Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Metabolism and Cardiovascular Risk (S2)

Organizer(s): E. Dale Abel, Ira J. Goldberg and Karin E. Bornfeldt
September 23 - 28, 2008
Beaver Run Resort · Breckenridge, Colorado
Abstract Deadline: June 24, 2008
Late Abstract Deadline: July 24, 2008
Scholarship Deadline: May 22, 2008
Early Registration Deadline: July 24, 2008

Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2008 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Cardiovascular disease is the major cause of mortality in developed countries and emerging economies worldwide. Important risk factors include diabetes, obesity, and dyslipidemia. Given the growing worldwide epidemic of obesity and the metabolic syndrome, there is a critical need to understand the biological mechanisms that confer this increased risk. The most current research in this area has identified important mechanisms linking dyslipidemia and inflammation to the development of atherosclerosis, the role of adipokines in linking metabolic dysfunction and cardiovascular disease, and the role of insulin resistance and mitochondrial dysfunction in the pathogenesis of cardiac dysfunction. Recent genome-wide association studies have identified novel genetic loci that may link metabolic disorders with increased risk. The goals of this meeting are to present the latest data on: (1) genetic studies linking metabolism and cardiovascular risk; (2) new insights into the mechanisms linking insulin resistance with atherosclerosis and cardiac dysfunction; and (3) new insights into the role of altered insulin signaling and lipotoxicity in promoting cardiovascular disease in individuals with diabetes and the metabolic syndrome. The program will catalyze interactions that are likely to lead to new approaches to tackle the translation of fundamental observations to the prevention of cardiovascular disease in these vulnerable populations.

Tuesday, September 23
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 8:30 PM	Keynote Address	Peak 5
	* E. Dale Abel, University of Utah School of Medicine

	Ruth McPherson, University of Ottawa Heart Institute Genetic Insights into Coronary Artery Disease
8:30 - 9:00 PM	Orientation for New Attendees and New Investigators Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.	Peak 5
Wednesday, September 24
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	New Genetic Insights Linking Metabolism and Cardiovascular Risk	Peak 5



	Markku Laakso, Kuopio University Central Hospital Genetics of Type 2 Diabetes

	* Alan D. Attie, University of Wisconsin-Madison Genes, Gene Networks, and Type 2 Diabetes




	Aldons J. Lusis, University of California, Los Angeles Systems Biology of Cardiovascular Disease
	Zhiguang Su, The Jackson Laboratory Short Talk: Obesity, Adiponectin, and HDL are Controlled by Common Genetic Factors in the Mouse
	Sudha B. Biddinger, Harvard University Short Talk: Hepatic Insulin Resistance Suppresses Cholesterologenic Gene Expression by Inhibiting SREBP-2
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Peaks 1-4
11:15 AM -	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Peaks 1-4
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Adipocytokines and Cardiovascular Risk	Peak 5
	* Scott A. Summers, Duke-NUS Graduate Medical School
	Kenneth Walsh, Boston University School of Medicine Adiponectin and Cardiac Injury
	Daniel T. Eitzman, University of Michigan Visceral Adipose Tissue and Atherosclerosis
	Cuihua Zhang, University of Missouri-Columbia TNF-Alpha and Vascular Dysfunction
	Anne Marie Minihane, Hugh Sinclair Nutrition Group Short Talk: Influence of a Leptin Receptor Gene Variant on Postprandial Triglyceride Metabolism: Impact of Gender
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Peaks 1-4
7:30 - 10:00 PM	Poster Session 1	Peaks 1-4
Thursday, September 25
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	Insulin and Akt Signaling in the Heart and Vasculature	Peak 5
	* Kenneth Walsh, Boston University School of Medicine
	E. Dale Abel, University of Utah School of Medicine Insulin and Growth Factor Regulation of Cardiac Mitochondria
	Anthony Rosenzweig, Beth Israel Deaconess Medical Center Akt and SGK Signaling in the Heart
	William C. Sessa, Yale University School of Medicine Role of Akt in the vasculature
	Paul Huang, Massachusetts General Hospital eNOS, Metabolic Diseases, and Cardiovascular Risk
	Elena Galkina, Eastern Virginia Medical School Short Talk: Accelerated Atherosclerosis in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous ApoE Knockout Mice
	Carlos Fernández-Hernando, New York University School of Medicine Short Talk: Endothelial Caveolin-1 Regulates the Progression of Atherosclerosis by Controlling LDL Infiltration, Expression of Vascular Adhesion Molecules and Production of Nitric Oxide
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 12:00 PM	Lunch	Peaks 1-4
12:00 - 2:30 PM	Poster Session 2	Peaks 1-4
2:30 - 4:30 PM	Workshop: Hot Topics in Cardiac and Vascular Metabolism	Peak 5
	* Ira J. Goldberg, Columbia University
	* Karin E. Bornfeldt, University of Washington School of Medicine

	Peter C. Lucas, University of Michigan The CARMA3-Bcl10-MALT1 Signalosome as a mediator of Angiotensin II-dependent NF-kappaB activation and atherogenesis
	Jenny E. Kanter, University of Washington Macrophage Long-Chain acyl-CoA Synthetase 1 Plays an Important Role in Lipid Loading by Inhibiting Cholesterol Efflux via ATP-Binding Cassette Transporter 1
	Heiko Bugger, University of Utah School of Medicine Increased Myocardial Fatty Acid Uptake by Acyl-CoA Synthetase 1 Impairs Mitochondrial Function and Dynamics

