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This meeting took place in 2010



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Cilia, Signaling and Human Disease (G1)


Organizer(s) Peter Jackson and Tim Stearns
February 21—26, 2010
Portola Hotel & Spa • Monterey, California USA
Abstract Deadline: Oct 21, 2009
Late Abstract Deadline: Nov 20, 2009
Scholarship Deadline: Oct 21, 2009
Early Registration Deadline: Dec 21, 2009

Supported by The Directors' Fund

Summary of Meeting:
Proteins mediating a host of signaling pathways are organized within primary cilia. Human genetic studies have identified many developmental and degenerative diseases linked to ciliary function. These “ciliopathies” include retinal degeneration, sensory and neurological deficiencies, polycystic kidney disease, and obesity. Molecular genetic studies have connected ciliary transport and assembly mechanisms to developmental pathways, including the Hedgehog pathway, and signaling pathways, including GPCR regulators, but much remains unclear. This meeting will focus on how signaling is organized within cilia. Presentations will span signaling, the cell biology of cilia, human and molecular genetics of ciliopathies, and the biology of ciliated tissues, including morphogen pathways, tissue repair, and links to cell cycle or tumor suppressor control. Drawing on broad expertise and multiple systems, we hope to discuss both well-validated and candidate ciliary genes. The goal is to better define pathways coordinating morphogenesis of ciliated tissue with ciliary assembly and signaling.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 21

15:00—19:30
Registration

18:30—19:30
Refreshments


MONDAY, FEBRUARY 22

07:00—08:00
Breakfast

08:00—11:00
Cell Biology of Cilia and Intraflagellar Transport
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tim Stearns, Stanford University, USA

Joel Rosenbaum, Yale University, USA
Role of IFT in trafficking of polypeptides to and from the ciliary membrane and axoneme

Jonathan Scholey, University of California, Davis, USA
Intraflagellar Transport Motors in C. elegans Neurons

George B. Witman, University of Massachusetts Medical School, USA
Chlamydomonas as a Model for Human Ciliopathies

Gregory J. Pazour, University of Massachusetts Medical School, USA
Trafficking Proteins to the Ciliary Membrane

Christopher J. Westlake, NCI-Frederick, USA
Short Talk: Building the Primary Cilium Membrane: Regulation of GEF Trafficking and Activity and a Rab11-Rab8 Cascade

09:20—09:40
Coffee Break

11:00—
On Own for Lunch and Recreation

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:00
Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jonathan Scholey, University of California, Davis, USA

Val C. Sheffield, University of Iowa, USA
Human Genetics, Function, and Physiology in Bardet-Biedl Syndrome

Maxence V. Nachury, Stanford University School of Medicine, USA
The BBSome is a coat complex for trafficking to the cilium / Discovery and characterization of tubulin acetyl-transferase

Juergen K. Naggert, The Jackson Laboratory, USA
Alstrom Syndrome, a Ciliopathy

Wallace Marshall, University of California, San Francisco, USA
Short Talk: The Flagellar Length Control System

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 23

07:00—08:00
Breakfast

08:00—11:15
Morphogen Pathways and Cilia
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* John Wallingford, University of Texas at Austin, USA

Matthew P. Scott, Stanford University, USA
Hedgehog Signaling: Tracking Down Smo

Andrew P. McMahon, Harvard University, USA
Defective Hedgehog Signaling

H. Joseph Yost, University of Utah, USA
FGF Signaling Pathways and Heparan Sulfate Proteoglycan Fine Structures Converge at Cilia in the Development of Diverse Epithelia

Martin Blum, University of Hohenheim, Germany
Short Talk: The Nodal Inhibitor Coco Represents the Critical Target of Leftward Flow in Xenopus

Ivan P.G. Moskowitz, University of Chicago, USA
Short Talk: An Allelic Series of Intraflagellar Transport Protein 172 Implicates a Quantitative Loss of Hedgehog Signaling in VACTERL with Hydrocephalus

Jeremy F. Reiter, University of California, San Francisco, USA
Ofd1, a Ciliopathy Gene, Regulates the Length and Distal Structure of Centrioles

09:20—09:40
Coffee Break

11:15—
On Own for Lunch and Recreation

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing

16:30—17:00
Coffee Available

17:00—19:00
Neural Development
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Matthew P. Scott, Stanford University, USA

Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center, USA
Trafficking in Primary Cilia and Hedgehog Signaling

Joseph G. Gleeson, University of California, San Diego, USA
Uncovering New Signaling Mechanisms in the Ciliopathy Disorders

Jonathan T. Eggenschwiler, Princeton University, USA
Short Talk: Broad-Minded Links Ciliary Assembly, Cell Cycle-Related Kinase Function, and Mammalian Hedgehog Signaling

Chris R. Kintner, The Salk Institute, USA
Developmental Mechanisms Specifying Different Cilia Subtypes

19:00—20:00
Social Hour with Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, FEBRUARY 24

