Granlibakken Tahoe Floorplan

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This meeting took place in 2010


Here are the related meetings in 2018:
Pushing the Limits of Healthspan and Longevity (D3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

New Insights into Healthspan and Diseases of Aging: From Molecular to Functional Senescence (B2)


Organizer(s) Sean M. Oldham, David A. Sinclair, Jan Vijg and Heidi Scrable
January 31—February 5, 2010
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Sep 24, 2009
Late Abstract Deadline: Oct 30, 2009
Scholarship Deadline: Sep 24, 2009
Early Registration Deadline: Nov 30, 2009

Supported by The Directors' Fund

Summary of Meeting:
Aging can be defined as the gradual loss of the ability of the organism to maintain homeostasis. Our aim will be to focus on the molecular and cellular mechanisms by which tissue and organ function deteriorate and homeostasis fails rather than on longevity itself, which has been the theme of previous Keystone Symposia meetings on aging. Work from a variety of models is recognizing that organisms, especially humans, are complicated systems in which interventions that extend lifespan might not necessarily block the aging and loss of function in specific organs or tissues and vice versa. Continuing this approach will help us gain an understanding and appreciation of the complexity that underlies aging in humans. The aim of this meeting is to reveal the integration and communication between pathways and systems during functional aging and their relationship with longevity. This meeting will highlight important questions to address in future research. Most importantly, what are the common and disparate causes underlying the cellular and physiological mechanisms responsible for human senescent phenotypes?

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 31

15:00—19:30
Registration

Pre Function
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
Andrzej Bartke, Southern Illinois University School of Medicine, USA
Growth Hormone: Elixir of Youth or Dangerous Snake Oil?


MONDAY, FEBRUARY 1

07:00—08:00
Breakfast

Granhall
08:00—11:15
Aging Pathways I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Marc Tatar, Brown University, USA

Cynthia Kenyon, Calico, USA
Insulin and Aging

Leonard P. Guarente, Massachusetts Institute of Technology, USA
Sirtuins Aging and Disease

Daniel E.L. Promislow, University of Washington, USA
Networks and the Evolution of Aging

Anne Brunet, Stanford University, USA
The Plasticity of Aging Describing the Role of FoxO3 in Maintaining Neuronal Stem Cell Pool

William B. Mair, Harvard School of Public Health, USA
Short Talk: AMPK and Calcineurin extend lifespan via the CREB Regulated Transcription Co-activator (CRTC-1)

Maaike van den Berg, University of Bristol, UK
Short Talk: Regulation of FOXO4 through ROS Regulated Ral-JIP1-JNK Complex Assembly

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Aging Pathways II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA

Jennifer Cermak, Sirtris, a GSK Company, USA
Targeting Sirtuins: Drug Development for Diseases of Aging

Robert S. Garofalo, , USA
Insulin Resistane: Insights from high resolution transcriptional profiling

Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA
Role of Nutrient Sensing TOR Pathway in Obesity and Aging

Matthew D. McGee, Buck Institute for Research on Aging, USA
Short Talk: 3D Digital Atlas of Aging in C. elegans

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour

Bay

TUESDAY, FEBRUARY 2

07:00—08:00
Breakfast

Granhall
08:00—11:15
Molecules and Aging I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* David A. Sinclair, Harvard Medical School, USA

Jan Vijg, Albert Einstein College of Medicine, USA
Genomic Instability, Transcriptional Deregulation and Aging

Judith Campisi, Buck Institute for Research on Aging, USA
The Double Edged Sword of Cellular Senescence

George M. Martin, University of Washington, USA
Human diseases of Ageing and their evolutionary substrates

Norman E. Sharpless, University of North Carolina School of Medicine, USA
Cell Cycle Control and Mammalian Aging

Raul Mostoslavsky, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: The Histone Deacetylase SIRT6 Functions as a Master Regulator of Glucose Homeostasis

Eduardo Nunes Chini, Mayo Clinic, USA
Short Talk: CD38 and DBC1: regulators of the non-oxidative functions of NAD; role of inhibitors of the longevity related enzyme SIRT1

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Molecules and Aging II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Jan Vijg, Albert Einstein College of Medicine, USA

Heidi Scrable, Mayo Clinic, USA
p53 and Aging

David A. Sinclair, Harvard Medical School, USA
A tale of two Sirts

Rafael de Cabo, NIA, National Institutes of Health, USA
From Molecules to Nutritional Interventions for Healthy Aging

* Philipp Oberdoerffer, NCI, National Institutes of Health, USA
Short Talk: A Mechanistic Link between DNA Damage, Chromatin and Aging

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour

Bay

WEDNESDAY, FEBRUARY 3

07:00—08:00
Breakfast

Granhall
08:00—11:15
Cells and Organelles Aging
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Heidi Scrable, Mayo Clinic, USA

