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Complications of Diabetes and Obesity (J7)

Organizer(s): Ann Marie Schmidt, George L. King and Thomas M. Coffman
February 24 - March 1, 2009
Fairmont Hotel Vancouver  ·  Vancouver, British Columbia
Abstract Deadline: October 23, 2008
Late Abstract Deadline: November 25, 2008
Scholarship Deadline: October 23, 2008
Early Registration Deadline: December 29, 2008


Sponsored by Pfizer Global Research & Development

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.


Joint meeting: Dissecting the Vasculature: Function, Molecular Mechanisms and Malfunction (J8)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).



This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
The complications of diabetes and obesity are emerging as major health problems in the United States and world-wide. Obesity-linked complications may lead to the development of insulin resistance and, ultimately, hyperglycemia. Thus, the study of mechanisms underlying and linking these disorders holds promise for the identification of mechanism-targeted therapeutic agents. In addition to frank and often destructive recruitment of immune responses, diabetes and obesity are significantly modified by host and environment factors. Such factors as hypertension, innate aging, failure of effective pro- or anti- angiogenesis programs, genetic and epigenetic factors may influence the phenotype and outcome in diabetes and obesity. The goals of the meeting will be to integrate these concepts in close collaboration with the “Dissecting the Vasculature” concurrent meeting group. Beginning with the vessel, and addressing superimposed and modifying factors, this program will facilitate greater understanding of mechanisms linked to diabetes and its complications and obesity.

