00 PM Poster Viewing Rio Grande
2:00 - 4:30 PM Workshop 1: What Targets the lgH/lgL Loci for VDJ Recombination, CSR, and SHM? Don Fernando Hall
* F. Nina Papavasiliou, Rockefeller University
* Michel C. Nussenzweig, Rockefeller University
Workshop 1A: AID Targeting (Cis and Trans-acting Elements)
Sebastian D. Fugmann, National Institute of Aging, National Institutes o
Identification of Cis-Regulatory Elements Targeting AID-Mediated Sequence Diversification to the Chicken Immunoglobulin Light Chain Gene
Barbara K. Birshtein, Albert Einstein College Of Medicine
Active DNA Demethylation in the Immunoglobulin Heavy Chain 3’ Regulatory Region during Class Switch Recombination Involves GADD45A
Rebecca K. Delker, Rockefeller University
Elucidating the Mechanism of Specificity Achieved by Activation Induced Cytidine Deaminase
Urszula Nowak, Weill Cornell Graduate School of Medical Sciences
AID in Class Switch Recombination
Kevin M. McBride, Rockefeller University
Identification of AID Interacting Proteins
Anne Durandy, Hôpital Necker-Enfants Malade
Human PMS2 Deficiency is Associated with Impaired Immunoglobulin Class Switch Recombination
Jing Wang, Immune Disease Institute
Mechanistic Factors That Promote Recurrent Translocations in Peripheral B Lymphocytes
Workshop 1B: RAg Interactions, VDJ Recombination and Allelic Exclusion
Moshe J. Sadofsky, Albert Einstein College Of Medicine
A New Protein Interaction Motif in the Rag1 N-Terminal Domain
Jane A. Skok, New York University School of Medicine
Recombinase-Dependent Homologous Pairing of Ig Alleles: A Novel Regulatory Aspect of Allelic Exclusion
Laurel A. Eckhardt, Hunter College of CUNY
A Role for the IgH Intronic Enhancer, Eu, in Enforcing Allelic Exclusion
2:30 - 4:30 PM Workshop 2: Dysregulated B Cells in Autoimmunity Council Chambers
* Peter E. Lipsky, NIAMS, National Institutes of Health
* John F. Kearney, University of Alabama at Birmingham
Michelle L. Harris, Yale University School of Medicine
APRIL Promotes AM14 Rheumatoid Factor B-Cell Activation and Maturation
Andrea Bottaro, University of Rochester School of Medicine and Dentistry
Accumulation and Relocation of B Cells in the Popliteal Lymph Nodes of TNF-Transgenic Mice Accompanies Development of Knee Arthritis
Sarah R. Fintushel, University of Pennsylvania
B Cell Recirculation through Skin
Tineke Cantaert, Academic Medical Center
Ectopic Lymphoid Neogenesis is not Functionally Competent to Drive Humoral Autoimmunity in Rheumatoid Synovitis
Julie Kujawa, Biogen Idec
Abnormalities in Lymphoid Subsets and Architecture Associated with the Onset of Autoimmunity in an Interferon-Accelerated Murine Lupus Model
Magdalena A. Berkowska, Erasmus MC
Molecular Analysis of Human Memory B-cell Subsets Suggests Different Origins and Maturation Pathways
2:30 - 4:30 PM Workshop 3: Computation and Mathematical Modeling in the Study of B Cell Biology Bataan
* Ramit Mehr, Bar-Ilan University
B Cell Immunomics - From Analyzing Single Mutations to Modeling Cell Populations
Andrew M. Collins, University of New South Wales
Immunoglobulin Sequences of Different Isotypes and from Patients with Different Diseases Show Distinct Patterns of Somatic Point Mutation
Ying Li, University of Chicago
Gene Regulatory Model for B Cell Fate Specification
Yoram Louzoun, Bar Ilan University
Autoantibody Repertoire Shift as Early Clinical Marker of Cancer
Kamila Karolina Matulewicz, University Hospital of Georg August University
Dissecting the Molecular Events in Burkitt’s Lymphoma
Michael Meyer-Hermann, Frankfurt Institute for Advanced Studies (FIAS)
Coherent Data, Divergent Interpretations: Mathematical Modeling Clarifies the Interpretation of Two-Photon Imaging Data of Germinal Centers
Jamie L. Duke, Yale University
