| Sunday, March 29 |
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3:00 - 7:30 PM
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Registration
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Van Horne Foyer
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6:30 - 7:30 PM
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Refreshments
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Van Horne Foyer
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7:30 - 9:30 PM
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Keynote Session (Joint)
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Van Horne Ballroom
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Jenny P. Ting,
University of North Carolina at Chapel Hill
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Giorgio Trinchieri,
National Cancer Institute at Frederick
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Shizuo Akira,
Osaka University
TLRs and Inflammation
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Ira Mellman,
Genentech, Inc.
Cell Biology of Antigen Processing by Dendritic Cells
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| Monday, March 30 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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7:00 - 8:00 AM
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Poster Setup
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Mezzanine 2
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8:00 - 11:30 AM
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Phagocytosis and Antigen Presentation
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Van Horne Ballroom C, Shaughnessy/Beatty
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Ira Mellman,
Genentech, Inc.
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Sebastian Amigorena,
Institut Curie
A New Soluble Ligand of DCSign Present in Human Semen Inhibits HIV Trans-Infection of T Cells
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David G. Russell,
Cornell University
Reprogramming Phagosomal Function in Macrophages and Dendritic Cells
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Jose A. Villadangos,
Walter and Eliza Hall Institute
Antigen Presentation Specializations in the Dendritic Cell Network
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Romina Silvana Goldszmid,
CCR, NCI, National Institutes of Health
Short Talk: Host ER-Parasitophorous Vacuole Interaction Provides a Route of Entry for Antigen Cross-Presentation in Toxoplasma Infected Dendritic Cells
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Bali Pulendran,
Emory University
Modulating Vaccine Responses with Innate Immunity
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:30 AM - 12:30 PM
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Lunch
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Mezzanine 2
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12:00 - 2:30 PM
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Poster Session 1
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Mezzanine 2
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12:00 - 5:00 PM
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Poster Viewing
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 1: Antigen Presentation and T Cell Activation
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Van Horne Ballroom C
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Sebastian Amigorena,
Institut Curie
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Sofia Bogiatzi,
Institut Curie
Reciprocal Inhibition of the TSLP and Th17 Immune Pathways
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Anuradha Ray,
University of Pittsburgh School of Medicine
Dual c-kit-Stem Cell Factor Upregulation by Allergens in Dendritic Cells Promotes IL-6 but Limits IL-12 Impacting T Helper Cell Differentiation and Allergic Asthma
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Thomas Duhen,
Institute for Research in Biomedicine
Identification and Characterization of IL-22-Only Producing CD4+ T Cells: Role of Plasmacytoid DC for their Differentiation
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Guillaume Hoeffel,
Massachusetts General Hospital
HIV Antigen Crosspresentation Pathways from Apoptotic, Infected CD4+ T Cells, in Plasmacytoid Dendritic Cell
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Roger V. Belizaire,
Washington University in St. Louis
Exogenous Antigen Enters the Major Histocompatibility Complex (MHC) Class I Processing and Presentation Pathway via Multiple Endocytic Compartments with Distinct Molecular and Proteolytic Requirements
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Roberto A. Maldonado,
Harvard Medical School
Rapamycin- and TGFbeta-Treated Dendritic Cells Induce Tolerance and de novo Differentiation of Regulatory T Cells in vitro and in vivo
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Mireille H. Lahoud,
Walter and Eliza Hall Institute
Clec9A on the Surface of Dendritic Cells is a Dead Cell Recognition Molecule
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David Sancho,
CNIC-Spanish National Cardiovascular Research Centre
Identification of a Dendritic Cell Receptor that Couples Sensing of Necrosis to Immunity
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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DCs in Tolerance, Immunity, and T Cell Differentiation
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Van Horne Ballroom C, Shaughnessy/Beatty
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Bali Pulendran,
Emory University
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Daniel J. Cua,
Schering-Plough Biopharma
The IL-23/IL-17 Axis
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Yong-Jun Liu,
University of Texas MD Anderson Cancer Center
Thymic Stromal Lymphopoietin Program Dendritic Cells to Induce TH2 Inflammation through a Unique Set of Signal Codes
