Keystone Symposia Conference | Stem Cells, Cancer and Aging

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Meeting Program

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Monday, September 29
3:00 - 7:00 PM	Registration and Sign-Up for Biopolis Tours Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Foyer
6:00 - 10:00 PM	ISD Board of Directors Meeting	Enterprise
Tuesday, September 30
7:00 - 8:00 AM	Breakfast	Canning
7:00 AM- 12:00 PM	Poster Setup	Stamford Foyer
8:00 - 8:15 AM	Welcoming Remarks Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	Lim Chuan Poh, Chairman, Agency for Science, Technology & Research (A*STAR)
8:15 - 8:30 AM	Opening Remarks Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	David P. Lane, Experimental Therapeutic Centre, Singapore
	Hans C. Clevers, Hubrecht Institute, Netherlands
8:30 AM- 12:00 PM	Models of Aging Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* David P. Lane, Experimental Therapeutic Centre, Singapore
	Jan H. J. Hoeijmakers, Erasmus Medical Center, Netherlands DNA Repair and the Connection between Cancer and Aging
	Lawrence A. Donehower, Baylor College of Medicine, USA Insights into Stem Cells and Aging Provided by A P53 Mutant Mouse

	Heidi Scrable, University of Virginia, USA p53 and IGF: An Ancient Connection
	Mary Ellen Perry, OPASI, OD, National Institutes of Health, USA p53 and Aging in Experimental Animals
9:40 - 10:00 AM	Coffee Break	Stamford Foyer
12:00 - 1:00 PM	Lunch	Canning
1:00 - 2:00 PM	ISD Award Lecture: Anne McLaren Memorial Lecturer Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* Hans C. Clevers, Hubrecht Institute, Netherlands
	Magdalena Zernicka-Goetz, University of Cambridge, UK Cell Fate, Plasticity and Pluripotency in the Early Mouse embryo
2:00 - 2:30 PM	Coffee Available	Stamford Foyer
2:30 - 4:00 PM	Regulating Tumor Suppression Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* Hans C. Clevers, Hubrecht Institute, Netherlands
	Gerard I. Evan, University of California, San Francisco, USA Switchable Tumor Suppression Models to Control Cancer and Aging


	Alea A. Mills, Cold Spring Harbor Laboratory, USA p63 Deficiency and Aging
4:00 - 6:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Foyer
5:00 - 6:00 PM	Social Hour	Stamford Foyer
Wednesday, October 1
7:00 - 8:00 AM	Breakfast	Canning
7:00 AM- 12:00 PM	Poster Setup	Stamford Foyer
8:00 - 11:30 AM	Signaling Pathways in Cancer and Development Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* Jean-Paul Thiery, Institute of Molecular and Cellular Biology, Singapore
	Hans C. Clevers, Hubrecht Institute, Netherlands Identification of Stem Cells in Small Intestine and Colon by a Single Marker Gene LGR5

	Yoshiaki Ito, Institute of Molecular and Cell Biology, Singapore RUNX3, a Novel Gate Keeper of Colon Carcinogenesis
	Vinay B. Tergaonkar, Institute of Molecular and Cell Biology, Singapore New Controls of the NF-kappa B Pathway
	Michael Karin, University of California, San Diego, USA Inflammatory Processes in Metastatic Progression
9:40 - 10:00 AM	Coffee Break	Stamford Foyer
11:30 AM- 12:30 PM	Lunch	Canning
12:30 - 2:30 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Foyer
2:00 - 2:30 PM	Coffee Available	Stamford Foyer
2:30 - 4:30 PM	Counting Stem Cells Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* Gerard I. Evan, University of California, San Francisco, USA
	Connie J. Eaves, British Columbia Cancer Agency, Canada Title to be Determined

	Andrei V. Gudkov, Roswell Park Cancer Institute, USA Saving Stem Cells to Survive Radiation


	Hongyan Wang, Duke-NUS Graduate Medical School Singapore, Singapore Short Talk: Brain Tumor Suppressors and Neural Stem Cell Self-Renewal in Drosophila
5:00 - 6:00 PM	ISD Membership Meeting	Stamford Ballroom
Thursday, October 2
7:00 - 8:00 AM	Breakfast	Canning
7:00 AM- 12:00 PM	Poster Setup	Stamford Foyer
8:00 - 9:00 AM	Keynote Address Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* Neal G. Copeland, Institute of Molecular and Cell Biology, Singapore
	Arnold J. Levine, Institute for Advanced Study, USA Single Nucleotide Polymorphisms in the p53 Pathway
9:00 - 11:30 AM	New Models to Find Novel Cancer and Aging Pathways Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* Arnold J. Levine, Institute for Advanced Study, USA
	Xin Lu, Ludwig Institute for Cancer Research, UK ASPP2 Mediates Senescence and Inhibits Autophagy and Tumourgenicity Induced by H-RasV12