Computational Modeling of Genome-Wide Targeting of Somatic Hypermutation
Tom Kepler, Duke University
Adjuvants and the Reorganization of Leukocytes in Humoral Immunity: A Computational Systems Approach
4:30 - 5:00 PM Coffee Available Rio Grande B/C
5:00 - 7:00 PM Selection and Survival of Primary B Cells Bataan
John F. Kearney, University of Alabama at Birmingham
Primary B Cell Repertoire Determination
Sarah F. Andrews, University of Chicago
Short Talk: Transitional B Cells Exhibit a BCR-Specific Nuclear Defect in Gene Transcription
Shiv Pillai, Massachusetts General Hospital
The role of a 9-O sialylacetylesterase in peripheral B cell development and autoimmunity
* Michael P. Cancro, University of Pennsylvania
Molecular and Cellular Cross-Talk in the Actions of BLyS Ligands and Receptors
7:00 - 8:00 PM Social Hour w/ Lite Bites Rio Grande
7:30 - 10:00 PM Poster Session 1 Rio Grande
Thursday, February 26
7:00 - 8:00 AM Breakfast Rio Grande
8:00 - 11:15 AM Differentiation Decisions Bataan
Robert C. Rickert, Burnham Institute for Medical Research
Short Talk: Distinct Roles for Foxo1 at Multiple Stages of B Cell Differentiation
Eric Meffre, Yale University School of Medicine
Autoreactive B Cell Counterselection in Humans
* Mark J. Shlomchik, Yale University School of Medicine
Activating autoreactive B Cells: Roles of T cells, Tolls and Time
Stephen C. Jameson, University of Minnesota Medical School
Short Talk: KLF2 Deficiency dysregulates multiple B Cell Subsets
Jean-Claude Weill, INSERM
Multiple Layers of B cell memory with different effector functions
David M. Tarlinton, Walter and Eliza Hall Institute of Medical Research
Molecular Regulation of Memory
9:20 - 9:40 AM Coffee Break Rio Grande B/C
11:15 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Rio Grande
1:00 - 10:00 PM Poster Viewing Rio Grande
2:00 - 4:30 PM Workshop 4: What is B Cell Memory? How are Cells Committed to Memory or Plasma Cell Differentiation? Don Fernando Hall
* Ian C.M. MacLennan, University of Birmingham
Workshop 4A: Commitment to Germinal Center of Plasmablast Differentiation
Daniel James Hodson, Babraham Institute
The RNA Binding Protein TIS11b is Expressed in the Germinal Centre and Suppresses Immune Regulatory Genes
Shinu A. John, University at Buffalo, State University of New York
ETS-1 Plays a Unique and Non-Redundant Role in Inhibiting Blimp-1 Activity and Preventing Plasma Cell Differentiation
B. Hilda Ye, Albert Einstein College Of Medicine
STAT3 and NF-kappaB Synergistically Promote Plasma Cell Differentiation Through Upregulation of IRF4 and Blimp-1
Tyani D. Chan, Garvan Institute of Medical Research
In vivo Dynamics and Affinty Regulation of Early T-dependent B Cell Responses
Workshop 4B: B Cell Memory
Jeremy Foote, University of Alabama at Birmingham
Generation of B cell memory to the TI-2 antigen a 1.3-dextran
Eliver Eid Bou Ghosn, Stanford University
Novel Properties of B-1 Memory
Ismail Dogan, Hôpital Necker
B Cell Memory Subsets
Kim Good, Yale University
Role of PD-1 in Memory B Cell Formation and Responses
Workshop 4C: The Regulation of Plasmblast Maturation and Survival
Sefat Khuda, University of Virginia
Deregulated c-Myc Negatively Controls B Cell Immunity
Bimba Franziska Hoyer, Charité University Medicine
Bimba Franziska Hoyer, Charité University Medicine
Dong-Mi Shin, NIAID, National Institutes of Health
Interferon Regulatory Factor 6 (IRF6) Influences Late B Cell Differentiation
Selina Chen-Kiang, Weill Medical College of Cornell University
The Cdk4/6 Inhibitor p18INK4c Targets Rapidly Cycling and Apoptotic Plasma Cell Precursors for Homeostatic Control of Terminal Plasma Cell Differentiation
2:30 - 4:30 PM Workshop 5: Interactions between B Cells and the Innate Immune System Bataan
* Silvia Bolland, NIAID, National Institutes of Health
