| Sunday, March 22 |
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3:00 - 7:30 PM
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Registration
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Longs Peak Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 9:30 PM
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Keynote Address (Joint)
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Grays Peak / Longs Peak
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Brigitte Autran,
Hôpital Pitié-Salpétrière, UPMC
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Didier Trono,
Ecole Polytechnique Fédérale de Lausanne
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Francoise Barré-Sinoussi,
Institut Pasteur
HIV Diversity and Pathogenesis
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Rafi Ahmed,
Emory University School of Medicine
Vaccination and Immune Memory
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| Monday, March 23 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud / Shavano / Torreys
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8:00 - 11:00 AM
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Host Genomics and HIV Disease (Joint)
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Columbine Ballroom
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*
Didier Trono,
Ecole Polytechnique Fédérale de Lausanne
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Amalio Telenti,
Centre Hospitalier Universitaire Vaudois
Evolutionary and Integrative Genomics of Susceptibility to HIV
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Mary Carrington,
NCI, National Institutes of Health
Immunogenetic Variation Characterizing Exceptional Control of HIV
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Bruce D. Walker,
Ragon Institute of MGH, MIT and Harvard
HIV Controllers: A Model for T Cell Vaccination?
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Ioannis Theodorou,
INSERM U543
Short Talk: Distinct Genetic Loci Control Plasma HIV-RNA and Cellular HIV-DNA Levels in HIV-1 Infection: The ANRS Genome Wide Association 01 Study
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David I. Watkins,
University of Wisconsin-Madison
Vaccine-Induced Cellular Responses Control Acute SIV Replication after Heterologous Challenge
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM -
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On Own for Lunch
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11:00 AM - 12:30 PM
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Hands On Computer Workshop on Los Alamos Sequence Database
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
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Castle Peaks
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11:00 AM - 1:00 PM
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Poster Setup
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Red Cloud / Shavano / Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Red Cloud / Shavano / Torreys
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Hiding from Immunity: Reservoirs and Latency
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Grays/Longs Peaks
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Douglas D. Richman,
University of California, San Diego
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Robert F. Siliciano,
Johns Hopkins School of Medicine
Quantitative Analysis of the Control of HIV Replication by Drugs and Vaccines
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Joel Nee-lartey Blankson,
Johns Hopkins School of Medicine
HIV-1 Latency and Low Level Viremia in Elite Suppressors
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Dana H. Gabuzda,
Dana Farber Cancer Institute
Macrophage Reservoirs
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Matthias Geyer,
Max Planck Institute for Molecular Physiology
Short Talk: Structural Insights into the Cyclin T1–Tat–TAR RNA Transcription Activation Complex
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud / Shavano / Torreys
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7:30 - 10:00 PM
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Poster Session 1
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Red Cloud / Shavano / Torreys
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| Tuesday, March 24 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud / Shavano / Torreys
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8:00 - 11:00 AM
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Immune Control of HIV and Virus Escape (Joint)
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Columbine Ballroom
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Bruce D. Walker,
Ragon Institute of MGH, MIT and Harvard
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Giuseppe Pantaleo,
Centre Hospitalier Universitaire Vaudois
Immune Correlates of Protection to HIV
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Joseph M. McCune,
University of California, San Francisco
Short Talk: Immune Control in Pathogenic and Nonpathogenic SIV Infection
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Mark Connors,
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Short Talk: Effective Control of HIV by CD8+ T-Cells is Associated with Infected CD4+ T Cell Elimination: Ramifications for T Cell Based Vaccines
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Philip J. Goulder,
University of Oxford
HIV Escape and T-Cell Control of HIV
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George M. Shaw,
University of Alabama at Birmingham
HIV-1 Sequences in Acute and Early Infection Reveal the Genetic Identity, Biological Phenotype, and Precise Evolutionary Pathways of Transmitted/Founder Viruses and their Progeny
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM -
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On Own for Lunch
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11:00 AM - 12:30 PM
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Hands On Computer Workshop on Los Alamos Sequence Database
Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.