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Erica L. Granger,
Pennsylvania State College of Medicine
Short Talk: Persistence of MHC Class I-Restricted Antigen Presentation Following Acute Virus Infection Requires Direct and then Cross Presentation
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Vijay K. Kuchroo,
Brigham and Women's Hospital, Harvard Medical School
Tim-3 and Expansion of Regulatory Antigen Presenting Cells
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7:00 PM -
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On Own for Dinner
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| Tuesday, March 31 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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8:00 - 11:15 AM
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Dendritic Cell Precursors
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Van Horne Ballroom C, Shaughnessy/Beatty
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Gwendalyn J. Randolph,
Mount Sinai School of Medicine
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Carlos Ardavin,
National Center for Biotechnology
Monocyte-Derived Dendritic Cells
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Steffen Jung,
Weizmann Institute of Science
Probing Origins and in vivo Functions of Dendritic Cells
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Markus G. Manz,
Institute for Research in Biomedicine
Lymphoid-Organ Dendritic Cell Homeostasis in Steady-State and Inflammation
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Kang Liu,
Rockefeller University
Short Talk: Dendritic Cell Development and Homeostasis in vivo
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Boris Reizis,
Columbia University
Plasmacytoid Dendritic Cell Differentiation
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Florent Ginhoux,
Singapore Immunology Network
Short Talk: Flt3 and Id2-Dependent CD103+ DCs in Non-Lymphoid Tissues Form a Specific DC Lineage Related to Lymphoid CD8+ DCs
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Mezzanine 2
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1:00 - 10:00 PM
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Poster Viewing
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Mezzanine 2
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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Recent Advances
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Van Horne Ballroom C, Shaughnessy/Beatty
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Maria Rescigno,
European Institute of Oncology
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Dominique Kaiserlian,
INSERM-U851
Role of Liver Plasmacytoid DC in Oral Tolerance
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Yvette van Kooyk,
Vrije University Medical Center
Targeting of DC by Glycosylated Antigens
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Ana-Maria Lennon-Dumenil,
Institut Curie
Coordinated Regulation of Antigen Presentation and Dendritic Cell Migration
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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7:30 - 10:00 PM
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Poster Session 2
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Mezzanine 2
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| Wednesday, April 1 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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8:00 - 11:15 AM
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Dendritic Cells in Disease
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Van Horne Ballroom C, Shaughnessy/Beatty
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Yong-Jun Liu,
University of Texas MD Anderson Cancer Center
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Miriam Merad,
Mount Sinai Medical Center
Origin of Dendritic Cell Diversity Controls Tissue Immunity
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Gwendalyn J. Randolph,
Mount Sinai School of Medicine
Monocytes, Dendritic Cells, and their Migration in Atherosclerosis
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Jerry Aldridge,
St. Jude Children's Research Hospital
Short Talk: tipDCs — The Necessary Evil of Lethal Influenza Infection
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Maria Rescigno,
European Institute of Oncology
DCs in Intestinal Disease
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Giorgio Trinchieri,
National Cancer Institute at Frederick
TLR Signaling in DC: Lessons from Fibroblasts
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Vanja Sisirak,
INSERM U590 Centre Léon Berard
Short Talk: Breast Tumor Environment Alters Human Plasmacytoid Dendritic Cells Functions
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Mezzanine 2
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1:00 - 10:00 PM
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Poster Viewing
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 2: Systems Biology of Dendritic Cells
Supported by the Society for Mathematical Biology and the NIH-funded PRiME (Program for Research on Immune Modeling and Experimentation) Initiative
The immune system acts across multiple scales of space and time involving complex interactions and feedback. Computational modeling provides a framework to integrate observational data collected from multiple modes of experimentation and can provide insight into immune cell function in health and disease. Computational approaches have been increasingly applied to problems in immunology, providing methods that range from the inference of transcriptional programs to the prediction of drug treatment effects on viral dynamics. This workshop will cover recent advances and potential applications of computational modeling and methods to dendritic cells.