* Gregg J. Silverman, University of California, San Diego
VH Inheritance Determines Apoptotic Cell Neo-Antigen Recognition by Antibodies that Regulate Phagocytosis and Inflammatory Responses by Immature Dendritic Cells
Elizabeth A. Leadbetter, Brigham and Women's Hospital
Characterizing iNK T and B Cell Memory Responses to Lipid Antigen
Marcus R. Clark, University Of Chicago
Endocytic Sequestration of the B Cell Antigen Receptor and Toll-like Receptor 9 in Anergic Cells
Rebecca Anne Sweet, Yale University
Extrafollicular Activation of Autoreactive RF B Cells Leads to Memory B Cell Development
John H. Kehrl, NIAID, National Institutes of Health
Toll-Like Receptor 4 Signaling Augments B lymphocyte Migratory and Proliferative Programs, and Overcomes the Restriction that Limits Access to the Dark Zones of Germinal Centers
Almut Meyer-Bahlburg, Seattle Children's Research Institute
Reduced c-myc Expression Levels Limit Follicular Mature B Cell Cycling in Response to TLR Signals
Lenka L. Allan, University of British Columbia
Apolipoprotein-mediated Lipid Antigen Presentation in B cells
2:30 - 4:30 PM Workshop 6: Regulating B Lineage Specification and Commitment Council Chambers
* Ranjan Sen, National Institute of Aging, National Institutes of Health
* Shiv Pillai, Massachusetts General Hospital
John David Colgan, University of Iowa
The Justy Mutation Identifies the Gon4L Gene as an Essential regulator of B Cell Development
Qi Yang, University of Pittsburgh
E47 Controls the Developmental Integrity and Cell Cycle Quiescence of Multipotential Hematopoietic Progenitors during Progression to B Lineage
James R. Hagman, National Jewish Medical and Research Center
Combined Haploinsufficiency of Ebf1 and Runx1 Genes Impedes B Cell Lineage Progression and Identity
Stephen L. Nutt, Walter and Eliza Hall Institute
Myb Is Critical For Early B Cell Development
Hans-Willem E. Snoeck, Mount Sinai School of Medicine
Differential Specification of Lymphoid Progenitor Populations to Distinct B Cell Development Programs
Jane Seagal, Immune Disease Institute
Developmental Plasticity of Mature B Cell Populations
David M. Allman, University of Pennsylvania
Unique Requirement for AKT1 and AKT2 in Marginal Zone B Cell Development
4:30 - 5:00 PM Coffee Available Rio Grande B/C
5:00 - 7:00 PM B Cell Activation and Regulation Bataan
Susan K. Pierce, NIAID, National Institutes of Health
A “conformation-induced oligomerization” Model for the Initiation of B cell receptor signaling
Michael Reth, Max Planck Institute for Immunobiology
BCR Signaling Pathways: From Autoinhibition to Activation
Thomas L. Rothstein, Feinstein Institute for Medical Research
Short Talk: Reprogramming BCR Signaling through Receptor Crosstalk
* Ann Marshak-Rothstein, University of Massachusetts Medical School
Modulation of autoreactive B cell responses by IFNbeta and BCR engagement
7:00 - 8:00 PM Social Hour w/ Lite Bites Rio Grande
7:30 - 10:00 PM Poster Session 2 Rio Grande
Friday, February 27
7:00 - 8:00 AM Breakfast Rio Grande
8:00 - 11:00 AM B Cell Niches, Contacts, and Effector Function Bataan
Rita Carsetti, Bambino Gesù Children Hospital
Mucosal B Cell Ontogeny in Mouse and Man
Nicole Baumgarth, University of California, Davis
Short Talk: B cells in the context of Influenca
Michael C. Carroll, Immune Disease Institute/Harvard
Short Talk: Directed Trafficking of Chemokines and Small Antigens into LNs via Follicular Conduits
Shiv Pillai, Massachusetts General Hospital
Interlude
* Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Berlin
Plasma Cell Niches and Dynamics
Frances E. Lund, University of Rochester Medical Center
Effector B Cell Subsets: Multiple antibody independent roles for B cells in immunity
Louis B. Justement, University of Alabama, Birmingham
