Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Immunologic Memory and Host Defense (B6)

Organizer(s): Daniel C. Douek, Robert A. Seder, Stephen P. Schoenberger and Susan M. Kaech
February 8 - 13, 2009
Keystone Resort · Keystone, Colorado
Abstract Deadline: October 8, 2008
Late Abstract Deadline: November 6, 2008
Scholarship Deadline: October 8, 2008
Early Registration Deadline: December 8, 2008

Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Immunologic Memory, Persisting Microbes and Chronic Disease (B6)
February 6 - 11, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Immune memory has a critical role in mediating protection against infections as well as potentiating certain allergic and autoimmune diseases. Hence a thorough understanding of the cellular and molecular mechanisms regulating adaptive immune memory will have important clinical application. In this regard, there has been great progress in understanding how the innate immune response influences adaptive immunity. Furthermore, improved methods to visualize immune responses in vivo, characterize the phenotypic and functional properties of adaptive immune responses and how lymphoid and non-lymphoid compartments influence the maintenance of such responses has substantially improved our understanding in this area. However, major hurdles still relate to difficulties in eliciting sustained T cell responses sufficient to mediate protection in humans with current vaccines. The goal of the meeting will be to focus on basic mechanisms for how T and B cells are programmed to induce and sustain immunity. The program is designed to integrate information from mouse, non-human primate and human studies to encompass all relevant areas related to control of memory T and B cell responses. In summary, this meeting should facilitate translational research that will impact vaccines and interventions for infectious disease, cancer and autoimmune/allergic disease.

Sunday, February 8
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address	Grays Peak / Longs Peak
	* Robert A. Seder, NIAID, National Institutes of Health
	* Susan M. Kaech, Yale University School of Medicine
	Rafi Ahmed, Emory University School of Medicine Immunologic Memory of T Cells
Monday, February 9
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Innate Influence on Adaptive Memory	Grays Peak / Longs Peak
	* Robert A. Seder, NIAID, National Institutes of Health Innate Influence on the Quality of T Cell Responses


	Bali Pulendran, Emory University Modulating Vaccine Responses with Innate Immunity
	Jürg Tschopp, University of Lausanne The Inflammasome

	Murali Krishna Kaja, University of Washington Innate Influence on T Cells
	Joseph C. Sun, Memorial Sloan-Kettering Cancer Center Short Talk: Adaptive Immune Features of Natural Killer Cells
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 1: Measuring Events in Immune Activation	Grays Peak / Longs Peak
	* Rafick-Pierre Sekaly, University of Montreal FOXO3A: A Critical Integrator of Signals Leading to B and T Cell Memory

	Dietmar Zehn, Swiss Vaccine Research Institute CD8 Response Kinetics
	Inka Albrecht, German Rheumatism Research Center Twist1 Acts as an Internal Brake of Th1 Induced Chronic Inflammation
	Spencer Stonier, MD Anderson Cancer Center Characterization of Cell Surface IL-15 Expression by Myeloid Cell Populations
	Michael Quigley, Dana-Farber Cancer Institute Gene Expression Profiling of Tetramer-sorted Human T Cells can Distinguish Functionality and Disease Outcome in HIV
	David Farrar, University of Texas Southwestern Medical Center Dynamic Programming of Effector and Central Memory CD8+ T cells by IL-12 and IFN-a
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Memory T Cell Subsets and Host Defense	Grays Peak / Longs Peak
	* Alexander Y. Rudensky, Memorial Sloan-Kettering Cancer Center Molecular Control of Regulatory T Cells
	Federica Sallusto, Institute for Research in Biomedicine Th17 Cells and Host Defense
	E. John Wherry, University of Pennsylvania Coregulation of CD8+ T Cell Exhaustion during Chronic Viral Infection by Multiple Inhibitory Receptors
	Nathan W. Schmidt, University of Iowa Short Talk: Memory CD8 T Cell Responses Exceeding a Large, but Definable Threshold Provide Long-term Immunity to Malaria
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 1	Quandary 1-3
Tuesday, February 10
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	T Cells: Homeostasis and Maintenance	Grays Peak / Longs Peak
	* Marc K. Jenkins, University of Minnesota Medical School Mechanisms of Immune Memory by Bacterial Antigen-specific CD4+ T Cells
	Gabrielle T. Belz, Walter and Eliza Hall Institute of Medical Research Coordinate Regulation of Effector and Memory Expansion and Differentiation
	Annette Oxenius, Institute for Microbiology, ETH Zürich T Cell Responses in Chronic Viral Infections
	Stephen C. Jameson, University of Minnesota Medical School Pre-existing Antigen Specific Memory Like Cells in Unprimed Mice

	Carmen Gerlach, Netherlands Cancer Institute Short Talk: Effector and Memory CD8+ T Cells Constitute a Single Lineage
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
2:30 - 4:30 PM	Workshop 2: Vaccines and T Cell Memory	Grays Peak / Longs Peak
	* Mark K. Slifka, Oregon Health & Science University Will Viral Virulence Dictate the Level of Immunological Memory to Orthopoxviruses?
	* Mario Roederer, National Institutes of Health The Unique Immunogenicity Profile of Aerosol Vaccination in Nonhuman Primates