	Xiaoyue Pan, SUNY Downstate Medical Center Clock is Required for Diurnal and Food-Entrained Regulation of Plasma Lipids and Lipoproteins
	Zoltan P. Arany, Dana Farber Cancer Institute Regulation of VEGF and Angiogenesis by the Transcriptional Coactivator PGC-1alpha
	Denis J. Glenn, University of California, San Francisco Transgenic Expression of DGAT1 in Cardiac Myocytes Results in Cardiac Steatosis
	Adam Raymond Wende, University of Utah Short-term, Cardiac Specific Overexpression of GLUT4 does not Rescue Metabolic and Contractile Dysfunction in the Diabetic Heart
	Leo Timmers, University Medical Center Utrecht Cardioprotective Effects of Exenatide, a Glucagon-Like Peptide 1 Receptor Agonist
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Signaling Mechanisms Regulating Mitochondrial Function and Metabolism	Peak 5
	* Margaret P. Chandler, Case Western Reserve University
	Daniel P. Kelly, Burnham at Lake Nona PGC1, Mitochondria and Cardiac Dysfunction in Insulin Resistance and Diabetes
	Jiandie Lin, University of Michigan Medical School Transcriptional Networks in the Control of Energy Metabolism
	Martin E. Young, University Alabama Birmingham Circadian Clocks and Cardiac Metabolism
	Michael N. Sack, National Institutes of Health Short Talk: PGC-1alpha Integrates Insulin Signaling, Mitochondrial Regulation and Bioenergetic Function in Skeletal Muscle
7:00 PM -	On Own for Dinner
Friday, September 26
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	Inflammation, Lipids and Other Risk Factors	Peak 5


	Christopher K. Glass, University of California, San Diego Transcriptional Regulation of Macrophage Function
	* Ajay Chawla, Stanford University Medical Center Macrophage Activation in Obesity and Insulin Resistance
	Kitt F. Petersen, Yale University School of Medicine Lipid-Mediated Insulin Resistance


	Li Wang, University of Utah Nuclear Receptor SHP in Metabolic Regulation
	Michael G. Usher, University of Michigan Short Talk: The Mineralocorticoid Receptor Controls Macrophage Polarization in Cardiovascular Inflammation
	Ming-Dong Wang, University of Ottawa Heart Institute Short Talk: SR-BI Deficiency in Macrophage Labeled with LDL-Derived Cholesterol Leads to Reduced in vivo Reverse Cholesterol Transport
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Peaks 1-4
11:15 AM -	On Own for Lunch
1:00 - 10:00 PM	Poster Viewing	Peaks 1-4
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:15 PM	Vascular Metabolism	Peak 5
	* Alan R. Tall, Columbia University
	Ira J. Goldberg, Columbia University Glucose and Lipids in Cardiovascular Diseases
	Clay F. Semenkovich, Washington University School of Medicine Vascular Metabolism and Atherosclerosis

	Jerry L. Nadler, Eastern Virginia Medical School Inflammatory Mechanisms Linking Metabolic Changes and Atherosclerosis
	Cecilia M. Giachelli, University of Washington Regulation of Vascular Calcification
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Peaks 1-4
7:30 - 10:00 PM	Open Viewing Poster Sessions 1 & 2	Peaks 1-4
Saturday, September 27
7:00 - 8:00 AM	Breakfast	Peaks 1-4
8:00 - 11:15 AM	Lipid Signaling and Lipotoxicity	Peak 5
	* M. Mahmood Hussain†, SUNY Downstate Medical Center
	Rudolf Zechner, University of Graz Adipose Triglyceride Lipase
	* Jean E. Schaffer, Washington University School of Medicine Lipotoxicity: Mapping the Response to Metabolic Stress
	Jay W. Heinecke, University of Washington School of Medicine Proteomics Implicates a Macrophage Sterol-Regulated Network in Atherogenesis
	Scott A. Summers, Duke-NUS Graduate Medical School Ceramides, Insulin Resistance, and Metabolic Disease
	Luuk Jon Rijzewijk, Vrije Universiteit University Medical Center Short Talk: The Phenotype of Human Diabetic-Lipotoxic Cardiomyopathy and the Effects of Anti-Steatotic PPARgamma-Agonist Therapy: Studies with PET and MRI/MRS
	Babak Razani, Washington University School of Medicine Short Talk: Cardiac Fatty Acid Synthase Mediates Survival with Acute Stress
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Molecular Mechanisms of Atherosclerosis	Peak 5

	Alan R. Tall, Columbia University Anti-Atherogenic Mechanisms of HDL
	* Karin E. Bornfeldt, University of Washington School of Medicine Diabetes-Accelerated Atherosclerosis: Evidence from a Mouse Model
	Edward A. Fisher, New York University School of Medicine Regulation of Atherosclerosis Regression in Novel Mouse Models and the Effects of Hyperglycemia
	Jason Voogt, KineMed, Inc. Short Talk: In vivo Effects of Two ApoA-1 Mimetics on Plasma Cholesterol Flux, de novo Cholesterol Synthesis and Reverse Cholesterol Transport
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Peaks 1-4
8:00 - 11:00 PM	Entertainment	Peaks 1-4
Sunday, September 28
	Departure

*Session Chair †Speaker invited, not yet responded.