| Sunday, January 25 |
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3:00 - 7:30 PM
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Registration
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Longs Peak Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 8:30 PM
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Keynote Address
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Grays Peak
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JoAnne L. Flynn,
University of Pittsburgh School of Medicine
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Douglas B. Young,
Imperial College London
The Best Laid Schemes of Mice and Men . . .
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8:30 - 9:00 PM
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Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.
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Grays Peak/Longs Peak
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| Monday, January 26 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud/Shavano
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8:00 - 11:15 AM
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Life and Death within the Phagocyte
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Grays Peak/Longs Peak
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Vojo Deretic,
University of New Mexico
Autophagy: a Cell Sanitation, Survival and Death Process
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David G. Russell,
Cornell University
Mycobacterium Tuberculosis and the Intracellular Environment
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Ulrich E. Schaible,
Research Center Borstel, London School of Hygiene
Host Innate Defense and Mycobacterial Virulence
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Sabine Ehrt,
Weill Cornell Medical College
Mycobacterial Survival Strategies in the Phagosome
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Volker Briken,
University of Maryland
Short Talk: Molecular Mechanism of Mycobacterium tuberculosis nuoG Mediated Host Macrophage Apoptosis Inhibition
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Frédéric Altare,
Unité INSERM U892
Short Talk: Nutrient-Rich Reservoir for M. Tuberculosis Persistence
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Red Cloud/Shavano
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1:00 - 10:00 PM
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Poster Viewing
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Red Cloud/Shavano
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Early/Innate Immune Responses to TB
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Grays Peak/Longs Peak
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Valerie F. Quesniaux,
Centre National de la Recherche Scientifique
Toll-Like Receptors in Tuberculosis
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Clifford V. Harding,
Case Western Reserve University
Regulation of APCs and Class II MHC by TLR2 and Mycobacterium tuberculosis
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Stefan Ehlers,
Research Center Borstel
Short Talk: Non-Classical Macrophage Activation in Experimental TB – Consequences for Reactivation and Lung Pathology
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Padmini Salgame,
University of Medicine and Dentistry for New Jersey
Short Talk: Coexisting Helminth Infection Induces Inhibition of Pulmonary Anti-Tuberculosis Defense
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud/Shavano
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7:30 - 10:00 PM
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Poster Session 1
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Red Cloud/Shavano
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| Tuesday, January 27 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud/Shavano
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8:00 - 11:00 AM
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Key Pathways in Bacterial Metabolism
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Grays Peak/Longs Peak
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Christopher M. Sassetti,
University of Massachusetts Medical School
Carbon Metabolism Comes Full Circle
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Valerie Mizrahi,
University of the Witwatersrand - MMRU
Novel and Vulnerable Pathways of DNA Metabolism in Mycobacteria
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Jeffery S. Cox,
University of California, San Francisco
Protein Secretion, Novel and Conserved Systems
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Carolyn R. Bertozzi,
University of California, Berkeley
Mycobacterial Sulfation Pathways
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Koen Andries,
Tibotec
Short Talk: ATP Synthase, A New Validated Target for TB Treatment
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Red Cloud/Shavano
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1:00 - 10:00 PM
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Poster Viewing
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Red Cloud/Shavano
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2:30 - 4:30 PM
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Workshop on TB Drug Discovery: Connecting Academia and Industry
Summary: In this 2 hour workshop gaps in TB drug discovery and issues around Academia-Industry collaborations will be discussed. This will be done in the format of a podium discussion with audience participation. 12 representatives from academia, industry, the TB Alliance and the Gates Foundation will form the podium discussion group . After a short introduction by Thomas Dick (Novartis), Koen Andries (Tibotec) will briefly address one of the major questions in TB drug discovery, namely the approach issue ‘target-vs-cell-based screens’. Chris Earl (Bio Ventures for Global Health) will talk about biotech solutions for neglected disease. Jose Garcia-Bustos (GSK) and Tanjore Balganesh (Astrazeneca) will present a few slides on ‘Views from Industry’ to highlight issues and gaps from the industry side. After that, Clif Barry (NIH) and Jim Sacchettini (Texas A&M) will present a few slides on ‘Views from Academia’. Each short presentation is expected to raise key issues and questions in order to stimulate / guide the discussion.
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Grays Peak / Longs Peak
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Thomas N.A. Dick,
Novartis Institute for Tropical Diseases
Introduction: Connecting Academia and Industry
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Ken Duncan,
Bill & Melinda Gates Foundation
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Koen Andries,
Tibotec
Filling the Gap: What can YOU do?
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Christopher D. Earl,
BIO Ventures for Global Health
Building Biotech Solutions for Diseases of the Developing World
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Jose F. Garcia-Bustos,
GlaxoSmithKline
and
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Clifton E. Barry III,
NIAID, National Institutes of Health
and
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M. Gerard Waters,
Global Alliance for Tuberculosis Drug Development
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James C. Sacchettini,
Texas A & M University
How Can We Improve Academia - Industry Interaction 2: Views from Academia
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Makoto Matsumoto,
Otsuka Pharmaceutical Co. Ltd.