Thomas A. Rando, Stanford University School of Medicine, USA
Stem cell aging, DNA damage and asymmetric cell division

Leanne Jones, University of California, Los Angeles, USA
Stem Cell-Niche Cell Interactions during Aging

Amy J. Wagers, Harvard University, USA
Reversing Dysfunction of Aged Tissue Stem Cells

* Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Stem Cell Renewal and changes in stem cell function during aging

Pier Lorenzo Puri, Sanford-Burnham Medical Research Institute, USA
Short Talk: DNA Damage Signaling to MyoD and the Control of the Genomic Stability of Skeletal Muscles during Development and Aging

Giana Angelo, Fred Hutchinson Cancer Research Center, USA
Short Talk: Adult Worms Protect Germline Stem Cells and Extend their Reproductive Span in Response to Starvation

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop: Stress, Mitochondria, and Aging

Mountain/Lake
Nicholas Day, Buck Institute for Research on Aging, USA
A Novel Inducible Mouse Model of Endogenous Mitochondrial Oxidative Stress Causes Heart Disease

Hadise Kabil, University of Michigan, USA
Activity of the Transsulfuration Pathway Determines Lifespan Extension in Response to Dietary Restriction in Drosophila

* Pankaj Kapahi, Buck Institute for Research on Aging, USA
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

David B. Lombard, University of Michigan, USA
Mitochondrial Protein Acetylation in Calorie Restriction and Aging

Iain Scott, University of Pittsburgh, USA
The Functional Characterization of SIRT3 Modulation of Complex V of the Electron Transfer Chain

Cristiano Simone, Consorzio Mario Negri Sud, Italy
FoxO3A Localizes to Mitochondria and Regulates the Expression of the Mitochondrial Genome in Response to Nutrient Deprivation

Michael C. Velarde, Institute of Biology, Philippines
Superoxide Dismutase 2 Deficiency Promotes Cellular Senescence and Excessive Differentiation in Mouse Epidermis

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Cells and Organelles Aging II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake
* Sean M. Oldham, Sanford-Burnham Medical Research Institute, USA

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy and Aging

Andrew G. Dillin, University of California, Berkeley, USA
Aging as an Event of Proteostasis Decline

Michael S. Grotewiel, Virginia Commonwealth University, USA
Age-Related Locomotor Impairment in Drosophila

Theodore W. Peters, Buck Institute for Research on Aging, USA
Short Talk: Age-Dependent Accumulation of Insoluble Proteins is Conserved Across Taxa

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 3

Bay
20:00—21:00
Social Hour

Bay

THURSDAY, FEBRUARY 4

07:00—08:00
Breakfast

Granhall
08:00—11:15
Physiological Systems, Aging and Disease I
Meeting has ended...abstracts no longer viewable online.
Session is Sponsored by The Ellison Medical Foundation

Mountain/Lake
* Amy J. Wagers, Harvard University, USA

Paul Joseph Shaw, Washington University, USA
Sleep Aging

Michael O. Thorner, University of Virginia, USA
Potential Role of Ghrelin Mimetics in Preventing Frailty and Partially Reversing Sarcopenia of Aging

Marc Tatar, Brown University, USA
Drosophila as a Model for Analysis of Innate Immune Aging

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Cardiac Aging

Matthew Gill, Buck Institute for Research on Aging, USA
Short Talk: Endocannabinoid signaling and aging in C. elegans

Richard A. Kerber, University of Louisville, USA
Short Talk: Association of Gene Expression Patterns in Lymphoblastoid Cell Lines with Familial Longevity and Survival

09:20—09:40
Coffee Break

Pre Function
11:15
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Physiological Systems, Aging and Disease II
Meeting has ended...abstracts no longer viewable online.
Session is Sponsored by The Ellison Medical Foundation

Mountain/Lake
* Anne Brunet, Stanford University, USA

Monica Driscoll, Rutgers University, USA
Genetic and Pharmacological Extension of Healthspan in a Simple Animal Model

Richard A. Miller, University of Michigan, USA
Cell Stress and Aging

Bradley J. Willcox, Pacific Health Research Institute, USA
Pathophysiological and Sociopsychological Evidence for Active and Resilient Centenarian

Floyd (Ski) Chilton, Wake Forest University School of Medicine, USA
Short Talk: Impact of the Varying Frequencies at Common Genetic Variants in the FADS Gene Cluster on Circulating Levels of Inflammatory Fatty Acids in African Americans and Caucasians

19:00—20:00
Social Hour

Alumni
20:00—21:00
Dinner

Granhall
20:00—23:00
Entertainment

Granhall

FRIDAY, FEBRUARY 5

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

The Ellison Medical Foundation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AG034755-01




We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Gerontological Society of America


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676