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Castle Peaks
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11:00 AM - 1:00 PM
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Poster Setup
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Red Cloud / Shavano / Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Red Cloud / Shavano / Torreys
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2:30 - 3:30 PM
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Workshop 1A: New Therapeutics
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Grays/Longs Peaks
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Dana H. Gabuzda,
Dana Farber Cancer Institute
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Daria J. Hazuda,
Merck Research Laboratories
Integrase Inhibitors
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Mike Westby,
Pfizer Global Research and Development
CCR5 Antagonists as HIV Entry Inhibitors
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Navid Madani,
Dana Farber Cancer Institute
New Entry Inhibitors: Interaction of Small-Molecule CD4 Mimics with a Highly Conserved Pocket on the HIV gp120 Envelope Glycoprotein
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3:30 - 4:30 PM
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Workshop 1B: Th17 Cells
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Grays/Longs Peaks
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Robert F. Siliciano,
Johns Hopkins School of Medicine
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Aimee El Hed,
New York University School of Medicine
Human Th17 Cells are Highly Susceptible to CCR5-Tropic HIV Infection and are Preferentially Depleted in Infected Individuals
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Nicolas Manel,
New York University Medical Center
The Differentiation of Human Th17 Cells Requires TGF-beta and Induction of the Nuclear Receptor RORgammat and this Renders T Cells more Susceptible to HIV-1 Infection
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Petronela Ancuta,
Centre de Recherche de l'Universite de Montreal
HIV Replicates in CCR6+IFN-gamma+IL-17+ but Not CCR6negIFN-gamma+IL-10+ Primary CD4+ T-Cell Subsets
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Anna Aldovini,
Children's Hospital Boston and Harvard Medical School
Tat-Induced FOXO3a is a Key Mediator of Apoptosis in HIV-1-Infected Human CD4+ T-Lymphocytes
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Models of HIV Immunobiology
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Grays/Longs Peaks
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Frank Kirchhoff,
University of Ulm
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Guido Silvestri,
University of Pennsylvania School of Medicine
SIV Infection of African Monkeys: A New Paradigm for AIDS Pathogenesis and Vaccines
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Cecilia Cheng-Mayer,
Aaron Diamond AIDS Research Center
Coreceptor switching in the SHIV/macaque model
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Sarah L. Rowland-Jones,
MRC Human Immunology Unit
Long-term non-progression with HIV infection: lessons from HIV-2
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud / Shavano / Torreys
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7:30 - 10:00 PM
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Poster Session 2
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Red Cloud / Shavano / Torreys
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| Wednesday, March 25 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud / Shavano / Torreys
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8:00 - 11:00 AM
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New Insights in HIV Replication
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Grays/Longs Peaks
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Michael H. Malim,
King's College London School of Medicine
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Frank Kirchhoff,
University of Ulm
Role of Nef in vivo and in vitro
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Christopher Aiken,
Vanderbilt University School of Medicine
Cyclophilin A and HIV-1 Uncoating
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Nathaniel R. Landau,
New York University School of Medicine
Vpr and DNA Damage
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John C. Guatelli,
University of California, San Diego
Short Talk: Vpu Antagonizes BST-2-Mediated Restriction of HIV-1 Release via b-TrCP and Endo-Lysosomal Trafficking
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Andres Finzi,
Dana Farber Cancer Institute
Short Talk: A Layered Structure in the HIV-1 gp120 Inner Domain Regulates gp41 Interaction and Facilitates Transitions into the CD4-Bound Conformation
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Red Cloud / Shavano / Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Red Cloud / Shavano / Torreys
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1:30 - 4:30 PM
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NIAID Workshop on Identification and Validation of New Cellular Co-Factors in HIV Replication. Organized by Roger Miller and Opendra Sharma, DAIDS, NIAID. Moderators: Roger Ptak and Warner Greene.
The objective of the workshop will be to discuss the current status of the field; determine the best approach for validating the mechanism of action of host molecules in primary cells; and, promote development of assays which recreate the activity of a cellular co-factor, or a cellular restriction, with the goal of producing a high throughput screening assay for testing chemical compound libraries.
