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Pathogenesis and Control of Emerging Infections and Drug-Resistant Organisms (S4)

Organizer(s): B. Brett Finlay, Alan Cowman, Stephen Hughes, Sumalee Kamchonwongpaisan, Valerie Mizrahi and Philippe J. Sansonetti
October 22 - 27, 2008
Royal Orchid Sheraton Hotel  ·  Bangkok, Thailand
Abstract Deadline: June 23, 2008
Late Abstract Deadline: July 28, 2008
Scholarship Deadline: June 23, 2008
Early Registration Deadline: August 25, 2008


Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.



This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
This meeting will review the most recent developments in the molecular and cellular analysis of infectious disease processes, and how discoveries in this field can be translated into innovative tools (i.e. diagnostic assays, new drugs, vaccines and other therapeutics) for better surveillance and control. Emphasis will be on the neglected infectious and parasitic diseases that plague the developing world (with lessons taken from better studied organisms), and on issues such as drug resistance that are common themes, regardless of geographic and economic situations.

Wednesday, October 22
2:00 - 5:00 PM Registration Group Lobby
5:00 - 5:30 PM Transportation by Boat to Dinner Event Royal Orchid Sheraton Pier
5:30 - 6:00 PM Social Hour Royal Navy Hall
6:00 - 10:00 PM Joint Dinner with Grand Challenges in Global Health Conference
The GCGH and Keystone Joint Dinner: A semi-formal dinner at the Royal Thai Navy Convention Hall, with an address by HRH Princess Maha Chakri Sirindhorn. HRH Princess Maha Chakri Sirindhorn is also President of the Prince Mahidol Award Foundation. This is a joint dinner for Grand Challenges in Global Health and Keystone Symposia participants and is an event not to be missed! Protocol dictates that guests may not arrive to the hotel after 4pm, nor depart the event before the end of the formalities. (Note: Attire recommendations below) http://www.princemahidolaward.org Attire for all meeting sessions is business casual. The same applies to evening events, with the exception of the dinner on Wednesday, October 22nd at the Royal Thai Navy Convention Hall. For this event, in honor of HRH Princess Machachakri Sirindhom, who will be attending this event, smart business casual is recommended. Thai ladies will often wear a silk costume for any function attended by royalty, but for non-Thai ladies, a smart dress (not evening gown) is preferred. For men a pair of business pants and open neck shirt is recommended.
Royal Navy Hall
10:00 - 10:30 PM Transportation by Boat to Hotel Royal Navy Hall
Thursday, October 23
7:00 - 8:00 AM Breakfast etc Restaurant
7:00 - 8:00 AM Poster Setup Riverside Ballrooms
8:00 - 8:30 AM Orientation and Opening Remarks Ballroom 2-3
8:30 - 11:30 AM Infection Biology Ballroom 2-3
Craig R. Roy, Yale University School of Medicine
Modulation of Host Cell Functions by Type IV Effector Proteins
Dana Philpott, University of Toronto
Role of Nod-like Receptors in Innate and Adaptive Immunity
William R. Jacobs, Jr., Albert Einstein College of Medicine
IKEPLUS, A Recombinant M. smegmatis that Elicits Bacteriocidal Immunity Against Virulent M. tuberculosis
Arturo Zychlinsky, Max Planck Institute for Infection Biology
Neutrophil Extracellular Traps
9:40 - 10:00 AM Coffee Break Riverside Foyer/Ballrooms
11:30 AM - 12:30 PM Lunch Ballroom 1/Riverside
12:00 - 2:00 PM Poster Session 1 Riverside Ballrooms
2:00 - 4:00 PM HIV Drug Resistance Ballroom 2-3
Edward V. Arnold, Rutgers University
RT Structure and Structure-Guided Design of Novel Inhibitors Targeting Multiple Sites
* Stephen Hughes, NCI-Frederick, NIH
HIV-1 RT: Drug Resistance and Drug Development
Alexandre Alcaïs, University of Paris René Descartes-INSERM U550