07:00—08:00
Breakfast

08:00—11:15
Sensory Events and Cilia
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Jeremy F. Reiter, University of California, San Francisco, USA

Piali Sengupta, Brandeis University, USA
Generation and Maintenance of Specialized Sensory Cilia in C. elegans

Abigail Tadenev, Johns Hopkins School of Medicine, USA
Short Talk: Olfactory Phenotypes of BBS8-Null Mice

Jagesh V. Shah, Harvard Medical School, USA
Short Talk: Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

Tomer Avidor-Reiss, Harvard Medical School, USA
Centriole and Cilia - Formation and Inheritance

Brian D. Dynlacht, New York University School of Medicine, USA
CP110 and Control of the Centriole and Cilia Biogenesis

John Wallingford, University of Texas at Austin, USA
Planar Cell Polarity and Ciliogenesis

09:20—09:40
Coffee Break

11:15—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:15
Kidneys, Cysts, and Cystic Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Brian D. Dynlacht, New York University School of Medicine, USA

Peter C. Harris, Mayo Clinic, USA
Role of Cilia in ADPKD and ARPKD

Friedhelm Hildebrandt, Howard Hughes Medical Institute and Boston Children’s Hospital, Harvard Medical School, USA
Genes and Mechanisms of Nephronophthisis-Like Ciliopathies

Peter K. Jackson, Stanford University, USA
The NPHP-Joubert-Meckel-Gruber Network

Michel R. Leroux, Simon Fraser University, Canada
Short Talk: Ciliary Transition Zone Proteins are Required for Proper Basal Body Positioning, Structural Integrity of the Ciliary Gate, and Proper Formation of the Axoneme

Rebecca D. Burdine, Princeton University, USA
Short Talk: Seahorse and Kurly are Members of a Cytoplasmic Complex that Functions in Cilia Motility and Downstream Phenotypes

19:15—20:15
Social Hour with Lite Bites


THURSDAY, FEBRUARY 25

07:00—08:00
Breakfast

08:00—11:00
Cell Cycle, Tumor Suppressors, and Cancer
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Peter K. Jackson, Stanford University, USA

Elizabeth Petri Henske, Brigham and Women's Hospital, USA
Tuberous Sclerosis, LAM, and the Primary Cilium: Where are the Links?

James G. Umen, Donald Danforth Plant Science Center, USA
Short Talk: A Cyclin Dependent Kinase Mutant from Chlamydomonas Reveals a Conserved Role for the Retinoblastoma Tumor Suppressor Pathway in Cilia Biogenesis

Wilhelm Krek, Institute of Molecular Health Sciences, ETH Zürich, Switzerland
VHL Tumor Suppression Mechanisms: From Maintenance of the Primary Cilium to Promotion of Error-free Mitosis

Benedicte Delaval, ,
The Cilia Protein IFT88 Forms Novel Mitotic Complexes and Functions in Spindle Pole Organization and the Orientation of the Mitotic Spindle and the Plane of Cell Division

Tim Stearns, Stanford University, USA
From Microarrays to Cell Biology

09:20—09:40
Coffee Break

11:00—
On Own for Lunch and Recreation

14:30—16:30
Workshop: Short Talk Symposium

* Peter K. Jackson, Stanford University, USA

* Tim Stearns, Stanford University, USA

Cosima T. Baldari, University of Siena, Italy
Intraflagellar Transport is Required for Polarized Recycling of the TCR/CD3 Complex to the Immune Synapse

Saikat Mukhopadhyay, University of Texas Southwestern Medical Center, USA
"A Short Story of a Known Complex and an Unkown Cargo"

Heather H. Ward, University of New Mexico, USA
A Multimeric GTPase Complex is Required for Trafficking Membrane Cystoproteins to Primary Cilia

Marina Bershteyn, University of California, San Francisco, USA
MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling

Sander Basten, University Medical Center Utrecht, Netherlands
Ciliary Gene LRRC50 and Tumorigenesis

Peter G. Czarnecki, Beth Israel Deconess Medical Center, USA
Meckel-Gruber Syndrome Proteins MKS1 and MKS3 in Ciliary Homeostasis and Wnt Signaling

16:30—17:00
Coffee Available

17:00—19:00
Cilia, Evolution, and Human Disease
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Anthony Oro, Stanford University, USA

Arturo Alvarez-Buylla, University of California, San Francisco, USA
Primary Cilia in Neural Stem Cells and Cancer

Mónica Bettencourt Dias, Instituto Gulbenkian de Ciência, Portugal
Centriole Biogenesis and Evolution

Bill Wickstead, University of Nottingham, UK
Short Talk: Reconstructing the Evolutionary History of the Centriole from Protein Components

Nicholas Katsanis, Duke University Medical Center, USA
Total Mutational Load and Ciliary Disease

19:00—20:00
Social Hour with Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 26

 
Departure


*Session Chair †Speaker invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Pubget Inc.

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
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Phone:+1 970-262-2676