Short Talk: Cross-Talk between Marginal Zone B Cells and Marginal Zone Macrophages
9:20 - 9:40 AM Coffee Break Rio Grande B/C
11:00 AM - On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Rio Grande
1:00 - 10:00 PM Poster Viewing Rio Grande
2:30 - 4:30 PM Workshop 7: Unique Aspects of Mucosal Immunity Don Fernando Hall
* Katherine L. Knight, Loyola University Chicago
SangKon Oh, Baylor Research Institute
A T Cell-Dependent Mechanism for the Induction of Human Mucosal Homing IgA-Secreting Plasmablasts
Douglas A. Kuperman, Northwestern University
Secretory IgA is Increased in the Airways of 12/15-lipoxygenase Deficient Mice
Bertrand Huard, Centre Medical Universitaire
Neutrophils Create Survival Niches Rich in APRIL for Plasma Cells
Henrik E. Mei, German Rheumatism Research Center
Blood-borne Human Plasma Cells are Derived from Mucosal Immune Responses and are Refractory to Therapeutic B Cell Depletion
Hyemee Joo, University of Tennessee
The State of B Cell Memory in the Lung is Profoundly Influenced by the Nature of Immunization
Kristina Rothaeusler, California National Primate Research Center
Evidence for Extrafollicular Foci-derived Self-renewing Lung Tissue Plasma Cells following Influenza Virus Infection
* Troy D. Randall, University of Rochester Medical Center
Milky Spots in the Omentum Independently Support T-dependent B Cell Responses to Peritoneal Antigens
Wojciech Wojciechowski, University of Rochester
TNF-alpha Producing B Cells are Involved in the Generation of Protective Immunity against Intestinal Nematode Parasite Heligmosmoides Polygyrus
Venkata A. Yeramilli, Loyola University Chicago
B Lymphocyte Development in GALT
2:30 - 4:30 PM Workshop 8: Integrating Signaling Cascades Council Chambers
* Thomas L. Rothstein, Feinstein Institute for Medical Research
* Robert T. Woodland, University of Massachusetts Medical School
Introduction
Kevin L. Otipoby, Immune Disease Institute
BCR Expression Regulates Gsk3 activation, c-Myc Protein Levels and B Cell Proliferation
Josquin Nys, National Institute for Medical Research
to provide comment for above presentation
Shannon O'Neill, University of Colorado Denver & National Jewish Health
Monophosphorylation of the Igá ITAM Initiates an Inhibitory Cascade Required for B Cell Anergy
Lenka Teodorovic, National Jewish Health
to provide comment for above presentation
H. Christine Patterson, Immune Disease Institute
Negative Regulation of B Cell Antigen Receptor Signaling Strength by Ig Alpha Serine/Threonine Phosphorylation Inhibits Poly- and Autoreactive Plasma Cell Formation
Corinne Lara DePersis, University of Colorado Health Science Center
to provide comment for above presentation
Sarah Rowland, University of Colorado Denver & National Jewish Health
Suboptimal BCR Levels and Tonic BCR Signals Prevent Differentiation of Immature B Cells
Nichol E. Holodick, Boston University School of Medicine
to provide comment for above presentation
Bazarragchaa Damdinsuren, National Institute on Aging, National Institutes of Health
Functional Consequences of Single Round Antigen Receptor Signaling in Naïve B Cells
2:30 - 4:30 PM Workshop 9: Epigenetic Regulation and microRNA Control Bataan
* Ann J. Feeney, The Scripps Research Institute
* Rafael Casellas, NIAMS, National Institutes of Health
Sergei B. Koralov, Harvard University
Role of miRNAs in B Cell Development
Stefan Kuchen, National Institutes of Health
A Systems Approach Using Genome-Wide Small RNA Profiling for Studying B Cell Development, Activation, and Differentiation
Giuseppe Testa, European Institute of Oncology
Functional Dissection of Histone Lysine Methylation in B Cell specification
Marieta Caganova, FIRC Institute of Molecular Oncology Foundation
The Role of the Polycomb Group Protein Ezh2 in Adaptive B Cell Immunity and Terminal Differentiation
