| Sunday, March 29 |
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3:00 - 7:30 PM
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Registration
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Van Horne Foyer
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6:30 - 7:30 PM
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Refreshments
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Van Horne Foyer
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7:30 - 9:30 PM
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Keynote Session (Joint)
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Van Horne Ballroom
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Jenny P. Ting,
University of North Carolina at Chapel Hill
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Giorgio Trinchieri,
National Cancer Institute at Frederick
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Shizuo Akira,
Osaka University
TLRs and Inflammation
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Ira Mellman,
Genentech, Inc.
Cell Biology of Antigen Processing by Dendritic Cells
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| Monday, March 30 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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7:00 - 8:00 AM
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Poster Setup
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Mezzanine 2
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8:00 - 11:15 AM
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TLRs - I
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Van Horne Ballroom A,B
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*
Siamon Gordon,
University of Oxford
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Bruce A. Beutler,
The Scripps Research Institute
Mutagenesis in the Analysis of Pathogen Sensing Pathways
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Luke A.J. O'Neill,
Trinity College Dublin
The IL-1 Receptor / Toll-Like Receptor Superfamily: 10 Years of Progress
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Ruslan M. Medzhitov,
Yale University School of Medicine
A Mechanism of an Allergen-Induced Immune Response
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Eicke Latz,
University of Massachusetts Medical School
Pattern Recognition + Nalp3 Inflammasome
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Sarah E. Ewald,
University of California, Berkeley
Short Talk: The Ectodomain of Toll-like Receptor 9 is Cleaved to Generate a Functional Receptor
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Markus G. Manz,
Institute for Research in Biomedicine
Short Talk: Human Bone Marrow Multipotent Mesenchymal Stromal Cells Sense TLR4-Agonists and Subsequently Enhance Myelopoiesis
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Stephanie C. Eisenbarth,
Yale University
Short Talk: Activation of Adaptive Immunity but not Th2 Differentiation by the Nalp3 Inflammasome
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM - 12:30 PM
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Lunch
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Mezzanine 2
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12:00 - 2:30 PM
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Poster Session 1
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Mezzanine 2
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12:00 - 5:00 PM
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Poster Viewing
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 1: TLR and Other Pathogen Sensors
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Van Horne Ballroom A,B
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Michael Carty,
Trinity College Dublin
Regulation of TRIF- dependent TLR Signaling by the Adaptor SARM
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Ping Zhang,
University of Alabama, Birmingham
TLR2-dependent Modulation of Osteoclastogenesis by Porphyromonas gingivalis
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Brendan J. Jenkins,
Monash Institute of Medical Research
Interplay between the Interleukin-6 Cytokine Family and Toll-like Receptors in Inflammation and Gastric Tumorigenesis
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Jaime Pascual,
Burnham Institute
Molecular Mimicry in Innate Immunity: Crystal Structure of a Bacteria TIR Virulence Factor
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Kathryn J. Moore,
New York University Medical Center
CD36 Ligands Promote Sterile Inflammation through Assembly of a TLR 4 and 6 Heterodimer
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Emily L. Lowe,
University of California, Cedars-Sinai Medical Center
TLR2 is Protective in Colitis-associated Colorectal Cancer
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Yue Guan,
University of Illinois at Urbana-Champaign
Human Toll-like Receptors 10 and 1 Share Common Mechanisms of Innate Immune Sensing but not Signaling
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Anca Dorhoi,
Max Planck Institute for Infection Biology
The Adaptor Protein CARD9 is Essential for Tuberculosis Control
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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TLRs - II
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Van Horne Ballroom A,B
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*
Luke A.J. O'Neill,
Trinity College Dublin
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Siamon Gordon,
University of Oxford
Regulation of Macrophage Function by Surface Receptors and TH2 Cytokines
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Ann Marshak-Rothstein,
University of Massachusetts Medical School
BCR, TLR and IFNaR Regulation of Autoreactive B Cells
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Arthur M. Krieg,
Pfizer Research Technology Center
Therapeutic Usage of Nucleic Acid TLR Agonists
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Wajahat Z. Mehal,
Yale University
Short Talk: Acetaminophen Induced Hepatotoxicity is Dependent on TLR7/9 and the NALP3 Inflammasome
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7:00 PM -
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On Own for Dinner
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| Tuesday, March 31 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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8:00 - 11:15 AM
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NLR/NBD-LRR Proteins, Pathways and Diseases
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Van Horne Ballroom A,B
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Jürg Tschopp,
University of Lausanne
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Jonathan D.G. Jones,
Sainsbury Laboratory
Using Pathogen Effectors to Understand Host Resistance Mechanisms
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Jenny P. Ting,
University of North Carolina at Chapel Hill
NLR in Diseases and Health
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Vishva M. Dixit,
Genentech, Inc.