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Shaughnessy/Beatty
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Sonja I. Buschow,
Nijmegen Centre for Molecular Life Sciences
DC-ATLAS: Dissecting Signal Transduction in the Dendritic Cell with a Systems Biology Approach
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Laszlo Nagy,
University of Debrecen
Interrelated Nuclear Receptor Signaling Connects Lipids, the Genome and Immune Function in Dendritic Cells
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Uri Hershberg,
Yale University School of Medicine
Transcriptional Cascades in Dendritic Cells during Anti-Viral Responses
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Simeone Marino,
University of Michigan Medical School
Roles of Dendritic Cells in the Immune Response to Bacterial and Viral Infections
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Burkhard Ludewig,
Katonal Hospital St. Gallen
A Systems Immunological Approach to Plasmacytoid Dendritic Cell Function in Cytophatic Virus Infection
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Elodie Segura,
Walter and Elizabeth Hall Institute
Novel Functional Specialization of Dendritic Cell Subsets Revealed by Plasma Membrane Comparative Proteomic Analysis
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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Regulation of Type I Interferon Production
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Van Horne Ballroom C, Shaughnessy/Beatty
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Giorgio Trinchieri,
National Cancer Institute at Frederick
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Keiko Ozato,
NICHD, National Institutes of Health
Molecular Mechanism of Type I Interferon Transcription in Dendritic Cells
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Gunther Hartmann,
Universitätsklinikum Bonn
Ligands for RIG-I: Induction of IFN by siRNA
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Elina I. Zuniga,
University of California, San Diego
Short Talk: Persistent Virus Infection Inhibits Type I Interferon Production by Plasmacytoid Dendritic Cells to Facilitate Opportunistic Infections
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Wei Cao,
University of Texas MD Anderson Cancer Center
Short Talk: Identification of a Biological Ligand for Human Plasmacytoid Dendritic Cell Receptor ILT7
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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7:30 - 10:00 PM
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Poster Session 3
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Mezzanine 2
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| Thursday, April 2 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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7:00 - 8:00 AM
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Poster Setup
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Mezzanine 2
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8:00 - 11:15 AM
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PRRs in Dendritic Cells and Macrophages (Joint)
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Van Horne Ballroom
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Daniel Kastner,
National Institutes of Health
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Marco Colonna,
Washington University School of Medicine
A Novel Signaling Pathway for Myeloid Cells Proliferation and Survival
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Gordon D. Brown,
University of Aberdeen
Lessons form Dectin-1: Insights Into Chronic Fungal Infection
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Alan Sher,
NIAID, National Institutes of Health
Th1/Th2 Polarizing Functions of Dendritic Cells in the Immune Response to Parasites
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Christine A. Biron,
Brown University
Changing Access to STATs in the Regulation of Type 1 IFN Effects on Immune Cell Subsets
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Stephen M. Hedrick,
University of California, San Diego
Short Talk: FoxO3 Controls the Magnitude of T Cell Immune Responses by Modulating Dendritic Cell Function
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Nora A. Barrett,
Brigham and Women's Hospital
Short Talk: Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM - 12:00 PM
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Lunch
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Mezzanine 2
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12:00 - 2:30 PM
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Poster Session 4
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Mezzanine 2
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12:00 - 5:00 PM
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Poster Viewing
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 3: Differentiation, Trafficking and Function of DC
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Van Horne Ballroom C
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Gwendalyn J. Randolph,
Mount Sinai School of Medicine
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Aymeric Rivollier,
NIAID, National Institutes of Health
Monocytes are Precursors of F4/80highCD11cint Macrophage-Like Cells and CD11chighF4/80int Dendritic Cells in the Mouse Colon
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Michael D. Gunn,
Duke University Medical Center
Blood-derived Inflammatory Dendritic Cells in Lymph Nodes Stimulate Acute Th1 Immune Responses
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Guy Shakhar,
Weizmann Institute of Science
Visualizing DC Mobilization in the Skin of Live Mice Suggests how DCs Travel Inside Lymphatics and how Their Intravasation is Regulated
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Emma Lo Kuan,
Mount Sinai School of Medicine
DC Trafficking from Perinodal Adipose Tissues to Lymph Nodes
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Cherié L. Butts,
U.S. Food & Drug Administration
Regulation of Dendritic Cell Function by Progesterone
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Scott B. Drutman,
New York University School of Medicine
Mature Dendritic Cells Exhibit a Broad Capacity for Antigen Capture and Presentation that can be Modulated by their Distribution
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Marcin T. Kortylewski,
Beckman Research Institute, City of Hope
Stat3 Targeting in Dendritic Cells Eliminates a Major Brake for TLR9 Agonist-Based Immunotherapy
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Nicolas Chevrier,
Broad Institute
Large Non-Coding RNAs: New Players in the Toll-like Receptor Pathways
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 6:40 PM
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Dendritic Cells in Cancer and Cancer Therapy
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Van Horne Ballroom C, Shaughnessy/Beatty
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Ralph M. Steinman,
Rockefeller University
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Sebastian Amigorena,
Institut Curie
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Jacques F. Banchereau,
Baylor Institute for Immunology Research
Cancer Associated Dendritic Cells
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Guido Kroemer,
INSERM, U848, Institut Gustave Roussy
Immunogenic Cell Death for Optimal Anti-Cancer Chemotherapy
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Carl G. Figdor,
Radboud University Nijmegen Medical Centre / NCMLS
Human Plasmacytoid Dendritic Cells in Cancer and Cancer Therapy
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6:40 - 7:15 PM
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Concluding Remarks
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Van Horne Ballroom C, Shaughnessy/Beatty
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Ralph M. Steinman,
Rockefeller University
Dendritic Cells: Translating Innate to Adaptive Immunity to Help Discover Vaccines
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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8:15 - 11:00 PM
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Entertainment
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Mezzanine 2
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| Friday, April 3 |
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Departure
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