	Neal G. Copeland, Institute of Molecular and Cell Biology, Singapore Harnessing Transposons for Cancer Gene Discovery

	Edison T. Liu, Genome Institute of Singapore, Singapore Comprehensive Identification of Genomic Rearrangements in Human Cancer
9:00 - 9:20 AM	Coffee Break	Stamford Foyer
11:30 AM- 12:30 PM	Lunch	Canning
12:30 - 2:30 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Foyer
2:00 - 2:30 PM	Coffee Available	Stamford Foyer
2:30 - 4:30 PM	New Targets and Therapeutic Approaches to Cancer and Aging Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	* Xin Lu, Ludwig Institute for Cancer Research, UK
	Gregory L. Verdine, Harvard University, USA Drugging “Undruggable” Targets in Cancer
	David P. Lane, Experimental Therapeutic Centre, Singapore Small Molecule Switches to Control p53 Activity

	Axel Ullrich, Max Planck Institute of Biochemistry, Germany The Singapore OncoGenome Project as Part of an Effort to Develop a Portfolio of Targeted Cancer Therapeutics
Friday, October 3
7:00 - 8:00 AM	Breakfast	Canning
7:30 - 8:30 AM	Transfer to Biopolis
8:30 - 10:30 AM	Cancer Stem Cells Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Biopolis
	* Xin Lu, Ludwig Institute for Cancer Research, UK
	Sean J. Morrison, University of Michigan/HHMI, USA Cancer Stem Cells in the Hematopoietic System


	Colin L. Stewart, Institute of Medical Biology, Singapore The Lamins and the Functional Architecture of the Nucleus in Disease and Aging

	Daniel G. Tenen, Harvard Institutes of Medicine, National University of Singapore, USA Transcription Factor C/EBP alpha Regulates Hematopoietic Stem Cell Proliferation and Maintenance during Aging
10:30 - 11:00 AM	Coffee Break	Biopolis Foyer
11:00 AM- 12:00 PM	ISD Award Lecture: Jean Brachet Memorial Lecturer Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Biopolis
	* Hans C. Clevers, Hubrecht Institute, Netherlands
	Giulio Cossu, University of Milan, Italy Towards Cell Therapy for Muscular Dystrophies
12:00 - 1:00 PM	Lunch Catered by Biopolis Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Biopolis
12:30 - 2:00 PM	Optional Tour of Biopolis
12:30 - 2:00 PM	Transfer to Hotel
2:30 - 3:00 PM	Coffee Available	Stamford Foyer
3:00 - 4:45 PM	More Adult Stem Cells in the Self-Renewing Tissues Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	Davor Solter, Institute of Medical Biology, Singapore Preformation Versus Epigenesis in Driving Mammalian Development


	Jean-Paul Thiery, Institute of Molecular and Cellular Biology, Singapore Potentiality of Mammary Epithelial Cells with a Basal Phenotype

4:45 - 5:00 PM	Meeting Sum Up Registered attendees for this meeting can view Abstracts for this session starting on 08/29/2008	Stamford Ballroom
	Xin Lu, Ludwig Institute for Cancer Research, UK
	Arnold J. Levine, Institute for Advanced Study, USA
5:00 - 6:00 PM	Social Hour	Stamford Foyer
Saturday, October 4
	Departure
*=Session Chair †=Speaker invited, not yet responded.

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Recent studies on the effect of polymorphisms in human tumor suppressor pathways on cancer incidence and longevity have confirmed long held views of the link between the key processes that control human aging and cancer incidence. One interpretation of these findings is that the stem cell is the key target for carcinogenesis. Further, the thresholds that regulate stem cell death in response to damage make the bargain between too-resilient stem cells, which result in long life but increased cancer risk, and too-sensitive stem cells, which ablate the occurrence of cancer but can shorten life span through stem cell exhaustion. Dramatic progress in the understanding of signaling pathways and points of intervention which will be debated in this meeting offers the enticing prospect of regulating these pathways to extend healthy lifespan and reduce cancer incidence in the human population.

Stem Cells, Cancer and Aging (S3)