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Veronique Anne Dartois,
Novartis Institute of Tropical Diseases
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Pathology and Transmission of Tuberculosis
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Grays Peak/Longs Peak
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Gilla Kaplan,
Public Health Research Institute, UMDNJ
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Elizabeth L. Corbett,
London School of Hygiene and Tropical Medicine/Malawi-Liverpool-Wellcome Trust Clinical Research Programme
TB Transmission and Susceptibility
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Henry Charles Mwandumba,
University of Liverpool
Conditions in the Human Lung during Active Tuberculosis
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Denise Kirschner,
University of Michigan
A Multi-Scale Peek at Granuloma Formation in TB
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud/Shavano
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7:30 - 10:00 PM
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Poster Session 2
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Red Cloud/Shavano
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| Wednesday, January 28 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud/Shavano
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8:00 - 11:00 AM
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Insights from Animal Models: New Approaches
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Grays Peak/Longs Peak
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Lalita Ramakrishnan,
University of Washington
A Forward Genetic Screen in the Zebrafish Reveals a Human TB Susceptibility Locus
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David S. Schneider,
Stanford University School of Medicine
Balancing Resistance and Tolerance During Infections in the Fly
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JoAnne L. Flynn,
University of Pittsburgh School of Medicine
Non-Human Primate Model of Tuberculosis. What can we learn about TB?
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Gilla Kaplan,
Public Health Research Institute, UMDNJ
Host and Pathogen Contribution to Pathology
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM - 1:00 PM
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Poster Setup
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Red Cloud/Shavano
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11:00 AM - 2:00 PM
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Symposium on Tuberculosis Databases and Bioinformatics Tools
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Grays Peak/Longs Peak
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Gary K. Schoolnik,
Stanford University
Welcome, Workshop Goals
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Adamandia Kapopoulou,
Ecole Polytechnique Federale de Lausanne
Tuberculist
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James Galagan,
Broad Institute of Massachusetts Institute of Technology and Harvard
TBDatabase: A Database that Integrates Expression and Genomics Data and which Provides Suites of Bioinformatics Tools
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Barry A. Bunin,
Collaborative Drug Discovery Inc.
Collaborative Drug Discovery Database
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Thomas R. Holton,
University of California, Los Angeles
WebTB.org and the TB Structural Genomics Consortium: Tools for searching and annotating the TB genome
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Shubhada Godbole,
University of Texas Southwestern Medical Center
BioHealthBase: A Comprehensive Integrated Database and Analysis Resource for TB Research
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Kristin Kremer,
National Institute of Public Health and the Environment
Usefulness of DNA Fingerprint Databases to Study the Epidemiology and Phylogeny of TB
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Stefan Niemann,
Research Center Borstel
MIRU-VNTRplus Database: Online Identification of Clinical Isolates Based on Reference Collections and Analysis of Molecular Typing Data
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Gary K. Schoolnik,
Stanford University
Discussion: Unmet Bioinformatic Needs; How can they be Addressed?
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1:00 - 10:00 PM
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Poster Viewing
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Red Cloud/Shavano
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Bacterial Response to the Evolving Host Environments
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Grays Peak/Longs Peak
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Eric J. Rubin,
Harvard School of Public Health
The Essential Irony of Tuberculosis
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Helena I. M. Boshoff,
NIAID, National Institutes of Health
Nitroimidazoles for TB: Mechanism of Killing
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William Bishai,
Johns Hopkins School of Medicine
Slipping the Host a Mycobacterial Mickey Finn
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Adrie J. C. Steyn,
University of Alabama at Birmingham
Short Talk: Mycobacterium tuberculosis WhiB3 maintains Intrabacterial Redox Homeostasis by Modulating Virulence Lipid Anabolism to Subvert Macrophage Function
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud/Shavano
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7:30 - 10:00 PM
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Poster Session 3
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Red Cloud/Shavano
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| Thursday, January 29 |
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7:00 - 8:00 AM
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Breakfast
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Red Cloud/Shavano
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7:00 - 8:00 AM
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Poster Setup
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Red Cloud/Shavano
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8:00 - 11:00 AM
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Action and Reaction in the Immune Control of Tuberculosis
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Grays Peak/Longs Peak
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Michael Stephen Glickman,
Sloan-Kettering Cancer Institute
Discovery of a Novel Pathway that Integrates rRNA Transcription with DNA damage
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Gary K. Schoolnik,
Stanford University
Mycobacterium tuberculosis (Mtb)Expression Signatures of Host Immune Status
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Katerina Heran Darwin,
New York University School of Medicine
Discovery of a Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis
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Shahin Shafiani,
University of Washington
Short Talk: Pathogen-Specific Regulatory T Cells Impair Protective Immunity in Tuberculosis
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Tige Rustad,
Seattle Biomedical Research Institute
Short Talk: The DosR Regulon and the Enduring Hypoxic Response: Identification, Regulation and In Vivo Relevance
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM - 12:00 PM
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Lunch
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Quandary Peaks
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12:00 - 2:30 PM
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Poster Session 4
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Red Cloud/Shavano
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12:00 - 5:00 PM
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Poster Viewing
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Red Cloud/Shavano
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Bacterial Physiology and Drug Targets
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Grays Peak/Longs Peak
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Thomas N.A. Dick,
Novartis Institute for Tropical Diseases
One Plus One does not Equal Two: In Vitro – in Vivo Disconnect in TB Drug Discovery
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James C. Sacchettini,
Texas A & M University
Mtb Whole Genome Sequencing: Detecting Drug-Pathogen Interactions
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Clifton E. Barry III,
NIAID, National Institutes of Health
Rethinking the Concept of a Good TB Drug “Target”
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Red Cloud/Shavano
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8:00 - 11:00 PM
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Entertainment
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Red Cloud/Shavano
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| Friday, January 30 |
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Departure
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