Tuesday, February 24
3:00 - 7:30 PM Registration BC Foyer
6:30 - 7:30 PM Refreshments Pacific Ballroom
7:30 - 8:30 PM Keynote Address (Joint) British Columbia Ballroom
* William F. Jackson, Michigan State University
* Ann Marie Schmidt, Columbia University
Joseph Loscalzo, Brigham and Women's Hospital/Harvard Medical School
Redox Dysregulation in Vascular Disease
Wednesday, February 25
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:15 AM Glucose and Other Metabolites: Actions on Target Cells Columbia Ballroom
* Michael A. Brownlee, Albert Einstein College Of Medicine
Unifying Mechanisms and the Complications of Diabetes
Ann Marie Schmidt, Columbia University
RAGE, Inflammation and the Complications of Diabetes
George L. King, Joslin Diabetes Center
Protein Kinase C and the Complications of Diabetes
Paul Fernyhough, St Boniface Research Centre
Mitochondrial Stress and the Pathogenesis of Diabetic Neuropathy
Adriana Machado-Lima, University of Sao Paulo
Short Talk: Glycated Albumin Isolated from Uncontrolled Type 1 and Type 2 Diabetes Mellitus Patients Impairs Cell Cholesterol Removal and Induces Lipid Accumulation in Macrophages
Bruce A. Perkins, University of Toronto
Short Talk: Excess Urinary Excretion of Markers of Glycation Predict Subsequent Early Renal Function Decline in Type 1 Diabetes
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Pacific Ballroom
1:00 - 10:00 PM Poster Viewing Pacific Ballroom
2:30 - 4:30 PM Workshop 1: Techniques (Joint) British Columbia Ballroom
* Karen Lounsbury, University of Vermont
Paul L. Hermonat, University of Arkansas for Medical Sciences
Viral Gene Therapy Targeting the Vasculature
W. Gil Wier, University of Maryland School of Medicine
Techniques for Imaging Signal Transduction in the Vasculature
Lloyd P. Aiello, Joslin Diabetes Center
Designing Clinical Trials - The Fruits of Translational Research
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Insulin Resistance and Actions Columbia Ballroom
* C. Ronald Kahn, Joslin Diabetes Center
Insulin Actions and Cardiovascular Pathologies
Michael J. Quon, National Institutes of Health
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: From Cells to Humans
Nir Barzilai, Albert Einstein College of Medicine
Aging and Insulin Resistance
Manuel Roman Benito, Universidad de Complutense
Short Talk: Compensated and Non-Compensated Insulin Resistance Induces Differential Cardiovascular Damage in Obese BATIRKO Mice
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
7:30 - 10:00 PM Poster Session 1 Pacific Ballroom
Thursday, February 26
7:00 - 8:00 AM Breakfast Pacific Ballroom
7:00 - 8:00 AM Poster Setup Pacific Ballroom
8:00 - 11:15 AM Inflammation and Immunity: Links to Diabetes and Obesity Columbia Ballroom
Anthony W. Ferrante, Columbia University
Inflammatory Mechanisms and Obesity
Ajay Chawla, Stanford University Medical Center
Macrophage Activation, Obesity and Insulin Resistance
* Douglas Golenbock, University of Massachusetts Medical School
Toll Like Receptors - Linking Innate and Adaptive Immunity
Ishwarlal Jialal, University of California, Davis
Diabetes (both Type 1 & 2) is a Pro-Inflammatory State?
Patricia W. Bedard, Wyeth Pharmaceuticals
Short Talk: CX3CR1 Contributes to Adipose Tissue Macrophage Infiltration and Insulin Resistance on a High Fat, High Sucrose Diet
Zhaoyun Zhang, Joslin Diabetes Center
Short Talk: Overexpressing G6PD Reduces Oxidant Stress Induced by High Glucose via PKA Activation in Endothelial Cells
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - 12:00 PM Lunch Pacific Ballroom
12:00 - 2:30 PM Poster Session 2 Pacific Ballroom
2:30 - 4:30 PM Workshop 2: Funding for the Young Cardiovascular and Diabetes Investigator (Joint) British Columbia Ballroom
* Nancy J. Rusch, University of Arkansas for Medical Sciences
* Ann Marie Schmidt, Columbia University
Cristina Rabadan-Diehl, The National Institutes of Health
Ronald Kohanski, The National Institutes of Health
Teresa Jones, The National Institutes of Health, USA
R. Clinton Webb, American Heart Association
Barbara A. Araneo, Juvenile Diabetes Research Foundation
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Regeneration and Diabetes Columbia Ballroom
Douglas Zochodne, University of Calgary
Diabetes and Regenerative Failure of Peripheral Neurons
* Martin Friedlander, The Scripps Research Institute
Cell-Based Therapies for Diabetic Retinopathy
Omaida C. Velazquez, University of Miami, Jackson Memorial Hospital
The Potential Role of Hyperoxia and Endothelial Progenitor Cell Mobilization in Diabetic Wound Healing
Alex F. Chen, University of Pittsburgh School of Medicine
Short Talk: Restoration of Endothelial Progenitor Cell Function with Manganese Superoxide Dismutase Gene Transfer in Type 2 Diabetic Wound Healing
7:00 PM - On Own for Dinner
Friday, February 27
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:15 AM Novel Targets and Treatments for Diabetes and its Complications Columbia Ballroom
Lloyd P. Aiello, Joslin Diabetes Center
Novel Targets and Treatments for Diabetic Retinopathy and Macular Edema
Kumar Sharma, University of California San Diego
A Systems Biology Understanding of Diabetic Nephropathy Based on Novel Anti-Fibrosis Treatments and Biomarkers
* Ravichandran Ramasamy, Columbia University
Aldose Reductase & Rage: Key Targets for Cardioprotective Interventions in Diabetes
Nobuyo Maeda, University of North Carolina
Antioxidant Defense against Diabetic Cardiovascular Disease
Lokesh Kumar Bhatt, School of Pharmacy and Technology Management
Short Talk: Enhancement of MMP2 and MMP9 Inhibition in Presence of Aspirin, a COX Inhibitor: A New Therapeutic Approach in Treatment of Diabetic Neuropathy
Jia Liu, Joslin Diabetes Center
Short Talk: Plasma Kallikrein Exacerbates Intracerebral Hemorrhage Expansion in Diabetic Rats
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - On Own for Lunch
11:15 AM - 1:00 PM Poster Setup Vancouver Island Room
1:00 - 10:00 PM Poster Viewing Pacific Ballroom
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Cellular Mechanisms, Shaping the Nature and Severity of Complications Columbia Ballroom
Erwin P. Böttinger, Mount Sinai School of Medicine
Impact of Podocyte Injury in Diabetes
Thomas M. Coffman, Duke University Medical Center
Impact of Hypertension and the Renin-Angiotensin System
* Geoffrey Cash Gurtner, Stanford University
Impaired Neovascularization in Diabetes and Aging
Sandeep Raha, McMaster University
Short Talk: Maternal Obesity Results in Placental Mitochondrial Dysfunction and Compromised Neonatal Health
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
7:30 - 10:00 PM Poster Session 3 Pacific Ballroom
Saturday, February 28
7:00 - 8:00 AM Breakfast Pacific Ballroom
8:00 - 11:15 AM Hypertension and Angiogenesis - Responses to Vascular Injury/Genomics - Disease Models and Human Genomics (Joint) British Columbia Ballroom
* Ronald J. Korthuis, University of Missouri
* Thomas M. Coffman, Duke University Medical Center
Susan Quaggin, Samuel Lunenfeld Research Institute
Angiogenesis and Diabetic Nephropathy
Maria B. Grant, University of Florida
Vascular Repair Strategies for Diabetic Retinopathy- Mobilization and Differentiation of Hematopoietic Stem Cell by IGFBP-3
Geert W. Schmid-Schönbein, University of California, San Diego
A Molecular Mechanism for Blood Pressure Elevation, Type II Diabetes, Immune Suppression and Microvascular Rarefaction in the Spontaneously Hypertensive Rat
Frank Chip Brosius III, University of Michigan
Flipped Signaling: Consequences of Altered Glucose Transporter Expression in Vascular Cells
Julia V. Busik, Michigan State University
Short Talk: Inhibition of Sphingomyelinases Protects from Inflammation, Vascular Degeneration and Neovascularization in Retinopathy Animal Models
David A. Antonetti, Pennsylvania State University
Short Talk: Atypical PKC Inhibitors Block both VEGF and TNF alpha Induced Endothelial Permeability
9:20 - 9:40 AM Coffee Break BC Foyer
11:15 AM - On Own for Lunch
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Genetics and Epigenetics Columbia Ballroom
* John Sedor, Case Western Reserve School of Medicine
Genetics of Diabetic Nephropathy
Rama Natarajan, Beckman Research Institute of City of Hope
Epigenetics, Metabolic Memory, Inflammation and Diabetic Complications
Juro Sakai, University of Tokyo
Short Talk: PPARgamma/RXRalpha Heterodimer Induces Histone Modification Enzyme PR-Set7/Setd8 and Promotes Adipogenesis through a Positive Feedback Loop
Monika A. Niewczas, Joslin Diabetes Center
Short Talk: TNF alpha Related Markers Predict Glomerular Filtration Rate (GFR) Decline but not an Increase in Urinary Albumin Excretion in Patients with Early Diabetic Nephropathy: Results of a Prospective Study
7:00 - 8:00 PM Social Hour w/ Lite Bites Pacific Ballroom
8:00 - 11:00 PM Entertainment Pacific Ballroom
Sunday, March 1
Departure
*Session Chair   †Speaker invited, not yet responded.



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