Human Genetics of Infectious Diseases: From Proof-of-Principle Towards New Paradigm
4:00 - 4:30 PM Coffee Break Riverside Foyer/Ballrooms
4:30 - 6:30 PM Workshop 1: TB Ballroom 2-3
* Tanya Parish, Barts and the London
Jean-Philippe Carralot, Institut Pasteur Korea
HTS/HCS Genome-wide siRNA Screening of Host Genes Involved in the Blockage of Phagolysosome Maturation and in the Survival of M. Tuberculosis in Raw 264.7 Macrophages
Thuong Nguyen, Oxford University Clinical Research Unit
Epiregulin (EREG) Variation is Associated with Tuberculosis
Liana Tsenova, Public Health Research Institute
Immunomodulation with CC-3052 Accelerates Antibiotics Efficacy in Experimental M. Tuberculosis Infection
Catherine Vilchèze, Howard Hughes Medical Institute - AECOM
Novel Inhibitors of InhA Efficiently Kill Multidrug-resistant Tuberculosis
Saradee Warit, National Center for Genetic Engineering and Biotechnology
Mechanism of Clarithromycin Sensitivity in Clinical Isolates of Mycobacterium Tuberculosis
Martin Handfield, University of Florida
Probing for Mycobacterial in vivo Induced Antigens in Tuberculosis
Rajpal Singh Kashyap, Central India Institute of Medical Sciences
Evaluation of ELISA-based Antigen Detection Kit for Diagnosis of Pulmonary and Extrapulmonory Tuberculosis
Amnuay Khumsung, Mahidol University
XDR-TB Testing using MTT Assay
Friday, October 24
7:00 - 8:00 AM Breakfast etc Restaurant
7:00 - 8:00 AM Poster Setup Riverside Ballrooms
8:00 - 11:30 AM Malaria Ballroom 2-3
Robert Ménard, Institut Pasteur
In vivo Imaging of Plasmodium Pre-erythrocytic Stages in a Rodent Model
Louis Schofield, Walter and Eliza Hall Institute of Medical Research
Malaria and Vaccines
Daniel E. Goldberg, Washington University
Characterization of a Potential Drug Target: Plasmodium Calpain
* Alan Cowman, Walter and Eliza Hall Institute of Medical Research
Invasion and Remodeling of the Human Erythrocyte by the Malaria Parasite
Sumalee Kamchonwongpaisan, BIOTEC, Thailand National Science and Technology Development Agency
Basic Understanding of Artemisinin Action against Plasmodium falciparum In Vitro
Yongyuth Yuthavong, BIOTEC, Thailand National Science and Technology Development Agency
Development of Target-Based Antimalarials
10:00 - 10:20 AM Coffee Break Riverside Foyer/Ballrooms
11:30 AM - 12:30 PM Lunch Ballroom 1/Riverside
12:00 - 2:00 PM Poster Session 2 Riverside Ballrooms
2:00 - 5:00 PM Diarrhea and Vaccines Ballroom 2-3
E. Peter Greenberg, University of Washington
What's New in ACYL-Homoserine Lactone Quorum Sensing: Strange Signals and Strange Receptors
Julian Guttman, Simon Fraser University
Epithelial Cell Alterations that Influence Diarrhea Generation during Attaching and Effacing Bacterial Infections
* John J. Mekalanos, Harvard Medical School
Secretion Systems in the Pathobiology of Vibrio and Pseudomonas Disease
3:20 - 3:40 PM Coffee Break Riverside Foyer/Ballrooms
Saturday, October 25
7:00 - 8:00 AM Breakfast etc Restaurant
7:00 - 8:00 AM Poster Setup Riverside Ballrooms
8:00 - 11:30 AM TB (and XDR) Ballroom 2-3
Megan Murray, Harvard School of Public Health
The Molecular Evolution of Extensively Drug Resistant Tuberculosis
* Valerie Mizrahi, University of the Witwatersrand - MMRU
Environment-Dependent Mutators and their Role in the Evolution of Drug Resistance in Mycobacterium tuberculosis
Nacer Lounis, Tibotec
Diarylquinolines Have the Potential to Shorten TB Treatment Duration
Douglas B. Young, Imperial College London
Drugs for Latent TB: A Grand Challenge in Global Health
Martin W. Bratschi, National University of Singapore
Short Talk: Development of a Lipid - Based Biomarker for TB Infection in Mouse
Priscille Marie Brodin, Inserm Avenir Institut Pasteur
Short Talk: High Content Screening of M. Tuberculosis Infected Macrophage and Impact on TB-drug Discovery
9:20 - 9:40 AM Coffee Break Riverside Foyer/Ballrooms