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Grays/Longs Peaks
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Carl W. Dieffenbach,
NIAID, National Institutes of Health
Workshop Objectives
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Roger Ptak,
Southern Research Institute
Cataloging the HIV-Human Protein Interaction Network
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John A. T. Young,
The Salk Institute
Genome-Wide Screeing of HIV-Host Interactions
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Vineet N. KewalRamani,
NCI, National Institutes of Health
Regulation of HIV-1 Nuclear Entry
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Warner C. Greene,
Gladstone Institute of Virology and Immunology
Small Molecule Inhibitors of the Vif-APOBEC3G Interaction of HIV-1 Identified by High Throughput Screening
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Dana H. Gabuzda,
Dana Farber Cancer Institute
Small Molecule Inhibitors of the Vif-APOBEC3G Interaction of HIV-1 Identified by High Throughput Screening
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Tariq M. Rana,
Burnham Institute for Medical Research
Small Molecule Inhibitors of the Vif-APOBEC3G Interaction of HIV-1 Identified by High Throughput Screening
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Warner C. Greene,
Gladstone Institute of Virology and Immunology
Wrap-Up and Future Directions
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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HIV at the Mucosa: Portal of Entry and Front-Line Defense (Joint)
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Columbine Ballroom
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Daniel C. Douek,
NIAID, National Institutes of Health
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Ashley T. Haase,
University of Minnesota
Keynote Address: Quest for Design Principles for an Effective HIV Vaccine/Microbicide in Studies of SIV Pathogenesis
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Alison Simmons,
Weatherall Institute of Molecular Medicine
Dendritic Cell Factors Required for HIV-1 Infection
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Ronald S. Veazey,
Tulane National Primate Research Center
_7 Integrin Expression on CD4+ T Cells as a Surrogate Marker for Tracking Intestinal CD4+ T Cell Loss in SIV Infection
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Satya Dandekar,
University of California, Davis
Short Talk: Mechanisms of Impaired Gut Mucosal Defenses during HIV and SIV Infections
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud / Shavano / Torreys
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7:30 - 10:00 PM
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Poster Session 3
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Red Cloud / Shavano / Torreys
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| Thursday, March 26 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud / Shavano / Torreys
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7:00 - 8:00 AM
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Poster Setup
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Red Cloud / Shavano / Torreys
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8:00 - 11:00 AM
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Innate Antiviral Immunity
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Grays/Longs Peaks
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Christopher Aiken,
Vanderbilt University School of Medicine
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Michael H. Malim,
King's College London School of Medicine
APOBEC3 Proteins and Intrinsic Resistance to HIV-1 Infection
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Warner C. Greene,
Gladstone Institute of Virology and Immunology
The Role of APOBEC3 Enzymes in Counteracting “Retro-Threats”, Both Foreign and Domestic
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Greg J. Towers,
University College London
Inhibition of Retroviral Infection by TRIMCyp and Tetherin Reveals a Delicate Balance between Viral Countermeasures and Host Restriction
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Didier Trono,
Ecole Polytechnique Fédérale de Lausanne
Epigenetic Control of Retroelements
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM - 12:00 PM
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Lunch
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Red Cloud / Shavano / Torreys
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12:00 - 2:30 PM
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Poster Session 4
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Red Cloud / Shavano / Torreys
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Virus Spread
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Grays/Longs Peaks
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Alison Simmons,
Weatherall Institute of Molecular Medicine
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Olivier Schwartz,
Institut Pasteur
Mechanisms of Direct HIV Lymphocyte-to-Lymphocyte Transfer: Role of “Polysynapses”
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Thomas J. Hope,
Northwestern University, Feinberg School of Medicine
Interaction of HIV with Cells within Intact Mucosal Tissue
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Vincent Piguet,
University Hospital of Geneva
Mechanisms of DC-T Cell HIV-1 Transmission via an Infectious Synapse
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Walther Mothes,
Yale University School of Medicine
Short Talk: Retroviral Assembly is Directed Towards Sites of Cell-Cell Contact
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Sriram Subramaniam,
National Institutes of Health
Short Talk: 3D Architecture of the Virological Synapse and Structural Mechanisms of HIV Entry
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7:15 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud / Shavano / Torreys
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8:00 - 11:00 PM
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Entertainment
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Red Cloud / Shavano / Torreys
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| Friday, March 27 |
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Departure
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