Ramesh Subrahmanyam, National Institute on Aging, National Institutes of Health
Rearrangement Associated Epigenetic Changes Distinguish DJH Junctions for VH Recombination
Chaggai E. Rosenbluh, Hebrew University Medical School
Epigenetic Regulation - A Key Mediator of Allelic Exclusion
Zhixin Zhang, University of Nebraska Medical Center
Association with the Nuclear Matrix is Essential for Pax5 to Fully Activate its Target Genes in Murine Pro B
Julita A. Ramirez, National Jewish Health
Opposing Effects of Swi/Snf and Mi-2 NuRD Chromatin Remodeling Complexes on Epigenetic Reprogramming by EBF and Pax5
4:30 - 5:00 PM Coffee Available Rio Grande B/C
5:00 - 7:15 PM B Cells on the Move Bataan
Facundo D. Batista, London Research Institute, Cancer Research UK
Early events in B cell response to antigen
Jason G. Cyster, University of California, San Francisco
Dynamics of B Cell Antigen Encounter
* Ronald N. Germain, NIAID, National Institutes of Health
Visualizing the Cell-Cell Interactions Underlying Humoral Immune Responses
Marc K. Jenkins, University of Minnesota Medical School
Analysis of Antigen-Specific Memory B Cell Formation in Normal Mice
7:00 - 8:00 PM Social Hour w/ Lite Bites Rio Grande
7:30 - 10:00 PM Poster Session 3 Rio Grande
Saturday, February 28
7:00 - 8:00 AM Breakfast Rio Grande
8:00 - 11:30 AM Therapeutic Manipulation of B Cell Subsets Bataan
Jennifer Howitt Anolik, University of Rochester
B Cell Subsets Targeted by Rituximab: Understanding Clinical and Immunological Outcomes After B Cell Depletion in Autoimmune Disease
* Hergen Spits, Genentech
Immortalization of BCR+ Antibody Producing Human B Cells by Genetic Programming
Jacques F. Banchereau, Baylor Institute for Immunology Research
Development of B Cell Targeted Vaccines
Barton F. Haynes, Duke University Medical Center
Induction of B Cell Polyclonal Differentiation and Apoptosis With Massive Gastrointestinal Tract Germinal Center Loss In the Earliest Stages of HIV-1 Infection
Kenneth K. Yu, California Institute of Technology
Short Talk: Engineering Immunity Against HIV: A Stem Cell Vaccine
Meinrad Busslinger, Research Institute of Molecular Pathology
Pax5 in Normal and Neoplastic B Cell Development
Geetha P. Bansal, NIAID, National Institutes of Health
Short Talk: Update on NIAID Funding Opportunities
9:20 - 9:40 AM Coffee Break Rio Grande B/C
11:00 AM - On Own for Lunch
2:30 - 4:30 PM Workshop 10: Targeted Vaccine Strategies for Chronic Infection Don Fernando Hall
* Nancy L. Haigwood, Oregon Health and Science University
Workshop 10A: B Cells and Non-HIV Infections
Filiz Demircik, Uniklinik
The Role of B Cells in Murine Cytomegalovirus (MCMV) Infection
Denise A. Kaminski, University of Rochester
Nucleoprotein-Immune Antibody Protects Against Influenza Virus by a T Cell-Mediated Mechanism
Shane Crotty, La Jolla Institute for Allergy and Immunology
Characterization of Protective B Cell Responses to Vaccinia virus, the Smallpox Vaccine, and Generation of Protective Human Monoclonal Antibodies
Workshop 10B: B Cells and HIV Infections
Julien van Grevenynghe†, Pavillon Edouard Asselin
Depletion of Peripheral CD19+CD27+ Memory B-cells from HIV-Infected Individuals is Associated with FOXO3a Activation
Oluwadamilola Unuigbe, Malawi-Liverpool Wellcome Trust
The Loss of B Cell Memory to Pneumococcal Protein Antigens in Malawian Children during HIV Infection
Rogier W. Sanders, Weill Medical College of Cornell University
Enhancing the Immunogenicity of HIV-1 Envelope Glycoprotein Trimers by Fusion to CD40 Ligand
Mattias Forsell, Karolinska Institutet
Direct Interaction of a Viral Surface Protein with its Primary Receptor is Required for B Cell Receptor Recognition of a Conserved Co-Receptor Binding Surface.