	Rene A. Van Lier, Academic Medical Center Human CMV Infection Induces Rapid and Lasting Changes in Gene Expression in the CD8+ T Cell Compartment
	Cheryl H. Rozanski, Roswell Park Cancer Institute CD28 Supports Normal Plasma Cell Survival and Interactions with the Microenvironment
	Kylie Margaret Quinn, NIAID, National Institutes of Health Priming of CD4+ T Cells with Protein and Poly I:C Increases Subsequent Boosting of CD8+ but not CD4+ T Cell Responses
	Derek Trobaugh, University of Massachusetts Medical School Qualitative and Quantitative Differences in Effector Functions of Virus-specific and -Cross-reactive T Cells in Mice Immunized with Related Flaviviruses
	Lindsay E. Edwards, University of Colorado Denver & National Jewish Health Generation of Protective CD8+ T cell Memory in CD4+ Deficient Hosts
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Tissues, Traffic and Circulation	Grays Peak / Longs Peak
	David L. Woodland, Trudeau Institute Site-Specific Control of T Cell Memory



	Andrea Cerutti, Mount Sinai School of Medicine Role of Innate Signaling Networks in Mucosal Immunoglobulin Heavy Chain Class Switching

	* Daniel C. Douek, NIAID, National Institutes of Health Tissue-Specific Differences and T Cell Loss in HIV Infection
	James J. Campbell, Brigham and Women's Hospital Short Talk: Specificity and Dissemination of Antigen-Experienced, Tissue-Tropic T Lymphocytes
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 2	Quandary 1-3
Wednesday, February 11
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Memory B Cell Differentiation	Grays Peak / Longs Peak
	* Stuart G. Tangye, Garvan Institute of Medical Research Cytokine Signaling in Human B Cell Differentiation

	Mark J. Shlomchik, Yale University School of Medicine Intrinsic Properties of Memory B Cells
	John C. Cambier, University of Colorado Denver Health Sciences Center Molecular Basis of B Cell Anergy and its Disruption by Innate and T Cell-Derived Signals
	Ross M. Kedl, University of Colorado Health Sciences Center Navigating the Boundary between Innate and Adaptive Immune Responses


	Kim Good, Yale University Short Talk: Role of PD-1 in Memory B Cell Formation and Responses
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	The Genetics and Biochemistry of Memory	Grays Peak / Longs Peak
	Steven L. Reiner, University of Pennsylvania Inducing the T Cell Fates Required for Immunity
	Donna L. Farber, University of Maryland School of Medicine Biochemical Signaling Pathways for Memory CD4 T Cell Recall and Homeostasis
	* Susan M. Kaech, Yale University School of Medicine Regulation of CD8 T Cell Memory Induction
	Erika L. Pearce, University of Pennsylvania Short Talk: Enhancing CD8 T Cell Memory by Modulating Fatty Acid Metabolism
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 3	Quandary 1-3
Thursday, February 12
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	T Cells: Differentiation and Functional Capacity	Grays Peak / Longs Peak
	John T. Harty, University of Iowa Controlling Memory CD8 T Cell Differentiation
	Rose Zamoyska, University of Edinburgh The Influence of Signal Strength on the Differentiation of Effector and Memory T Cells
	* Stephen P. Schoenberger, La Jolla Institute for Allergy and Immunology How to Make a Memory CD8 T Cell

	Yasmine Belkaid, NIAID, National Institutes of Health Plasticity of Regulatory T Cells During Infection
	Ryan T. Sowell, Rush University Medical Center Short Talk: CD27 is Preferentially Required for Generation and Maintenance of Some Memory CD8 T Cell Subsets
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
2:30 - 4:30 PM	Workshop 3: Immunodominance and TCR Repertoire	Grays Peak / Longs Peak
	* David A. Price, NIAID, National Institutes of Health Deconvoluting Adaptive T Cell Immunity: Clonotype Selection and Biological Outcome
	* Bridie Day, University of Melbourne Investigating the Determinants of Antigen-Specific TCR Repertoire Diversity

	Rebekka Ariane Geiger, Institute for Research in Biomedicine Repertoire Analysis of Human Naive and Memory CD4+ T Cells Reveals Affinity Maturation during the Immune Response
	Pradyot Dash, St Jude Children's Research Hospital Influenza A KbPB1703 Epitope Specific CD8 T Cell Receptor Chain Repertoire Analysis: Priming with Fewer Epitopes Broadens Recruitment of the Influenza KbPB1703 Repertoire
	Laurent Malherbe, Blood Center of Wisconsin Stability of MHC Class II:Peptide Complexes Governs Th Cell Clonal Selection
	Vanessa Venturi, University of New South Wales A Molecular Basis for the Sharing of T Cell Receptor beta-Chains
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 6:45 PM	Why Memory Might Be Important: Cancer, Autoimmunity and Vaccines	Grays Peak / Longs Peak
	* Nicholas P. Restifo, National Cancer Institute, National Institutes of Health T Cell Control of Cancer

	Matthias G. von Herrath, La Jolla Institute for Allergy and Immunology Memory to beta Cells - Good or Bad?
	Kanta Subbarao, NIAID, National Institutes of Health Active and Passive Immunization Against Avian Influenza Viruses
6:45 - 7:30 PM	Concluding Remarks	Grays Peak / Longs Peak
	Peter C. Doherty, University of Melbourne Looking Back at Memory
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
8:00 - 11:00 PM	Entertainment	Quandary 1-3
Friday, February 13
	Departure

*Session Chair †Speaker invited, not yet responded.