11:30 AM - 12:30 PM Lunch Ballroom 1/Riverside
12:00 - 2:00 PM Poster Session 3 Riverside Ballrooms
2:00 - 4:30 PM Respiratory Pathogens Ballroom 2-3
Maria Rescigno, European Institute of Oncology
Handling of Bacteria by Dendritic Cells at Mucosal Surfaces
* Birgitta Henriques Normark, Karolinska Institutet
The Role of pneumococcal pili in Carriage and in Invasive Disease
Scott D. Gray-Owen, University of Toronto
The Pathogenic Neisseria: Dancing with Humans
Jeremy Farrar, Oxford University Clinical Research Unit - Hospital for Tropical Diseases
Globalization and Infectious Diseases: A Threat and an Opportunity for Collaborative Clinical Science
4:30 - 5:00 PM Coffee Available Riverside Foyer/Ballrooms
5:00 - 7:30 PM Workshop 2: Malaria Ballroom 2-3
* Alan Cowman, Walter and Eliza Hall Institute of Medical Research
* Sumalee Kamchonwongpaisan, BIOTEC, Thailand National Science and Technology Development Agency
Brendan S. Crabb, Burnet Institute
A Putative Protein Translocon at the Parasitophorous Vacuole Membrane of Plasmodium falcipaum
Charles F. Battrell, Micronics, Inc.
Rapid POC Molecular Detection of Fever Pathogens
Violet Vakunseh Bumah, University of Buea
Molecular Analysis of Parasite and Human Host Determinants in Sera from Individuals Susceptible or Immune to Malaria
Babalwa Zani, Medical Research Council
The Suitability of Amodiaquine for Combination with Artesunate for the Treatment of Uncomplicated Malaria: A Systematic Review
Chairat Uthaipibull, National Center for Genetic Engineering and Biotechnology
Development of P. falciparum Parasites Expressing P. vivax Dihydrofolate Reductase-Thymidylate Synthase Enzyme as Model for anti-P. vivax Screening
Eva-Rachele Pesce, Rhodes University
Pfj4, a Plasmodium falciparum Hsp40 that Cooperates with the Molecular Chaperone PfHsp70-1
Raymond Hui, University of Toronto
Structural and Chemical Biology of Apicomplexan Parasites
Sunday, October 26
7:00 - 8:00 AM Breakfast etc Restaurant
8:00 - 11:30 AM Vaccines Ballroom 1
Gordon Dougan, Wellcome Trust Sanger Institute
Vaccines Against Invasive Salmonellosis
Cecil Czerkinsky, International Vaccine Institute
Mucosal Immunity and Vaccine Development
Rino Rappuoli, Novartis Vaccines & Diagnostics
Meningococcus and Neglected Diseases
Adrian V.S. Hill, Jenner Institute, Oxford University
Vectored Vaccines against Intracellular Pathogens
* Stefan H.E. Kaufmann, Max Planck Institute for Infection Biology-Berlin
Translating Basic Research in Tuberculosis into Vaccine and Biomarker Development
9:20 - 9:40 AM Coffee Break Riverside Foyer/Ballrooms
11:30 AM - 2:30 PM On Own for Lunch
2:30 - 4:00 PM Workshop 3: HIV Ballroom 1
* Stephen Hughes, NCI-Frederick, NIH
Peter D. Kwong, Vaccine Research Center, National Institutes of Health
Targeting the Receptor-Binding Sites on HIV-1 gp120
Elijah Martim Songok, Kenya Medical Research Institute
Short Talk: Evidence of Nevirapine Resistance in Rural Kenya
Wiriya Rutvisuttinunt, Armed Forces Research Institute of Medical Sciences
Short Talk: Interactions between HIV-1 Reverse Transcriptase and the Downstream Template Strand in Stable Complexes with Primer-Template
4:00 - 4:30 PM Coffee Break Riverside Foyer/Ballrooms
4:30 - 5:45 PM Combatting Emerging Pathogens Ballroom 1
* Robert E.W. Hancock, University of British Columbia
Selectively Modulating Innate Immunity
Sarah Randolph, University of Oxford
Predicting Arrival, Establishment and Spread of Exotic Diseases
5:45 - 6:30 PM Malaria Vaccines Ballroom 1
Stefan H.I. Kappe, Seattle Biomedical Research Institute
Live Attenuated Malaria Vaccine Design
7:00 - 8:00 PM Social Hour w/ Lite Bites Riverside Ballroom
8:00 - 11:00 PM Entertainment Riverside Ballroom
Monday, October 27
Departure
*Session Chair   †Speaker invited, not yet responded.



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