2:30 - 4:30 PM Workshop 11: Drug Targets for Immune Modulation Council Chambers
* John G. Monroe, Genentech, Inc.
Inbal Binsky, Weizmann Institute
CD74 Induces the Expression of TAp63, which Regulates B-CLL Survival and Migration to the Bone Marrow
* Lisa Borghesi, University of Pittsburgh
Targeted Knockdown of the B Lineage Transcriptional Activator E2A in B Cell Chronic Lymphocytic Leukemia (CLL) Enhances Lenalidomide Sensitivity and Regulates Cellular Proliferation
Bridget S. Wilson, University of New Mexico School of Medicine
Select gamma-Secretase Inhibitors Induce Apoptosis in Pre-B ALL Cells and Disrupt the Balance between Constitutive Notch Signaling and Repression
Laura R. Wasil, Graduate School of Public Health
Immortalization of B Cells by Epstein-Barr Virus Requires both the Products of the Latent Membrane Protein 2 Gene
Geetha Chalasani, University of Pittsburgh
B Cells Promote Development of Alloreactive Memory T Cells
Peggy L. Kendall, Vanderbilt University Medical Center
Bruton’s Tyrosine Kinase Deficiency Ameliorates Type 1 Diabetes
Yue Wang, MedImmune Inc
An Afucosylated Anti-human-CD19 Antibody Exhibits Potent Depletion of Bone Marrow and Peripheral B Cells in Mice
Chung Park, NIAID, National Institutes of Health
B Lymphocytes Exit Lymph Nodes through Cortical Lymphatic Sinusoids Near to Lymph Node Follicles by a Mechanism Independent of S1P-Mediated Chemotaxis
2:30 - 4:30 PM Workshop 12: Human B Cell Subsets in Health and Disease Bataan
* Iñaki E. Sanz, University of Rochester
Santi Suryani, Garvan Institute of Medical Research
Characterisation of Human Transitional B cell Subsets
Panida Sriaroon, University of South Florida
Memory CD27+ B220- B Cell Subpopulation is Decreased in Human Immunodeficiency Virus Disease (HIV) on Therapy, Common Variable Immune Deficiency (CVID) and Systemic Lupus Erythematosus (SLE)
Isabelle Isnardi, Hospital for Special Surgery
Defective Receptor Editing Results in the Appearance of Anergic B cells in Humans
Jonathan Michael Irish, Stanford University
Abnormal B cell Receptor Signaling in a Subset of Lymphoma B cells Distinguishes Follicular Lymphoma Patients with Poor Clinical Outcomes
Isabelle Bekeredjian-Ding, University of Heidelberg
Immunostimulatory DNA ODN and BAFF/BlyS Selectively Target Human IgM+ B cell Subsets
Patrick C. Wilson, University of Chicago
A Memory Compartment Origin for Early Antibody-Secreting B cells during the Anti-Influenza Vaccine Response
4:30 - 5:00 PM Coffee Available Rio Grande B/C
5:00 - 7:15 PM Transformation Bataan
Jeffrey L. Browning, Biogen Idec, Inc.
Blockade of the Lymphotoxin-LIGHT Pathway and the Treatment of Autoimmune Disease
Jing Wang, Immune Disease Institute
Short Talk: DNA double strand breaks, translocations, and B cell lymphoma
* Rafael Casellas, NIAMS, National Institutes of Health
AID tumorigenic activity
Lin He, University of California, Berkeley
Mir17-92 as a putative oncogene for B cell lymphomas
7:15 - 8:15 PM Social Hour w/ Lite Bites Rio Grande
8:15 - 11:00 PM Entertainment Rio Grande
Sunday, March 1
Departure
*Session Chair   †Speaker invited, not yet responded.



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