The Inflammasone: A Dynamic Caspase Activating Apparatus
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John C. Reed,
Burnham Institute for Medical Research
Linking Innate Immunity with the Cell Death Machinery: Interactions of NLR and Bcl-2 Family Proteins
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Tara L. Roberts,
Queensland Institute of Medical Research
Short Talk: The Role of HIN200 Family Proteins in the Response to Cytosolic DNA
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Tsan Xiao,
NIAID, National Institutes of Health
Short Talk: The Structure of NALP1/NLRP1 Leucine-rich Repeats Illustrates a Potential Ligand-binding Site
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Mezzanine 2
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1:00 - 10:00 PM
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Poster Viewing
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Mezzanine 2
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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NLR/NBD-LRR Proteins, Pathways and Diseases - II
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Van Horne Ballroom A,B
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*
Vishva M. Dixit,
Genentech, Inc.
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Jürg Tschopp,
University of Lausanne
Malarial Hemozoin is a Nalp3 Inflammasome Activating Danger Signal
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Gabriel Nuñez,
University of Michigan
Function of Nod-Like Receptors in Innate Immunity
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Dana Philpott,
University of Toronto
Nod Proteins and the Interaction of Innate and Adaptive Immunity
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Koichi Kobayashi,
Dana Farber Cancer Institute
Short Talk: The Role of Nod2-Rip2 Signaling Pathway in the Regulation of Commensal Microbiota in the Intestine
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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7:30 - 10:00 PM
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Poster Session 2
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Mezzanine 2
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| Wednesday, April 1 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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8:00 - 11:15 AM
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Viral Sensors
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Van Horne Ballroom A,B
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Shizuo Akira,
Osaka University
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Takashi Fujita,
Institute for Virus Research, Kyoto University
Solution Structures of MDA5 and LGP2 C-Terminal Domains: Identification of the RNA Recognition Loop in RIG-I Like Receptors
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Hong-Bing Shu,
Wuhan University
Virus-Triggered Signaling Pathways
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Caetano Reis e Sousa,
Cancer Research UK, London Research Institute
Innate Anti-Viral Responses
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Kate A. Fitzgerald,
University of Massachusetts Medical School
Molecular Mechanisms of DNA Sensing
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Stephanie J. DeWitte-Orr,
McMaster University
Short Talk: Scavenger Class A-Like Receptor (SLR): A Pathogen Recognition Receptor Mediating DsRNA-Induced Antiviral Responses
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Axel Kirchhofer,
Gene Center
Short Talk: Structural and Functional Analysis of RIG-I Like Helicases
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Mezzanine 2
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1:00 - 10:00 PM
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Poster Viewing
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 2: NLR and Other Pathogen Sensors
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Van Horne Ballroom A,B
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*
Gordon D. Brown,
University of Aberdeen
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Olaf Groß,
University of Lausanne
Adjuvanticity of the Synthetic Cord Factor Analog TDB for subunit M. tuberculosis Vaccination Requires Card9-dependent Innate Immune Activation
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Tilmann Bürckstümmer,
Center for Molecular Medicine
An Orthogonal Proteomic/Genomic Screen Identifies DSIRE as Cytoplasmic DNA Sensor for the Inflammasome
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Paul Glyndwr Thomas,
St. Jude's Children's Research Hospital
NLRP3 (NALP3/CIAS1/Cryopyrin) Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
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Joseph A. Duncan,
University of North Carolina, Chapel Hill
Staphylococcus aureus a-hemolysin Induces IL-1B Production and Inflammatory Cell Death through Activation of Host NLRP3
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Monique Willart,
Ghent University
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Edward A. Miao,
Institute for Systems Biology
NLRC4 is an Innate Immune Detector of the Bacterial Type III Secretion Apparatus
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Takeshi Ichinohe,
Yale University School of Medicine
Inflammasome Recognition of Influenza Virus is Essential for Adaptive Immune Responses
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Fengyi Wan,
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Ribosomal Protein S3: A Novel Non-Rel Subunit of NF-kappaB Confers Regulatory Specificity
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2:30 - 4:30 PM
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Workshop 3: RLH and Other Pathogen Sensors
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Van Horne Ballroom C
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*
Tsan Xiao,
NIAID, National Institutes of Health
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William J. Kaiser,
Emory University School of Medicine
RHIM-dependent Control of NF-kappaB and Cell Death Activation via the DNA-dependent Activator of Interferon Regulatory Factors (DAI/ZBP1/DLM-1)
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Pingwei Li,
Texas A&M University
The RIG-I Like Receptor LGP2 Recognizes the Termini of Double-Stranded RNA
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Julien Pothlichet,
Institut Pasteur
A Comprehensive Study of Human RIG-I Single-Nucleotide Polymorphisms (SNPs) Identifies Two Variants with a Major Functional Impact on Antiviral Host Response
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Mehul S. Suthar,
University of Washington
The RLR Signaling Pathway is Essential in Triggering an Innate Immune Response to WNV Infection
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Szu-Ting Chen,
National Yang-Ming University
CLEC5A, A Pattern Recognition Receptor to Flavivirus
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Terry K. Means,
Massachusetts General Hospital
RNAi Identifies an Important Role for Scavenger Receptors in Fungal Immunity
