Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Type 2 Diabetes and Insulin Resistance (J3)

Organizer(s): Kitt F. Petersen and Laurie J. Goodyear
January 20 - 25, 2009
Fairmont Banff Springs · Banff, Alberta
Abstract Deadline: September 23, 2008
Late Abstract Deadline: October 23, 2008
Scholarship Deadline: September 23, 2008
Early Registration Deadline: November 20, 2008

Sponsored by Hoffmann-La Roche, Inc. and Novartis Institutes for BioMedical Research

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Obesity: Novel Aspects of the Regulation of Body Weight (J4)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Diabetes (Z6)
April 12 - 17, 2010

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The current rise in the prevalence of type 2 diabetes and the metabolic syndrome is believed to be a result of increasingly sedentary lifestyles combined with ready access to energy rich food sources in genetically susceptible individuals leading to insulin resistance. Studies of insulin signaling and its interactions with nutrient and hormonal pathways are central to our understanding of insulin resistance and the pathogenesis of type 2 diabetes. In recent years several areas have become the main focus of interest: the role of lipid and lipid metabolites in the pathogenesis of insulin resistance in muscle and liver; the role of mitochondrial function and biogenesis in the oxidative capacity of muscle and the relation to insulin resistance and susceptibility to the metabolic syndrome; the mechanisms of inflammation-induced insulin resistance; the role of adipocytes and their production of adipocytokines; as well as the mechanistic integration of b-cell failure and insulin resistance. The conference will bring together leaders in the academic and pharmaceutical communities to present the latest developments in these areas of research.

Tuesday, January 20
3:00 - 7:30 PM	Registration	Van Horne Foyer
6:30 - 7:30 PM	Refreshments	Van Horne Foyer
7:30 - 8:30 PM	Keynote Address (Joint)	Van Horne Ballroom A,B

	Bruce M. Spiegelman, Harvard Medical School Transcriptional Control of Adipogenesis and Energy Balance

Wednesday, January 21
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Genetics of Obesity and Diabetes (Joint)	Van Horne Ballroom A,B
	* Randy J. Seeley, University of Cincinnati
	Philippe Froguel, Imperial College of London GWA Enlighten Obesity and Diabetes Physiology
	Jeffrey M. Friedman, Rockefeller University Talk Title to be Determined

	Eric Schadt, Pacific Biosciences In silico Alternatives to Association Studies

	Andrew Hattersley, Peninsula Medical School What have we Learnt from Finding the BMI and Obesity Gene FTO?
	Satya Dash, University of Cambridge Short Talk: An Inherited Disorder of Glucose Transporter 4 Translocation in a Family with Acanthosis Nigricans, Post-prandial Hyperinsulinemia and a Truncation Mutation in TBC1D4
	Cecilia Lindgren, Oxford University Short Talk: Analysis of Genome-Wide Scans Identifies Potential Novel Common Susceptibility Loci for Central Obesity
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Roles of Cytokines, Lipid Mediators, and Inflammation I	Van Horne Ballroom A,B
	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center Immunological Effects of Obesity and Targeted Reversal to Treat Insulin Resistance and Diabetes

	Alon Chen, Weizmann Institute of Science Urocortins, New Peptides Involved in beta Cell Regulation and Glucose Homeostasis
	* Barbara B. Kahn, Beth Israel Deaconess Medical Center Glucose Sensing in the Adipocyte: Role for Carbohydrate Response Element Binding Protein (ChREBP)
	Stephan Wueest, University Children's Hospital Short Talk: Basal Lipolysis, not the Degree of Insulin Resistance, Differentiates Large from Small Isolated Adipocytes in High-Fat Fed Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 1	Mezzanine 2
Thursday, January 22
7:00 - 8:00 AM	Breakfast	Mezzanine 2
7:00 - 8:00 AM	Poster Setup	Mezzanine 2
8:00 - 11:15 AM	Insulin Resistance and Lipotoxicity I (Joint)	Van Horne Ballroom A,B
	* Kitt F. Petersen, Yale University School of Medicine
	Gerald I. Shulman, Howard Hughes Medical Institute, Yale University School of Medicine Molecular Mechanisms of Insulin Resistance
	Jay D. Horton, University of Texas Southwestern Medical Center Hepatic Steatosis and the SREBP Pathway
	Sonia Caprio, Yale University School of Medicine Ectopic Fat Distribution and Insulin Resistance in Obese Adolescents: Does it Matter?
	Ronald M. Evans, The Salk Institute Nuclear Receptors: Engineering Metabolism to Enhance Athletic Performance
	Qunfeng Jiang, Karolinska Institutet Short Talk: In-vivo Metabolic Studies in Muscle-Specific Calcineurin Transgenic Mice
	Christopher L. Karp, Cincinnati Children's Hospital Research Foundation Short Talk: Regulation of Energy Metabolism by the RP105/TLR Axis
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM - 12:00 PM	Lunch	Mezzanine 2
12:00 - 2:30 PM	Poster Session 2	Mezzanine 2
12:00 - 5:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Roles of Cytokines, Lipid Mediators, and Inflammation II	Van Horne Ballroom A,B
	* Clay F. Semenkovich, Washington University School of Medicine Genotoxic Stress, Lipogenesis and the Metabolic Syndrome
	Samuel Klein, Washington University School of Medicine Metabolic Implications of Visceral Fat and Nonalcoholic Fatty Liver Disease in Obesity
	Michael Karin, University of California, San Diego Lipid Activation of Stress-Responsive Kinases and Insulin Resistance

7:00 PM -	On Own for Dinner
Friday, January 23
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Insulin Resistance and Lipotoxicity II	Van Horne Ballroom A,B
	Michael P. Czech, University of Massachusetts Medical School RNAi-Based Therapeutic Strategies Targeting Inflammation and Metabolic Disease
	* Amira Klip, Hospital for Sick Children Lipotoxicity-Induced Insulin Resistance at Different Levels in Muscle Cells

	Domenico Accili, Columbia University Insulin Resistance: A Critical Reappraisal

	Gökhan S. Hotamisligil, Harvard University School of Public Health ER Stress, Inflammation and Lipotoxicity in Metabolic Regulation
	Varman T. Samuel, Yale University Short Talk: Fasting Hyperglycemia in Type 2 Diabetes Mellitus Develops Without Increased Expression of Phosphoenolpuyrvate Carboxykinase or Glucose 6-Phosphatase
	Megan Moriarty, University of Colorado, Denver Short Talk: Partial Knock-Down of p85alpha In Vivo with Anti-Sense Oligonucleotide Improves Insulin Sensitivity in Diet-induced Obese Mice
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Beta-Cell Function, Failure and Protection	Van Horne Ballroom A,B
	Klaus H. Kaestner, University of Pennsylvania School of Medicine HNF-4 in Beta-Cell Proliferation and Glucose Homeostasis
	* Susan Bonner-Weir, Joslin Diabetes Center Islet Cell Progenitors
	Steven Kahn, Vetarans Administration Puget Sound Health Care System and University of Washington ß-Cell Loss in Type 2 Diabetes

	Richard G. Kibbey, Yale University Short Talk: Glucose Toxicity Induces Alpha-Cell Dysregulation that Leads to Hyperglycemia
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 3	Mezzanine 2
Saturday, January 24
7:00 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Advances in Treatment and Therapeutic Intervention in Obesity and Diabetes (Joint)	Van Horne Ballroom A,B
	* Steven Kahn, Vetarans Administration Puget Sound Health Care System and University of Washington
	Lee M. Kaplan, Massachusetts General Hospital Physiological Responses to Bariatric Surgery
	D. Grahame Hardie, University of Dundee AMPK – an Energy Sensor and a Drug Target in Diabetes and the Metabolic Syndrome
	* Laurie J. Goodyear, Joslin Diabetes Center Exercise and Diabetes: The Emerging Roles of AMPK and AMPK-related Kinases
	Richard D. Dimarchi, Indiana University Chemical Biotechnology Applied to Endocrine Hormones
	Jian Yang, University of South Alabama College of Medicine Short Talk: AMP-Activated Protein Kinase Suppresses LXR-Dependent Sterol Regulatory Element-Binding Protein-1c Transcription in Rat Hepatoma McA-RH7777 Cells
	Tamer Coskun, Eli Lilly and Company Short Talk: FGF21 Corrects Obesity in Mice
9:20 - 9:40 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Mitochondria/ROS/SIRTs	Van Horne Ballroom A,B
	* Samuel Klein, Washington University School of Medicine

	Kitt F. Petersen, Yale University School of Medicine Lipid Mediated Insulin Resistance
	David A. Sinclair, Harvard Medical School Sirtuins as Modulators of Metabolism and Longevity
	Marc R. Montminy, The Salk Institute for Biological Studies Regulation of Hepatic Gluconeogenesis by the CREB Coactivator TORC2 and the Forkhead Transcription Factor FOXO1
	Julia Szendroedi, University Düsseldorf Short Talk: Mitochondrial Dysfunction in the Liver of Patients with Type 2 Diabetes
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
8:00 - 11:00 PM	Entertainment	Mezzanine 2
Sunday, January 25
	Departure

*Session Chair †Speaker invited, not yet responded.