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Juergen M. Ruland,
Technical University of Munich
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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Evolution of Pattern Recognition Molecules
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Van Horne Ballroom A,B
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Max D. Cooper,
Emory University
Evolution of LRR- Based Variable Lymphocyte Receptors
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Jules A. Hoffmann,
Institute of Cellular and Molecular Biology
Drosophila Pathogen Sensors
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Frederick M. Ausubel,
Massachusetts General Hospital
Innate Immunity in C. elegans
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Qing Zhang,
Burnham Institute for Medical Research
Short Talk: Direct Connector Genes Give Rise to Novel Topology of the Innate Immune Network in Amphioxus
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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7:30 - 10:00 PM
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Poster Session 3
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Mezzanine 2
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| Thursday, April 2 |
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7:00 - 8:00 AM
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Breakfast
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Mezzanine 2
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7:00 - 8:00 AM
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Poster Setup
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Mezzanine 2
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8:00 - 11:15 AM
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PRRs in Dendritic Cells and Macrophages (Joint)
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Van Horne Ballroom
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*
Daniel Kastner,
National Institutes of Health
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Marco Colonna,
Washington University School of Medicine
A Novel Signaling Pathway for Myeloid Cells Proliferation and Survival
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Gordon D. Brown,
University of Aberdeen
Lessons form Dectin-1: Insights Into Chronic Fungal Infection
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Alan Sher,
NIAID, National Institutes of Health
Th1/Th2 Polarizing Functions of Dendritic Cells in the Immune Response to Parasites
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Christine A. Biron,
Brown University
Changing Access to STATs in the Regulation of Type 1 IFN Effects on Immune Cell Subsets
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Stephen M. Hedrick,
University of California, San Diego
Short Talk: FoxO3 Controls the Magnitude of T Cell Immune Responses by Modulating Dendritic Cell Function
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Nora A. Barrett,
Brigham and Women's Hospital
Short Talk: Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells
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9:20 - 9:40 AM
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Coffee Break
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Van Horne Foyer
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11:15 AM - 12:00 PM
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Lunch
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Mezzanine 2
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12:00 - 2:30 PM
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Poster Session 4
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Mezzanine 2
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12:00 - 5:00 PM
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Poster Viewing
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Mezzanine 2
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2:30 - 4:30 PM
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Workshop 4: PAMP Sensors and Diseases
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Van Horne Ballroom A,B
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*
Daniela I. Verthelyi,
U.S. Food and Drug Administration
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John Vincent Forrester,
University of Aberdeen
A Role for Dectin-1 in T-cell Mediated Autoimmune Inflammation
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Seth L. Masters,
Trinity College Dublin
Mutations Affecting The Interleukin-1 Receptor Antagonist (IL-1Ra) Cause A New Autoinflammatory Disease
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Kathleen Azzam Smoak,
NIEHS, National Institutes of Health
Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation
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Christophe M. Filippi,
La Jolla Institute for Allergy and Immunology
Virus Utilizes TLR2 to Enhance CD4+CD25+ Regulatory T Cells in vivo and Confer them with Protective Capacity in Autoimmune Diabetes
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Anna-Marie Fairhurst,
University of Texas, Southwestern Medical Center
Innate Mechanisms in Autoimmunity
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Menno P.J. de Winther,
Cardiovascular Research Institute, Maastricht
Myeloid Type I Interferon Signaling Promotes Atherogenesis
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Li Wen,
Yale University
The Role of Gut Flora through MyD88 in Type 1 Diabetes Development in NOD Mice
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Jessica Gage,
University of Ottawa Heart Institute
Specific Loss of Toll-like Receptor 2 on Bone Marrow Derived Cells Decreases Atherosclerosis in LDL Receptor Null Mice
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4:30 - 5:00 PM
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Coffee Available
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Van Horne Foyer
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5:00 - 7:00 PM
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SNPs, Clinical Diseases and Pattern Recognition Molecules/Sensors
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Van Horne Ballroom A,B
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*
Alan Sher,
NIAID, National Institutes of Health
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Adrian V.S. Hill,
Jenner Institute, Oxford University
Innate Immunity Polymorphisms and Susceptibility to Human Infectious Diseases
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Judy H. Cho,
Yale School of Medicine
NOD2, Innate Immunity and Human Diseases
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Daniel Kastner,
National Institutes of Health
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Mezzanine 2
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8:15 - 11:00 PM
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Entertainment
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Mezzanine 2
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| Friday, April 3 |
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Departure
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